List of Suppliers' Coating Systems Additives Excipients Application used in Alphapharm Brand of Minocycline Hydrochloride on PharmaCompass.com

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Synopsis

Synopsis

Chemistry

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Also known as: 13614-98-7, Minocycline hcl, Arestin, Solodyn, Minomycin, Minocin
Molecular Formula
C23H28ClN3O7
Molecular Weight
493.9  g/mol
InChI Key
WTJXVDPDEQKTCV-VQAITOIOSA-N
FDA UNII
0020414E5U

Minocycline Hydrochloride
A TETRACYCLINE analog, having a 7-dimethylamino and lacking the 5 methyl and hydroxyl groups, which is effective against tetracycline-resistant STAPHYLOCOCCUS infections.
1 2D Structure

Minocycline Hydrochloride

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(4S,4aS,5aR,12aR)-4,7-bis(dimethylamino)-1,10,11,12a-tetrahydroxy-3,12-dioxo-4a,5,5a,6-tetrahydro-4H-tetracene-2-carboxamide;hydrochloride
2.1.2 InChI
InChI=1S/C23H27N3O7.ClH/c1-25(2)12-5-6-13(27)15-10(12)7-9-8-11-17(26(3)4)19(29)16(22(24)32)21(31)23(11,33)20(30)14(9)18(15)28;/h5-6,9,11,17,27-28,31,33H,7-8H2,1-4H3,(H2,24,32);1H/t9-,11-,17-,23-;/m0./s1
2.1.3 InChI Key
WTJXVDPDEQKTCV-VQAITOIOSA-N
2.1.4 Canonical SMILES
CN(C)C1C2CC3CC4=C(C=CC(=C4C(=C3C(=O)C2(C(=C(C1=O)C(=O)N)O)O)O)O)N(C)C.Cl
2.1.5 Isomeric SMILES
CN(C)[C@H]1[C@@H]2C[C@@H]3CC4=C(C=CC(=C4C(=C3C(=O)[C@@]2(C(=C(C1=O)C(=O)N)O)O)O)O)N(C)C.Cl
2.2 Other Identifiers
2.2.1 UNII
0020414E5U
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Akamin

2. Akne Puren

3. Akne-puren

4. Aknemin

5. Aknin Mino

6. Aknin-mino

7. Aknosan

8. Apo Minocycline

9. Apo-minocycline

10. Arestin

11. Blemix

12. Cyclomin

13. Cyclops

14. Dentomycin

15. Dynacin

16. Hydrochloride, Minocycline

17. Icht Oral

18. Icht-oral

19. Klinomycin

20. Lederderm

21. Mestacine

22. Minakne

23. Mino Wolff

24. Mino-wolff

25. Minocin

26. Minocin Mr

27. Minoclir

28. Minocycline

29. Minocycline Monohydrochloride

30. Minocycline, (4r-(4 Alpha,4a Beta,5a Beta,12a Beta))-isomer

31. Minolis

32. Minomycin

33. Minoplus

34. Minotab

35. Minox 50

36. Monohydrochloride, Minocycline

37. Mynocine

2.3.2 Depositor-Supplied Synonyms

1. 13614-98-7

2. Minocycline Hcl

3. Arestin

4. Solodyn

5. Minomycin

6. Minocin

7. Dynacin

8. Periocline

9. Ximino

10. Minocycline (hydrochloride)

11. Vectrin

12. Minomax

13. (4s,4as,5ar,12as)-4,7-bis(dimethylamino)-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide Hydrochloride

14. Mynocine Hydrochloride

15. Minocycline (as Hydrochloride)

16. Minocycline, Hydrochloride

17. 4,7-bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-2-naphthacenecarboxamide Monohydrochloride

18. 0020414e5u

19. Tri-mino

20. Nsc-141993

21. Dsstox_cid_24545

22. Dsstox_rid_80306

23. Dsstox_gsid_44545

24. (4s,4as,5ar,12ar)-4,7-bis(dimethylamino)-1,10,11,12a-tetrahydroxy-3,12-dioxo-4a,5,5a,6-tetrahydro-4h-tetracene-2-carboxamide;hydrochloride

25. [4s-(4alpha,4aalpha,5aalpha,12aalpha)]-4,7-bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxonaphthacene-2-carboxamide Monohydrochloride

26. Lederderm

27. Mynocine

28. Acnez

29. Minomycin Chloride

30. Chebi:50697

31. (4s-(4alpha,4aalpha,5aalpha,12aalpha))-4,7-bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxonaphthacene-2-carboxamide Monohydrochloride

32. [4s-(4?,4a?,5a?,12a?)]-4,7-bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a,tetrahydroxy-1,11-dioxo-2-naphthacenecarboxamide

33. 2-naphthacenecarboxamide, 4,7-bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-, Hydrochloride (1:2), (4s,4as,5ar,12as)-

34. Einecs 237-099-7

35. Minocycline Hydrochloride (internal Use)

36. C23h27n3o7.hcl

37. Minocycline, Hcl

38. Unii-0020414e5u

39. Ncgc00096006-01

40. Prestwick_626

41. Arestin (tn)

42. Dynacin (tn)

43. Minocin (tn)

44. Solodyn (tn)

45. Minocycline Hydrochloride [usp:jan]

46. 7-dimethylamino-6-demethyl-6-deoxytetracycline, Hcl

47. Mfcd00083669

48. Minocyclinhydrochlorid

49. Amzeeq

50. Minolira

51. Zilxi

52. Minomycin Hydrochloride

53. Schembl2537

54. Cas-13614-98-7

55. 2-naphthacenecarboxamide, 4,7-bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-, Monohydrochloride, (4s-(4alpha,4aalpha,5aalpha,12aalpha))-

56. Mls002548863

57. Spectrum1500414

58. Fxfm-244

59. Chembl1200881

60. Chembl4576719

61. Dtxsid8044545

62. Hms1568p12

63. Pharmakon1600-01500414

64. Bcp06597

65. Tox21_111250

66. Tox21_113183

67. Tox21_301590

68. Ccg-40107

69. Nsc757120

70. S4226

71. Minocycline Hydrochloride [mi]

72. Minocycline Hydrochloride, Crystalline

73. Akos015951312

74. Minocycline Hydrochloride (jp17/usp)

75. Tox21_111250_1

76. Cs-1256

77. Minocycline Hydrochloride [jan]

78. Nc00460

79. Nsc-757120

80. Minocycline Hydrochloride [mart.]

81. Minocycline Hydrochloride [vandf]

82. Ncgc00178854-03

83. Ncgc00255988-01

84. Ac-22362

85. As-75306

86. Hy-17412

87. Minocycline Hydrochloride [usp-rs]

88. Minocycline Hydrochloride [who-dd]

89. Smr001906766

90. M2288

91. D00850

92. Minocycline Hydrochloride [orange Book]

93. Minocycline Hydrochloride [usp Monograph]

94. 614m987

95. Sr-01000075625

96. Q-201407

97. Sr-01000075625-1

98. Q27104777

99. Minocycline Hydrochloride, Antibiotic For Culture Media Use Only

100. Minocycline Hydrochloride, European Pharmacopoeia (ep) Reference Standard

101. Minocycline Hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material

102. Minocycline Hydrochloride, United States Pharmacopeia (usp) Reference Standard

103. (4s,12as,4as,5ar)-4,7-bis(dimethylamino)-3,10,12,12a-tetrahydroxy-1,11-dioxo-4,5,6,12a,4a,5a-hexahydronaphthacene-2-carboxamide Hydrochloride

104. (4s,4as,5ar,12as)-4,7-bis(dimethylamino)-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamidehydrochloride

105. 2-naphthacenecarboxamide, 4,7-bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-, Monohydrochloride, (4s-(4.alpha.,4a.alpha.,5a.alpha.,12a.alpha.))-

2.4 Create Date
2011-12-26
3 Chemical and Physical Properties
Molecular Weight 493.9 g/mol
Molecular Formula C23H28ClN3O7
Hydrogen Bond Donor Count6
Hydrogen Bond Acceptor Count9
Rotatable Bond Count3
Exact Mass493.1615779 g/mol
Monoisotopic Mass493.1615779 g/mol
Topological Polar Surface Area165 Ų
Heavy Atom Count34
Formal Charge0
Complexity971
Isotope Atom Count0
Defined Atom Stereocenter Count4
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Drug and Medication Information
4.1 Drug Information
1 of 10  
Drug NameArestin
PubMed HealthMinocycline
Drug ClassesAmebicide, Intestinal, Antiacne, Antiacne Antibacterial, Antibiotic, Antiprotozoal, Tetracycline
Drug LabelARESTIN (minocycline hydrochloride) Microspheres is a subgingival sustained-release product containing the antibiotic minocycline hydrochloride incorporated into a bioresorbable polymer, Poly (glycolide-co-dl-lactide) or PGLA, for professional subg...
Active IngredientMinocycline hydrochloride
Dosage FormPowder, extended release
RouteDental
Strengtheq 1mg base
Market StatusPrescription
CompanyOrapharma

2 of 10  
Drug NameDynacin
Drug LabelMinocycline hydrochloride, is a semisynthetic derivative of tetracycline, 4,7-Bis(dimethylamino)1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1, 11-dioxo-2naphthacenecarboxamide monohydrochloride. Its structural formula is:C23H27N3O7...
Active IngredientMinocycline hydrochloride
Dosage FormCapsule
RouteOral
Strengtheq 100mg base; eq 75mg base
Market StatusPrescription
CompanyCnty Line Pharms

3 of 10  
Drug NameMinocin
PubMed HealthMinocycline, Regular Release (By mouth)
Drug ClassesAmebicide, Intestinal, Antiacne, Antibiotic, Antiprotozoal
Drug LabelMINOCIN minocycline hydrochloride, is a semisynthetic derivative of tetracycline, 4,7-Bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-2-naphthacenecarboxamide monohydrochloride.Its structural formula is:C23H27N...
Active IngredientMinocycline hydrochloride
Dosage FormCapsule; Injectable
RouteInjection; Oral
Strengtheq 100mg base; eq 50mg base; eq 100mg base/vial
Market StatusPrescription
CompanyRempex Pharms; Precision Dermat

4 of 10  
Drug NameMinocycline hydrochloride
Drug LabelTo reduce the development of drug-resistant bacteria and maintain the effectiveness of minocycline hydrochloride capsules and other antibacterial drugs, minocycline hydrochloride capsules should be used only to treat or prevent infections that are pr...
Active IngredientMinocycline hydrochloride
Dosage FormTablet, extended release; Tablet; Capsule
Routeoral; Oral
Strength65mg; 115mg; eq 100mg base; eq 50mg base; eq 105mg base; eq 65mg base; eq 115mg base; eq 75mg base; eq 90mg base; eq 80mg base; 55mg; eq 45mg base; eq 55mg base; eq 135mg base
Market StatusTentative Approval; Prescription
CompanyMylan Pharms; Ranbaxy; Teva; Mylan Labs; Sun Pharm Inds; Aurobindo Pharma; Lupin; Barr Labs; Sandoz; Par Pharm; Watson Labs; Ranbaxy Labs; Dr Reddys Labs; Impax Labs

5 of 10  
Drug NameSolodyn
PubMed HealthMinocycline
Drug ClassesAmebicide, Intestinal, Antiacne, Antiacne Antibacterial, Antibiotic, Antiprotozoal, Tetracycline
Drug LabelMinocycline hydrochloride, a semi synthetic derivative of tetracycline, is [4S-(4,4a,5a,12a)]-4,7-Bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-2-naphthacenecarboxamide mono hydrochloride. The structura...
Active IngredientMinocycline hydrochloride
Dosage FormTablet, extended release
RouteOral
Strengtheq 105mg base; eq 65mg base; eq 115mg base; eq 80mg base; eq 55mg base
Market StatusPrescription
CompanyMedicis

6 of 10  
Drug NameArestin
PubMed HealthMinocycline
Drug ClassesAmebicide, Intestinal, Antiacne, Antiacne Antibacterial, Antibiotic, Antiprotozoal, Tetracycline
Drug LabelARESTIN (minocycline hydrochloride) Microspheres is a subgingival sustained-release product containing the antibiotic minocycline hydrochloride incorporated into a bioresorbable polymer, Poly (glycolide-co-dl-lactide) or PGLA, for professional subg...
Active IngredientMinocycline hydrochloride
Dosage FormPowder, extended release
RouteDental
Strengtheq 1mg base
Market StatusPrescription
CompanyOrapharma

7 of 10  
Drug NameDynacin
Drug LabelMinocycline hydrochloride, is a semisynthetic derivative of tetracycline, 4,7-Bis(dimethylamino)1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1, 11-dioxo-2naphthacenecarboxamide monohydrochloride. Its structural formula is:C23H27N3O7...
Active IngredientMinocycline hydrochloride
Dosage FormCapsule
RouteOral
Strengtheq 100mg base; eq 75mg base
Market StatusPrescription
CompanyCnty Line Pharms

8 of 10  
Drug NameMinocin
PubMed HealthMinocycline, Regular Release (By mouth)
Drug ClassesAmebicide, Intestinal, Antiacne, Antibiotic, Antiprotozoal
Drug LabelMINOCIN minocycline hydrochloride, is a semisynthetic derivative of tetracycline, 4,7-Bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-2-naphthacenecarboxamide monohydrochloride.Its structural formula is:C23H27N...
Active IngredientMinocycline hydrochloride
Dosage FormCapsule; Injectable
RouteInjection; Oral
Strengtheq 100mg base; eq 50mg base; eq 100mg base/vial
Market StatusPrescription
CompanyRempex Pharms; Precision Dermat

9 of 10  
Drug NameMinocycline hydrochloride
Drug LabelTo reduce the development of drug-resistant bacteria and maintain the effectiveness of minocycline hydrochloride capsules and other antibacterial drugs, minocycline hydrochloride capsules should be used only to treat or prevent infections that are pr...
Active IngredientMinocycline hydrochloride
Dosage FormTablet, extended release; Tablet; Capsule
Routeoral; Oral
Strength65mg; 115mg; eq 100mg base; eq 50mg base; eq 105mg base; eq 65mg base; eq 115mg base; eq 75mg base; eq 90mg base; eq 80mg base; 55mg; eq 45mg base; eq 55mg base; eq 135mg base
Market StatusTentative Approval; Prescription
CompanyMylan Pharms; Ranbaxy; Teva; Mylan Labs; Sun Pharm Inds; Aurobindo Pharma; Lupin; Barr Labs; Sandoz; Par Pharm; Watson Labs; Ranbaxy Labs; Dr Reddys Labs; Impax Labs

10 of 10  
Drug NameSolodyn
PubMed HealthMinocycline
Drug ClassesAmebicide, Intestinal, Antiacne, Antiacne Antibacterial, Antibiotic, Antiprotozoal, Tetracycline
Drug LabelMinocycline hydrochloride, a semi synthetic derivative of tetracycline, is [4S-(4,4a,5a,12a)]-4,7-Bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-2-naphthacenecarboxamide mono hydrochloride. The structura...
Active IngredientMinocycline hydrochloride
Dosage FormTablet, extended release
RouteOral
Strengtheq 105mg base; eq 65mg base; eq 115mg base; eq 80mg base; eq 55mg base
Market StatusPrescription
CompanyMedicis

5 Pharmacology and Biochemistry
5.1 MeSH Pharmacological Classification

Anti-Bacterial Agents

Substances that inhibit the growth or reproduction of BACTERIA. (See all compounds classified as Anti-Bacterial Agents.)


5.2 FDA Pharmacological Classification
5.2.1 Pharmacological Classes
Tetracyclines [CS]; Tetracycline-class Drug [EPC]

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Minocycline hydrochloride

Registration Number : 304MF10123

Registrant's Address : Rua da Estacao, 1 e 1A, 2600-726 Castanheira do Ribatejo, Portugal

Initial Date of Registration : 2022-08-17

Latest Date of Registration : 2022-08-17

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Minocyclohydrochloride

Registration Number : 217MF10699

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Initial Date of Registration : 2005-10-07

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Minocycline hydrochloride

Registration Number : 219MF10124

Registrant's Address : Sete Casas 2674-506 Loures PORTUGAL

Initial Date of Registration : 2007-04-18

Latest Date of Registration : 2017-12-06

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04-Jan-2021
29-Aug-2024
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Drugs in Development

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Details:

Mino-Lok (MLT) is a novel antibiotic lock therapy that combines minocycline with edetate disodium, which is investigated for the treatment of patients with catheter-related blood stream infections.


Lead Product(s): Minocycline Hydrochloride,Edetate Calcium Disodium,Ethanol

Therapeutic Area: Infections and Infectious Diseases Product Name: Mino-Lok

Highest Development Status: Phase IIIProduct Type: Small molecule

Partner/Sponsor/Collaborator: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable May 21, 2024

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01

26th North American ISSX
Not Confirmed
26th North American ISSX
Not Confirmed

Details : Mino-Lok (MLT) is a novel antibiotic lock therapy that combines minocycline with edetate disodium, which is investigated for the treatment of patients with catheter-related blood stream infections.

Product Name : Mino-Lok

Product Type : Small molecule

Upfront Cash : Not Applicable

May 21, 2024

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Details:

DFD-29 (minocycline hydrochloride) has anti-inflammatory properties independent of their antibacterial activity that correlate with certain aspects of the pathophysiology. It is being evaluated for the treatment of papulopustular rosacea.


Lead Product(s): Minocycline Hydrochloride

Therapeutic Area: Dermatology Product Name: DFD-29

Highest Development Status: Phase IIIProduct Type: Small molecule

Partner/Sponsor/Collaborator: Dr. Reddy\'s Laboratories

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable March 18, 2024

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02

26th North American ISSX
Not Confirmed
26th North American ISSX
Not Confirmed

Details : DFD-29 (minocycline hydrochloride) has anti-inflammatory properties independent of their antibacterial activity that correlate with certain aspects of the pathophysiology. It is being evaluated for the treatmen...

Product Name : DFD-29

Product Type : Small molecule

Upfront Cash : Not Applicable

March 18, 2024

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Details:

The funding will support the anticipated expenses for DFD-29 (minocycline hydrochloride), being developed for the treatment of rosacea, including an upcoming New Drug Application submission and preparation for its potential commercial launch.


Lead Product(s): Minocycline Hydrochloride

Therapeutic Area: Dermatology Product Name: DFD-29

Highest Development Status: Phase IIIProduct Type: Small molecule

Partner/Sponsor/Collaborator: SWK Holdings

Deal Size: Undisclosed Upfront Cash: Undisclosed

Deal Type: Financing January 02, 2024

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03

26th North American ISSX
Not Confirmed
26th North American ISSX
Not Confirmed

Details : The funding will support the anticipated expenses for DFD-29 (minocycline hydrochloride), being developed for the treatment of rosacea, including an upcoming New Drug Application submission and preparation for ...

Product Name : DFD-29

Product Type : Small molecule

Upfront Cash : Undisclosed

January 02, 2024

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Details:

Mino-Lok (MLT) is a novel antibiotic lock therapy that combines minocycline with edetate disodium, which is investigated for the treatment of patients with catheter-related blood stream infections.


Lead Product(s): Minocycline Hydrochloride,Edetate Calcium Disodium,Ethanol

Therapeutic Area: Infections and Infectious Diseases Product Name: Mino-Lok

Highest Development Status: Phase IIIProduct Type: Small molecule

Partner/Sponsor/Collaborator: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable January 02, 2024

blank

04

26th North American ISSX
Not Confirmed
26th North American ISSX
Not Confirmed

Details : Mino-Lok (MLT) is a novel antibiotic lock therapy that combines minocycline with edetate disodium, which is investigated for the treatment of patients with catheter-related blood stream infections.

Product Name : Mino-Lok

Product Type : Small molecule

Upfront Cash : Not Applicable

January 02, 2024

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Details:

DFD-29 (minocycline hydrochloride) has anti-inflammatory properties independent of their antibacterial activity that correlate with certain aspects of the pathophysiology. It is being evaluated in phase 3 trials for the treatment of papulopustular rosacea.


Lead Product(s): Minocycline Hydrochloride

Therapeutic Area: Dermatology Product Name: DFD-29

Highest Development Status: Phase IIIProduct Type: Small molecule

Partner/Sponsor/Collaborator: Dr. Reddy\'s Laboratories

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable December 05, 2023

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05

26th North American ISSX
Not Confirmed
26th North American ISSX
Not Confirmed

Details : DFD-29 (minocycline hydrochloride) has anti-inflammatory properties independent of their antibacterial activity that correlate with certain aspects of the pathophysiology. It is being evaluated in phase 3 trial...

Product Name : DFD-29

Product Type : Small molecule

Upfront Cash : Not Applicable

December 05, 2023

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Details:

Through the divestment, Elutia sells its Orthobiologics business unit to Berkeley Biologics, including Company’s lead drug-eluting product, CanGaroo featuring an advanced biomatrix and the drugs rifampin and minocycline for extended antibiotic protection.


Lead Product(s): Rifampicin,Minocycline Hydrochloride

Therapeutic Area: Infections and Infectious Diseases Product Name: CanGaroo RM

Highest Development Status: PreclinicalProduct Type: Small molecule

Partner/Sponsor/Collaborator: Berkeley Biologics

Deal Size: $35.0 million Upfront Cash: $35.0 million

Deal Type: Divestment November 09, 2023

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06

Elutia

U.S.A
arrow
26th North American ISSX
Not Confirmed

Elutia

U.S.A
arrow
26th North American ISSX
Not Confirmed

Details : Through the divestment, Elutia sells its Orthobiologics business unit to Berkeley Biologics, including Company’s lead drug-eluting product, CanGaroo featuring an advanced biomatrix and the drugs rifampin and ...

Product Name : CanGaroo RM

Product Type : Small molecule

Upfront Cash : $35.0 million

November 09, 2023

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Details:

DFD-29 (minocycline hydrochloride modified release capsules) has anti-inflammatory properties independent of their antibacterial activity that correlate with certain aspects of the pathophysiology. It is currently being investigated for the treatment of papulopustular rosacea.


Lead Product(s): Minocycline Hydrochloride

Therapeutic Area: Dermatology Product Name: DFD-29

Highest Development Status: Phase IIIProduct Type: Small molecule

Partner/Sponsor/Collaborator: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable October 20, 2023

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07

26th North American ISSX
Not Confirmed
26th North American ISSX
Not Confirmed

Details : DFD-29 (minocycline hydrochloride modified release capsules) has anti-inflammatory properties independent of their antibacterial activity that correlate with certain aspects of the pathophysiology. It is curren...

Product Name : DFD-29

Product Type : Small molecule

Upfront Cash : Not Applicable

October 20, 2023

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Details:

The net proceeds will support the Company’s advancement of its drug-eluting biomatrix products, including CanGaroo featuring an advanced biomatrix and the drugs rifampin and minocycline for extended antibiotic protection.


Lead Product(s): Rifampicin,Minocycline Hydrochloride

Therapeutic Area: Infections and Infectious Diseases Product Name: CanGaroo

Highest Development Status: PreclinicalProduct Type: Small molecule

Partner/Sponsor/Collaborator: HighCape Capital

Deal Size: $26.2 million Upfront Cash: Undisclosed

Deal Type: Private Placement September 19, 2023

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08

Elutia

U.S.A
arrow
26th North American ISSX
Not Confirmed

Elutia

U.S.A
arrow
26th North American ISSX
Not Confirmed

Details : The net proceeds will support the Company’s advancement of its drug-eluting biomatrix products, including CanGaroo featuring an advanced biomatrix and the drugs rifampin and minocycline for extended antibioti...

Product Name : CanGaroo

Product Type : Small molecule

Upfront Cash : Undisclosed

September 19, 2023

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Details:

Through the divestment, Elutia sells its Orthobiologics business unit to Berkeley Biologics, including Company’s lead drug-eluting product, CanGaroo featuring an advanced biomatrix and the drugs rifampin and minocycline for extended antibiotic protection.


Lead Product(s): Rifampicin,Minocycline Hydrochloride

Therapeutic Area: Infections and Infectious Diseases Product Name: CanGaroo

Highest Development Status: PreclinicalProduct Type: Small molecule

Partner/Sponsor/Collaborator: Berkeley Biologics

Deal Size: $35.0 million Upfront Cash: $35.0 million

Deal Type: Divestment September 18, 2023

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Elutia

U.S.A
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26th North American ISSX
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Elutia

U.S.A
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26th North American ISSX
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Details : Through the divestment, Elutia sells its Orthobiologics business unit to Berkeley Biologics, including Company’s lead drug-eluting product, CanGaroo featuring an advanced biomatrix and the drugs rifampin and ...

Product Name : CanGaroo

Product Type : Small molecule

Upfront Cash : $35.0 million

September 18, 2023

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Details:

Mino-Lok (MLT), a novel antibiotic lock therapy that combines minocycline with edetate disodium, which is investigated for the treatment of patients with catheter-related blood stream infections.


Lead Product(s): Minocycline Hydrochloride,Edetate Calcium Disodium,Ethanol

Therapeutic Area: Infections and Infectious Diseases Product Name: Mino-Lok

Highest Development Status: Phase IIIProduct Type: Small molecule

Partner/Sponsor/Collaborator: The University of Texas MD Anderson Cancer Center

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable August 10, 2023

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26th North American ISSX
Not Confirmed
26th North American ISSX
Not Confirmed

Details : Mino-Lok (MLT), a novel antibiotic lock therapy that combines minocycline with edetate disodium, which is investigated for the treatment of patients with catheter-related blood stream infections.

Product Name : Mino-Lok

Product Type : Small molecule

Upfront Cash : Not Applicable

August 10, 2023

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INTERMEDIATES SUPPLIERS

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01

26th North American ISSX
Not Confirmed
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26th North American ISSX
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CAS Number : 127-33-3

End Use API : Minocycline Hydrochloride

About The Company : Haorui, established in 1997, is a manufacturer and supplier of APIs, intermediates, veterinary and food additives. Meanwhile, it is assisting global pharmaceuti...

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02

26th North American ISSX
Not Confirmed
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26th North American ISSX
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CAS Number : 2449-05-0

End Use API : Minocycline Hydrochloride

About The Company : Haorui, established in 1997, is a manufacturer and supplier of APIs, intermediates, veterinary and food additives. Meanwhile, it is assisting global pharmaceuti...

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FDA Orange Book

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01

  • fda
  • EDQM
  • WHO-GMP

Virtual BoothStrides Pharma Science: Pioneering IP-driven formulations for niche finished dosage forms.

Flag India
Digital Content Digital Content

RLD : No

TE Code : AB

MINOCYCLINE HYDROCHLORIDE

Brand Name : MINOCYCLINE HYDROCHLORIDE

Dosage Form : TABLET;ORAL

Dosage Strength : EQ 50MG BASE

Approval Date : 2003-04-16

Application Number : 65131

RX/OTC/DISCN : RX

RLD : No

TE Code : AB

Strides Pharma Science

02

  • fda
  • EDQM
  • WHO-GMP

Virtual BoothStrides Pharma Science: Pioneering IP-driven formulations for niche finished dosage forms.

Flag India
Digital Content Digital Content

RLD : No

TE Code : AB

MINOCYCLINE HYDROCHLORIDE

Brand Name : MINOCYCLINE HYDROCHLORIDE

Dosage Form : TABLET;ORAL

Dosage Strength : EQ 75MG BASE

Approval Date : 2003-04-16

Application Number : 65131

RX/OTC/DISCN : RX

RLD : No

TE Code : AB

Strides Pharma Science

03

  • fda
  • EDQM
  • WHO-GMP

Virtual BoothStrides Pharma Science: Pioneering IP-driven formulations for niche finished dosage forms.

Flag India
Digital Content Digital Content

RLD : No

TE Code : AB

MINOCYCLINE HYDROCHLORIDE

Brand Name : MINOCYCLINE HYDROCHLORIDE

Dosage Form : TABLET;ORAL

Dosage Strength : EQ 100MG BASE

Approval Date : 2003-04-16

Application Number : 65131

RX/OTC/DISCN : RX

RLD : No

TE Code : AB

Strides Pharma Science

04

26th North American ISSX
Not Confirmed
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26th North American ISSX
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MINOCYCLINE HYDROCHLORIDE

Brand Name : MINOCYCLINE HYDROCHLORIDE

Dosage Form : TABLET, EXTENDED RELEASE;ORAL

Dosage Strength : EQ 115MG BASE

Approval Date : 2018-03-16

Application Number : 204453

RX/OTC/DISCN : RX

RLD : No

TE Code : AB

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BAUSCH

Canada
26th North American ISSX
Not Confirmed
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BAUSCH

Canada
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26th North American ISSX
Not Confirmed

MINOCYCLINE HYDROCHLORIDE

Brand Name : SOLODYN

Dosage Form : TABLET, EXTENDED RELEASE;ORAL

Dosage Strength : EQ 45MG BASE **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

Approval Date : 2006-05-08

Application Number : 50808

RX/OTC/DISCN : DISCN

RLD : Yes

TE Code :

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06

26th North American ISSX
Not Confirmed
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26th North American ISSX
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MINOCYCLINE HYDROCHLORIDE

Brand Name : MINOCYCLINE HYDROCHLORIDE

Dosage Form : TABLET, EXTENDED RELEASE;ORAL

Dosage Strength : EQ 65MG BASE

Approval Date : 2022-10-07

Application Number : 204394

RX/OTC/DISCN : RX

RLD : No

TE Code : AB

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26th North American ISSX
Not Confirmed
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26th North American ISSX
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MINOCYCLINE HYDROCHLORIDE

Brand Name : MINOCYCLINE HYDROCHLORIDE

Dosage Form : TABLET;ORAL

Dosage Strength : EQ 75MG BASE

Approval Date : 2016-01-29

Application Number : 90217

RX/OTC/DISCN : DISCN

RLD : No

TE Code :

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26th North American ISSX
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26th North American ISSX
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MINOCYCLINE HYDROCHLORIDE

Brand Name : MINOCYCLINE HYDROCHLORIDE

Dosage Form : CAPSULE;ORAL

Dosage Strength : EQ 50MG BASE

Approval Date : 2013-05-13

Application Number : 90867

RX/OTC/DISCN : RX

RLD : No

TE Code : AB

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09

26th North American ISSX
Not Confirmed
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26th North American ISSX
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MINOCYCLINE HYDROCHLORIDE

Brand Name : MINOCYCLINE HYDROCHLORIDE

Dosage Form : TABLET, EXTENDED RELEASE;ORAL

Dosage Strength : EQ 105MG BASE

Approval Date : 2014-09-25

Application Number : 91118

RX/OTC/DISCN : DISCN

RLD : No

TE Code :

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TORRENT

India
26th North American ISSX
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TORRENT

India
arrow
26th North American ISSX
Not Confirmed

MINOCYCLINE HYDROCHLORIDE

Brand Name : MINOCYCLINE HYDROCHLORIDE

Dosage Form : TABLET;ORAL

Dosage Strength : EQ 50MG BASE

Approval Date : 2004-01-06

Application Number : 65156

RX/OTC/DISCN : RX

RLD : No

TE Code : AB

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DRUG PRODUCT COMPOSITIONS

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DOSAGE - INJECTABLE;INJECTION - EQ 100MG BASE...DOSAGE - INJECTABLE;INJECTION - EQ 100MG BASE/VIAL

USFDA APPLICATION NUMBER - 50444

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DOSAGE - CAPSULE;ORAL - EQ 100MG BASE

USFDA APPLICATION NUMBER - 50649

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DOSAGE - CAPSULE;ORAL - EQ 50MG BASE

USFDA APPLICATION NUMBER - 50649

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DOSAGE - CAPSULE;ORAL - EQ 75MG BASE **Federa...DOSAGE - CAPSULE;ORAL - EQ 75MG BASE **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

USFDA APPLICATION NUMBER - 50649

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DOSAGE - POWDER, EXTENDED RELEASE;DENTAL - EQ...DOSAGE - POWDER, EXTENDED RELEASE;DENTAL - EQ 1MG BASE

USFDA APPLICATION NUMBER - 50781

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DOSAGE - TABLET, EXTENDED RELEASE;ORAL - EQ 1...DOSAGE - TABLET, EXTENDED RELEASE;ORAL - EQ 105MG BASE

USFDA APPLICATION NUMBER - 50808

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DOSAGE - TABLET, EXTENDED RELEASE;ORAL - EQ 1...DOSAGE - TABLET, EXTENDED RELEASE;ORAL - EQ 115MG BASE

USFDA APPLICATION NUMBER - 50808

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DOSAGE - TABLET, EXTENDED RELEASE;ORAL - EQ 1...DOSAGE - TABLET, EXTENDED RELEASE;ORAL - EQ 135MG BASE **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

USFDA APPLICATION NUMBER - 50808

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DOSAGE - TABLET, EXTENDED RELEASE;ORAL - EQ 4...DOSAGE - TABLET, EXTENDED RELEASE;ORAL - EQ 45MG BASE **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

USFDA APPLICATION NUMBER - 50808

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DOSAGE - TABLET, EXTENDED RELEASE;ORAL - EQ 5...DOSAGE - TABLET, EXTENDED RELEASE;ORAL - EQ 55MG BASE

USFDA APPLICATION NUMBER - 50808

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DOSAGE - TABLET, EXTENDED RELEASE;ORAL - EQ 6...DOSAGE - TABLET, EXTENDED RELEASE;ORAL - EQ 65MG BASE

USFDA APPLICATION NUMBER - 50808

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DOSAGE - TABLET, EXTENDED RELEASE;ORAL - EQ 8...DOSAGE - TABLET, EXTENDED RELEASE;ORAL - EQ 80MG BASE

USFDA APPLICATION NUMBER - 50808

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DOSAGE - TABLET, EXTENDED RELEASE;ORAL - EQ 9...DOSAGE - TABLET, EXTENDED RELEASE;ORAL - EQ 90MG BASE **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

USFDA APPLICATION NUMBER - 50808

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DATA COMPILATION #PharmaFlow

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NEWS #PharmaBuzz

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Global Sales Information

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Patents & EXCLUSIVITIES

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US Patents

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01

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26th North American ISSX
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BAUSCH

Canada
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MINOCYCLINE HYDROCHLORIDE

US Patent Number : 8268804

Drug Substance Claim :

Drug Product Claim :

Application Number : 50808

Patent Use Code : U-1078

Delist Requested :

Patent Use Description : TREATMENT OF ACNE

Patent Expiration Date : 2025-06-24

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02

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26th North American ISSX
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BAUSCH

Canada
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26th North American ISSX
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MINOCYCLINE HYDROCHLORIDE

US Patent Number : 7790705

Drug Substance Claim :

Drug Product Claim :

Application Number : 50808

Patent Use Code : U-1078

Delist Requested :

Patent Use Description : TREATMENT OF ACNE

Patent Expiration Date : 2025-06-24

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03

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26th North American ISSX
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BAUSCH

Canada
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26th North American ISSX
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MINOCYCLINE HYDROCHLORIDE

US Patent Number : 9192615

Drug Substance Claim :

Drug Product Claim : Y

Application Number : 50808

Patent Use Code :

Delist Requested :

Patent Use Description :

Patent Expiration Date : 2031-11-17

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BAUSCH

Canada
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26th North American ISSX
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MINOCYCLINE HYDROCHLORIDE

US Patent Number : 8722650

Drug Substance Claim :

Drug Product Claim :

Application Number : 50808

Patent Use Code : U-1078

Delist Requested :

Patent Use Description : TREATMENT OF ACNE

Patent Expiration Date : 2025-06-24

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26th North American ISSX
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BAUSCH

Canada
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26th North American ISSX
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MINOCYCLINE HYDROCHLORIDE

US Patent Number : 8268804

Drug Substance Claim :

Drug Product Claim :

Application Number : 50808

Patent Use Code : U-1078

Delist Requested :

Patent Use Description : TREATMENT OF ACNE

Patent Expiration Date : 2025-06-24

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26th North American ISSX
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BAUSCH

Canada
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26th North American ISSX
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MINOCYCLINE HYDROCHLORIDE

US Patent Number : 8252776

Drug Substance Claim :

Drug Product Claim :

Application Number : 50808

Patent Use Code : U-124

Delist Requested :

Patent Use Description : TREATMENT OF ACNE

Patent Expiration Date : 2025-06-24

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26th North American ISSX
Not Confirmed

BAUSCH

Canada
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26th North American ISSX
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MINOCYCLINE HYDROCHLORIDE

US Patent Number : 8268804

Drug Substance Claim :

Drug Product Claim :

Application Number : 50808

Patent Use Code : U-1078

Delist Requested :

Patent Use Description : TREATMENT OF ACNE

Patent Expiration Date : 2025-06-24

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26th North American ISSX
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JOURNEY

South Korea
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26th North American ISSX
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MINOCYCLINE HYDROCHLORIDE

US Patent Number : 8252776

Drug Substance Claim :

Drug Product Claim :

Application Number : 201922

Patent Use Code : U-124

Delist Requested :

Patent Use Description : TREATMENT OF ACNE

Patent Expiration Date : 2025-06-24

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26th North American ISSX
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JOURNEY

South Korea
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26th North American ISSX
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MINOCYCLINE HYDROCHLORIDE

US Patent Number : 10946101

Drug Substance Claim :

Drug Product Claim :

Application Number : 213690

Patent Use Code : U-1631

Delist Requested :

Patent Use Description : TREATMENT OF INFLAMMAT...

Patent Expiration Date : 2030-10-01

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26th North American ISSX
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JOURNEY

South Korea
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26th North American ISSX
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MINOCYCLINE HYDROCHLORIDE

US Patent Number : 8268804

Drug Substance Claim :

Drug Product Claim :

Application Number : 201922

Patent Use Code : U-124

Delist Requested :

Patent Use Description : TREATMENT OF ACNE

Patent Expiration Date : 2025-06-24

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Health Canada Patents

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01

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Minocycline Hydrochloride

Brand Name : ARESTIN MICROSPHERES

Patent Number : 1330533

Filing Date : 1988-05-24

Strength per Unit : 1mg/4mg Cartridge

Dosage Form : Extended Release Powder

Human Or VET : Human

Route of Administration : Sub Gingival

Patent Expiration Date : 2011-07-05

Date Granted : 1994-07-05

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Country
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Minocycline Hydrochloride

Brand Name :

Patent Number : 2006105

Filing Date :

Strength per Unit :

Dosage Form :

Human Or VET :

Route of Administration :

Patent Expiration Date : 2009-12-20

Date Granted :

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26th North American ISSX
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Minocycline Hydrochloride

Brand Name :

Patent Number : 2006106

Filing Date :

Strength per Unit :

Dosage Form :

Human Or VET :

Route of Administration :

Patent Expiration Date : 2009-12-20

Date Granted :

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