List of Related Excipient Companies and Suppliers of Almotriptan Malate by Dfe Pharma on PharmaCompass.com

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ACTIVE PHARMA INGREDIENTS

15 API Suppliers, 6 USDMF, 1 CEP/COS, 5 EU WC, 3 NDC API, 9 Listed Suppliers, $ API Reference Price

15 API Suppliers
6 USDMF
1 CEP/COS
5 EU WC
3 NDC API
9 Listed Suppliers
$ API Reference Price

FINISHED DOSAGE FORMULATIONS

25 FDF Dossiers, 8 FDA Orange Book, 11 Europe, 6 Canada

25 FDF Dossiers
8 FDA Orange Book
11 Europe
6 Canada

DRUG PRODUCT COMPOSITIONS

TABLET;ORAL - EQ 12.5MG BASE **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**, TABLET;ORAL - EQ 6.25MG BASE **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

drugProductComposition
TABLET;ORAL - EQ 12.5MG BASE **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**
TABLET;ORAL - EQ 6.25MG BASE **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

RELATED EXCIPIENT COMPANIES

1 Minakem, 1 Rochem International Inc, 14 SPI Pharma, 2 Seqens, 2 DKSH, 2 Jai Radhe Sales, 4 Boai NKY Pharmaceuticals Ltd, 1 Chynops Pharma, 10 Gangwal Healthcare, 1 Nanjing Well Pharmaceutical, 1 Pfanstiehl, 1 ACG Worldwide, 3 Actylis, 1 Alcedo Pharmachem, 7 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd, 20 BASF, 10 Corel Pharma Chem, 4 DFE Pharma, 2 Finar, 6 Gangwal Chemicals, 5 Ideal Cures Pvt Ltd, 3 Ingredion Pharma Solutions, 17 Kerry, 3 Kima Chemical, 6 Lonza Capsugel, 6 Microlex e.U, 1 NEWEDGE Overseas, 2 Nomisma Healthcare, 2 Novo Excipients, 4 Pharmatrans-Sanaq, 3 Pluviaendo, 4 Prachin Chemical, 1 Qianhao Chemical (Hebei) Co., Ltd, 1 Qualicaps, 15 Roquette, 6 Seppic, 5 Shanghai Shenmei Pharmaceutical Technology Co., Ltd, 1 Shanghai Welltone Material Technology Co., Ltd, 1 Shijiazhuang Huaxu Pharmaceutical, 10 Sigachi Industries, 2 The Dow Chemical Company, 2 Ulanqab Kema New Material, 1 Valens Pharmachem, 3 Vasa Pharmachem

relatedExcipients
1 Minakem
1 Rochem International Inc
14 SPI Pharma
2 Seqens
2 DKSH
2 Jai Radhe Sales
4 Boai NKY Pharmaceuticals Ltd
1 Chynops Pharma
10 Gangwal Healthcare
1 Nanjing Well Pharmaceutical
1 Pfanstiehl
1 ACG Worldwide
3 Actylis
1 Alcedo Pharmachem
7 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd
20 BASF
10 Corel Pharma Chem
4 DFE Pharma
2 Finar
6 Gangwal Chemicals
5 Ideal Cures Pvt Ltd
3 Ingredion Pharma Solutions
17 Kerry
3 Kima Chemical
6 Lonza Capsugel
6 Microlex e.U
1 NEWEDGE Overseas
2 Nomisma Healthcare
2 Novo Excipients
4 Pharmatrans-Sanaq
3 Pluviaendo
4 Prachin Chemical
1 Qianhao Chemical (Hebei) Co., Ltd
1 Qualicaps
15 Roquette
6 Seppic
5 Shanghai Shenmei Pharmaceutical Technology Co., Ltd
1 Shanghai Welltone Material Technology Co., Ltd
1 Shijiazhuang Huaxu Pharmaceutical
10 Sigachi Industries
2 The Dow Chemical Company
2 Ulanqab Kema New Material
1 Valens Pharmachem
3 Vasa Pharmachem

EXCIPIENTS BY APPLICATIONS

48 Fillers, Diluents & Binders, 45 Coating Systems & Additives, 30 Direct Compression, 29 Disintegrants & Superdisintegrants, 27 Controlled & Modified Release, 19 Granulation, 19 Thickeners and Stabilizers, 15 Solubilizers, 14 Co-Processed Excipients, 14 Chewable & Orodispersible Aids, 12 Taste Masking, 11 Film Formers & Plasticizers, 10 Lubricants & Glidants, 10 Topical, 9 Parenteral, 5 Empty Capsules, 5 API Stability Enhancers, 4 Vegetarian Capsules, 4 Coloring Agents, 3 Rheology Modifiers, 2 Emulsifying Agents

DIGITAL CONTENT

2 NEWS #PharmaBuzz

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2 NEWS #PharmaBuzz

GLOBAL SALES INFORMATION

1 US Medicaid Prescriptions, 4 Finished Drug Prices

globalSalesInformation
1 US Medicaid Prescriptions
4 Finished Drug Prices

PATENTS & EXCLUSIVITIES

2 Health Canada Patents

patents
2 Health Canada Patents

REF. STANDARDS & IMPURITIES

2 USP , 1 Others

otherSolutions
2 USP
1 Others

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

$ 9,514

MARKET PLACE

API

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

0 DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

1,799,862

Annual Reports (USD Million)

Finished Drug Prices

197 RELATED EXCIPIENT COMPANIES

335EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: 181183-52-8, Almotriptan maleate, Axert, Las 31416 d,l-malate acid, Almotriptan (malate), Almogran

Molecular Formula

C₂₁H₃₁N₃O₇S

Molecular Weight

469.6 g/mol

InChI Key

QHATUKWEVNMHRY-UHFFFAOYSA-N

FDA UNII

PJP312605E

Almotriptan Malate is the malate salt of almotriptan, a sulfonamide triptan with vasoconstrictor activity. Almotriptan selectively binds to and activates serotonin 5-HT 1B and 1D receptors in the central nervous system (CNS), thereby causing cerebral blood vessel constriction. This may lead to pain relief from vascular headaches. Almotriptan may also relieve vascular headaches by preventing the release of vasoactive neuropeptides from perivascular trigeminal axons in the dura mater during a migraine, by reducing extravasation of plasma proteins, and by decreasing the release of other mediators of inflammation from the trigeminal nerve.

1 2D Structure

Almotriptan Malate

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

N,N-dimethyl-2-[5-(pyrrolidin-1-ylsulfonylmethyl)-1H-indol-3-yl]ethanamine;2-hydroxybutanedioic acid

2.1.2 InChI

InChI=1S/C17H25N3O2S.C4H6O5/c1-19(2)10-7-15-12-18-17-6-5-14(11-16(15)17)13-23(21,22)20-8-3-4-9-20;5-2(4(8)9)1-3(6)7/h5-6,11-12,18H,3-4,7-10,13H2,1-2H3;2,5H,1H2,(H,6,7)(H,8,9)

2.1.3 InChI Key

QHATUKWEVNMHRY-UHFFFAOYSA-N

2.1.4 Canonical SMILES

CN(C)CCC1=CNC2=C1C=C(C=C2)CS(=O)(=O)N3CCCC3.C(C(C(=O)O)O)C(=O)O

2.2 Other Identifiers

2.2.1 UNII

PJP312605E

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Almogran

2. Almotriptan

3. Axert

2.3.2 Depositor-Supplied Synonyms

1. 181183-52-8

2. Almotriptan Maleate

3. Axert

4. Las 31416 D,l-malate Acid

5. Almotriptan (malate)

6. Almogran

7. Pnu-180638e

8. Almotriptan Malate [usan]

9. Almotriptan D,l-hydrogenmalate

10. Chebi:53781

11. Las-31416 D,l-malate Acid

12. Pjp312605e

13. 181183-52-8(almotriptan Malate)

14. Las-31416-d,l-malate-acid

15. N,n-dimethyl-2-(5-((pyrrolidin-1-ylsulfonyl)methyl)-1h-indol-3-yl)ethan-1-amine 2-hydroxysuccinate

16. 1-(((3-(2-(dimethylamino)ethyl)indol-5-yl)methyl)sulfonyl)pyrrolidine Malate (1:1)

17. 1-(((3-(2-(dimethylamino)ethyl)-1h-indol-5-yl)methyl)sulfonyl)pyrrolidine, Hydroxybutanedioate (1:1)

18. N,n-dimethyl-2-[5-(pyrrolidin-1-ylsulfonylmethyl)-1h-indol-3-yl]ethanamine;2-hydroxybutanedioic Acid

19. Pnu 180638e

20. Unii-pjp312605e

21. Sr-05000001986

22. Axert (tn)

23. Almotriptan Malate (usp)

24. 1-[[[2-(dimethyl-amino)ethyl]-1h-indol-5-yl]methyl]sulfonyl]pyrrolidine Malate

25. Almotriptan Malate (axert)

26. 1-(((3-(2-(dimethylamino)ethyl)-1h-indol-5-yl)methyl)sulfonyl)pyrrolidine, Hydroxybutanedionate (1:1)

27. Mls006010048

28. Schembl221131

29. Almotriptan Maleate [mi]

30. Chembl1200521

31. Dtxsid1044225

32. Almotriptan Malate [vandf]

33. Almotriptan Malate(pnu180638)

34. Hms3651a12

35. Hms3884p05

36. Almotriptan Malate [mart.]

37. Almotriptan Malate [usp-rs]

38. Almotriptan Malate [who-dd]

39. Bcp05632

40. Hy-b0383

41. Mfcd08067740

42. Pnu180638

43. S2096

44. (zznon-labelled)almotriptan-d6 Malate

45. Akos015950790

46. Bcp9000276

47. Ccg-269445

48. Pnu 180638

49. Almotriptan Malate [orange Book]

50. Almotriptan Malate [ep Monograph]

51. Almotriptan Malate [usp Monograph]

52. As-12142

53. Butanedioic Acid, Hydroxy-, Compd. With 1-(((3-(2-(dimethylamino)ethyl)-1h-indol-5-yl)methyl)sulfonyl)pyrrolidine (1:1)

54. Smr004701216

55. Ft-0661519

56. Sw219418-1

57. D02825

58. F14758

59. J-011571

60. Sr-05000001986-2

61. Q27124206

62. 1-(((3-(2-(dimethylamino)ethyl)indol-5-yl)methyl)sulfonyl)pyrrolidine Malate

63. 3-[2-(dimethylamino)ethyl]-5-(pyrrolidin-1-ylsulfonylmethyl )-1h-indole Malate

64. 1-(((3-(2-(dimethylamino)ethyl)-1h-indol-5-yl)methyl)sulfonyl)pyrrolidine Hydroxybutanedioate

65. Butanedioic Acid, 2-hydroxy-, Compd. With N,n-dimethyl-5-[(1-pyrrolidinylsulfonyl)methyl]-1h-indole-3-ethanamine (1:1)

2.4 Create Date

2005-08-08

3 Chemical and Physical Properties

Molecular Formula	C₂₁H₃₁N₃O₇S
Molecular Weight	469.6 g/mol
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	9
Rotatable Bond Count	9
Exact Mass	469.18827151 g/mol
Monoisotopic Mass	469.18827151 g/mol
Topological Polar Surface Area	160 Å²
Heavy Atom Count	32
Formal Charge	0
Complexity	612
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	1
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Drug and Medication Information

4.1 Drug Information

1 of 2
Drug Name	Almotriptan malate
Drug Label	AXERT (almotriptan malate) Tablets contain almotriptan malate, a selective 5-hydroxytryptamine1B/1D (5-HT1B/1D) receptor agonist. Almotriptan malate is chemically designated as 1-[[[3-[2-(Dimethylamino)ethyl]-1H-indol-5-yl]methyl]sulfonyl]pyrrolidi...
Active Ingredient	Almotriptan malate
Dosage Form	Tablet
Route	oral
Strength	6.25mg; 12.5mg
Market Status	Tentative Approval
Company	Teva Pharms

2 of 2
Drug Name	Almotriptan malate
Drug Label	AXERT (almotriptan malate) Tablets contain almotriptan malate, a selective 5-hydroxytryptamine1B/1D (5-HT1B/1D) receptor agonist. Almotriptan malate is chemically designated as 1-[[[3-[2-(Dimethylamino)ethyl]-1H-indol-5-yl]methyl]sulfonyl]pyrrolidi...
Active Ingredient	Almotriptan malate
Dosage Form	Tablet
Route	oral
Strength	6.25mg; 12.5mg
Market Status	Tentative Approval
Company	Teva Pharms

5 Pharmacology and Biochemistry

5.1 MeSH Pharmacological Classification

Serotonin Receptor Agonists

Endogenous compounds and drugs that bind to and activate SEROTONIN RECEPTORS. Many serotonin receptor agonists are used as ANTIDEPRESSANTS; ANXIOLYTICS; and in the treatment of MIGRAINE DISORDERS. (See all compounds classified as Serotonin Receptor Agonists.)

5.2 FDA Pharmacological Classification

5.2.1 Pharmacological Classes

Serotonin 1d Receptor Agonists [MoA]; Serotonin-1b and Serotonin-1d Receptor Agonist [EPC]; Serotonin 1b Receptor Agonists [MoA]

API SUPPLIERS

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USDMF

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CEP/COS

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EU WC

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Listed Suppliers

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API Reference Price

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Number of Transactions

Total Quantity (KGS)

Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

Importing Country	Total Quantity (KGS)	Average Price (USD/KGS)	Number of Transactions

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DOSAGE - TABLET;ORAL - EQ 12.5MG BASE **Feder...DOSAGE - TABLET;ORAL - EQ 12.5MG BASE **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

USFDA APPLICATION NUMBER - 21001

DOSAGE - TABLET;ORAL - EQ 6.25MG BASE **Feder...DOSAGE - TABLET;ORAL - EQ 6.25MG BASE **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

USFDA APPLICATION NUMBER - 21001

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List of Related Excipient Companies and Suppliers of Almotriptan Malate by Dfe Pharma on PharmaCompass.com

Almotriptan Malate

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CHEMISTRY

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ACTIVE PHARMA INGREDIENTS

15 API Suppliers

6 USDMF

1 CEP/COS

5 EU WC

3 NDC API

9 Listed Suppliers

$ API Reference Price

FINISHED DOSAGE FORMULATIONS

25 FDF Dossiers

8 FDA Orange Book

11 Europe

6 Canada

DRUG PRODUCT COMPOSITIONS

TABLET;ORAL - EQ 12.5MG BASE **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

TABLET;ORAL - EQ 6.25MG BASE **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

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EXCIPIENTS BY APPLICATIONS

48 Fillers, Diluents & Binders

45 Coating Systems & Additives

30 Direct Compression

29 Disintegrants & Superdisintegrants

27 Controlled & Modified Release

19 Granulation

19 Thickeners and Stabilizers

15 Solubilizers

14 Co-Processed Excipients

14 Chewable & Orodispersible Aids

12 Taste Masking

11 Film Formers & Plasticizers

TABLET;ORAL - EQ 12.5MG BASE Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons

TABLET;ORAL - EQ 6.25MG BASE Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons