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    Synopsis

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    Chemistry

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    Also known as: 114977-28-5, Taxotere, Docetaxel anhydrous, Docetaxol, Rp-56976, Docetaxel winthrop
    Molecular Formula
    C43H53NO14
    Molecular Weight
    807.9  g/mol
    InChI Key
    ZDZOTLJHXYCWBA-VCVYQWHSSA-N
    FDA UNII
    699121PHCA
    Docetaxel
    A semisynthetic analog of PACLITAXEL used in the treatment of locally advanced or metastatic BREAST NEOPLASMS and NON-SMALL CELL LUNG CANCER.
    Docetaxel anhydrous is a Microtubule Inhibitor. The physiologic effect of docetaxel anhydrous is by means of Microtubule Inhibition.
    1 2D Structure

    Docetaxel

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    [(1S,2S,3R,4S,7R,9S,10S,12R,15S)-4-acetyloxy-1,9,12-trihydroxy-15-[(2R,3S)-2-hydroxy-3-[(2-methylpropan-2-yl)oxycarbonylamino]-3-phenylpropanoyl]oxy-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.03,10.04,7]heptadec-13-en-2-yl] benzoate
    2.1.2 InChI
    InChI=1S/C43H53NO14/c1-22-26(55-37(51)32(48)30(24-15-11-9-12-16-24)44-38(52)58-39(3,4)5)20-43(53)35(56-36(50)25-17-13-10-14-18-25)33-41(8,34(49)31(47)29(22)40(43,6)7)27(46)19-28-42(33,21-54-28)57-23(2)45/h9-18,26-28,30-33,35,46-48,53H,19-21H2,1-8H3,(H,44,52)/t26-,27-,28+,30-,31+,32+,33-,35-,41+,42-,43+/m0/s1
    2.1.3 InChI Key
    ZDZOTLJHXYCWBA-VCVYQWHSSA-N
    2.1.4 Canonical SMILES
    CC1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C(C(C5=CC=CC=C5)NC(=O)OC(C)(C)C)O)O)OC(=O)C6=CC=CC=C6)(CO4)OC(=O)C)O)C)O
    2.1.5 Isomeric SMILES
    CC1=C2[C@H](C(=O)[C@@]3([C@H](C[C@@H]4[C@]([C@H]3[C@@H]([C@@](C2(C)C)(C[C@@H]1OC(=O)[C@@H]([C@H](C5=CC=CC=C5)NC(=O)OC(C)(C)C)O)O)OC(=O)C6=CC=CC=C6)(CO4)OC(=O)C)O)C)O
    2.2 Other Identifiers
    2.2.1 UNII
    699121PHCA
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Docetaxel Anhydrous

    2. Docetaxel Hydrate

    3. Docetaxel Trihydrate

    4. Docetaxol

    5. N Debenzoyl N Tert Butoxycarbonyl 10 Deacetyltaxol

    6. N-debenzoyl-n-tert-butoxycarbonyl-10-deacetyltaxol

    7. Nsc 628503

    8. Rp 56976

    9. Rp-56976

    10. Rp56976

    11. Taxoltere Metro

    12. Taxotere

    2.3.2 Depositor-Supplied Synonyms

    1. 114977-28-5

    2. Taxotere

    3. Docetaxel Anhydrous

    4. Docetaxol

    5. Rp-56976

    6. Docetaxel Winthrop

    7. Docetaxel [inn]

    8. Emdoc

    9. Docefrez

    10. Nsc 628503

    11. N-debenzoyl-n-tert-butoxycarbonyl-10-deacetyltaxol

    12. Rp 56976

    13. Txl

    14. Taxotere (tn)

    15. Nsc-628503

    16. N-debenzoyl-n-(tert-butoxycarbonyl)-10-deacetyltaxol

    17. Chebi:4672

    18. 699121phca

    19. Nsc628503

    20. N-debenzoyl-n-(tert-butoxycarbonyl)-10-deacetylpaclitaxel

    21. Dsstox_cid_20464

    22. Dsstox_rid_79497

    23. Dsstox_gsid_40464

    24. (2alpha,5beta,7beta,10beta,13alpha)-4-(acetyloxy)-13-({(2r,3s)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoyl}oxy)-1,7,10-trihydroxy-9-oxo-5,20-epoxytax-11-en-2-yl Benzoate

    25. [(1s,2s,3r,4s,7r,9s,10s,12r,15s)-4-acetyloxy-1,9,12-trihydroxy-15-[(2r,3s)-2-hydroxy-3-[(2-methylpropan-2-yl)oxycarbonylamino]-3-phenylpropanoyl]oxy-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.03,10.04,7]heptadec-13-en-2-yl] Benzoate

    26. Docetaxel, Trihydrate

    27. Taxotel

    28. Docetaxolum

    29. Taxoel

    30. Docetaxel Kabi

    31. Docetaxel Intermediate

    32. Bind 014

    33. Taxotere(r)

    34. Ckd-810

    35. (1s,2s,3r,4s,7r,9s,10s,12r,15s)-4-(acetyloxy)-15-{[(2r,3s)-3-{[(tert-butoxy)carbonyl]amino}-2-hydroxy-3-phenylpropanoyl]oxy}-1,9,12-trihydroxy-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.0^{3,10}.0^{4,7}]heptadec-13-en-2-yl Benzoate

    36. (2ar,4s,4as,6r,9s,11s,12s,12ar,12bs)-12b-acetoxy-9-(((2r,3s)-3-((tert-butoxycarbonyl)amino)-2-hydroxy-3-phenylpropanoyl)oxy)-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1h-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxet-12-yl Benzoate

    37. Cas-114977-28-5

    38. Docetaxolum [inn-latin]

    39. Docecad

    40. Unii-699121phca

    41. Docetaxel Teva

    42. Docetaxel Accord

    43. Mfcd00871399

    44. Docetaxel 114977-28-5

    45. Dtxsid0040464

    46. Hsdb 6965

    47. Xrp-6976l

    48. Anx-514

    49. Sdp-014

    50. Sid 530

    51. Docetaxel (tn)

    52. Docetaxel- Bio-x

    53. Ncgc00181306-01

    54. Ncgc00181306-02

    55. 5?,20-epoxy-1,7?,10?-trihydroxy-9-oxotax-11-ene-2?,4,13?-triyl 4-acetate 2-benzoate 13-[(2r,3s)-3-[[(1,1-dimethylethoxy)carbonyl]amino]-2-hydroxy-3-phenylpropanoate]

    56. Taxotere (aventis)

    57. Docetaxel, Anhydrous

    58. Cid148124

    59. N-debenzoyl-n-boc-10-deacetyl Taxol

    60. Docetaxel - Taxotere

    61. Docetaxel Mylan

    62. Rp56976

    63. Bind-014

    64. Docetaxel (jan/inn)

    65. Docetaxel [jan]

    66. Docetaxel [mi]

    67. Chembl92

    68. Docetaxel [hsdb]

    69. Schembl4419

    70. Docetaxel Teva Pharma

    71. Gtpl6809

    72. Bind 014 [who-dd]

    73. Bdbm36351

    74. Syp-0704a

    75. Zdzotljhxycwba-vcvyqwhssa-

    76. Amy4356

    77. 114977-28-5, Docetaxel

    78. Hms2089k08

    79. Ex-a1206

    80. Hy-b0011

    81. Tox21_112781

    82. Tox21_113088

    83. Ac-383

    84. Docetaxel Anhydrous [who-dd]

    85. Zinc85537053

    86. Akos015960718

    87. Akos024457953

    88. Tox21_112781_1

    89. Cs-1144

    90. Db01248

    91. Ks-1452

    92. Isocyanatoethylmethacrylatepolymer

    93. Docetaxel, Purum, >=97.0% (hplc)

    94. Ncgc00181306-04

    95. Ncgc00242509-01

    96. 4-(acetyloxy)-13alpha-({(2r,3s)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoyl}oxy)-1,7beta,10beta-trihydroxy-9-oxo-5beta,20-epoxytax-11-en-2alpha-yl Benzoate

    97. Bd164373

    98. Benzenepropanoic Acid, Beta-(((1,1-dimethylethoxy)carbonyl)amino)-alpha-hydroxy-, 12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1h-cyclodeca(3,4)benz(1,2-b)oxet-9-yl Ester

    99. Cabazitaxel Metabolite (rp56976)

    100. D4102

    101. D07866

    102. Ab01273941-01

    103. Ab01273941-02

    104. Q420436

    105. Sr-01000003023

    106. W-60384

    107. Q-100074

    108. Sr-01000003023-5

    109. Brd-k30577245-001-04-3

    110. Brd-k30577245-341-01-9

    111. Z1551429742

    112. Anhydrous Docetaxel, European Pharmacopoeia (ep) Reference Standard

    113. (2ar,4s,4as,6r,9s,11s,12s,12ar,12bs)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1h-cyclodeca[3,4]benz[1,2-b]oxet-9-yl (ar,bs)-b-[[(1,1-dimethylethoxy)carbonyl]amino]-a-hydroxybenzenepropanoate

    114. (2beta,5beta,7alpha,8alpha,10alpha,13alpha)-4-(acetyloxy)-13-({(2r,3s)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoyl}oxy)-1,7,10-trihydroxy-9-oxo-5,20-epoxytax-11-en-2-yl Benzoate

    115. (2r,3s)-n-carboxy-3-phenylisoserine, N-tert-butyl Ester, 13-ester With 5.beta.,20-epoxy-1,2.alpha.,4,7.beta.,10.beta.,13.alpha.-hexahydroxytax-11-en-9-one 4-acetate 2-benzoate

    116. [2ar-[2a?,4?,4a?,6?,9?(?r*,?s*),11?,12?,12a?,12b?]]-?-[[(1,1-dimethylethoxy)carbonyl]amino]-?-hydroxy-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1h-cyclodeca[3,4]benz[1,2-b]oxet-9-yl Ester Benzenepropanoic Acid

    117. [acetoxy-[(2r,3s)-3-(tert-butoxycarbonylamino)-2-hydroxy-3-phenyl-propanoyl]oxy-trihydroxy-tetramethyl-oxo-[?]yl] Benzoate

    118. 114915-20-7

    119. Benzenepropanoic Acid, Beta-(((1,1-dimethylethoxy)carbonyl)amino)-alpha-hydroxy-, (2ar,4s,4as,6r,9s,11s,12s,12ar,12bs)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1h-cyclodeca(3,4)benz(1,2-b)oxet-9-yl Ester, (alphar,betas)-

    120. Benzenepropanoic Acid,1-dimethylethoxy)carbonyl]amino]-.alpha.-hydroxy-, (2ar,4s,4as,6r,9s,11s,12s,12ar,12bs)-12b-(acetyloxy)-12-(benzyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1h-cyclodeca[3,4]benz[1,2-b]oxet-9-yl Ester, (.alpha.r,.beta.s)

    2.4 Create Date
    2005-06-24
    3 Chemical and Physical Properties
    Molecular Weight 807.9 g/mol
    Molecular Formula C43H53NO14
    XLogP31.6
    Hydrogen Bond Donor Count5
    Hydrogen Bond Acceptor Count14
    Rotatable Bond Count13
    Exact Mass807.34660536 g/mol
    Monoisotopic Mass807.34660536 g/mol
    Topological Polar Surface Area224 Ų
    Heavy Atom Count58
    Formal Charge0
    Complexity1660
    Isotope Atom Count0
    Defined Atom Stereocenter Count11
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 6  
    Drug NameDocefrez
    PubMed HealthDocetaxel (Injection)
    Drug ClassesAntineoplastic Agent
    Active IngredientDocetaxel
    Dosage FormInjectable
    RouteInjection
    Strength80mg/vial; 20mg/vial
    Market StatusPrescription
    CompanySun Pharma Global

    2 of 6  
    Drug NameDocetaxel
    Drug LabelDocetaxel is an antineoplastic agent belonging to the taxoid family. It is prepared by semisynthesis beginning with a precursor extracted from the renewable needle biomass of yew plants. The chemical name for docetaxel is (2R,3S)-N-carboxy-3-phenylis...
    Active IngredientDocetaxel
    Dosage FormInjectable
    RouteInjection
    Strength160mg/16ml (10mg/ml); 130mg/13ml (10mg/ml); 80mg/4ml (20mg/ml); 200mg/20ml (10mg/ml); 80mg/8ml (10mg/ml); 20mg/2ml (10mg/ml); 80mg/2ml (40mg/ml); 160mg/8ml (20mg/ml); 20mg/ml (20mg/ml); 140mg/7ml (20mg/ml); 20mg/0.5ml (40mg/ml)
    Market StatusPrescription
    CompanyHospira; Accord Hlthcare; Pfizer Labs; Sandoz; Actavis

    3 of 6  
    Drug NameTaxotere
    PubMed HealthDocetaxel (Injection)
    Drug ClassesAntineoplastic Agent
    Drug LabelDocetaxel is an antineoplastic agent belonging to the taxoid family. It is prepared by semisynthesis beginning with a precursor extracted from the renewable needle biomass of yew plants. The chemical name for docetaxel is (2R,3S)-N-carboxy-3-phenylis...
    Active IngredientDocetaxel
    Dosage FormInjectable
    RouteInjection
    Strength160mg/8ml (20mg/ml); 80mg/4ml (20mg/ml); 20mg/ml (20mg/ml)
    Market StatusPrescription
    CompanySanofi Aventis Us

    4 of 6  
    Drug NameDocefrez
    PubMed HealthDocetaxel (Injection)
    Drug ClassesAntineoplastic Agent
    Active IngredientDocetaxel
    Dosage FormInjectable
    RouteInjection
    Strength80mg/vial; 20mg/vial
    Market StatusPrescription
    CompanySun Pharma Global

    5 of 6  
    Drug NameDocetaxel
    Drug LabelDocetaxel is an antineoplastic agent belonging to the taxoid family. It is prepared by semisynthesis beginning with a precursor extracted from the renewable needle biomass of yew plants. The chemical name for docetaxel is (2R,3S)-N-carboxy-3-phenylis...
    Active IngredientDocetaxel
    Dosage FormInjectable
    RouteInjection
    Strength160mg/16ml (10mg/ml); 130mg/13ml (10mg/ml); 80mg/4ml (20mg/ml); 200mg/20ml (10mg/ml); 80mg/8ml (10mg/ml); 20mg/2ml (10mg/ml); 80mg/2ml (40mg/ml); 160mg/8ml (20mg/ml); 20mg/ml (20mg/ml); 140mg/7ml (20mg/ml); 20mg/0.5ml (40mg/ml)
    Market StatusPrescription
    CompanyHospira; Accord Hlthcare; Pfizer Labs; Sandoz; Actavis

    6 of 6  
    Drug NameTaxotere
    PubMed HealthDocetaxel (Injection)
    Drug ClassesAntineoplastic Agent
    Drug LabelDocetaxel is an antineoplastic agent belonging to the taxoid family. It is prepared by semisynthesis beginning with a precursor extracted from the renewable needle biomass of yew plants. The chemical name for docetaxel is (2R,3S)-N-carboxy-3-phenylis...
    Active IngredientDocetaxel
    Dosage FormInjectable
    RouteInjection
    Strength160mg/8ml (20mg/ml); 80mg/4ml (20mg/ml); 20mg/ml (20mg/ml)
    Market StatusPrescription
    CompanySanofi Aventis Us

    4.2 Therapeutic Uses

    Antineoplastic Agents; Tubulin Modulators

    National Library of Medicine's Medical Subject Headings. Docetaxel. Online file (MeSH, 2014). Available from, as of December 18, 2014: https://www.nlm.nih.gov/mesh/2014/mesh_browser/MBrowser.html

    Taxotere is indicated for the treatment of patients with locally advanced or metastatic breast cancer after failure of prior chemotherapy. Taxotere in combination with doxorubicin and cyclophosphamide is indicated for the adjuvant treatment of patients with operable node-positive breast cancer. /Included in US product labeling/

    NIH; DailyMed. Current Medication Information for Taxotere (Docetaxel) Injection, Solution, Concentrate (Updated: November 2014). Available from, as of March 25, 2015: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=45e6dce4-92e2-4ad1-bf11-bbcefb753636

    Taxotere as a single agent is indicated for the treatment of patients with locally advanced or metastatic non-small cell lung cancer after failure of prior platinum-based chemotherapy. Taxotere in combination with cisplatin is indicated for the treatment of patients with unresectable, locally advanced or metastatic non-small cell lung cancer who have not previously received chemotherapy for this condition. /Included in US product labeling/

    NIH; DailyMed. Current Medication Information for Taxotere (Docetaxel) Injection, Solution, Concentrate (Updated: November 2014). Available from, as of March 25, 2015: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=45e6dce4-92e2-4ad1-bf11-bbcefb753636

    Taxotere in combination with prednisone is indicated for the treatment of patients with androgen independent (hormone refractory) metastatic prostate cancer. /Included in US product labeling/

    NIH; DailyMed. Current Medication Information for Taxotere (Docetaxel) Injection, Solution, Concentrate (Updated: November 2014). Available from, as of March 25, 2015: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=45e6dce4-92e2-4ad1-bf11-bbcefb753636

    For more Therapeutic Uses (Complete) data for DOCETAXEL (8 total), please visit the HSDB record page.

    4.3 Drug Warning

    /BOXED WARNING/ WARNING: TOXIC DEATHS. The incidence of treatment-related mortality associated with Taxotere therapy is increased in patients with abnormal liver function, in patients receiving higher doses, and in patients with non-small cell lung carcinoma and a history of prior treatment with platinum-based chemotherapy who receive Taxotere as a single agent at a dose of 100 mg/sq m.

    NIH; DailyMed. Current Medication Information for Taxotere (Docetaxel) Injection, Solution, Concentrate (Updated: November 2014). Available from, as of March 25, 2015: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=45e6dce4-92e2-4ad1-bf11-bbcefb753636

    /BOXED WARNING/ WARNING: HEPATOTOXICITY. Taxotere should not be given to patients with bilirubin > upper limit of normal (ULN), or to patients with AST and/or ALT >1.5 x ULN concomitant with alkaline phosphatase >2.5 x ULN. Patients with elevations of bilirubin or abnormalities of transaminase concurrent with alkaline phosphatase are at increased risk for the development of grade 4 neutropenia, febrile neutropenia, infections, severe thrombocytopenia, severe stomatitis, severe skin toxicity, and toxic death. Patients with isolated elevations of transaminase >1.5 x ULN also had a higher rate of febrile neutropenia grade 4 but did not have an increased incidence of toxic death. Bilirubin, AST or ALT, and alkaline phosphatase values should be obtained prior to each cycle of Taxotere therapy

    NIH; DailyMed. Current Medication Information for Taxotere (Docetaxel) Injection, Solution, Concentrate (Updated: November 2014). Available from, as of March 25, 2015: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=45e6dce4-92e2-4ad1-bf11-bbcefb753636

    /BOXED WARNING/ WARNING: NEUTROPENIA. Taxotere therapy should not be given to patients with neutrophil counts of <1500 cells/cu mm. In order to monitor the occurrence of neutropenia, which may be severe and result in infection, frequent blood cell counts should be performed on all patients receiving Taxotere.

    NIH; DailyMed. Current Medication Information for Taxotere (Docetaxel) Injection, Solution, Concentrate (Updated: November 2014). Available from, as of March 25, 2015: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=45e6dce4-92e2-4ad1-bf11-bbcefb753636

    /BOXED WARNING/ WARNING: HYPERSENSITIVITY REACTIONS. Severe hypersensitivity reactions characterized by generalized rash/erythema, hypotension and/or bronchospasm, or very rarely fatal anaphylaxis, have been reported in patients who received a 3-day dexamethasone premedication. Hypersensitivity reactions require immediate discontinuation of the Taxotere infusion and administration of appropriate therapy Taxotere must not be given to patients who have a history of severe hypersensitivity reactions to Taxotere or to other drugs formulated with polysorbate 80.

    NIH; DailyMed. Current Medication Information for Taxotere (Docetaxel) Injection, Solution, Concentrate (Updated: November 2014). Available from, as of March 25, 2015: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=45e6dce4-92e2-4ad1-bf11-bbcefb753636

    For more Drug Warnings (Complete) data for DOCETAXEL (45 total), please visit the HSDB record page.

    4.4 Drug Indication

    For the treatment of patients with locally advanced or metastatic breast cancer after failure of prior chemotherapy. Also used as a single agent in the treatment of patients with locally advanced or metastatic non-small cell lung cancer after failure of prior platinum-based chemotherapy. It is also used in combination with prednisone, in the treatment of patients with androgen independent (hormone refractory) metastatic prostate cancer. Furthermore, docetaxel has uses in the treatment of gastric adenocarinoma and head and neck cancer.

    FDA Label

    * Breast cancer :

    Docetaxel Accord in combination with doxorubicin and cyclophosphamide is indicated for the adjuvant treatment of patients with:

    - operable node-positive breast cancer ;

    - operable node-negative breast cancer .

    For patients with operable node-negative breast cancer , adjuvant treatment should be restricted to patients eligible to receive chemotherapy according to internationally established criteria for primary therapy of early breast cancer .

    Docetaxel Accord in combination with doxorubicin is indicated for the treatment of patients with locally advanced or metastatic breast cancer who have not previously received cytotoxic therapy for this condition.

    Docetaxel Accord monotherapy is indicated for the treatment of patients with locally advanced or metastatic breast cancer after failure of cytotoxic therapy. Previous chemotherapy should have included an anthracycline or an alkylating agent.

    Docetaxel Accord in combination with trastuzumab is indicated for the treatment of patients with metastatic breast cancer whose tumours overexpress HER2 and who previously have not received chemotherapy for metastatic disease.

    Docetaxel Accord in combination with capecitabine is indicated for the treatment of patients with locally advanced or metastatic breast cancer after failure of cytotoxic chemotherapy. Previous therapy should have included an anthracycline.

    * Non-small-cell lung cancer :

    Docetaxel Accord is indicated for the treatment of patients with locally advanced or metastatic non-small-cell lung cancer after failure of prior chemotherapy.

    Docetaxel Accord in combination with cisplatin is indicated for the treatment of patients with unresectable, locally advanced or metastatic non-small-cell lung cancer , in patients who have not previously received chemotherapy for this condition.

    * Prostate cancer :

    Docetaxel Accord in combination with prednisone or prednisolone is indicated for the treatment of patients with hormone refractory metastatic prostate cancer .

    * Gastric adenocarcinoma:

    Docetaxel Accord in combination with cisplatin and 5-fluorouracil is indicated for the treatment of patients with metastatic gastric adenocarcinoma, including adenocarcinoma of the gastroesophageal junction, who have not received prior chemotherapy for metastatic disease.

    * Head and neck cancer :

    Docetaxel Accord in combination with cisplatin and 5-fluorouracil is indicated for the induction treatment of patients with locally advanced squamous cell carcinoma of the head and neck.

    * Breast cancer :

    Taxotere in combination with doxorubicin and cyclophosphamide is indicated for the adjuvant treatment of patients with:

    - operable node-positive breast cancer ;

    - operable node-negative breast cancer .

    For patients with operable node-negative breast cancer , adjuvant treatment should be restricted to patients eligible to receive chemotherapy according to internationally established criteria for primary therapy of early breast cancer .

    Taxotere in combination with doxorubicin is indicated for the treatment of patients with locally advanced or metastatic breast cancer who have not previously received cytotoxic therapy for this condition.

    Taxotere monotherapy is indicated for the treatment of patients with locally advanced ormetastatic breast cancer after failure of cytotoxic therapy. Previous chemotherapy should have included an anthracycline or an alkylating agent.

    Taxotere in combination with trastuzumab is indicated for the treatment of patients with metastatic breast cancer whose tumours overexpress HER2 and who previously have not received chemotherapy for metastatic disease.

    Taxotere in combination with capecitabine is indicated for the treatment of patients with locally advanced or metastatic breast cancer after failure of cytotoxic chemotherapy. Previous therapy should have included an anthracycline.

    * Non-small-cell lung cancer :

    Taxotere is indicated for the treatment of patients with locally advanced or metastatic non-small-cell lung cancer after failure of prior chemotherapy.

    Taxotere in combination with cisplatin is indicated for the treatment of patients with unresectable, locally advanced or metastatic non-small-cell lung cancer , in patients who have not previously received chemotherapy for this condition.

    * Prostate cancer :

    Taxotere in combination with prednisone or prednisolone is indicated for the treatment of patients with hormone refractory metastatic prostate cancer .

    * Gastric adenocarcinoma:

    Taxotere in combination with cisplatin and 5-fluorouracil is indicated for the treatment of patients with metastatic gastric adenocarcinoma, including adenocarcinoma of the gastroesophageal junction, who have not received prior chemotherapy for metastatic disease.

    * Head and neck cancer :

    Taxotere in combination with cisplatin and 5-fluorouracil is indicated for the induction treatment of patients with locally advanced squamous cell carcinoma of the head and neck.

    * Breast cancer :

    Docetaxel Winthrop in combination with doxorubicin and cyclophosphamide is indicated for the adjuvant treatment of patients with:

    - operable node-positive breast cancer ;

    - operable node-negative breast cancer .

    For patients with operable node-negative breast cancer , adjuvant treatment should be restricted to patients eligible to receive chemotherapy according to internationally established criteria for primary therapy of early breast cancer .

    Docetaxel Winthrop in combination with doxorubicin is indicated for the treatment of patients with locally advanced or metastatic breast cancer who have not previously received cytotoxic therapy for this condition.

    Docetaxel Winthrop monotherapy is indicated for the treatment of patients with locally advanced or metastatic breast cancer after failure of cytotoxic therapy. Previous chemotherapy should have included an anthracycline or an alkylating agent.

    Docetaxel Winthrop in combination with trastuzumab is indicated for the treatment of patients with metastatic breast cancer whose tumours overexpress HER2 and who previously have not received chemotherapy for metastatic disease.

    Docetaxel Winthrop in combination with capecitabine is indicated for the treatment of patients with locally advanced or metastatic breast cancer after failure of cytotoxic chemotherapy. Previous therapy should have included an anthracycline.

    * Non-small-cell lung cancer :

    Docetaxel Winthrop is indicated for the treatment of patients with locally advanced or metastatic non-small-cell lung cancer after failure of prior chemotherapy.

    Docetaxel Winthrop in combination with cisplatin is indicated for the treatment of patients with unresectable, locally advanced or metastatic non-small-cell lung cancer , in patients who have not previously received chemotherapy for this condition.

    * Prostate cancer :

    Docetaxel Winthrop in combination with prednisone or prednisolone is indicated for the treatment of patients with hormone-refractory metastatic prostate cancer .

    * Gastric adenocarcinoma:

    Docetaxel Winthrop in combination with cisplatin and 5-fluorouracil is indicated for the treatment of patients with metastatic gastric adenocarcinoma, including adenocarcinoma of the gastroesophageal junction, who have not received prior chemotherapy for metastatic disease.

    * Head and neck cancer :

    Docetaxel Winthrop in combination with cisplatin and 5-fluorouracil is indicated for the induction treatment of patients with locally advanced squamous cell carcinoma of the head and neck.

    * Breast cancer :

    Taxespira in combination with doxorubicin and cyclophosphamide is indicated for the adjuvant treatment of patients with:

    - operable node-positive breast cancer ;

    - operable node-negative breast cancer .

    For patients with operable node-negative breast cancer , adjuvant treatment should be restricted to patients eligible to receive chemotherapy according to internationally established criteria for primary therapy of early breast cancer .

    Taxespira in combination with doxorubicin is indicated for the treatment of patients with locally advanced or metastatic breast cancer who have not previously received cytotoxic therapy for this condition.

    Taxespira monotherapy is indicated for the treatment of patients with locally advanced or metastatic breast cancer after failure of cytotoxic therapy. Previous chemotherapy should have included an anthracycline or an alkylating agent.

    Taxespira combination with trastuzumab is indicated for the treatment of patients with metastatic breast cancer whose tumours over express HER2 and who previously have not received chemotherapy for metastatic disease.

    Taxespira in combination with capecitabine is indicated for the treatment of patients with locally advanced or metastatic breast cancer after failure of cytotoxic chemotherapy. Previous therapy should have included an anthracycline.

    * Non-small cell lung cancer :

    Taxespira indicated for the treatment of patients with locally advanced or metastatic non-small cell lung cancer after failure of prior chemotherapy.

    Taxespira in combination with cisplatin is indicated for the treatment of patients with unresectable, locally advanced or metastatic non-small cell lung cancer , in patients who have not previously received chemotherapy for this condition.

    * Prostate cancer :

    Taxespira in combination with prednisone or prednisolone is indicated for the treatment of patients with hormone refractory metastatic prostate cancer .

    * Gastric adenocarcinoma:

    Taxespira in combination with cisplatin and 5-fluorouracil is indicated for the treatment of patients with metastatic gastric adenocarcinoma, including adenocarcinoma of the gastroesophageal junction, who have not received prior chemotherapy for metastatic disease.

    * Head and neck cancer :

    Taxespira in combination with cisplatin and 5-fluorouracil is indicated for the induction treatment of patients with locally advanced squamous cell carcinoma of the head and neck.

    * Breast cancer :

    Docetaxel Teva in combination with doxorubicin and cyclophosphamide is indicated for the adjuvant treatment of patients with:

    - operable node-positive breast cancer ;

    - operable node-negative breast cancer .

    For patients with operable node-negative breast cancer , adjuvant treatment should be restricted to patients eligible to receive chemotherapy according to internationally established criteria for primary therapy of early breast cancer .

    Docetaxel Teva in combination with doxorubicin is indicated for the treatment of patients with locally advanced or metastatic breast cancer who have not previously received cytotoxic therapy for this condition.

    Docetaxel Teva monotherapy is indicated for the treatment of patients with locally advanced or metastatic breast cancer after failure of cytotoxic therapy.

    Previous chemotherapy should have included an anthracycline or an alkylating agent.

    Docetaxel Teva in combination with trastuzumab is indicated for the treatment of patients with metastatic breast cancer whose tumours overexpress HER2 and who previously have not received chemotherapy for metastatic disease.

    Docetaxel Teva in combination with capecitabine is indicated for the treatment of patients with locally advanced or metastatic breast cancer after failure of cytotoxic chemotherapy. Previous therapy should have included an anthracycline.

    * Non-small-cell lung cancer :

    Docetaxel Teva is indicated for the treatment of patients with locally advanced or metastatic non-small-cell lung cancer after failure of prior chemotherapy.

    Docetaxel Teva in combination with cisplatin is indicated for the treatment of patients with unresectable, locally advanced or metastatic non-small-cell lung cancer , in patients who have not previously received chemotherapy for this condition.

    * Prostate cancer :

    Docetaxel Teva in combination with prednisone or prednisolone is indicated for the treatment of patients with hormone refractory metastatic prostate cancer .

    * Gastric adenocarcinoma:

    Docetaxel Teva in combination with cisplatin and 5-fluorouracil is indicated for the treatment of patients with metastatic gastric adenocarcinoma, including adenocarcinoma of the gastroesophageal junction, who have not received prior chemotherapy for metastatic disease.

    * Head and neck cancer :

    Docetaxel Teva in combination with cisplatin and 5 fluorouracil is indicated for the induction treatment of patients with locally advanced squamous cell carcinoma of the head and neck.

    * Breast cancer :

    Docetaxel Kabi in combination with doxorubicin and cyclophosphamide is indicated for the adjuvant treatment of patients with:

    - operable node-positive breast cancer ;

    - operable node-negative breast cancer .

    For patients with operable node-negative breast cancer , adjuvant treatment should be restricted to patients eligible to receive chemotherapy according to internationally established criteria for primary therapy of early breast cancer .

    Docetaxel Kabi in combination with doxorubicin is indicated for the treatment of patients with locally advanced or metastatic breast cancer who have not previously received cytotoxic therapy for this condition.

    Docetaxel Kabi monotherapy is indicated for the treatment of patients with locally advanced or metastatic breast cancer after failure of cytotoxic therapy. Previous chemotherapy should have included an anthracycline or an alkylating agent.

    Docetaxel Kabi in combination with trastuzumab is indicated for the treatment of patients with metastatic breast cancer whose tumours overexpress HER2 and who previously have not received chemotherapy for metastatic disease.

    Docetaxel Kabi in combination with capecitabine is indicated for the treatment of patients with locally advanced or metastatic breast cancer after failure of cytotoxic chemotherapy. Previous therapy should have included an anthracycline.

    * Non-small-cell lung cancer :

    Docetaxel Kabi is indicated for the treatment of patients with locally advanced or metastatic non-small-cell lung cancer after failure of prior chemotherapy.

    Docetaxel Kabi in combination with cisplatin is indicated for the treatment of patients with unresectable, locally advanced or metastatic non-small-cell lung cancer , in patients who have not previously received chemotherapy for this condition.

    * Prostate cancer :

    Docetaxel Kabi in combination with prednisone or prednisolone is indicated for the treatment of patients with castration-resistant metastatic prostate cancer .

    Docetaxel Kabi in combination with androgen-deprivation therapy (ADT), with or without prednisone or prednisolone, is indicated for the treatment of patients with metastatic hormone-sensitive prostate cancer .

    * Gastric adenocarcinoma:

    Docetaxel Kabi in combination with cisplatin and 5-fluorouracil is indicated for the treatment of patients with metastatic gastric adenocarcinoma, including adenocarcinoma of the gastroesophageal junction, who have not received prior chemotherapy for metastatic disease.

    * Head and neck cancer :

    Docetaxel Kabi in combination with cisplatin and 5-fluorouracil is indicated for the induction treatment of patients with locally advanced squamous cell carcinoma of the head and neck.

    Treatment of breast cancer , special forms of lung cancer (non-small-cell lung cancer ), prostate cancer , gastric cancer , or head and neck cancer .

    * Breast cancer :

    Docetaxel Teva Pharma monotherapy is indicated for the treatment of patients with locally advanced or metastatic breast cancer after failure of cytotoxic therapy. Previous chemotherapy should have included an anthracycline or an alkylating agent.

    * Non-small-cell lung cancer :

    Docetaxel Teva Pharma is indicated for the treatment of patients with locally advanced or metastatic non-small-cell lung cancer after failure of prior chemotherapy.

    Docetaxel Teva Pharma in combination with cisplatin is indicated for the treatment of patients with unresectable, locally advanced or metastatic non-small-cell lung cancer , in patients who have not previously received chemotherapy for this condition.

    * Prostate cancer :

    Docetaxel Teva Pharma in combination with prednisone or prednisolone is indicated for the treatment of patients with hormone refractory metastatic prostate cancer .

    Breast cancer

    Docetaxel in combination with doxorubicin and cyclophosphamide is indicated for the adjuvant treatment of patients with operable node-positive breast cancer .

    Docetaxel in combination with doxorubicin is indicated for the treatment of patients with locally advanced or metastatic breast cancer who have not previously received cytotoxic therapy for this condition.

    Docetaxel monotherapy is indicated for the treatment of patients with locally advanced or metastatic breast cancer after failure of cytotoxic therapy. Previous chemotherapy should have included an anthracycline or an alkylating agent.

    Docetaxel in combination with trastuzumab is indicated for the treatment of patients with metastatic breast cancer whose tumours over express HER2 and who previously have not received chemotherapy for metastatic disease.

    Docetaxel in combination with capecitabine is indicated for the treatment of patients with locally advanced or metastatic breast cancer after failure of cytotoxic chemotherapy. Previous therapy should have included an anthracycline.

    Non-small cell lung cancer

    Docetaxel is indicated for the treatment of patients with locally advanced or metastatic non-small cell lung cancer after failure of prior chemotherapy.

    Docetaxel in combination with cisplatin is indicated for the treatment of patients with unresectable, locally advanced or metastatic non-small cell lung cancer , in patients who have not previously received chemotherapy for this condition.

    Prostate cancer

    Docetaxel in combination with prednisone or prednisolone is indicated for the treatment of patients with hormone refractory metastatic prostate cancer .

    Gastric adenocarcinoma

    Docetaxel in combination with cisplatin and 5-fluorouracil is indicated for the treatment of patients with metastatic gastric adenocarcinoma, including adenocarcinoma of the gastroesophageal junction, who have not received prior chemotherapy for metastatic disease.

    Head and neck cancer

    Docetaxel in combination with cisplatin and 5-fluorouracil is indicated for the induction treatment of patients with locally advanced squamous cell carcinoma of the head and neck.

    Nasopharyngeal carcinoma

    5 Pharmacology and Biochemistry
    5.1 Pharmacology

    Docetaxel is a taxoid antineoplastic agent. It promotes the assembly of microtubules from tubulin dimers and stabilizes microtubules by preventing depolymerization. This stability results in the inhibition of the normal dynamic reorganization of the microtubule network that is essential for vital interphase and mitotic cellular functions. In addition, docetaxel induces abnormal arrays or "bundles" of microtubules throughout the cell cycle and multiple asters of microtubules during mitosis.

    5.2 MeSH Pharmacological Classification

    Tubulin Modulators

    Agents that interact with TUBULIN to inhibit or promote polymerization of MICROTUBULES. (See all compounds classified as Tubulin Modulators.)

    Antineoplastic Agents

    Substances that inhibit or prevent the proliferation of NEOPLASMS. (See all compounds classified as Antineoplastic Agents.)

    5.3 FDA Pharmacological Classification
    5.3.1 Active Moiety
    DOCETAXEL ANHYDROUS
    5.3.2 FDA UNII
    699121PHCA
    5.3.3 Pharmacological Classes
    Microtubule Inhibitor [EPC]; Microtubule Inhibition [PE]
    5.4 ATC Code

    L01CD02

    L01CD02

    L01CD02

    L01CD02

    L01CD02

    L01CD02

    L01CD02

    L01CD02

    L01CD02

    L01CD02

    S76 | LUXPHARMA | Pharmaceuticals Marketed in Luxembourg | Pharmaceuticals marketed in Luxembourg, as published by d'Gesondheetskeess (CNS, la caisse nationale de sante, www.cns.lu), mapped by name to structures using CompTox by R. Singh et al. (in prep.). List downloaded from https://cns.public.lu/en/legislations/textes-coordonnes/liste-med-comm.html. Dataset DOI:10.5281/zenodo.4587355

    L - Antineoplastic and immunomodulating agents

    L01 - Antineoplastic agents

    L01C - Plant alkaloids and other natural products

    L01CD - Taxanes

    L01CD02 - Docetaxel

    5.5 Absorption, Distribution and Excretion

    Absorption

    The pharmacokinetic profile is consistent with a three-compartment model. The area under the curve (AUC) was dose proportional following doses of 70 mg/m2 to 115 mg/m2 with infusion times of 1 to 2 hours.

    Route of Elimination

    Docetaxel was eliminated in both the urine and feces following oxidative metabolism of the tert-butyl ester group, but fecal excretion was the main elimination route. Within 7 days, urinary and fecal excretion accounted for approximately 6% and 75% of the administered radioactivity, respectively.

    Volume of Distribution

    The initial rapid decline represents distribution to the peripheral compartments and the late (terminal) phase is due, in part, to a relatively slow efflux of docetaxel from the peripheral compartment.

    113 L

    Clearance

    21 L/h/m2 [Total body clearance, cancer patients after IV administration of 20115 mg/m2]

    The initial rapid decline represents distribution to the peripheral compartments and the late (terminal) phase is due, in part, to a relatively slow efflux of docetaxel from the peripheral compartment. Mean steady state volume of distribution was 113 L. In vitro studies showed that docetaxel is about 94% protein bound, mainly to alpha1-acid glycoprotein, albumin, and lipoproteins. In three cancer patients, the in vitro binding to plasma proteins was found to be approximately 97%. Dexamethasone does not affect the protein binding of docetaxel.

    NIH; DailyMed. Current Medication Information for Taxotere (Docetaxel) Injection, Solution, Concentrate (Updated: November 2014). Available from, as of March 25, 2015: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=45e6dce4-92e2-4ad1-bf11-bbcefb753636

    A study of (14)C-docetaxel was conducted in three cancer patients. Docetaxel was eliminated in both the urine and feces following oxidative metabolism of the tert-butyl ester group, but fecal excretion was the main elimination route. Within 7 days, urinary and fecal excretion accounted for approximately 6% and 75% of the administered radioactivity, respectively. About 80% of the radioactivity recovered in feces is excreted during the first 48 hours as 1 major and 3 minor metabolites with very small amounts (less than 8%) of unchanged drug.

    NIH; DailyMed. Current Medication Information for Taxotere (Docetaxel) Injection, Solution, Concentrate (Updated: November 2014). Available from, as of March 25, 2015: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=45e6dce4-92e2-4ad1-bf11-bbcefb753636

    The pharmacokinetics of docetaxel have been evaluated in cancer patients after administration of 20 mg/m2 to 115 mg/sq m in phase 1 studies. The area under the curve (AUC) was dose proportional following doses of 70 mg/sq m to 115 mg/sq m with infusion times of 1 to 2 hours. Docetaxel's pharmacokinetic profile is consistent with a three-compartment pharmacokinetic model, with half-lives for the alpha, beta, and gamma phases of 4 min, 36 min, and 11.1 hr, respectively. Mean total body clearance was 21 L/hr/sq m.

    NIH; DailyMed. Current Medication Information for Taxotere (Docetaxel) Injection, Solution, Concentrate (Updated: November 2014). Available from, as of March 25, 2015: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=45e6dce4-92e2-4ad1-bf11-bbcefb753636

    It is not known whether docetaxel is excreted in human milk.

    NIH; DailyMed. Current Medication Information for Taxotere (Docetaxel) Injection, Solution, Concentrate (Updated: November 2014). Available from, as of March 25, 2015: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=45e6dce4-92e2-4ad1-bf11-bbcefb753636

    5.6 Metabolism/Metabolites

    Hepatic. In vitro drug interaction studies revealed that docetaxel is metabolized by the CYP3A4 isoenzyme (1 major, 3 minor metabolites).

    Docetaxel, a potent antimicrotubule agent widely used in the treatment of ovarian, breast and lung cancer, is extensively metabolized in various animal species, including humans. The metabolism of docetaxel to its primary metabolite, hydroxydocetaxel, is mediated by cytochrome P450 isozymes CYP3A2 and CYP3A4 in rats and humans, respectively....

    PMID:11561777 Nallani SC et al; Cancer Chemother Pharmacol 48 (2): 115-22 (2001)

    In vitro drug interaction studies revealed that docetaxel is metabolized by the CYP3A4 isoenzyme, and its metabolism may be modified by the concomitant administration of compounds that induce, inhibit, or are metabolized by cytochrome P450 3A4.

    NIH; DailyMed. Current Medication Information for Taxotere (Docetaxel) Injection, Solution, Concentrate (Updated: November 2014). Available from, as of March 25, 2015: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=45e6dce4-92e2-4ad1-bf11-bbcefb753636

    Docetaxel has known human metabolites that include Hydroxy-Docetaxel.

    S73 | METXBIODB | Metabolite Reaction Database from BioTransformer | DOI:10.5281/zenodo.4056560

    5.7 Biological Half-Life

    Dose-dependent. Doses of 70 mg per square meter of body surface area (mg/m 2 ) or higher produce a triphasic elimination profile. With lower doses, assay limitations precluded detection of the terminal elimination phase. The half-life of the alpha, beta, and gamma phase are 4 minutes, 36 minutes, and 11.1 hours, respectively.

    5.8 Mechanism of Action

    Docetaxel interferes with the normal function of microtubule growth. Whereas drugs like colchicine cause the depolymerization of microtubules in vivo, docetaxel arrests their function by having the opposite effect; it hyper-stabilizes their structure. This destroys the cell's ability to use its cytoskeleton in a flexible manner. Specifically, docetaxel binds to the β-subunit of tubulin. Tubulin is the "building block" of microtubules, and the binding of docetaxel locks these building blocks in place. The resulting microtubule/docetaxel complex does not have the ability to disassemble. This adversely affects cell function because the shortening and lengthening of microtubules (termed dynamic instability) is necessary for their function as a transportation highway for the cell. Chromosomes, for example, rely upon this property of microtubules during mitosis. Further research has indicated that docetaxel induces programmed cell death (apoptosis) in cancer cells by binding to an apoptosis stopping protein called Bcl-2 (B-cell leukemia 2) and thus arresting its function.

    Docetaxel is an antineoplastic agent that acts by disrupting the microtubular network in cells that is essential for mitotic and interphase cellular functions. Docetaxel binds to free tubulin and promotes the assembly of tubulin into stable microtubules while simultaneously inhibiting their disassembly. This leads to the production of microtubule bundles without normal function and to the stabilization of microtubules, which results in the inhibition of mitosis in cells. Docetaxel's binding to microtubules does not alter the number of protofilaments in the bound microtubules, a feature which differs from most spindle poisons currently in clinical use.

    NIH; DailyMed. Current Medication Information for Taxotere (Docetaxel) Injection, Solution, Concentrate (Updated: November 2014). Available from, as of March 25, 2015: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=45e6dce4-92e2-4ad1-bf11-bbcefb753636

    Docetaxel, a semisynthetic taxane, has exhibited significant single-agent activity against prostatic tumors. In phase I/II studies, single-agent docetaxel and the combination of docetaxel plus estramustine were effective in inducing prostate-specific antigen reductions of > or = 50% in men with androgen-independent prostate cancer (AIPC). The underlying reason for docetaxel's clinical activity against prostate cancer has been a focus of ongoing research. Docetaxel is believed to have a twofold mechanism of antineoplastic activity: (1) inhibition of microtubular depolymerization, and (2) attenuation of the effects of bcl-2 and bcl-xL gene expression. Taxane-induced microtubule stabilization arrests cells in the G(2)M phase of the cell cycle and induces bcl-2 phosphorylation, thereby promoting a cascade of events that ultimately leads to apoptotic cell death. In preclinical studies, docetaxel had a higher affinity for tubulin and was shown to be a more potent inducer of bcl-2 phosphorylation than paclitaxel. Laboratory evidence also supports the clinical evaluation of docetaxel-based combinations that include agents such as trastuzumab and/or estramustine. The pathways for docetaxel-induced apoptosis appear to differ in androgen-dependent and androgen-independent prostate cancer cells. Further elucidation of these differences will be instrumental in designing targeted regimens for the treatment of localized and advanced prostate cancer.

    Pienta KJ; Semin Oncol 28 (4 Suppl 15): 3-7 (2001)

    API Reference Price

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Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1724005800,"product":"DOCETAXEL TRIHYDRATE","address":"PLOT NO.10, SHOP NO.80,","city":"RAICHUR , KARNATAKA","supplier":"QILU PHARMACEUTICAL","supplierCountry":"CHINA","foreign_port":"BEIJING","customer":"SHILPA MEDICARE","customerCountry":"INDIA","quantity":"7.64","actualQuantity":"7636","unit":"GMS","unitRateFc":"28.5","totalValueFC":"222362.3","currency":"USD","unitRateINR":"2418.2","date":"19-Aug-2024","totalValueINR":"18465566.1","totalValueInUsd":"222362.3","indian_port":"SEZ\/Mahaboobnagar","hs_no":"29339990","bill_no":"5126266","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"BEIJING","supplierAddress":"ADD:317,XINLUO ROAD,HIGH- TECH ZONE JINAN SDNF China","customerAddress":"PLOT NO.10, SHOP NO.80,"}]
    07-Jan-2021
    21-Aug-2024
    KGS
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    Average Price (USD/KGS)

    Number of Transactions

    Total Quantity (KGS)

    Total Value (USD)

    Quantity (KGS) & Unit rate (USD/KGS) over time

    API Imports and Exports

    Importing Country Total Quantity
    (KGS)    		 Average Price
    (USD/KGS)    		 Number of Transactions

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    DRUG PRODUCT COMPOSITIONS

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    DOSAGE - INJECTABLE;INJECTION - 160MG/8ML (20...DOSAGE - INJECTABLE;INJECTION - 160MG/8ML (20MG/ML)

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    DOSAGE - INJECTABLE;INJECTION - 20MG/0.5ML (4...DOSAGE - INJECTABLE;INJECTION - 20MG/0.5ML (40MG/ML)

    USFDA APPLICATION NUMBER - 201195

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    DOSAGE - INJECTABLE;INJECTION - 80MG/4ML (20M...DOSAGE - INJECTABLE;INJECTION - 80MG/4ML (20MG/ML)

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    DOSAGE - INJECTABLE;INJECTION - 80MG/2ML (40M...DOSAGE - INJECTABLE;INJECTION - 80MG/2ML (40MG/ML)

    USFDA APPLICATION NUMBER - 201195

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    DOSAGE - INJECTABLE;INJECTION - 160MG/8ML (20...DOSAGE - INJECTABLE;INJECTION - 160MG/8ML (20MG/ML)

    USFDA APPLICATION NUMBER - 20449

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    DOSAGE - INJECTABLE;INJECTION - 20MG/ML (20MG...DOSAGE - INJECTABLE;INJECTION - 20MG/ML (20MG/ML)

    USFDA APPLICATION NUMBER - 20449

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    DOSAGE - INJECTABLE;INJECTION - 40MG/ML **Fed...DOSAGE - INJECTABLE;INJECTION - 40MG/ML **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

    USFDA APPLICATION NUMBER - 20449

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    DOSAGE - INJECTABLE;INJECTION - 80MG/4ML (20M...DOSAGE - INJECTABLE;INJECTION - 80MG/4ML (20MG/ML)

    USFDA APPLICATION NUMBER - 20449

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    DOSAGE - INJECTABLE;INJECTION - 160MG/8ML (20...DOSAGE - INJECTABLE;INJECTION - 160MG/8ML (20MG/ML)

    USFDA APPLICATION NUMBER - 205934

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    DOSAGE - INJECTABLE;INJECTION - 20MG/ML (20MG...DOSAGE - INJECTABLE;INJECTION - 20MG/ML (20MG/ML)

    USFDA APPLICATION NUMBER - 205934

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    DOSAGE - INJECTABLE;INJECTION - 80MG/4ML (20M...DOSAGE - INJECTABLE;INJECTION - 80MG/4ML (20MG/ML)

    USFDA APPLICATION NUMBER - 205934

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    DOSAGE - INJECTABLE;INJECTION - 20MG/VIAL

    USFDA APPLICATION NUMBER - 22534

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    DOSAGE - INJECTABLE;INJECTION - 80MG/VIAL

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