API Export of Caspofungin obtained from Indian Customs Trade Statistics

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Chemistry

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Also known as: Cancidas, Caspofungin diacetate, 179463-17-3, Mk 0991, L 743872, Cancidas (tn)
Molecular Formula
C56H96N10O19
Molecular Weight
1213.4  g/mol
InChI Key
OGUJBRYAAJYXQP-LLXMLGLCSA-N

Caspofungin
A cyclic lipopeptide echinocandin and beta-(1,3)-D-glucan synthase inhibitor that is used to treat internal or systemic MYCOSES.
1 2D Structure

Caspofungin

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
acetic acid;N-[(3S,6S,9S,11R,15S,18S,20R,21S,24S,25S)-21-(2-aminoethylamino)-3-[(1R)-3-amino-1-hydroxypropyl]-6-[(1S,2S)-1,2-dihydroxy-2-(4-hydroxyphenyl)ethyl]-11,20,25-trihydroxy-15-[(1R)-1-hydroxyethyl]-2,5,8,14,17,23-hexaoxo-1,4,7,13,16,22-hexazatricyclo[22.3.0.09,13]heptacosan-18-yl]-10,12-dimethyltetradecanamide
2.1.2 InChI
InChI=1S/C52H88N10O15.2C2H4O2/c1-5-28(2)24-29(3)12-10-8-6-7-9-11-13-39(69)56-34-26-38(68)46(55-22-21-54)60-50(75)43-37(67)19-23-61(43)52(77)41(36(66)18-20-53)58-49(74)42(45(71)44(70)31-14-16-32(64)17-15-31)59-48(73)35-25-33(65)27-62(35)51(76)40(30(4)63)57-47(34)72;2*1-2(3)4/h14-17,28-30,33-38,40-46,55,63-68,70-71H,5-13,18-27,53-54H2,1-4H3,(H,56,69)(H,57,72)(H,58,74)(H,59,73)(H,60,75);2*1H3,(H,3,4)/t28?,29?,30-,33-,34+,35+,36-,37+,38-,40+,41+,42+,43+,44+,45+,46+;;/m1../s1
2.1.3 InChI Key
OGUJBRYAAJYXQP-LLXMLGLCSA-N
2.1.4 Canonical SMILES
CCC(C)CC(C)CCCCCCCCC(=O)NC1CC(C(NC(=O)C2C(CCN2C(=O)C(NC(=O)C(NC(=O)C3CC(CN3C(=O)C(NC1=O)C(C)O)O)C(C(C4=CC=C(C=C4)O)O)O)C(CCN)O)O)NCCN)O.CC(=O)O.CC(=O)O
2.1.5 Isomeric SMILES
CCC(C)CC(C)CCCCCCCCC(=O)N[C@H]1C[C@H]([C@H](NC(=O)[C@@H]2[C@H](CCN2C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H]3C[C@H](CN3C(=O)[C@@H](NC1=O)[C@@H](C)O)O)[C@@H]([C@H](C4=CC=C(C=C4)O)O)O)[C@@H](CCN)O)O)NCCN)O.CC(=O)O.CC(=O)O
2.2 Synonyms
2.2.1 MeSH Synonyms

1. Cancidas

2. Caspofungin

3. Caspofungin Msd

4. L 743,872

5. L 743872

6. L-743,872

7. L-743872

8. L743,872

9. L743872

10. Mk 0991

11. Mk-0991

12. Mk0991

2.2.2 Depositor-Supplied Synonyms

1. Cancidas

2. Caspofungin Diacetate

3. 179463-17-3

4. Mk 0991

5. L 743872

6. Cancidas (tn)

7. Mk-0991

8. Caspofungin Acetate- Bio-x

9. Schembl149293

10. L 743873

11. Chembl4297142

12. Caspofungin Acetate (jan/usan)

13. Mfcd08141839

14. Akos025401982

15. Ac-27763

16. Bc164293

17. D02501

18. F20901

19. 463c173

2.3 Create Date
2006-06-06
3 Chemical and Physical Properties
Molecular Weight 1213.4 g/mol
Molecular Formula C56H96N10O19
Hydrogen Bond Donor Count18
Hydrogen Bond Acceptor Count22
Rotatable Bond Count23
Exact Mass1212.68532087 g/mol
Monoisotopic Mass1212.68532087 g/mol
Topological Polar Surface Area487 Ų
Heavy Atom Count85
Formal Charge0
Complexity1930
Isotope Atom Count0
Defined Atom Stereocenter Count14
Undefined Atom Stereocenter Count2
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count3
4 Drug and Medication Information
4.1 Drug Information
1 of 2  
Drug NameCaspofungin acetate
Active IngredientCaspofungin acetate
Dosage FormInjectable
Routeinjection
Strength70mg/vial; 50mg/vial
Market StatusTentative Approval
CompanySandoz

2 of 2  
Drug NameCaspofungin acetate
Active IngredientCaspofungin acetate
Dosage FormInjectable
Routeinjection
Strength70mg/vial; 50mg/vial
Market StatusTentative Approval
CompanySandoz

4.2 Drug Indication

- Treatment of invasive candidiasis in adult or paediatric patients.

- Treatment of invasive aspergillosis in adult or paediatric patients who are refractory to or intolerant of amphotericin B, lipid formulations of amphotericin B and/or itraconazole. Refractoriness is defined as progression of infection or failure to improve after a minimum of 7 days of prior therapeutic doses of effective antifungal therapy.

- Empirical therapy for presumed fungal infections (such as Candida or Aspergillus) in febrile, neutropaenic adult or paediatric patients.


Fungal infections


5 Pharmacology and Biochemistry
5.1 MeSH Pharmacological Classification

Antifungal Agents

Substances that destroy fungi by suppressing their ability to grow or reproduce. They differ from FUNGICIDES, INDUSTRIAL because they defend against fungi present in human or animal tissues. (See all compounds classified as Antifungal Agents.)


Enzyme Inhibitors

Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction. (See all compounds classified as Enzyme Inhibitors.)


5.2 FDA Pharmacological Classification
5.2.1 Pharmacological Classes
Lipopeptides [CS]; Echinocandin Antifungal [EPC]
5.3 ATC Code

J02AX04


API Reference Price

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NITYANAND ROAD ANDHERI EAST"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q3","strtotime":1692297000,"product":"CASPOFUNGIN ACETATE","address":"1209,1210,1211,CABIN A,12TH FLOOR, ,UNIVERSAL MAJESTIC, P L LOKHANDE MARG CHEMBUR,MAHARASHTPIN-400071","city":"CHEMBUR","supplier":"BRIGHTGENE BIO-MEDICAL TECHNOLOGY CO LIMITED","supplierCountry":"CHINA","foreign_port":"NA","customer":"AQUATIC REMEDIES LIMITED","customerCountry":"INDIA","quantity":"1.00","actualQuantity":"1","unit":"KGS","unitRateFc":"90000","totalValueFC":"90649.3","currency":"USD","unitRateINR":"7460539","date":"18-Aug-2023","totalValueINR":"7535898","totalValueInUsd":"90649.3","indian_port":"SAHAR AIR","hs_no":"29420090","bill_no":"0","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"1209,1210,1211,CABIN A,12TH FLOOR, ,UNIVERSAL MAJESTIC, P L LOKHANDE MARG CHEMBUR,MAHARASHTPIN-400071"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q3","strtotime":1694716200,"product":"CASPOFUNGIN ACETATE (LIST3 SR NO 103)( LIST 1 SR NO 103)","address":"2NF FLOOR,BUILDING A,","city":"ANDHERI[W],MUMBAI,","supplier":"SHENZHEN SIJIA PHARMACEUTICAL CO LTD","supplierCountry":"CHINA","foreign_port":"SHANGHAI","customer":"GUFIC BIOSCIENCES","customerCountry":"INDIA","quantity":"1.00","actualQuantity":"1000","unit":"GMS","unitRateFc":"77","totalValueFC":"77757.3","currency":"USD","unitRateINR":"6464.2","date":"15-Sep-2023","totalValueINR":"6464150","totalValueInUsd":"77757.3","indian_port":"Madras Air","hs_no":"29419090","bill_no":"7856106","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"SHANGHAI","supplierAddress":"B305 HUIZHONG MINGYUAN NO 99 DENGLIANG R OAD NANSHAN DISTRICT SHENZHENCITY CHINA 518052 , , CHINA CHINA","customerAddress":"2NF FLOOR,BUILDING A,"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q4","strtotime":1697826600,"product":"CASPOFUNGIN ACETATE (LIST3 SR NO 103)( LIST 1 SR NO 103)","address":"2NF FLOOR,BUILDING A,","city":"ANDHERI[W],MUMBAI,","supplier":"SHENZHEN SIJIA PHARMACEUTICAL CO LTD","supplierCountry":"CHINA","foreign_port":"SHANGHAI","customer":"GUFIC BIOSCIENCES","customerCountry":"INDIA","quantity":"1.00","actualQuantity":"1000","unit":"GMS","unitRateFc":"77","totalValueFC":"77872.1","currency":"USD","unitRateINR":"6483.4","date":"21-Oct-2023","totalValueINR":"6483400","totalValueInUsd":"77872.1","indian_port":"Madras Air","hs_no":"29419090","bill_no":"8420774","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"SHANGHAI","supplierAddress":"B305 HUIZHONG MINGYUAN NO 99 DENGLIANG R OAD NANSHAN DISTRICT SHENZHENCITY CHINA 518052 , , CHINA CHINA","customerAddress":"2NF FLOOR,BUILDING A,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q1","strtotime":1704825000,"product":"CASPOFUNGIN ACETATE","address":"101, SITARAM MANSION,","city":"KAROL BAGH, NEW DELHI","supplier":"BRIGHTGENE BIO-MEDICAL TECHNOLOGY CO.,LTD","supplierCountry":"CHINA","foreign_port":"SHANGHAI - PU DONG","customer":"JODAS EXPOIM PVT. LTD","customerCountry":"INDIA","quantity":"1.00","actualQuantity":"1","unit":"KGS","unitRateFc":"85000","totalValueFC":"86235.8","currency":"USD","unitRateINR":"7161250","date":"10-Jan-2024","totalValueINR":"7161250","totalValueInUsd":"86235.8","indian_port":"Hyderabad Air","hs_no":"29419090","bill_no":"9603614","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"SHANGHAI - PU DONG","supplierAddress":"TECHNOLOGY CO LTD BUILDING C25-C28NO.218 XINGHU ROADSDNF China","customerAddress":"101, SITARAM MANSION,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q1","strtotime":1706553000,"product":"CASPOFUNGIN ACETATE (LIST3 SR NO 103)( LIST 1 SR NO 103) (INV NO TPR24116&TRP24118)","address":"2NF FLOOR,BUILDING A,","city":"ANDHERI[W],MUMBAI,","supplier":"RELIABLE PHARMATECH TIANJIN ","supplierCountry":"CHINA","foreign_port":"SHANGHAI","customer":"GUFIC BIOSCIENCES","customerCountry":"INDIA","quantity":"2.00","actualQuantity":"2000","unit":"GMS","unitRateFc":"77","totalValueFC":"155960.8","currency":"USD","unitRateINR":"6475.7","date":"30-Jan-2024","totalValueINR":"12951400","totalValueInUsd":"155960.8","indian_port":"Madras Air","hs_no":"29419090","bill_no":"9901175","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"SHANGHAI","supplierAddress":"ZUOANMINGDI XIANSHUIGU JINNAN DISTRICT T IANJIN 300350 CHINASDNF CHINA","customerAddress":"2NF FLOOR,BUILDING A,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q1","strtotime":1709577000,"product":"CASPOFUNGIN ACETATE (LIST 3 SR NO 103) (IGST LIST NO 1 SR NO103)","address":"407\/408,SHARDA CHAMBERS,","city":"MUMBAI, MAHARASHTRA.","supplier":"M\/S RULAND CHEMISTRY (NANJING) CO LTD","supplierCountry":"CHINA","foreign_port":"SHANGHAI","customer":"BDR PHARMACEUTICALS","customerCountry":"INDIA","quantity":"0.70","actualQuantity":"0.7005","unit":"KGS","unitRateFc":"76930.8","totalValueFC":"54446.3","currency":"USD","unitRateINR":"6454491.1","date":"05-Mar-2024","totalValueINR":"4521371","totalValueInUsd":"54446.3","indian_port":"Bombay Air","hs_no":"29419090","bill_no":"2436265","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"SHANGHAI","supplierAddress":"RM.1201 HEPING MANSIONNO.22 EAST BEIJING ROADNANJING CHINA 210008 CN","customerAddress":"407\/408,SHARDA CHAMBERS,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1720895400,"product":"CASPOFUNGIN ACETATE","address":"Plot No.4C, MN science & technology biotech park phase-I","city":"Hyderabad","supplier":"MS\/. BRIGHTGENE BIO-MEDICAL","supplierCountry":"CHINA","foreign_port":"SHANGHAI - PU DONG","customer":"PRATHYAK LABORATORIES PRIVATE LIMITED","customerCountry":"INDIA","quantity":"0.28","actualQuantity":"0.28","unit":"KGS","unitRateFc":"130000","totalValueFC":"37016.9","currency":"USD","unitRateINR":"10978500","date":"14-Jul-2024","totalValueINR":"3073980","totalValueInUsd":"37016.9","indian_port":"Hyderabad Air","hs_no":"29419090","bill_no":"4501084","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"SHANGHAI - PU DONG","supplierAddress":"TECHNOLOGY CO., LTD, BUILDING C25-C28, NO. 218 XINGHU ROAD, SUZHOU INDUSTRIAL PARK,SUZHOU, JIANGSU, CHINA CN","customerAddress":"Plot No.4C, MN science & technology biotech park phase-I"}]
19-Jan-2021
16-Jul-2024
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FDF Dossiers

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01

  • fda
  • EDQM
  • WHO-GMP

Virtual BoothCentrient is a leading manufacturer of Beta-Lactam Antibiotics and a provider of next-generation Statins and Antifungals.

Flag Netherlands
Digital Content Digital Content

Regulatory Info :

Registration Country : Netherlands

Caspofungin

Brand Name :

Dosage Form : Powder Concentrate for Infusion Solution

Dosage Strength : 50MG

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Netherlands

Centrient Pharmaceuticals

02

  • fda
  • EDQM
  • WHO-GMP

Virtual BoothCentrient is a leading manufacturer of Beta-Lactam Antibiotics and a provider of next-generation Statins and Antifungals.

Flag Netherlands
Digital Content Digital Content

Regulatory Info :

Registration Country : Netherlands

Caspofungin

Brand Name :

Dosage Form : Powder Concentrate for Infusion Solution

Dosage Strength : 70MG

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Netherlands

Centrient Pharmaceuticals

03

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26th North American ISSX
Not Confirmed

Caspofungin

Brand Name : Caspofungin 50mg Aspen

Dosage Form : INF

Dosage Strength : 50mg

Packaging : 10X1mg

Approval Date :

Application Number :

Regulatory Info : Generic

Registration Country : South Africa

Aspen API Comapny Banner

04

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26th North American ISSX
Not Confirmed

Caspofungin

Brand Name : Caspofungin 70mg Aspen

Dosage Form : INF

Dosage Strength : 70mg

Packaging : 10X1mg

Approval Date :

Application Number :

Regulatory Info : Generic

Registration Country : South Africa

Aspen API Comapny Banner

05

  • fda
  • EDQM
  • WHO-GMP

Virtual BoothPolfa Tarchomin is a leading Polish pharmaceutical company with 200 year tradition in manufacture and sale of pharmaceutical products.

Flag Poland
Digital Content Digital Content

Regulatory Info : Dossier Availability: Q2 2024

Registration Country : Poland

Caspofungin

Brand Name :

Dosage Form : Powder for Infusion Solution

Dosage Strength : 50MG

Packaging :

Approval Date :

Application Number :

Regulatory Info : Dossier Availability: Q2 2024

Registration Country : Poland

Polfa Tarchomin

06

  • fda
  • EDQM
  • WHO-GMP

Virtual BoothPolfa Tarchomin is a leading Polish pharmaceutical company with 200 year tradition in manufacture and sale of pharmaceutical products.

Flag Poland
Digital Content Digital Content

Regulatory Info : Dossier Availability: Q2 2024

Registration Country : Poland

Caspofungin

Brand Name :

Dosage Form : Powder for Infusion Solution

Dosage Strength : 70MG

Packaging :

Approval Date :

Application Number :

Regulatory Info : Dossier Availability: Q2 2024

Registration Country : Poland

Polfa Tarchomin

07

NanoAlvand

Iran
  • fda
  • EDQM
  • WHO-GMP

Virtual BoothNanoAlvand is the entrance to Global Markets as a trusted Highly Potent Products manufacturer.

Flag Iran
Digital Content Digital Content

Regulatory Info :

Registration Country : Iran

Caspofungin

Brand Name : Letocan

Dosage Form : Vial

Dosage Strength : 50MG

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Iran

NanoAlvand

08

NanoAlvand

Iran
  • fda
  • EDQM
  • WHO-GMP

Virtual BoothNanoAlvand is the entrance to Global Markets as a trusted Highly Potent Products manufacturer.

Flag Iran
Digital Content Digital Content

Regulatory Info :

Registration Country : Iran

Caspofungin

Brand Name : Letocan

Dosage Form : Vial

Dosage Strength : 70MG

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Iran

NanoAlvand

09

Pharmathen SA

Greece
  • fda
  • EDQM
  • WHO-GMP

Virtual BoothPharmathen provides life cycle Management solutions for branded pharma, as well as to develop & establish new technology platforms.

Flag Greece
Digital Content Digital Content

Regulatory Info : EU Approved

Registration Country : Greece

Caspofungin

Brand Name :

Dosage Form : Powder For Concentrate For Solution For Infusion

Dosage Strength : 50MG

Packaging :

Approval Date :

Application Number :

Regulatory Info : EU Approved

Registration Country : Greece

Pharmathen

10

Pharmathen SA

Greece
  • fda
  • EDQM
  • WHO-GMP

Virtual BoothPharmathen provides life cycle Management solutions for branded pharma, as well as to develop & establish new technology platforms.

Flag Greece
Digital Content Digital Content

Regulatory Info : EU Approved

Registration Country : Greece

Caspofungin

Brand Name :

Dosage Form : Powder For Concentrate For Solution For Infusion

Dosage Strength : 70MG

Packaging :

Approval Date :

Application Number :

Regulatory Info : EU Approved

Registration Country : Greece

Pharmathen
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DRUG PRODUCT COMPOSITIONS

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DOSAGE - POWDER;INTRAVENOUS - 50MG/VIAL

USFDA APPLICATION NUMBER - 21227

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DOSAGE - POWDER;INTRAVENOUS - 70MG/VIAL

USFDA APPLICATION NUMBER - 21227

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FDF DOSSIERS

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A healthcare consulting service provider is looking for suppliers of Various Finished Dosage Formulations for commercial purposes. The suppliers must support this enquiry with BE study for oral formulations, zone IVb stability data and EUGMP. 1. Caspofungin (50 mg) Vials. The required quantity in the first year is 1,000 units, in the second year is 2,000 units and in the third year is 3,000 units. The packaging should be in box 1 vial. 2. Caspofungin (70 mg) Vials. The required quantity in the first year is 1,000 units, in the second year is 1,000 units and in the third year is 2,000 units. The packaging should be in box 1 vial. 3. Fluconazole (200 mg/ 100 ml) Oral Solution. The required quantity in the first year is 30,000 units, in the second year is 40,000 units and in the third year is 50,000 units. The packaging should be in box 1 bottle. 4. Levofloxacin (750 mg/ 150 ml) Oral Solution. The required quantity in the first year is 100,000 units, in the second year is 150,000 units and in the third year is 200,000 units. The packaging should be in box 1 bottle. 5. Vildagliptin (50 mg) + Metformin (500 mg) Tablets. The required quantity in the first year is 500,000 units, in the second year is 1,000,000 units and in the third year is 1,500,000 units. The packaging should be box 6 blisters x 10 tablets. 6. Vildagliptin (50 mg) + Metformin (850 mg) Tablets. The required quantity in the first year is 2,000,000 units, in the second year is 3,000,000 units and in the third year is 5,000,000 units. The packaging should be box 6 blisters x 10 tablets. 7. Vildagliptin (50 mg) + Metformin (1000 mg) Tablets. The required quantity in the first year is 2,000,000 units, in the second year is 3,000,000 units and in the third year is 5,000,000 units. The packaging should be box 6 blisters x 10 tablets.
09 Jun 2021

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09 Jun 2021

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09 Jun 2021

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