List of Related Excipient Companies and Suppliers of Anidulafungin by Jai Radhe Sales on PharmaCompass.com

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ACTIVE PHARMA INGREDIENTS

20 API Suppliers, 2 USDMF, 2 EU WC, 3 KDMF, 6 NDC API, 18 Listed Suppliers, $ API Reference Price

20 API Suppliers
2 USDMF
2 EU WC
3 KDMF
6 NDC API
18 Listed Suppliers
$ API Reference Price

INTERMEDIATES

1 Intermediates Suppliers

1 Intermediates Suppliers

FINISHED DOSAGE FORMULATIONS

20 FDF Dossiers, 3 FDA Orange Book, 8 Europe, 1 Canada, 3 South Africa, 5 Listed Dossiers

20 FDF Dossiers
3 FDA Orange Book
8 Europe
1 Canada
3 South Africa
5 Listed Dossiers

RELATED EXCIPIENT COMPANIES

1 Rochem International Inc, 14 SPI Pharma, 1 Jai Radhe Sales, 1 Nanjing Well Pharmaceutical, 1 Pfanstiehl, 3 Actylis, 2 BASF, 5 Gangwal Chemicals, 1 Ingredion Pharma Solutions, 2 Kerry, 2 Microlex e.U, 1 Nanjing Bold Chemical, 1 Pluviaendo, 3 Roquette, 6 Seppic, 1 Shanghai Shenmei Pharmaceutical Technology Co., Ltd, 2 Shijiazhuang Huaxu Pharmaceutical, 1 Sigachi Industries

relatedExcipients
1 Rochem International Inc
14 SPI Pharma
1 Jai Radhe Sales
1 Nanjing Well Pharmaceutical
1 Pfanstiehl
3 Actylis
2 BASF
5 Gangwal Chemicals
1 Ingredion Pharma Solutions
2 Kerry
2 Microlex e.U
1 Nanjing Bold Chemical
1 Pluviaendo
3 Roquette
6 Seppic
1 Shanghai Shenmei Pharmaceutical Technology Co., Ltd
2 Shijiazhuang Huaxu Pharmaceutical
1 Sigachi Industries

EXCIPIENTS BY APPLICATIONS

17 Fillers, Diluents & Binders, 11 Chewable & Orodispersible Aids, 11 Parenteral, 11 Solubilizers, 11 Direct Compression, 10 Taste Masking, 4 Co-Processed Excipients, 3 Thickeners and Stabilizers, 3 Disintegrants & Superdisintegrants, 3 Granulation, 3 Topical, 3 Emulsifying Agents, 2 API Stability Enhancers, 2 Film Formers & Plasticizers, 2 Surfactant & Foaming Agents, 1 Rheology Modifiers

excipientsByApplications
17 Fillers, Diluents & Binders
11 Chewable & Orodispersible Aids
11 Parenteral
11 Solubilizers
11 Direct Compression
10 Taste Masking
4 Co-Processed Excipients
3 Thickeners and Stabilizers
3 Disintegrants & Superdisintegrants
3 Granulation
3 Topical
3 Emulsifying Agents
2 API Stability Enhancers
2 Film Formers & Plasticizers
2 Surfactant & Foaming Agents
1 Rheology Modifiers

DIGITAL CONTENT

1 DATA COMPILATION #PharmaFlow, 3 NEWS #PharmaBuzz

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1 DATA COMPILATION #PharmaFlow
3 NEWS #PharmaBuzz

GLOBAL SALES INFORMATION

6 Finished Drug Prices

globalSalesInformation
6 Finished Drug Prices

MARKET PLACE

6 APIs, 1 Intermediates

marketPlace
6 APIs
1 Intermediates

PATENTS & EXCLUSIVITIES

4 Health Canada Patents

patents
4 Health Canada Patents

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

$ 179,170

MARKET PLACE

API

FDF

1INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

0 DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

Annual Reports (USD Million)

Finished Drug Prices

48 RELATED EXCIPIENT COMPANIES

97EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: Eraxis, 166663-25-8, Ecalta, V-echinocandin, Ver-002, Ly303366

Molecular Formula

C₅₈H₇₃N₇O₁₇

Molecular Weight

1140.2 g/mol

InChI Key

JHVAMHSQVVQIOT-MFAJLEFUSA-N

FDA UNII

9HLM53094I

Echinocandin antifungal agent that is used in the treatment of CANDIDEMIA and CANDIDIASIS.

Anidulafungin is an Echinocandin Antifungal.

1 2D Structure

Anidulafungin

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

N-[(3S,6S,9S,11R,15S,18S,20R,21R,24S,25S,26S)-6-[(1S,2S)-1,2-dihydroxy-2-(4-hydroxyphenyl)ethyl]-11,20,21,25-tetrahydroxy-3,15-bis[(1R)-1-hydroxyethyl]-26-methyl-2,5,8,14,17,23-hexaoxo-1,4,7,13,16,22-hexazatricyclo[22.3.0.09,13]heptacosan-18-yl]-4-[4-(4-pentoxyphenyl)phenyl]benzamide

2.1.2 InChI

InChI=1S/C58H73N7O17/c1-5-6-7-24-82-40-22-18-35(19-23-40)33-10-8-32(9-11-33)34-12-14-37(15-13-34)51(74)59-41-26-43(70)54(77)63-56(79)47-48(71)29(2)27-65(47)58(81)45(31(4)67)61-55(78)46(50(73)49(72)36-16-20-38(68)21-17-36)62-53(76)42-25-39(69)28-64(42)57(80)44(30(3)66)60-52(41)75/h8-23,29-31,39,41-50,54,66-73,77H,5-7,24-28H2,1-4H3,(H,59,74)(H,60,75)(H,61,78)(H,62,76)(H,63,79)/t29-,30+,31+,39+,41-,42-,43+,44-,45-,46-,47-,48-,49-,50-,54+/m0/s1

2.1.3 InChI Key

JHVAMHSQVVQIOT-MFAJLEFUSA-N

2.1.4 Canonical SMILES

CCCCCOC1=CC=C(C=C1)C2=CC=C(C=C2)C3=CC=C(C=C3)C(=O)NC4CC(C(NC(=O)C5C(C(CN5C(=O)C(NC(=O)C(NC(=O)C6CC(CN6C(=O)C(NC4=O)C(C)O)O)C(C(C7=CC=C(C=C7)O)O)O)C(C)O)C)O)O)O

2.1.5 Isomeric SMILES

CCCCCOC1=CC=C(C=C1)C2=CC=C(C=C2)C3=CC=C(C=C3)C(=O)N[C@H]4C[C@H]([C@H](NC(=O)[C@@H]5[C@H]([C@H](CN5C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H]6C[C@H](CN6C(=O)[C@@H](NC4=O)[C@@H](C)O)O)[C@@H]([C@H](C7=CC=C(C=C7)O)O)O)[C@@H](C)O)C)O)O)O

2.2 Other Identifiers

2.2.1 UNII

9HLM53094I

2.3 Synonyms

2.3.1 MeSH Synonyms

1. 1-((4r,5r)-4,5-dihydroxy-n2-((4''-(pentyloxy)(1,1':4',1''-terphenyl)-4-yl)carbonyl)-l-ornithine)-echinocandin B

2. Eraxis

3. Ly 303366

4. Ly-303366

5. Ly303366

2.3.2 Depositor-Supplied Synonyms

1. Eraxis

2. 166663-25-8

3. Ecalta

4. V-echinocandin

5. Ver-002

6. Ly303366

7. Ly-303366

8. Anidulafungin (ly303366)

9. Ver002

10. Chebi:55346

11. 9hlm53094i

12. D70013

13. D-70013

14. N-[(3s,6s,9s,11r,15s,18s,20r,21r,24s,25s,26s)-6-[(1s,2s)-1,2-dihydroxy-2-(4-hydroxyphenyl)ethyl]-11,20,21,25-tetrahydroxy-3,15-bis[(1r)-1-hydroxyethyl]-26-methyl-2,5,8,14,17,23-hexaoxo-1,4,7,13,16,22-hexazatricyclo[22.3.0.09,13]heptacosan-18-yl]-4-[4-(4-pentoxyphenyl)phenyl]benzamide

15. Anidulafungin [usan]

16. Anidulafungina

17. Anidulafungine

18. Anidulafunginum

19. Unii-9hlm53094i

20. Anidulafungin [usan:inn:ban]

21. Anidulafungin [mi]

22. Anidulafungin [inn]

23. Schembl38292

24. Anidulafungin [vandf]

25. (4r,5r)-4,5-dihydroxy-n(sup 2)-((4'-(pentyloxy)-p-terphenyl-4-yl)carbonyl)-l-ornithyl-l-threonyl-trans-4-hydroxy-l-prolyl-(s)-4-hydroxy-4-(p-hydroxyphenyl)-l-threonyl-l-threonyl-(3s,4s)-3-hydroxy-4-methyl-l-proline Cyclic (6-1)-peptide

26. Anidulafungin [mart.]

27. Anidulafungin [who-dd]

28. Chembl264241

29. Anidulafungin [ema Epar]

30. Anidulafungin [orange Book]

31. Bdbm50417554

32. Mfcd00917070

33. S4286

34. Ccg-270647

35. Cs-1824

36. Db00362

37. Ncgc00386349-01

38. Hy-13553

39. Sw222238-1

40. A13436

41. 663a258

42. J-010304

43. Q4764531

44. (4r,5r)-4,5-dihydroxy-n(sup 2)-((4''-(pentyloxy)-p-terphenyl-4-yl)carbonyl)-l-ornithyl-l-threonyl-trans-4-hydroxy-l-prolyl-(s)-4-hydroxy-4-(p-hydroxyphenyl)-l-threonyl-l-threonyl-(3s,4s)-3-hydroxy-4-methyl-l-proline Cyclic (6->1)-peptide

45. Echinocandin B, 1-((4r,5r)-4,5-dihydroxy-n(sup 2)-((4''-(pentyloxy)(1,1':4',1''-terphenyl)-4-yl)carbonyl)-l-ornithine)-

46. Echinocandin B, 1-((4r,5r)-4,5-dihydroxy-n2-((4''-(pentyloxy)(1,1':4',1''-terphenyl)-4-yl)carbonyl)-l-ornithine)

47. N-[(3s,6s,9s,11r,15s,18s,20r,21r,24s,25s,26s)-6-[(1s,2s)-1,2-dihydroxy-2-(4-hydroxyphenyl)ethyl]-11,20,21,25-tetrahydroxy-3,15-bis[(1r)-1-hydroxyethyl]-26-methyl-2,5,8,14,17,23-hexaoxo-1,4,7,13,16,22-hexaazatricyclo[22.3.0.0^{9,13}]heptacosan-18-yl]-4-{4-[4-(pentyloxy)phenyl]phenyl}benzamide

48. N-[[(1s,2s)-1,2-dihydroxy-2-(4-hydroxyphenyl)ethyl]-tetrahydroxy-bis[(1r)-1-hydroxyethyl]-methyl-hexaoxo-[?]yl]-4-[4-(4-pentoxyphenyl)phenyl]benzamide

49. N-{(2r,6s,9s,11r,12r,14as,15s,16s,20s,23s,25as)-23-[(1s,2s)-1,2-dihydroxy-2-(4-hydroxyphenyl)ethyl]-2,11,12,15-tetrahydroxy-6,20-bis[(1r)-1-hydroxyethyl]-16-methyl-5,8,14,19,22,25-hexaoxotetracosahydro-1h-dipyrrolo[2,1-c:2',1'-l][1,4,7,10,13,16]hexaazacyclohenicosin-9-yl}-4''-(pentyloxy)-1,1':4',1''-terphenyl-4-carboxamide

2.4 Create Date

2005-08-08

3 Chemical and Physical Properties

Molecular Formula	C₅₈H₇₃N₇O₁₇
Molecular Weight	1140.2 g/mol
XLogP3	2.3
Hydrogen Bond Donor Count	14
Hydrogen Bond Acceptor Count	17
Rotatable Bond Count	14
Exact Mass	1139.50629389 g/mol
Monoisotopic Mass	1139.50629389 g/mol
Topological Polar Surface Area	377 Å²
Heavy Atom Count	82
Formal Charge	0
Complexity	2150
Isotope Atom Count	0
Defined Atom Stereocenter Count	15
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

4 Drug and Medication Information

4.1 Drug Information

1 of 2
Drug Name	Eraxis
PubMed Health	Anidulafungin (Injection)
Drug Classes	Antifungal
Drug Label	ERAXIS for Injection is a sterile, lyophilized product for intravenous (IV) infusion that contains anidulafungin. ERAXIS (anidulafungin) is a semi-synthetic lipopeptide synthesized from a fermentation product of Aspergillus nidulans. Anidulafungin is...
Active Ingredient	Anidulafungin
Dosage Form	Injectable
Route	injection; Iv (infusion)
Strength	100mg/vial; 50mg; 50mg/vial
Market Status	Prescription
Company	Pfizer; Vicuron

2 of 2
Drug Name	Eraxis
PubMed Health	Anidulafungin (Injection)
Drug Classes	Antifungal
Drug Label	ERAXIS for Injection is a sterile, lyophilized product for intravenous (IV) infusion that contains anidulafungin. ERAXIS (anidulafungin) is a semi-synthetic lipopeptide synthesized from a fermentation product of Aspergillus nidulans. Anidulafungin is...
Active Ingredient	Anidulafungin
Dosage Form	Injectable
Route	injection; Iv (infusion)
Strength	100mg/vial; 50mg; 50mg/vial
Market Status	Prescription
Company	Pfizer; Vicuron

4.2 Drug Indication

For use in the treatment of the following fungal infections: Candidemia and other forms of Candida infections (intra-abdominal abscess, and peritonitis), Aspergillus infections, and esophageal candidiasis. Also considered an alternative treatment for oropharyngeal canaidiasis.

FDA Label

Treatment of invasive candidiasis in adults and paediatric patients aged 1 month to < 18 years.

5 Pharmacology and Biochemistry

5.1 Pharmacology

Anidulafungin is a semi-synthetic lipopeptide synthesized from a fermentation product of Aspergillus nidulans. Anidulafungin is an echinocandin, a class of antifungal drugs that inhibits the synthesis of 1,3-β-D-glucan, an essential component of fungal cell walls. Anidulafungin is active in vitro against many Candida, as well as some Aspergillus. Like other echinocandins, anidulafungin is not active against Cryptococcus neoformans, Trichosporon, Fusarium, or zygomycetes.

5.2 MeSH Pharmacological Classification

Antifungal Agents

Substances that destroy fungi by suppressing their ability to grow or reproduce. They differ from FUNGICIDES, INDUSTRIAL because they defend against fungi present in human or animal tissues. (See all compounds classified as Antifungal Agents.)

5.3 FDA Pharmacological Classification

5.3.1 Active Moiety

ANIDULAFUNGIN

5.3.2 FDA UNII

9HLM53094I

5.3.3 Pharmacological Classes

Lipopeptides [CS]; Echinocandin Antifungal [EPC]

5.4 ATC Code

J02AX06

J - Antiinfectives for systemic use

J02 - Antimycotics for systemic use

J02A - Antimycotics for systemic use

J02AX - Other antimycotics for systemic use

J02AX06 - Anidulafungin

5.5 Absorption, Distribution and Excretion

Route of Elimination

Less than 1% of the administered radioactive dose was excreted in the urine. Anidulafungin is not hepatically metabolized.

Volume of Distribution

30 to 50 L

Clearance

1 L/h

5.6 Metabolism/Metabolites

Hepatic metabolism of anidulafungin has not been observed. Anidulafungin is not a clinically relevant substrate, inducer, or inhibitor of cytochrome P450 (CYP450) isoenzymes. Anidulafungin undergoes slow chemical degradation at physiologic temperature and pH to a ring-opened peptide that lacks antifungal activity.

5.7 Biological Half-Life

40-50 hours

5.8 Mechanism of Action

Anidulafungin is a semi-synthetic echinocandin with antifungal activity. Anidulafungin inhibits glucan synthase, an enzyme present in fungal, but not mammalian cells. This results in inhibition of the formation of 1,3-β-D-glucan, an essential component of the fungal cell wall, ultimately leading to osmotic instability and cell death.

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API Reference Price

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