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    Also known as: 129318-43-0, Fosamax, Binosto, Fosamac, Onclast, Monosodium alendronate
    Molecular Formula
    C4H12NNaO7P2
    Molecular Weight
    271.08  g/mol
    InChI Key
    CAKRAHQRJGUPIG-UHFFFAOYSA-M
    FDA UNII
    4988K7X26P
    Alendronate Sodium
    A nonhormonal medication for the treatment of postmenopausal osteoporosis in women. This drug builds healthy bone, restoring some of the bone loss as a result of osteoporosis.
    1 2D Structure

    Alendronate Sodium

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    sodium;(4-amino-1-hydroxy-1-phosphonobutyl)-hydroxyphosphinate
    2.1.2 InChI
    InChI=1S/C4H13NO7P2.Na/c5-3-1-2-4(6,13(7,8)9)14(10,11)12;/h6H,1-3,5H2,(H2,7,8,9)(H2,10,11,12);/q;+1/p-1
    2.1.3 InChI Key
    CAKRAHQRJGUPIG-UHFFFAOYSA-M
    2.1.4 Canonical SMILES
    C(CC(O)(P(=O)(O)O)P(=O)(O)[O-])CN.[Na+]
    2.2 Other Identifiers
    2.2.1 UNII
    4988K7X26P
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. 4-amino-1-hydroxybutylidene 1,1-biphosphonate

    2. Alendronate

    3. Alendronate Monosodium Salt, Trihydrate

    4. Aminohydroxybutane Bisphosphonate

    5. Fosamax

    6. Mk 217

    7. Mk-217

    8. Mk217

    2.3.2 Depositor-Supplied Synonyms

    1. 129318-43-0

    2. Fosamax

    3. Binosto

    4. Fosamac

    5. Onclast

    6. Monosodium Alendronate

    7. Alendronate Sodium Anhydrous

    8. Alendronate Monosodium

    9. Mk 217

    10. Alendronic Acid Monosodium Salt

    11. Mk-217

    12. Sodium;(4-amino-1-hydroxy-1-phosphonobutyl)-hydroxyphosphinate

    13. Adrovance

    14. Fosavance

    15. G-704650

    16. Vantavo

    17. Onclast; Osteovan; Sodium Alendronate

    18. 4988k7x26p

    19. Osteovan

    20. Indrol

    21. Alend

    22. Neobon

    23. Alendronate (as Sodium)

    24. Phosphonic Acid, (4-amino-1-hydroxybutylidene)bis-, Monosodium Salt

    25. Nsc-722597

    26. Nsc-758931

    27. Almerol

    28. Avalent

    29. Bonalon

    30. Steovess

    31. Teiroc

    32. Unii-4988k7x26p

    33. Ahbutbp

    34. Ahbubp

    35. (4-amino-1-hydroxybutylidene)bisphosphonic Acid Monosodium Salt

    36. Chembl675

    37. Alendronic Acid Sodium Salt

    38. Gth-42j

    39. Gth-42v

    40. Gth-42w

    41. Schembl328770

    42. Gth-42

    43. Dtxsid70904501

    44. Mer-103

    45. Hms3604i12

    46. Hms3713p04

    47. Sodium Alendronate Anhydrous

    48. Bcp28464

    49. Alendronic Acid, Sodium Aldendronate

    50. Bdbm50247920

    51. Ex-101

    52. Mfcd01861681

    53. Akos015895071

    54. Ccg-220631

    55. Ks-1028

    56. Mk-0217

    57. Hy-108685

    58. Cs-0029477

    59. Mk 217;mk-217;mk217;sodium Alendronate

    60. A805927

    61. J-005667

    62. L-670452

    63. Q27259256

    64. Monosodium (4-amino-1-hydroxy-1-phosphonobutyl)phosphonate

    65. Sodium Hydrogen-4-amino-1-hydroxy-1-phosphonobutylphosphonate

    66. (4-amino-1-hydroxy-1-phosphonobutyl)phosphonic Acid Monosodium Salt

    67. 4-amino-1-hydroxybutylidene-1,1-bisphosphonic Acid Monosodium Salt

    68. P,p'-(4-amino-1-hydroxybutylidene)bis-phosphonic Acid Monosodium Salt

    69. Phosphonic Acid, P,p'-(4-amino-1-hydroxybutylidene)bis-, Sodium Salt (1:1)

    2.4 Create Date
    2007-11-13
    3 Chemical and Physical Properties
    Molecular Weight 271.08 g/mol
    Molecular Formula C4H12NNaO7P2
    Hydrogen Bond Donor Count5
    Hydrogen Bond Acceptor Count8
    Rotatable Bond Count5
    Exact Mass270.99867000 g/mol
    Monoisotopic Mass270.99867000 g/mol
    Topological Polar Surface Area164 Ų
    Heavy Atom Count15
    Formal Charge0
    Complexity293
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count1
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 6  
    Drug NameAlendronate sodium
    PubMed HealthAlendronate (By mouth)
    Drug ClassesCalcium Regulator
    Drug LabelFOSAMAX1 (alendronate sodium) is a bisphosphonate that acts as a specific inhibitor of osteoclast-mediated bone resorption. Bisphosphonates are synthetic analogs of pyrophosphate that bind to the hydroxyapatite found in bone.Alendronate sodium is che...
    Active IngredientAlendronate sodium
    Dosage FormTablet; Solution
    RouteOral
    Strengtheq 40mg base; eq 5mg base; eq 70mg base; eq 10mg base; eq 35mg base; eq 70mg base/75ml
    Market StatusPrescription
    CompanyWatson Labs; Teva Pharms; Austarpharma; Apotex; Aurobindo Pharma; Cadista Pharms; Dr Reddys Labs; Cipla; Sun Pharma Global; Mylan; Roxane

    2 of 6  
    Drug NameBinosto
    Drug LabelBINOSTO (alendronate sodium) is a bisphosphonate that acts as a specific inhibitor of osteoclast-mediated bone resorption. Bisphosphonates are synthetic analogs of pyrophosphate that bind to the hydroxyapatite found in bone.Alendronate sodium is chem...
    Active IngredientAlendronate sodium
    Dosage FormTablet, effervescent
    RouteOral
    Strengtheq 70mg base
    Market StatusPrescription
    CompanyMission Pharma

    3 of 6  
    Drug NameFosamax
    PubMed HealthAlendronate (By mouth)
    Drug ClassesCalcium Regulator
    Drug LabelFOSAMAX1 (alendronate sodium) is a bisphosphonate that acts as a specific inhibitor of osteoclast-mediated bone resorption. Bisphosphonates are synthetic analogs of pyrophosphate that bind to the hydroxyapatite found in bone.Alendronate sodium is che...
    Active IngredientAlendronate sodium
    Dosage FormTablet; Solution
    RouteOral
    Strengtheq 70mg base; eq 70mg base/75ml
    Market StatusPrescription
    CompanyMerck; Merck And

    4 of 6  
    Drug NameAlendronate sodium
    PubMed HealthAlendronate (By mouth)
    Drug ClassesCalcium Regulator
    Drug LabelFOSAMAX1 (alendronate sodium) is a bisphosphonate that acts as a specific inhibitor of osteoclast-mediated bone resorption. Bisphosphonates are synthetic analogs of pyrophosphate that bind to the hydroxyapatite found in bone.Alendronate sodium is che...
    Active IngredientAlendronate sodium
    Dosage FormTablet; Solution
    RouteOral
    Strengtheq 40mg base; eq 5mg base; eq 70mg base; eq 10mg base; eq 35mg base; eq 70mg base/75ml
    Market StatusPrescription
    CompanyWatson Labs; Teva Pharms; Austarpharma; Apotex; Aurobindo Pharma; Cadista Pharms; Dr Reddys Labs; Cipla; Sun Pharma Global; Mylan; Roxane

    5 of 6  
    Drug NameBinosto
    Drug LabelBINOSTO (alendronate sodium) is a bisphosphonate that acts as a specific inhibitor of osteoclast-mediated bone resorption. Bisphosphonates are synthetic analogs of pyrophosphate that bind to the hydroxyapatite found in bone.Alendronate sodium is chem...
    Active IngredientAlendronate sodium
    Dosage FormTablet, effervescent
    RouteOral
    Strengtheq 70mg base
    Market StatusPrescription
    CompanyMission Pharma

    6 of 6  
    Drug NameFosamax
    PubMed HealthAlendronate (By mouth)
    Drug ClassesCalcium Regulator
    Drug LabelFOSAMAX1 (alendronate sodium) is a bisphosphonate that acts as a specific inhibitor of osteoclast-mediated bone resorption. Bisphosphonates are synthetic analogs of pyrophosphate that bind to the hydroxyapatite found in bone.Alendronate sodium is che...
    Active IngredientAlendronate sodium
    Dosage FormTablet; Solution
    RouteOral
    Strengtheq 70mg base; eq 70mg base/75ml
    Market StatusPrescription
    CompanyMerck; Merck And

    4.2 Drug Indication

    Treatment of postmenopausal osteoporosis in patients at risk of vitamin-D insufficiency.

    Adrovance reduces the risk of vertebral and hip fractures.

    Treatment of postmenopausal osteoporosis in patients at risk of vitamin-D insufficiency.

    Fosavance reduces the risk of vertebral and hip fractures.

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Bone Density Conservation Agents

    Agents that inhibit BONE RESORPTION and/or favor BONE MINERALIZATION and BONE REGENERATION. They are used to heal BONE FRACTURES and to treat METABOLIC BONE DISEASES such as OSTEOPOROSIS. (See all compounds classified as Bone Density Conservation Agents.)

    5.2 FDA Pharmacological Classification
    5.2.1 Pharmacological Classes
    Diphosphonates [CS]; Bisphosphonate [EPC]
    5.3 ATC Code

    M05BB03

    M05BB03

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    13-Jan-2021
    21-Aug-2024
    KGS
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    Average Price (USD/KGS)

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    Total Quantity (KGS)

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    Quantity (KGS) & Unit rate (USD/KGS) over time

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    (KGS)    		 Average Price
    (USD/KGS)    		 Number of Transactions

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    DRUG PRODUCT COMPOSITIONS

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    DOSAGE - TABLET;ORAL - EQ 10MG BASE **Federal...DOSAGE - TABLET;ORAL - EQ 10MG BASE **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

    USFDA APPLICATION NUMBER - 20560

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    DOSAGE - TABLET;ORAL - EQ 35MG BASE **Federal...DOSAGE - TABLET;ORAL - EQ 35MG BASE **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

    USFDA APPLICATION NUMBER - 20560

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    DOSAGE - TABLET;ORAL - EQ 40MG BASE **Federal...DOSAGE - TABLET;ORAL - EQ 40MG BASE **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

    USFDA APPLICATION NUMBER - 20560

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    DOSAGE - TABLET;ORAL - EQ 5MG BASE **Federal ...DOSAGE - TABLET;ORAL - EQ 5MG BASE **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

    USFDA APPLICATION NUMBER - 20560

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    DOSAGE - TABLET;ORAL - EQ 70MG BASE

    USFDA APPLICATION NUMBER - 20560

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    DOSAGE - TABLET;ORAL - EQ 70MG BASE;2,800 IU

    USFDA APPLICATION NUMBER - 21762

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    DOSAGE - TABLET;ORAL - EQ 70MG BASE;5,600 IU

    USFDA APPLICATION NUMBER - 21762

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