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Chemistry

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Also known as: 33286-22-5, Diltiazem hcl, Cardizem, Dilzem, Dilzene, Masdil
Molecular Formula
C22H27ClN2O4S
Molecular Weight
451.0  g/mol
InChI Key
HDRXZJPWHTXQRI-BHDTVMLSSA-N
FDA UNII
OLH94387TE

Diltiazem Hydrochloride
A benzothiazepine derivative with vasodilating action due to its antagonism of the actions of CALCIUM ion on membrane functions.
1 2D Structure

Diltiazem Hydrochloride

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
[(2S,3S)-5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3-dihydro-1,5-benzothiazepin-3-yl] acetate;hydrochloride
2.1.2 InChI
InChI=1S/C22H26N2O4S.ClH/c1-15(25)28-20-21(16-9-11-17(27-4)12-10-16)29-19-8-6-5-7-18(19)24(22(20)26)14-13-23(2)3;/h5-12,20-21H,13-14H2,1-4H3;1H/t20-,21+;/m1./s1
2.1.3 InChI Key
HDRXZJPWHTXQRI-BHDTVMLSSA-N
2.1.4 Canonical SMILES
CC(=O)OC1C(SC2=CC=CC=C2N(C1=O)CCN(C)C)C3=CC=C(C=C3)OC.Cl
2.1.5 Isomeric SMILES
CC(=O)O[C@@H]1[C@@H](SC2=CC=CC=C2N(C1=O)CCN(C)C)C3=CC=C(C=C3)OC.Cl
2.2 Other Identifiers
2.2.1 UNII
OLH94387TE
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Aldizem

2. Cardil

3. Cardizem

4. Crd 401

5. Crd-401

6. Crd401

7. Dilacor

8. Dilacor Xr

9. Dilren

10. Diltiazem

11. Diltiazem Malate

12. Dilzem

13. Tiazac

2.3.2 Depositor-Supplied Synonyms

1. 33286-22-5

2. Diltiazem Hcl

3. Cardizem

4. Dilzem

5. Dilzene

6. Masdil

7. (+)-cis-diltiazem Hydrochloride

8. Tiazac

9. Crd-401

10. Altiazem

11. Deltazen

12. Diladel

13. Dilpral

14. Dilrene

15. Tildiem

16. Adizem

17. Herbesser

18. Dilacor

19. Lacerol

20. Zilden

21. Mono-tildiem

22. Bi-tildiem

23. Cardizem Cd

24. Cardizem La

25. Cardil

26. Dilren

27. Dilthiazem Hydrochloride

28. Diltiazem (hydrochloride)

29. Diltzac

30. Cartia

31. Rg 83606

32. (2s,3s)-5-(2-(dimethylamino)ethyl)-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]thiazepin-3-yl Acetate Hydrochloride

33. Taztia

34. Diltiazem Hcl (tiazac)

35. 103532-26-9

36. Mls000028432

37. Olh94387te

38. Rg 83606 Hcl

39. Chebi:645509

40. Anoheal

41. Nsc-759576

42. (+)-5-(2-(dimethylamino)ethyl)-cis-2,3-dihydro-3-hydroxy-2-(p-methoxyphenyl)-1,5-benzothiazepin-4(5h)-one Acetate (ester) Monohydrochloride

43. (2s,3s)-5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl Acetate Hydrochloride

44. [(2s,3s)-5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3-dihydro-1,5-benzothiazepin-3-yl] Acetate;hydrochloride

45. 38411-61-9

46. Dilzicardin

47. Anginyl

48. Angitil

49. Angizem

50. Britiazim

51. Calcicard

52. Calnurs

53. Cardiazem

54. Cirilen

55. Citizen

56. Clarute

57. Corazet

58. Dilatam

59. Dilatame

60. Dilcard

61. Dilgard

62. Dilicardin

63. Diltahexal

64. Diltelan

65. Diltiasyn

66. Diltikor

67. Diltime

68. Dinisor

69. Dodexen

70. Entrydil

71. Farmabes

72. Gadoserin

73. Helsibon

74. Incoril

75. Kaltiazen

76. Levozem

77. Longazem

78. Lytelsen

79. Metazem

80. Miocardie

81. Oxycardil

82. Pazeadin

83. Pentilzeno

84. Poltiazem

85. Presoken

86. Rg-83606

87. Smr000058375

88. Tilazem

89. Trumsal

90. Ziruvate

91. Bruzem

92. Carzem

93. Diatal

94. Dilfar

95. Dilsal

96. Diltam

97. Diltan

98. Doclis

99. Dyalac

100. Etizen

101. Etyzen

102. Herben

103. Kardil

104. Myonil

105. Slozen

106. Tiadil

107. Tiaves

108. Ubicor

109. Zildem

110. Carex

111. Coras

112. Dazil

113. Dilem

114. Dilso

115. Hesor

116. Tazem

117. Apo-diltiazem

118. Iski

119. Altiazem Retard

120. Cardizem Retard

121. Diltiazem Merck

122. Diltiazem Stada

123. Diltiazem Verla

124. Diltiazem-mepha

125. 33286-22-5 (hcl)

126. Cardil Retard

127. Dil-sonaramia

128. Diltiazem-isis

129. Dilzem Retard

130. Dinisor Retard

131. Myonil Retard

132. Novo-diltazem

133. Syn-diltiazem

134. Tildiem Retard

135. Diltiazem Basics

136. Diltiazem-cophar

137. Mfcd00069252

138. Uni Masdil

139. Wl Diltiazem

140. Altiazem Rr

141. Cardizem Sr

142. Diltiazem Awd

143. Diltiazem Gnr

144. Diltiazem Msd

145. Diltiazem-gry

146. Cirilen Ap

147. Diltiazem Henning

148. Diltiazem Upsa

149. Tildiem Cr

150. Tildiem La

151. Adizem-cd

152. Cartia Xt

153. Diltan Sr

154. Diltiazem Eu Rho

155. Dilzem Rr

156. Taztia Xt

157. Viazem Sr

158. Viazem Xl

159. Herbesser 60

160. (2s-cis)-3-acetoxy-5-(2-(dimethylamino)ethyl)-2,3-dihydro-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5h)-one Monohydrochloride

161. [(2s,3s)-5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3-dihydro-1,5-benzothiazepin-3-yl] Acetate;hydron;chloride

162. 1,5-benzothiazepin-4(5h)-one, 3-(acetyloxy)-5-(2-(dimethylamino)ethyl)-2,3-dihydro-2-(4-methoxyphenyl)-, Monohydrochloride, (+)-cis-

163. Herbesser 90 Sr

164. Tilazem 90

165. Diltiazem Chloridrate

166. Dilatam 120

167. Tilazem As 60

168. Tilazem As 90

169. Dilzereal 90 Retard

170. Herbesser 180 Sr

171. Dolizem

172. Iski-90 Sr

173. Diltia Xt

174. Dilt-xr

175. Dodexen A.p.

176. Presokin A. P.

177. Mk-793

178. Crd 401

179. Tiazac Extended Release

180. Sr-01000003042

181. Einecs 251-443-3

182. Dilacor Xr Extended Release Capsules

183. Unii-olh94387te

184. Milptin

185. Carzen

186. Slozem

187. Crd401

188. Dilthiazem Hcl

189. Dov Diltiazem

190. Uni-masdil

191. Cardizem Xl

192. Tiazac Xc

193. Cardizem (tn)

194. Prestwick_176

195. Acetate Hydrochloride

196. Einecs 253-918-0

197. Dilacor Xr (tn)

198. Cartia Xt (tn)

199. Opera_id_79

200. Diltiazem Hydrochloride [usan:usp:jan]

201. Dilt-cd (tn)

202. (+)-5-(2-(dimethylamino)ethyl)-cis-2,3-dihydro-3-hydroxy-2-(p-methoxyphenyl)-1,5-benzothiazepin-4(5h)-one Acetate Ester Monohydrochloride

203. 2-[(2s,3s)-3-(acetyloxy)-2-(4-methoxyphenyl)-4-oxo-3,4-dihydro-1,5-benzothiazepin-5(2h)-yl]-n,n-dimethylethanaminium Chloride

204. Chembl1697

205. Diltiazem Hydrochloride,(s)

206. Schembl15457

207. Mls001148257

208. Mls002222179

209. Diltiazem Hcl [vandf]

210. (+)-cis-diltiazem Hydrochlorid

211. Diltiazem For System Suitability

212. Dtxsid8040147

213. Amy8835

214. Slv-324

215. Ven-307

216. Hms1568k10

217. (2s-trans)-diltiazem Hydrochloride

218. Act02682

219. Bcp13814

220. Diltiazem Hydrochloride [mi]

221. Tox21_500327

222. Bnp-32762

223. Diltiazem Hydrochloride (jp17/usp)

224. Diltiazem Hydrochloride [jan]

225. S1865

226. 3,3,3-phosphinylidynetrispropionamide

227. Diltiazem Hydrochloride [usan]

228. Akos015961992

229. Ccg-220134

230. Ccg-221631

231. Diltiazem Hydrochloride [mart.]

232. Diltiazem Hydrochloride [vandf]

233. Ks-5089

234. Lp00327

235. Nc00558

236. Nsc 759576

237. Diltiazem Hydrochloride [usp-rs]

238. Diltiazem Hydrochloride [who-dd]

239. Tetrahydrobenzo[b][1,4]thiazepin-3-yl

240. Ncgc00093768-01

241. Ncgc00261012-01

242. (2s,3s)-(+)-3-acetoxy-2,3-dihydro-5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5h)-one Hydrochloride

243. 1,5-benzothiazepin-4(5h)-one, 2,3-dihydro-3-(acetyloxy)-5-(2-(dimethylamino)ethyl)-2-(4-methoxyphenyl)-, Monohydrochloride, Cis-(+)-

244. Ac-15189

245. Ac-32469

246. As-13703

247. Bd166408

248. Cis-(1)-3-acetoxy-5-(2-(dimethylamino)ethyl)-2,3-dihydro-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5h)-one Monohydrochloride

249. Hy-14656

250. (+)-cis-diltiazem Hydrochloride, >/=98%

251. (2s,3s)-5-(2-(dimethylamino)ethyl)-2

252. D3662

253. Diltiazem Hydrochloride [ep Impurity]

254. Diltiazem Hydrochloride [orange Book]

255. Eu-0100327

256. Sw196487-3

257. Diltiazem Hydrochloride [ep Monograph]

258. Bim-0050315.0001

259. D 2521

260. D00616

261. Diltiazem Hydrochloride [usp Monograph]

262. Diltiazem, Hydrochloride - Cas 33286-22-5

263. F20448

264. M01693

265. (+)-cis-diltiazem Hydrochloride, >=99% (hplc)

266. 286d225

267. Sr-01000075327

268. J-019130

269. Sr-01000003042-2

270. Sr-01000003042-4

271. Sr-01000075327-1

272. Q27105183

273. Diltiazem Hydrochloride 1.0 Mg/ml In Acetonitrile (as Free Base)

274. Diltiazem Hydrochloride, European Pharmacopoeia (ep) Reference Standard

275. Diltiazem Hydrochloride, United States Pharmacopeia (usp) Reference Standard

276. Diltiazem For System Suitability, European Pharmacopoeia (ep) Reference Standard

277. (2s,3s)-5-(2-(dimethylamino)ethyl)-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]thiazepin-3-yl Acetate Hcl

278. (2s,3s)-5-(2-(dimethylamino)ethyl)-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]thiazepin-3-ylacetatehydrochloride

279. (2s-cis)-3-(acetyloxy)-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5h)-one Hydrochloride

280. 1,5-benzothiazepin-4(5h)-one, 3-(acetyloxy)-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-, Hydrochloride (1:1), (2s,3s)-

281. Acetic Acid (2s,3s)-5-(2-dimethylamino-ethyl)-2-(4-methoxy-phenyl)-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepin-3-yl Ester; Hydrochloride

282. Cis-(+)-3-acetoxy-2,3-dihydro-5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-1,5-benzothiazepine-4(5h)-one Hydrochloride

283. Diltiazem Hydrochloride Solution, 1.0 Mg/ml In Acetonitrile (as Free Base), Ampule Of 1 Ml, Certified Reference Material

2.4 Create Date
2005-06-24
3 Chemical and Physical Properties
Molecular Weight 451.0 g/mol
Molecular Formula C22H27ClN2O4S
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count6
Rotatable Bond Count7
Exact Mass450.1380062 g/mol
Monoisotopic Mass450.1380062 g/mol
Topological Polar Surface Area84.4 Ų
Heavy Atom Count30
Formal Charge0
Complexity565
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Drug and Medication Information
4.1 Drug Information
1 of 16  
Drug NameCardizem
PubMed HealthDiltiazem
Drug ClassesAntianginal, Antihypertensive, Benzothiazepine, Calcium Channel Blocker, Cardiovascular Agent
Drug LabelCARDIZEM (diltiazem hydrochloride) is a calcium ion cellular influx inhibitor (slow channel blocker or calcium antagonist). Chemically, diltiazem hydrochloride is 1,5-Benzothiazepin-4(5H)-one, 3-(acetyloxy)-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-...
Active IngredientDiltiazem hydrochloride
Dosage FormTablet
RouteOral
Strength60mg; 30mg; 90mg; 120mg
Market StatusPrescription
CompanyValeant Intl

2 of 16  
Drug NameCardizem cd
Drug LabelCARDIZEM (diltiazem hydrochloride) is a calcium ion influx inhibitor (slow channel blocker or calcium antagonist). Chemically, diltiazem hydrochloride is 1,5-Benzothiazepin-4(5H)-one, 3-(acetyloxy)-5-[2-(dimethylamino)ethyl]-2, 3-dihydro-2-(4-metho...
Active IngredientDiltiazem hydrochloride
Dosage FormCapsule, extended release
RouteOral
Strength300mg; 180mg; 120mg; 360mg; 240mg
Market StatusPrescription
CompanyValeant Intl

3 of 16  
Drug NameCardizem la
PubMed HealthDiltiazem
Drug ClassesAntianginal, Antihypertensive, Benzothiazepine, Calcium Channel Blocker, Cardiovascular Agent
Drug LabelCARDIZEM LA (diltiazem hydrochloride) is a calcium ion cellular influx inhibitor (slow channel blocker or calcium antagonist). Chemically, diltiazem hydrochloride is 1,5-benzothiazepin-4(5H)-one, 3-(acetyloxy)-5-[2-(dimethylamino)ethyl]-2,3-dihydro...
Active IngredientDiltiazem hydrochloride
Dosage FormTablet, extended release
RouteOral
Strength300mg; 180mg; 420mg; 120mg; 360mg; 240mg
Market StatusPrescription
CompanyValeant Intl

4 of 16  
Drug NameCartia xt
PubMed HealthDiltiazem (Intravenous route)
Drug ClassesBenzothiazepine, Calcium Channel Blocker, Cardiovascular Agent
Drug LabelDiltiazem hydrochloride is a calcium ion cellular influx inhibitor (slow channel blocker or calcium antagonist). Chemically, diltiazem hydrochloride is 1,5-benzothiazepin-4(5H)one,3-(acetyloxy)-5-[2-(dimethylamino) ethyl]-2,3-dihydro-2-(4-methoxyphen...
Active IngredientDiltiazem hydrochloride
Dosage FormCapsule, extended release
RouteOral
Strength300mg; 180mg; 120mg; 240mg
Market StatusPrescription
CompanyActavis Labs Fl

5 of 16  
Drug NameDilacor xr
Drug LabelDILACOR XR (diltiazem hydrochloride, USP) is a calcium ion influx inhibitor (slow channel blocker or calcium antagonist). Chemically, diltiazem hydrochloride is 1,5-Benzothiazepin-4(5H)one,3-(acetyloxy)-5-[2-(dimethylamino) ethyl]-2,3-dihydro-2-(4-...
Active IngredientDiltiazem hydrochloride
Dosage FormCapsule, extended release
RouteOral
Strength180mg; 120mg; 240mg
Market StatusPrescription
CompanyWatson Labs

6 of 16  
Drug NameDiltiazem hydrochloride
Drug LabelDiltiazem is a calcium ion influx inhibitor (slow channel blocker or calcium antagonist). Chemically, diltiazem hydrochloride is 1,5-Benzothiazepin-4(5H)one,3-(acetyloxy)-5-[2-(dimethylamino) ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-, monohydrochloride...
Active IngredientDiltiazem hydrochloride
Dosage FormTablet, extended release; Injectable; Tablet; Capsule, extended release
Routeinjection; Injection; Oral
Strength300mg; 50mg/10ml; 180mg; 100mg/vial; 5mg/ml; 30mg; 60mg; 90mg; 125mg/25ml; 420mg; 120mg; 10mg/ml; 360mg; 240mg
Market StatusPrescription
CompanyIntl Medication; Bedford; Valeant Intl; Hospira; Hikma Maple; Actavis Labs Fl; Teva; Apotex; Hikma Farmaceutica; Teva Pharms Usa; Sandoz; Sun Pharma Global; Par Pharm; Mylan; Actavis; Akorn

7 of 16  
Drug NameTaztia xt
Drug LabelTAZTIA XT brand ofDILTIAZEM HYDROCHLORIDE EXTENDED-RELEASECAPSULES USP(ONCE-A-DAY DOSAGE)Rx Only...
Active IngredientDiltiazem hydrochloride
Dosage FormCapsule, extended release
RouteOral
Strength180mg; 120mg; 360mg; 300mg; 240mg
Market StatusPrescription
CompanyActavis Labs Fl

8 of 16  
Drug NameTiazac
Drug LabelTiazac (diltiazem hydrochloride) is a calcium ion cellular influx inhibitor (slow channel blocker). Chemically, diltiazem hydrochloride is 1,5-Benzothiazepin-4(5H)-one, 3-(acetyloxy)-5-[2-(dimethylamino)ethyl]-2, 3-dihydro-2-(4-methoxyphenyl)-, mon...
Active IngredientDiltiazem hydrochloride
Dosage FormCapsule, extended release
RouteOral
Strength180mg; 420mg; 120mg; 360mg; 300mg; 240mg
Market StatusPrescription
CompanyValeant Intl

9 of 16  
Drug NameCardizem
PubMed HealthDiltiazem
Drug ClassesAntianginal, Antihypertensive, Benzothiazepine, Calcium Channel Blocker, Cardiovascular Agent
Drug LabelCARDIZEM (diltiazem hydrochloride) is a calcium ion cellular influx inhibitor (slow channel blocker or calcium antagonist). Chemically, diltiazem hydrochloride is 1,5-Benzothiazepin-4(5H)-one, 3-(acetyloxy)-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-...
Active IngredientDiltiazem hydrochloride
Dosage FormTablet
RouteOral
Strength60mg; 30mg; 90mg; 120mg
Market StatusPrescription
CompanyValeant Intl

10 of 16  
Drug NameCardizem cd
Drug LabelCARDIZEM (diltiazem hydrochloride) is a calcium ion influx inhibitor (slow channel blocker or calcium antagonist). Chemically, diltiazem hydrochloride is 1,5-Benzothiazepin-4(5H)-one, 3-(acetyloxy)-5-[2-(dimethylamino)ethyl]-2, 3-dihydro-2-(4-metho...
Active IngredientDiltiazem hydrochloride
Dosage FormCapsule, extended release
RouteOral
Strength300mg; 180mg; 120mg; 360mg; 240mg
Market StatusPrescription
CompanyValeant Intl

11 of 16  
Drug NameCardizem la
PubMed HealthDiltiazem
Drug ClassesAntianginal, Antihypertensive, Benzothiazepine, Calcium Channel Blocker, Cardiovascular Agent
Drug LabelCARDIZEM LA (diltiazem hydrochloride) is a calcium ion cellular influx inhibitor (slow channel blocker or calcium antagonist). Chemically, diltiazem hydrochloride is 1,5-benzothiazepin-4(5H)-one, 3-(acetyloxy)-5-[2-(dimethylamino)ethyl]-2,3-dihydro...
Active IngredientDiltiazem hydrochloride
Dosage FormTablet, extended release
RouteOral
Strength300mg; 180mg; 420mg; 120mg; 360mg; 240mg
Market StatusPrescription
CompanyValeant Intl

12 of 16  
Drug NameCartia xt
PubMed HealthDiltiazem (Intravenous route)
Drug ClassesBenzothiazepine, Calcium Channel Blocker, Cardiovascular Agent
Drug LabelDiltiazem hydrochloride is a calcium ion cellular influx inhibitor (slow channel blocker or calcium antagonist). Chemically, diltiazem hydrochloride is 1,5-benzothiazepin-4(5H)one,3-(acetyloxy)-5-[2-(dimethylamino) ethyl]-2,3-dihydro-2-(4-methoxyphen...
Active IngredientDiltiazem hydrochloride
Dosage FormCapsule, extended release
RouteOral
Strength300mg; 180mg; 120mg; 240mg
Market StatusPrescription
CompanyActavis Labs Fl

13 of 16  
Drug NameDilacor xr
Drug LabelDILACOR XR (diltiazem hydrochloride, USP) is a calcium ion influx inhibitor (slow channel blocker or calcium antagonist). Chemically, diltiazem hydrochloride is 1,5-Benzothiazepin-4(5H)one,3-(acetyloxy)-5-[2-(dimethylamino) ethyl]-2,3-dihydro-2-(4-...
Active IngredientDiltiazem hydrochloride
Dosage FormCapsule, extended release
RouteOral
Strength180mg; 120mg; 240mg
Market StatusPrescription
CompanyWatson Labs

14 of 16  
Drug NameDiltiazem hydrochloride
Drug LabelDiltiazem is a calcium ion influx inhibitor (slow channel blocker or calcium antagonist). Chemically, diltiazem hydrochloride is 1,5-Benzothiazepin-4(5H)one,3-(acetyloxy)-5-[2-(dimethylamino) ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-, monohydrochloride...
Active IngredientDiltiazem hydrochloride
Dosage FormTablet, extended release; Injectable; Tablet; Capsule, extended release
Routeinjection; Injection; Oral
Strength300mg; 50mg/10ml; 180mg; 100mg/vial; 5mg/ml; 30mg; 60mg; 90mg; 125mg/25ml; 420mg; 120mg; 10mg/ml; 360mg; 240mg
Market StatusPrescription
CompanyIntl Medication; Bedford; Valeant Intl; Hospira; Hikma Maple; Actavis Labs Fl; Teva; Apotex; Hikma Farmaceutica; Teva Pharms Usa; Sandoz; Sun Pharma Global; Par Pharm; Mylan; Actavis; Akorn

15 of 16  
Drug NameTaztia xt
Drug LabelTAZTIA XT brand ofDILTIAZEM HYDROCHLORIDE EXTENDED-RELEASECAPSULES USP(ONCE-A-DAY DOSAGE)Rx Only...
Active IngredientDiltiazem hydrochloride
Dosage FormCapsule, extended release
RouteOral
Strength180mg; 120mg; 360mg; 300mg; 240mg
Market StatusPrescription
CompanyActavis Labs Fl

16 of 16  
Drug NameTiazac
Drug LabelTiazac (diltiazem hydrochloride) is a calcium ion cellular influx inhibitor (slow channel blocker). Chemically, diltiazem hydrochloride is 1,5-Benzothiazepin-4(5H)-one, 3-(acetyloxy)-5-[2-(dimethylamino)ethyl]-2, 3-dihydro-2-(4-methoxyphenyl)-, mon...
Active IngredientDiltiazem hydrochloride
Dosage FormCapsule, extended release
RouteOral
Strength180mg; 420mg; 120mg; 360mg; 300mg; 240mg
Market StatusPrescription
CompanyValeant Intl

4.2 Drug Indication

Treatment of chronic anal fissure


5 Pharmacology and Biochemistry
5.1 MeSH Pharmacological Classification

Antihypertensive Agents

Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS. (See all compounds classified as Antihypertensive Agents.)


Vasodilator Agents

Drugs used to cause dilation of the blood vessels. (See all compounds classified as Vasodilator Agents.)


Calcium Channel Blockers

A class of drugs that act by selective inhibition of calcium influx through cellular membranes. (See all compounds classified as Calcium Channel Blockers.)


Cardiovascular Agents

Agents that affect the rate or intensity of cardiac contraction, blood vessel diameter, or blood volume. (See all compounds classified as Cardiovascular Agents.)


5.2 FDA Pharmacological Classification
5.2.1 Pharmacological Classes
Calcium Channel Blocker [EPC]; Calcium Channel Antagonists [MoA]

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FABBRICA ITALIANA SINTETICI","supplierCountry":"ITALY","foreign_port":"MILAN - MALPENSA","customer":"INTAS PHARMACEUTICALS","customerCountry":"INDIA","quantity":"4.50","actualQuantity":"4.5","unit":"KGS","unitRateFc":"98","totalValueFC":"487.2","currency":"EUR","unitRateINR":"8991.5","date":"25-Nov-2023","totalValueINR":"40461.75","totalValueInUsd":"487.2","indian_port":"Ahmedabad Air","hs_no":"29349990","bill_no":"8944617","productDescription":"API","marketType":"REGULATED MARKET","country":"ITALY","selfForZScoreResived":"Pharma Grade","supplierPort":"MILAN - MALPENSA","supplierAddress":"VIALE MILANO,26 36705 MONTECCHIO MAGGIORE ITALY, , ItalySDNF Italy","customerAddress":"2ND FLOOR, CHINUBHAI CENTRE,"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q4","strtotime":1700850600,"product":"DILTIAZEM HYDROCHLORIDE (DILTIAZEM HYDROCHLORIDE EP\/BP\/IP\/USP\/PH.EUR.)","address":"2ND FLOOR, CHINUBHAI CENTRE,","city":"AHMEDABAD, GUJARAT","supplier":"F.I.S. 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04-Jan-2021
31-Aug-2024
KGS
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Average Price (USD/KGS)

Number of Transactions

Total Quantity (KGS)

Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

Importing Country Total Quantity
(KGS)
Average Price
(USD/KGS)
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DRUG PRODUCT COMPOSITIONS

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DOSAGE - TABLET;ORAL - 120MG

USFDA APPLICATION NUMBER - 18602

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DOSAGE - TABLET;ORAL - 30MG

USFDA APPLICATION NUMBER - 18602

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DOSAGE - TABLET;ORAL - 60MG

USFDA APPLICATION NUMBER - 18602

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DOSAGE - TABLET;ORAL - 90MG

USFDA APPLICATION NUMBER - 18602

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DOSAGE - CAPSULE, EXTENDED RELEASE;ORAL - 120...DOSAGE - CAPSULE, EXTENDED RELEASE;ORAL - 120MG

USFDA APPLICATION NUMBER - 20062

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DOSAGE - CAPSULE, EXTENDED RELEASE;ORAL - 180...DOSAGE - CAPSULE, EXTENDED RELEASE;ORAL - 180MG

USFDA APPLICATION NUMBER - 20062

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DOSAGE - CAPSULE, EXTENDED RELEASE;ORAL - 240...DOSAGE - CAPSULE, EXTENDED RELEASE;ORAL - 240MG

USFDA APPLICATION NUMBER - 20062

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DOSAGE - CAPSULE, EXTENDED RELEASE;ORAL - 300...DOSAGE - CAPSULE, EXTENDED RELEASE;ORAL - 300MG

USFDA APPLICATION NUMBER - 20062

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DOSAGE - CAPSULE, EXTENDED RELEASE;ORAL - 360...DOSAGE - CAPSULE, EXTENDED RELEASE;ORAL - 360MG

USFDA APPLICATION NUMBER - 20062

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DOSAGE - CAPSULE, EXTENDED RELEASE;ORAL - 120...DOSAGE - CAPSULE, EXTENDED RELEASE;ORAL - 120MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

USFDA APPLICATION NUMBER - 20092

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DOSAGE - CAPSULE, EXTENDED RELEASE;ORAL - 180...DOSAGE - CAPSULE, EXTENDED RELEASE;ORAL - 180MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

USFDA APPLICATION NUMBER - 20092

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DOSAGE - CAPSULE, EXTENDED RELEASE;ORAL - 240...DOSAGE - CAPSULE, EXTENDED RELEASE;ORAL - 240MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

USFDA APPLICATION NUMBER - 20092

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DOSAGE - CAPSULE, EXTENDED RELEASE;ORAL - 120...DOSAGE - CAPSULE, EXTENDED RELEASE;ORAL - 120MG

USFDA APPLICATION NUMBER - 20401

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DOSAGE - CAPSULE, EXTENDED RELEASE;ORAL - 180...DOSAGE - CAPSULE, EXTENDED RELEASE;ORAL - 180MG

USFDA APPLICATION NUMBER - 20401

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DOSAGE - CAPSULE, EXTENDED RELEASE;ORAL - 240...DOSAGE - CAPSULE, EXTENDED RELEASE;ORAL - 240MG

USFDA APPLICATION NUMBER - 20401

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DOSAGE - CAPSULE, EXTENDED RELEASE;ORAL - 300...DOSAGE - CAPSULE, EXTENDED RELEASE;ORAL - 300MG

USFDA APPLICATION NUMBER - 20401

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DOSAGE - CAPSULE, EXTENDED RELEASE;ORAL - 360...DOSAGE - CAPSULE, EXTENDED RELEASE;ORAL - 360MG

USFDA APPLICATION NUMBER - 20401

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DOSAGE - CAPSULE, EXTENDED RELEASE;ORAL - 420...DOSAGE - CAPSULE, EXTENDED RELEASE;ORAL - 420MG

USFDA APPLICATION NUMBER - 20401

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DOSAGE - TABLET, EXTENDED RELEASE;ORAL - 120M...DOSAGE - TABLET, EXTENDED RELEASE;ORAL - 120MG

USFDA APPLICATION NUMBER - 21392

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DOSAGE - TABLET, EXTENDED RELEASE;ORAL - 180M...DOSAGE - TABLET, EXTENDED RELEASE;ORAL - 180MG

USFDA APPLICATION NUMBER - 21392

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DOSAGE - TABLET, EXTENDED RELEASE;ORAL - 240M...DOSAGE - TABLET, EXTENDED RELEASE;ORAL - 240MG

USFDA APPLICATION NUMBER - 21392

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DOSAGE - TABLET, EXTENDED RELEASE;ORAL - 300M...DOSAGE - TABLET, EXTENDED RELEASE;ORAL - 300MG

USFDA APPLICATION NUMBER - 21392

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DOSAGE - TABLET, EXTENDED RELEASE;ORAL - 360M...DOSAGE - TABLET, EXTENDED RELEASE;ORAL - 360MG

USFDA APPLICATION NUMBER - 21392

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DOSAGE - TABLET, EXTENDED RELEASE;ORAL - 420M...DOSAGE - TABLET, EXTENDED RELEASE;ORAL - 420MG

USFDA APPLICATION NUMBER - 21392

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