List of Suppliers' Parenteral Excipients Application used in Altiazem Retard on PharmaCompass.com

Altiazem Retard

ChemWerth works in generic API development & supply, non-infringement patent strategy development and regulatory support.

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ACTIVE PHARMA INGREDIENTS

41 API Suppliers, 20 USDMF, 8 CEP/COS, 5 JDMF, 4 EU WC, 6 KDMF, 17 NDC API, 21 Listed Suppliers, $ API Reference Price

41 API Suppliers
20 USDMF
8 CEP/COS
5 JDMF
4 EU WC
6 KDMF
17 NDC API
21 Listed Suppliers
$ API Reference Price

DEVELOPMENTS

2 Drugs in Development

2 Drugs in Development

INTERMEDIATES

2 Intermediates Suppliers

2 Intermediates Suppliers

FINISHED DOSAGE FORMULATIONS

337 FDF Dossiers, 214 FDA Orange Book, 18 Europe, 78 Canada, 7 South Africa, 20 Listed Dossiers

337 FDF Dossiers
214 FDA Orange Book
18 Europe
78 Canada
7 South Africa
20 Listed Dossiers

DRUG PRODUCT COMPOSITIONS

TABLET;ORAL - 120MG, TABLET;ORAL - 30MG, TABLET;ORAL - 60MG, TABLET;ORAL - 90MG, CAPSULE, EXTENDED RELEASE;ORAL - 120MG, CAPSULE, EXTENDED RELEASE;ORAL - 180MG, CAPSULE, EXTENDED RELEASE;ORAL - 240MG, CAPSULE, EXTENDED RELEASE;ORAL - 300MG, CAPSULE, EXTENDED RELEASE;ORAL - 360MG, CAPSULE, EXTENDED RELEASE;ORAL - 120MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**, CAPSULE, EXTENDED RELEASE;ORAL - 180MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**, CAPSULE, EXTENDED RELEASE;ORAL - 240MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**, CAPSULE, EXTENDED RELEASE;ORAL - 120MG, CAPSULE, EXTENDED RELEASE;ORAL - 180MG, CAPSULE, EXTENDED RELEASE;ORAL - 240MG, CAPSULE, EXTENDED RELEASE;ORAL - 300MG, CAPSULE, EXTENDED RELEASE;ORAL - 360MG, CAPSULE, EXTENDED RELEASE;ORAL - 420MG, TABLET, EXTENDED RELEASE;ORAL - 120MG, TABLET, EXTENDED RELEASE;ORAL - 180MG, TABLET, EXTENDED RELEASE;ORAL - 240MG, TABLET, EXTENDED RELEASE;ORAL - 300MG, TABLET, EXTENDED RELEASE;ORAL - 360MG, TABLET, EXTENDED RELEASE;ORAL - 420MG

drugProductComposition
TABLET;ORAL - 120MG
TABLET;ORAL - 30MG
TABLET;ORAL - 60MG
TABLET;ORAL - 90MG
CAPSULE, EXTENDED RELEASE;ORAL - 120MG
CAPSULE, EXTENDED RELEASE;ORAL - 180MG
CAPSULE, EXTENDED RELEASE;ORAL - 240MG
CAPSULE, EXTENDED RELEASE;ORAL - 300MG
CAPSULE, EXTENDED RELEASE;ORAL - 360MG
CAPSULE, EXTENDED RELEASE;ORAL - 120MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**
CAPSULE, EXTENDED RELEASE;ORAL - 180MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**
CAPSULE, EXTENDED RELEASE;ORAL - 240MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**
CAPSULE, EXTENDED RELEASE;ORAL - 120MG
CAPSULE, EXTENDED RELEASE;ORAL - 180MG
CAPSULE, EXTENDED RELEASE;ORAL - 240MG
CAPSULE, EXTENDED RELEASE;ORAL - 300MG
CAPSULE, EXTENDED RELEASE;ORAL - 360MG
CAPSULE, EXTENDED RELEASE;ORAL - 420MG
TABLET, EXTENDED RELEASE;ORAL - 120MG
TABLET, EXTENDED RELEASE;ORAL - 180MG
TABLET, EXTENDED RELEASE;ORAL - 240MG
TABLET, EXTENDED RELEASE;ORAL - 300MG
TABLET, EXTENDED RELEASE;ORAL - 360MG
TABLET, EXTENDED RELEASE;ORAL - 420MG

RELATED EXCIPIENT COMPANIES

5 Evonik, 4 Rochem International Inc, 19 SPI Pharma, 2 Seqens, 9 DKSH, 2 Jai Radhe Sales, 6 Boai NKY Pharmaceuticals Ltd, 13 Gangwal Healthcare, 7 Nanjing Well Pharmaceutical, 2 Pfanstiehl, 4 ACG Worldwide, 10 Actylis, 1 Aeon Procare, 2 Alcedo Pharmachem, 8 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd, 32 BASF, 22 Corel Pharma Chem, 5 DFE Pharma, 2 Finar, 11 Gangwal Chemicals, 13 Ideal Cures Pvt Ltd, 4 Ingredion Pharma Solutions, 31 Kerry, 5 Kima Chemical, 6 Lonza Capsugel, 19 Microlex e.U, 1 Nanjing Bold Chemical, 2 Nomisma Healthcare, 2 Novo Excipients, 2 Pharmatrans-Sanaq, 9 Pluviaendo, 3 Prachin Chemical, 1 Qianhao Chemical (Hebei) Co., Ltd, 2 Qualicaps, 33 Roquette, 14 Seppic, 7 Shanghai Shenmei Pharmaceutical Technology Co., Ltd, 1 Shanghai Welltone Material Technology Co., Ltd, 2 Shijiazhuang Huaxu Pharmaceutical, 11 Sigachi Industries, 4 The Dow Chemical Company, 3 Ulanqab Kema New Material, 2 Valens Pharmachem, 3 Vasa Pharmachem, 3 Vertellus, 1 Zhejiang Huakang Pharmaceutical

relatedExcipients
5 Evonik
4 Rochem International Inc
19 SPI Pharma
2 Seqens
9 DKSH
2 Jai Radhe Sales
6 Boai NKY Pharmaceuticals Ltd
13 Gangwal Healthcare
7 Nanjing Well Pharmaceutical
2 Pfanstiehl
4 ACG Worldwide
10 Actylis
1 Aeon Procare
2 Alcedo Pharmachem
8 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd
32 BASF
22 Corel Pharma Chem
5 DFE Pharma
2 Finar
11 Gangwal Chemicals
13 Ideal Cures Pvt Ltd
4 Ingredion Pharma Solutions
31 Kerry
5 Kima Chemical
6 Lonza Capsugel
19 Microlex e.U
1 Nanjing Bold Chemical
2 Nomisma Healthcare
2 Novo Excipients
2 Pharmatrans-Sanaq
9 Pluviaendo
3 Prachin Chemical
1 Qianhao Chemical (Hebei) Co., Ltd
2 Qualicaps
33 Roquette
14 Seppic
7 Shanghai Shenmei Pharmaceutical Technology Co., Ltd
1 Shanghai Welltone Material Technology Co., Ltd
2 Shijiazhuang Huaxu Pharmaceutical
11 Sigachi Industries
4 The Dow Chemical Company
3 Ulanqab Kema New Material
2 Valens Pharmachem
3 Vasa Pharmachem
3 Vertellus
1 Zhejiang Huakang Pharmaceutical

EXCIPIENTS BY APPLICATIONS

103 Fillers, Diluents & Binders, 73 Coating Systems & Additives, 58 Controlled & Modified Release, 44 Direct Compression, 38 Thickeners and Stabilizers, 37 Solubilizers, 30 Granulation, 30 Taste Masking, 28 Film Formers & Plasticizers, 22 Parenteral, 22 Lubricants & Glidants, 22 Disintegrants & Superdisintegrants, 21 Co-Processed Excipients, 17 Chewable & Orodispersible Aids, 16 Topical, 11 Emulsifying Agents, 9 Empty Capsules, 7 Rheology Modifiers, 7 API Stability Enhancers, 5 Coloring Agents, 4 Vegetarian Capsules, 4 Surfactant & Foaming Agents, 1 Soft Gelatin

DIGITAL CONTENT

30 NEWS #PharmaBuzz

media
30 NEWS #PharmaBuzz

GLOBAL SALES INFORMATION

7 US Medicaid Prescriptions, 63 Finished Drug Prices, 1 Annual Reports

globalSalesInformation
7 US Medicaid Prescriptions
63 Finished Drug Prices
1 Annual Reports

MARKET PLACE

13 APIs, 1 FDF Dossiers

marketPlace
13 APIs
1 FDF Dossiers

PATENTS & EXCLUSIVITIES

25 Health Canada Patents

patents
25 Health Canada Patents

REF. STANDARDS & IMPURITIES

3 EDQM , 3 USP , 2 Others

otherSolutions
3 EDQM
3 USP
2 Others

ANALYTICAL

2 Analytical Methods

otherMethods
2 Analytical Methods

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

$ 93

MARKET PLACE

API

FDF

2INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

337

FDF Dossiers

214

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

2DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

30,765,493

Annual Reports (USD Million)

Finished Drug Prices

350 RELATED EXCIPIENT COMPANIES

609EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: 33286-22-5, Diltiazem hcl, Cardizem, Dilzem, Dilzene, Masdil

Molecular Formula

C₂₂H₂₇ClN₂O₄S

Molecular Weight

451.0 g/mol

InChI Key

HDRXZJPWHTXQRI-BHDTVMLSSA-N

FDA UNII

OLH94387TE

A benzothiazepine derivative with vasodilating action due to its antagonism of the actions of CALCIUM ion on membrane functions.

1 2D Structure

Diltiazem Hydrochloride

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

[(2S,3S)-5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3-dihydro-1,5-benzothiazepin-3-yl] acetate;hydrochloride

2.1.2 InChI

InChI=1S/C22H26N2O4S.ClH/c1-15(25)28-20-21(16-9-11-17(27-4)12-10-16)29-19-8-6-5-7-18(19)24(22(20)26)14-13-23(2)3;/h5-12,20-21H,13-14H2,1-4H3;1H/t20-,21+;/m1./s1

2.1.3 InChI Key

HDRXZJPWHTXQRI-BHDTVMLSSA-N

2.1.4 Canonical SMILES

CC(=O)OC1C(SC2=CC=CC=C2N(C1=O)CCN(C)C)C3=CC=C(C=C3)OC.Cl

2.1.5 Isomeric SMILES

CC(=O)O[C@@H]1[C@@H](SC2=CC=CC=C2N(C1=O)CCN(C)C)C3=CC=C(C=C3)OC.Cl

2.2 Other Identifiers

2.2.1 UNII

OLH94387TE

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Aldizem

2. Cardil

3. Cardizem

4. Crd 401

5. Crd-401

6. Crd401

7. Dilacor

8. Dilacor Xr

9. Dilren

10. Diltiazem

11. Diltiazem Malate

12. Dilzem

13. Tiazac

2.3.2 Depositor-Supplied Synonyms

1. 33286-22-5

2. Diltiazem Hcl

3. Cardizem

4. Dilzem

5. Dilzene

6. Masdil

7. (+)-cis-diltiazem Hydrochloride

8. Tiazac

9. Crd-401

10. Altiazem

11. Deltazen

12. Diladel

13. Dilpral

14. Dilrene

15. Tildiem

16. Adizem

17. Herbesser

18. Dilacor

19. Lacerol

20. Zilden

21. Mono-tildiem

22. Bi-tildiem

23. Cardizem Cd

24. Cardizem La

25. Cardil

26. Dilren

27. Dilthiazem Hydrochloride

28. Diltiazem (hydrochloride)

29. Diltzac

30. Cartia

31. Rg 83606

32. (2s,3s)-5-(2-(dimethylamino)ethyl)-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]thiazepin-3-yl Acetate Hydrochloride

33. Taztia

34. Diltiazem Hcl (tiazac)

35. 103532-26-9

36. Mls000028432

37. Olh94387te

38. Rg 83606 Hcl

39. Chebi:645509

40. Anoheal

41. Nsc-759576

42. (+)-5-(2-(dimethylamino)ethyl)-cis-2,3-dihydro-3-hydroxy-2-(p-methoxyphenyl)-1,5-benzothiazepin-4(5h)-one Acetate (ester) Monohydrochloride

43. (2s,3s)-5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl Acetate Hydrochloride

44. [(2s,3s)-5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3-dihydro-1,5-benzothiazepin-3-yl] Acetate;hydrochloride

45. 38411-61-9

46. Dilzicardin

47. Anginyl

48. Angitil

49. Angizem

50. Britiazim

51. Calcicard

52. Calnurs

53. Cardiazem

54. Cirilen

55. Citizen

56. Clarute

57. Corazet

58. Dilatam

59. Dilatame

60. Dilcard

61. Dilgard

62. Dilicardin

63. Diltahexal

64. Diltelan

65. Diltiasyn

66. Diltikor

67. Diltime

68. Dinisor

69. Dodexen

70. Entrydil

71. Farmabes

72. Gadoserin

73. Helsibon

74. Incoril

75. Kaltiazen

76. Levozem

77. Longazem

78. Lytelsen

79. Metazem

80. Miocardie

81. Oxycardil

82. Pazeadin

83. Pentilzeno

84. Poltiazem

85. Presoken

86. Rg-83606

87. Smr000058375

88. Tilazem

89. Trumsal

90. Ziruvate

91. Bruzem

92. Carzem

93. Diatal

94. Dilfar

95. Dilsal

96. Diltam

97. Diltan

98. Doclis

99. Dyalac

100. Etizen

101. Etyzen

102. Herben

103. Kardil

104. Myonil

105. Slozen

106. Tiadil

107. Tiaves

108. Ubicor

109. Zildem

110. Carex

111. Coras

112. Dazil

113. Dilem

114. Dilso

115. Hesor

116. Tazem

117. Apo-diltiazem

118. Iski

119. Altiazem Retard

120. Cardizem Retard

121. Diltiazem Merck

122. Diltiazem Stada

123. Diltiazem Verla

124. Diltiazem-mepha

125. 33286-22-5 (hcl)

126. Cardil Retard

127. Dil-sonaramia

128. Diltiazem-isis

129. Dilzem Retard

130. Dinisor Retard

131. Myonil Retard

132. Novo-diltazem

133. Syn-diltiazem

134. Tildiem Retard

135. Diltiazem Basics

136. Diltiazem-cophar

137. Mfcd00069252

138. Uni Masdil

139. Wl Diltiazem

140. Altiazem Rr

141. Cardizem Sr

142. Diltiazem Awd

143. Diltiazem Gnr

144. Diltiazem Msd

145. Diltiazem-gry

146. Cirilen Ap

147. Diltiazem Henning

148. Diltiazem Upsa

149. Tildiem Cr

150. Tildiem La

151. Adizem-cd

152. Cartia Xt

153. Diltan Sr

154. Diltiazem Eu Rho

155. Dilzem Rr

156. Taztia Xt

157. Viazem Sr

158. Viazem Xl

159. Herbesser 60

160. (2s-cis)-3-acetoxy-5-(2-(dimethylamino)ethyl)-2,3-dihydro-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5h)-one Monohydrochloride

161. [(2s,3s)-5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3-dihydro-1,5-benzothiazepin-3-yl] Acetate;hydron;chloride

162. 1,5-benzothiazepin-4(5h)-one, 3-(acetyloxy)-5-(2-(dimethylamino)ethyl)-2,3-dihydro-2-(4-methoxyphenyl)-, Monohydrochloride, (+)-cis-

163. Herbesser 90 Sr

164. Tilazem 90

165. Diltiazem Chloridrate

166. Dilatam 120

167. Tilazem As 60

168. Tilazem As 90

169. Dilzereal 90 Retard

170. Herbesser 180 Sr

171. Dolizem

172. Iski-90 Sr

173. Diltia Xt

174. Dilt-xr

175. Dodexen A.p.

176. Presokin A. P.

177. Mk-793

178. Crd 401

179. Tiazac Extended Release

180. Sr-01000003042

181. Einecs 251-443-3

182. Dilacor Xr Extended Release Capsules

183. Unii-olh94387te

184. Milptin

185. Carzen

186. Slozem

187. Crd401

188. Dilthiazem Hcl

189. Dov Diltiazem

190. Uni-masdil

191. Cardizem Xl

192. Tiazac Xc

193. Cardizem (tn)

194. Prestwick_176

195. Acetate Hydrochloride

196. Einecs 253-918-0

197. Dilacor Xr (tn)

198. Cartia Xt (tn)

199. Opera_id_79

200. Diltiazem Hydrochloride [usan:usp:jan]

201. Dilt-cd (tn)

202. (+)-5-(2-(dimethylamino)ethyl)-cis-2,3-dihydro-3-hydroxy-2-(p-methoxyphenyl)-1,5-benzothiazepin-4(5h)-one Acetate Ester Monohydrochloride

203. 2-[(2s,3s)-3-(acetyloxy)-2-(4-methoxyphenyl)-4-oxo-3,4-dihydro-1,5-benzothiazepin-5(2h)-yl]-n,n-dimethylethanaminium Chloride

204. Chembl1697

205. Diltiazem Hydrochloride,(s)

206. Schembl15457

207. Mls001148257

208. Mls002222179

209. Diltiazem Hcl [vandf]

210. (+)-cis-diltiazem Hydrochlorid

211. Diltiazem For System Suitability

212. Dtxsid8040147

213. Amy8835

214. Slv-324

215. Ven-307

216. Hms1568k10

217. (2s-trans)-diltiazem Hydrochloride

218. Act02682

219. Bcp13814

220. Diltiazem Hydrochloride [mi]

221. Tox21_500327

222. Bnp-32762

223. Diltiazem Hydrochloride (jp17/usp)

224. Diltiazem Hydrochloride [jan]

225. S1865

226. 3,3,3-phosphinylidynetrispropionamide

227. Diltiazem Hydrochloride [usan]

228. Akos015961992

229. Ccg-220134

230. Ccg-221631

231. Diltiazem Hydrochloride [mart.]

232. Diltiazem Hydrochloride [vandf]

233. Ks-5089

234. Lp00327

235. Nc00558

236. Nsc 759576

237. Diltiazem Hydrochloride [usp-rs]

238. Diltiazem Hydrochloride [who-dd]

239. Tetrahydrobenzo[b][1,4]thiazepin-3-yl

240. Ncgc00093768-01

241. Ncgc00261012-01

242. (2s,3s)-(+)-3-acetoxy-2,3-dihydro-5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5h)-one Hydrochloride

243. 1,5-benzothiazepin-4(5h)-one, 2,3-dihydro-3-(acetyloxy)-5-(2-(dimethylamino)ethyl)-2-(4-methoxyphenyl)-, Monohydrochloride, Cis-(+)-

244. Ac-15189

245. Ac-32469

246. As-13703

247. Bd166408

248. Cis-(1)-3-acetoxy-5-(2-(dimethylamino)ethyl)-2,3-dihydro-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5h)-one Monohydrochloride

249. Hy-14656

250. (+)-cis-diltiazem Hydrochloride, >/=98%

251. (2s,3s)-5-(2-(dimethylamino)ethyl)-2

252. D3662

253. Diltiazem Hydrochloride [ep Impurity]

254. Diltiazem Hydrochloride [orange Book]

255. Eu-0100327

256. Sw196487-3

257. Diltiazem Hydrochloride [ep Monograph]

258. Bim-0050315.0001

259. D 2521

260. D00616

261. Diltiazem Hydrochloride [usp Monograph]

262. Diltiazem, Hydrochloride - Cas 33286-22-5

263. F20448

264. M01693

265. (+)-cis-diltiazem Hydrochloride, >=99% (hplc)

266. 286d225

267. Sr-01000075327

268. J-019130

269. Sr-01000003042-2

270. Sr-01000003042-4

271. Sr-01000075327-1

272. Q27105183

273. Diltiazem Hydrochloride 1.0 Mg/ml In Acetonitrile (as Free Base)

274. Diltiazem Hydrochloride, European Pharmacopoeia (ep) Reference Standard

275. Diltiazem Hydrochloride, United States Pharmacopeia (usp) Reference Standard

276. Diltiazem For System Suitability, European Pharmacopoeia (ep) Reference Standard

277. (2s,3s)-5-(2-(dimethylamino)ethyl)-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]thiazepin-3-yl Acetate Hcl

278. (2s,3s)-5-(2-(dimethylamino)ethyl)-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]thiazepin-3-ylacetatehydrochloride

279. (2s-cis)-3-(acetyloxy)-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5h)-one Hydrochloride

280. 1,5-benzothiazepin-4(5h)-one, 3-(acetyloxy)-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-, Hydrochloride (1:1), (2s,3s)-

281. Acetic Acid (2s,3s)-5-(2-dimethylamino-ethyl)-2-(4-methoxy-phenyl)-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepin-3-yl Ester; Hydrochloride

282. Cis-(+)-3-acetoxy-2,3-dihydro-5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-1,5-benzothiazepine-4(5h)-one Hydrochloride

283. Diltiazem Hydrochloride Solution, 1.0 Mg/ml In Acetonitrile (as Free Base), Ampule Of 1 Ml, Certified Reference Material

2.4 Create Date

2005-06-24

3 Chemical and Physical Properties

Molecular Formula	C₂₂H₂₇ClN₂O₄S
Molecular Weight	451.0 g/mol
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	7
Exact Mass	450.1380062 g/mol
Monoisotopic Mass	450.1380062 g/mol
Topological Polar Surface Area	84.4 Å²
Heavy Atom Count	30
Formal Charge	0
Complexity	565
Isotope Atom Count	0
Defined Atom Stereocenter Count	2
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Drug and Medication Information

4.1 Drug Information

1 of 16
Drug Name	Cardizem
PubMed Health	Diltiazem
Drug Classes	Antianginal, Antihypertensive, Benzothiazepine, Calcium Channel Blocker, Cardiovascular Agent
Drug Label	CARDIZEM (diltiazem hydrochloride) is a calcium ion cellular influx inhibitor (slow channel blocker or calcium antagonist). Chemically, diltiazem hydrochloride is 1,5-Benzothiazepin-4(5H)-one, 3-(acetyloxy)-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-...
Active Ingredient	Diltiazem hydrochloride
Dosage Form	Tablet
Route	Oral
Strength	60mg; 30mg; 90mg; 120mg
Market Status	Prescription
Company	Valeant Intl

2 of 16
Drug Name	Cardizem cd
Drug Label	CARDIZEM (diltiazem hydrochloride) is a calcium ion influx inhibitor (slow channel blocker or calcium antagonist). Chemically, diltiazem hydrochloride is 1,5-Benzothiazepin-4(5H)-one, 3-(acetyloxy)-5-[2-(dimethylamino)ethyl]-2, 3-dihydro-2-(4-metho...
Active Ingredient	Diltiazem hydrochloride
Dosage Form	Capsule, extended release
Route	Oral
Strength	300mg; 180mg; 120mg; 360mg; 240mg
Market Status	Prescription
Company	Valeant Intl

3 of 16
Drug Name	Cardizem la
PubMed Health	Diltiazem
Drug Classes	Antianginal, Antihypertensive, Benzothiazepine, Calcium Channel Blocker, Cardiovascular Agent
Drug Label	CARDIZEM LA (diltiazem hydrochloride) is a calcium ion cellular influx inhibitor (slow channel blocker or calcium antagonist). Chemically, diltiazem hydrochloride is 1,5-benzothiazepin-4(5H)-one, 3-(acetyloxy)-5-[2-(dimethylamino)ethyl]-2,3-dihydro...
Active Ingredient	Diltiazem hydrochloride
Dosage Form	Tablet, extended release
Route	Oral
Strength	300mg; 180mg; 420mg; 120mg; 360mg; 240mg
Market Status	Prescription
Company	Valeant Intl

4 of 16
Drug Name	Cartia xt
PubMed Health	Diltiazem (Intravenous route)
Drug Classes	Benzothiazepine, Calcium Channel Blocker, Cardiovascular Agent
Drug Label	Diltiazem hydrochloride is a calcium ion cellular influx inhibitor (slow channel blocker or calcium antagonist). Chemically, diltiazem hydrochloride is 1,5-benzothiazepin-4(5H)one,3-(acetyloxy)-5-[2-(dimethylamino) ethyl]-2,3-dihydro-2-(4-methoxyphen...
Active Ingredient	Diltiazem hydrochloride
Dosage Form	Capsule, extended release
Route	Oral
Strength	300mg; 180mg; 120mg; 240mg
Market Status	Prescription
Company	Actavis Labs Fl

5 of 16
Drug Name	Dilacor xr
Drug Label	DILACOR XR (diltiazem hydrochloride, USP) is a calcium ion influx inhibitor (slow channel blocker or calcium antagonist). Chemically, diltiazem hydrochloride is 1,5-Benzothiazepin-4(5H)one,3-(acetyloxy)-5-[2-(dimethylamino) ethyl]-2,3-dihydro-2-(4-...
Active Ingredient	Diltiazem hydrochloride
Dosage Form	Capsule, extended release
Route	Oral
Strength	180mg; 120mg; 240mg
Market Status	Prescription
Company	Watson Labs

6 of 16
Drug Name	Diltiazem hydrochloride
Drug Label	Diltiazem is a calcium ion influx inhibitor (slow channel blocker or calcium antagonist). Chemically, diltiazem hydrochloride is 1,5-Benzothiazepin-4(5H)one,3-(acetyloxy)-5-[2-(dimethylamino) ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-, monohydrochloride...
Active Ingredient	Diltiazem hydrochloride
Dosage Form	Tablet, extended release; Injectable; Tablet; Capsule, extended release
Route	injection; Injection; Oral
Strength	300mg; 50mg/10ml; 180mg; 100mg/vial; 5mg/ml; 30mg; 60mg; 90mg; 125mg/25ml; 420mg; 120mg; 10mg/ml; 360mg; 240mg
Market Status	Prescription
Company	Intl Medication; Bedford; Valeant Intl; Hospira; Hikma Maple; Actavis Labs Fl; Teva; Apotex; Hikma Farmaceutica; Teva Pharms Usa; Sandoz; Sun Pharma Global; Par Pharm; Mylan; Actavis; Akorn

7 of 16
Drug Name	Taztia xt
Drug Label	TAZTIA XT brand ofDILTIAZEM HYDROCHLORIDE EXTENDED-RELEASECAPSULES USP(ONCE-A-DAY DOSAGE)Rx Only...
Active Ingredient	Diltiazem hydrochloride
Dosage Form	Capsule, extended release
Route	Oral
Strength	180mg; 120mg; 360mg; 300mg; 240mg
Market Status	Prescription
Company	Actavis Labs Fl

8 of 16
Drug Name	Tiazac
Drug Label	Tiazac (diltiazem hydrochloride) is a calcium ion cellular influx inhibitor (slow channel blocker). Chemically, diltiazem hydrochloride is 1,5-Benzothiazepin-4(5H)-one, 3-(acetyloxy)-5-[2-(dimethylamino)ethyl]-2, 3-dihydro-2-(4-methoxyphenyl)-, mon...
Active Ingredient	Diltiazem hydrochloride
Dosage Form	Capsule, extended release
Route	Oral
Strength	180mg; 420mg; 120mg; 360mg; 300mg; 240mg
Market Status	Prescription
Company	Valeant Intl

9 of 16
Drug Name	Cardizem
PubMed Health	Diltiazem
Drug Classes	Antianginal, Antihypertensive, Benzothiazepine, Calcium Channel Blocker, Cardiovascular Agent
Drug Label	CARDIZEM (diltiazem hydrochloride) is a calcium ion cellular influx inhibitor (slow channel blocker or calcium antagonist). Chemically, diltiazem hydrochloride is 1,5-Benzothiazepin-4(5H)-one, 3-(acetyloxy)-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-...
Active Ingredient	Diltiazem hydrochloride
Dosage Form	Tablet
Route	Oral
Strength	60mg; 30mg; 90mg; 120mg
Market Status	Prescription
Company	Valeant Intl

10 of 16
Drug Name	Cardizem cd
Drug Label	CARDIZEM (diltiazem hydrochloride) is a calcium ion influx inhibitor (slow channel blocker or calcium antagonist). Chemically, diltiazem hydrochloride is 1,5-Benzothiazepin-4(5H)-one, 3-(acetyloxy)-5-[2-(dimethylamino)ethyl]-2, 3-dihydro-2-(4-metho...
Active Ingredient	Diltiazem hydrochloride
Dosage Form	Capsule, extended release
Route	Oral
Strength	300mg; 180mg; 120mg; 360mg; 240mg
Market Status	Prescription
Company	Valeant Intl

11 of 16
Drug Name	Cardizem la
PubMed Health	Diltiazem
Drug Classes	Antianginal, Antihypertensive, Benzothiazepine, Calcium Channel Blocker, Cardiovascular Agent
Drug Label	CARDIZEM LA (diltiazem hydrochloride) is a calcium ion cellular influx inhibitor (slow channel blocker or calcium antagonist). Chemically, diltiazem hydrochloride is 1,5-benzothiazepin-4(5H)-one, 3-(acetyloxy)-5-[2-(dimethylamino)ethyl]-2,3-dihydro...
Active Ingredient	Diltiazem hydrochloride
Dosage Form	Tablet, extended release
Route	Oral
Strength	300mg; 180mg; 420mg; 120mg; 360mg; 240mg
Market Status	Prescription
Company	Valeant Intl

12 of 16
Drug Name	Cartia xt
PubMed Health	Diltiazem (Intravenous route)
Drug Classes	Benzothiazepine, Calcium Channel Blocker, Cardiovascular Agent
Drug Label	Diltiazem hydrochloride is a calcium ion cellular influx inhibitor (slow channel blocker or calcium antagonist). Chemically, diltiazem hydrochloride is 1,5-benzothiazepin-4(5H)one,3-(acetyloxy)-5-[2-(dimethylamino) ethyl]-2,3-dihydro-2-(4-methoxyphen...
Active Ingredient	Diltiazem hydrochloride
Dosage Form	Capsule, extended release
Route	Oral
Strength	300mg; 180mg; 120mg; 240mg
Market Status	Prescription
Company	Actavis Labs Fl

13 of 16
Drug Name	Dilacor xr
Drug Label	DILACOR XR (diltiazem hydrochloride, USP) is a calcium ion influx inhibitor (slow channel blocker or calcium antagonist). Chemically, diltiazem hydrochloride is 1,5-Benzothiazepin-4(5H)one,3-(acetyloxy)-5-[2-(dimethylamino) ethyl]-2,3-dihydro-2-(4-...
Active Ingredient	Diltiazem hydrochloride
Dosage Form	Capsule, extended release
Route	Oral
Strength	180mg; 120mg; 240mg
Market Status	Prescription
Company	Watson Labs

14 of 16
Drug Name	Diltiazem hydrochloride
Drug Label	Diltiazem is a calcium ion influx inhibitor (slow channel blocker or calcium antagonist). Chemically, diltiazem hydrochloride is 1,5-Benzothiazepin-4(5H)one,3-(acetyloxy)-5-[2-(dimethylamino) ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-, monohydrochloride...
Active Ingredient	Diltiazem hydrochloride
Dosage Form	Tablet, extended release; Injectable; Tablet; Capsule, extended release
Route	injection; Injection; Oral
Strength	300mg; 50mg/10ml; 180mg; 100mg/vial; 5mg/ml; 30mg; 60mg; 90mg; 125mg/25ml; 420mg; 120mg; 10mg/ml; 360mg; 240mg
Market Status	Prescription
Company	Intl Medication; Bedford; Valeant Intl; Hospira; Hikma Maple; Actavis Labs Fl; Teva; Apotex; Hikma Farmaceutica; Teva Pharms Usa; Sandoz; Sun Pharma Global; Par Pharm; Mylan; Actavis; Akorn

15 of 16
Drug Name	Taztia xt
Drug Label	TAZTIA XT brand ofDILTIAZEM HYDROCHLORIDE EXTENDED-RELEASECAPSULES USP(ONCE-A-DAY DOSAGE)Rx Only...
Active Ingredient	Diltiazem hydrochloride
Dosage Form	Capsule, extended release
Route	Oral
Strength	180mg; 120mg; 360mg; 300mg; 240mg
Market Status	Prescription
Company	Actavis Labs Fl

16 of 16
Drug Name	Tiazac
Drug Label	Tiazac (diltiazem hydrochloride) is a calcium ion cellular influx inhibitor (slow channel blocker). Chemically, diltiazem hydrochloride is 1,5-Benzothiazepin-4(5H)-one, 3-(acetyloxy)-5-[2-(dimethylamino)ethyl]-2, 3-dihydro-2-(4-methoxyphenyl)-, mon...
Active Ingredient	Diltiazem hydrochloride
Dosage Form	Capsule, extended release
Route	Oral
Strength	180mg; 420mg; 120mg; 360mg; 300mg; 240mg
Market Status	Prescription
Company	Valeant Intl

4.2 Drug Indication

Treatment of chronic anal fissure

5 Pharmacology and Biochemistry

5.1 MeSH Pharmacological Classification

Antihypertensive Agents

Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS. (See all compounds classified as Antihypertensive Agents.)

Vasodilator Agents

Drugs used to cause dilation of the blood vessels. (See all compounds classified as Vasodilator Agents.)

Calcium Channel Blockers

A class of drugs that act by selective inhibition of calcium influx through cellular membranes. (See all compounds classified as Calcium Channel Blockers.)

Cardiovascular Agents

Agents that affect the rate or intensity of cardiac contraction, blood vessel diameter, or blood volume. (See all compounds classified as Cardiovascular Agents.)

5.2 FDA Pharmacological Classification

5.2.1 Pharmacological Classes

Calcium Channel Blocker [EPC]; Calcium Channel Antagonists [MoA]

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API Reference Price

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FABBRICA ITALIANA SINTETICI S.P.A.","supplierCountry":"ITALY","foreign_port":"N\/A","customer":"PAR PHARMACEUTICAL","customerCountry":"INDIA","quantity":"2064.00","actualQuantity":"2064","unit":"KGS","unitRateFc":"95","totalValueFC":"199195.8","currency":"USD","unitRateINR":"8014.4","date":"30-May-2024","totalValueINR":"16541752","totalValueInUsd":"199195.8","indian_port":"Indore-EPZ\/SEZ","hs_no":"29349990","bill_no":"1003860","productDescription":"API","marketType":"REGULATED MARKET","country":"ITALY","selfForZScoreResived":"Pharma Grade","supplierPort":"N\/A","supplierAddress":"N\/A","customerAddress":"OLD NO.1\/63, NEW NO.1\/58 PUDUPAKKAM"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1721586600,"product":"DILTIAZEM HYDROCHLORIDE USP LOT NO-2038406","address":"1\/5, SANTOSH COMPLEX, ARMUGAM","city":"BANGALORE , KARNATAKA","supplier":"SAGENT PHARMACEUTICALS","supplierCountry":"UNITED STATES","foreign_port":"NEW YORK - JOHN F. K","customer":"MAIVA PHARMA PRIVATE ","customerCountry":"INDIA","quantity":"3.85","actualQuantity":"3.85","unit":"KGS","unitRateFc":"980","totalValueFC":"3841.5","currency":"USD","unitRateINR":"82859","date":"22-Jul-2024","totalValueINR":"319007.15","totalValueInUsd":"3841.5","indian_port":"Bangalore Air","hs_no":"29349990","bill_no":"4646079","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED STATES","selfForZScoreResived":"Pharma Grade","supplierPort":"NEW YORK - JOHN F. K","supplierAddress":"113, CONNCECTICUT COMPLEXPLATTSBURGH NY12903 US","customerAddress":"1\/5, SANTOSH COMPLEX, ARMUGAM"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1721586600,"product":"DILTIAZEM HYDROCHLORIDE USP LOT NO-2038406","address":"1\/5, SANTOSH COMPLEX, ARMUGAM","city":"BANGALORE , KARNATAKA","supplier":"SAGENT PHARMACEUTICALS","supplierCountry":"UNITED STATES","foreign_port":"NEW YORK - JOHN F. K","customer":"MAIVA PHARMA PRIVATE ","customerCountry":"INDIA","quantity":"29.09","actualQuantity":"29.09","unit":"KGS","unitRateFc":"980","totalValueFC":"29025.7","currency":"USD","unitRateINR":"82859","date":"22-Jul-2024","totalValueINR":"2410368.31","totalValueInUsd":"29025.7","indian_port":"Bangalore Air","hs_no":"29349990","bill_no":"4646079","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED STATES","selfForZScoreResived":"Pharma Grade","supplierPort":"NEW YORK - JOHN F. K","supplierAddress":"113, CONNCECTICUT COMPLEXPLATTSBURGH NY12903 US","customerAddress":"1\/5, SANTOSH COMPLEX, ARMUGAM"}]

Number of Transactions

Total Quantity (KGS)

Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

Importing Country	Total Quantity (KGS)	Average Price (USD/KGS)	Number of Transactions

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Drugs in Development

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DRUG PRODUCT COMPOSITIONS

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DOSAGE - TABLET;ORAL - 120MG

USFDA APPLICATION NUMBER - 18602

DOSAGE - TABLET;ORAL - 30MG

USFDA APPLICATION NUMBER - 18602

DOSAGE - TABLET;ORAL - 60MG

USFDA APPLICATION NUMBER - 18602

DOSAGE - TABLET;ORAL - 90MG

USFDA APPLICATION NUMBER - 18602

DOSAGE - CAPSULE, EXTENDED RELEASE;ORAL - 120...DOSAGE - CAPSULE, EXTENDED RELEASE;ORAL - 120MG

USFDA APPLICATION NUMBER - 20062

DOSAGE - CAPSULE, EXTENDED RELEASE;ORAL - 180...DOSAGE - CAPSULE, EXTENDED RELEASE;ORAL - 180MG

USFDA APPLICATION NUMBER - 20062

DOSAGE - CAPSULE, EXTENDED RELEASE;ORAL - 240...DOSAGE - CAPSULE, EXTENDED RELEASE;ORAL - 240MG

USFDA APPLICATION NUMBER - 20062

DOSAGE - CAPSULE, EXTENDED RELEASE;ORAL - 300...DOSAGE - CAPSULE, EXTENDED RELEASE;ORAL - 300MG

USFDA APPLICATION NUMBER - 20062

DOSAGE - CAPSULE, EXTENDED RELEASE;ORAL - 360...DOSAGE - CAPSULE, EXTENDED RELEASE;ORAL - 360MG

USFDA APPLICATION NUMBER - 20062

DOSAGE - CAPSULE, EXTENDED RELEASE;ORAL - 120...DOSAGE - CAPSULE, EXTENDED RELEASE;ORAL - 120MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

USFDA APPLICATION NUMBER - 20092

DOSAGE - CAPSULE, EXTENDED RELEASE;ORAL - 180...DOSAGE - CAPSULE, EXTENDED RELEASE;ORAL - 180MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

USFDA APPLICATION NUMBER - 20092

DOSAGE - CAPSULE, EXTENDED RELEASE;ORAL - 240...DOSAGE - CAPSULE, EXTENDED RELEASE;ORAL - 240MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

USFDA APPLICATION NUMBER - 20092

DOSAGE - CAPSULE, EXTENDED RELEASE;ORAL - 120...DOSAGE - CAPSULE, EXTENDED RELEASE;ORAL - 120MG

USFDA APPLICATION NUMBER - 20401

DOSAGE - CAPSULE, EXTENDED RELEASE;ORAL - 180...DOSAGE - CAPSULE, EXTENDED RELEASE;ORAL - 180MG

USFDA APPLICATION NUMBER - 20401

DOSAGE - CAPSULE, EXTENDED RELEASE;ORAL - 240...DOSAGE - CAPSULE, EXTENDED RELEASE;ORAL - 240MG

USFDA APPLICATION NUMBER - 20401

DOSAGE - CAPSULE, EXTENDED RELEASE;ORAL - 300...DOSAGE - CAPSULE, EXTENDED RELEASE;ORAL - 300MG

USFDA APPLICATION NUMBER - 20401

DOSAGE - CAPSULE, EXTENDED RELEASE;ORAL - 360...DOSAGE - CAPSULE, EXTENDED RELEASE;ORAL - 360MG

USFDA APPLICATION NUMBER - 20401

DOSAGE - CAPSULE, EXTENDED RELEASE;ORAL - 420...DOSAGE - CAPSULE, EXTENDED RELEASE;ORAL - 420MG

USFDA APPLICATION NUMBER - 20401

DOSAGE - TABLET, EXTENDED RELEASE;ORAL - 120M...DOSAGE - TABLET, EXTENDED RELEASE;ORAL - 120MG