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ACTIVE PHARMA INGREDIENTS

5 API Suppliers, 3 CEP/COS, 1 JDMF, 1 EU WC, 2 Listed Suppliers, $ API Reference Price

5 API Suppliers
3 CEP/COS
1 JDMF
1 EU WC
2 Listed Suppliers
$ API Reference Price

FINISHED DOSAGE FORMULATIONS

9 FDF Dossiers, 7 Europe, 2 Listed Dossiers

9 FDF Dossiers
7 Europe
2 Listed Dossiers

DIGITAL CONTENT

1 DATA COMPILATION #PharmaFlow, 1 NEWS #PharmaBuzz

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1 DATA COMPILATION #PharmaFlow
1 NEWS #PharmaBuzz

GLOBAL SALES INFORMATION

2 Finished Drug Prices

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2 Finished Drug Prices

MARKET PLACE

6 APIs

marketPlace
6 APIs

REF. STANDARDS & IMPURITIES

1 EDQM

otherSolutions
1 EDQM

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

$ 26

MARKET PLACE

API

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

0 DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

Annual Reports (USD Million)

Finished Drug Prices

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Chemistry

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Also known as: Isopropyl phenazone, 479-92-5, Isopropylantipyrine, Isopropylphenazone, 4-isopropylantipyrine, Isopropyrine

Molecular Formula

C₁₄H₁₈N₂O

Molecular Weight

230.31 g/mol

InChI Key

PXWLVJLKJGVOKE-UHFFFAOYSA-N

FDA UNII

OED8FV75PY

1 2D Structure

Propyphenazone

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

1,5-dimethyl-2-phenyl-4-propan-2-ylpyrazol-3-one

2.1.2 InChI

InChI=1S/C14H18N2O/c1-10(2)13-11(3)15(4)16(14(13)17)12-8-6-5-7-9-12/h5-10H,1-4H3

2.1.3 InChI Key

PXWLVJLKJGVOKE-UHFFFAOYSA-N

2.1.4 Canonical SMILES

CC1=C(C(=O)N(N1C)C2=CC=CC=C2)C(C)C

2.2 Other Identifiers

2.2.1 UNII

OED8FV75PY

2.3 Synonyms

2.3.1 MeSH Synonyms

1. 4-isopropyl-2,3-dimethyl-1-phenyl-3-pyrazoline-5-one

2. 4-isopropylantipyrine

3. Commotional

4. Demex

5. Hewedolor Propy

6. Isoprochin P

7. Isopropylphenazone

8. Propylphenazone

2.3.2 Depositor-Supplied Synonyms

1. Isopropyl Phenazone

2. 479-92-5

3. Isopropylantipyrine

4. Isopropylphenazone

5. 4-isopropylantipyrine

6. Isopropyrine

7. Isopropylantipyrin

8. Larodon

9. Isopropylantipyrinum

10. Propifenazona

11. Propyphenazonum

12. Propyphenazon

13. Budirol

14. Cibalgina

15. Yoshipyrin

16. 1,5-dimethyl-2-phenyl-4-propan-2-ylpyrazol-3-one

17. 1-phenyl-2,3-dimethyl-4-isopropyl-3-pyrazolin-5-one

18. 1-phenyl-2,3-dimethyl-4-isopropylpyrazol-5-one

19. 4-isopropyl-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one

20. Antipyrine, 4-isopropyl-

21. Chebi:135538

22. 3h-pyrazol-3-one, 1,2-dihydro-1,5-dimethyl-4-(1-methylethyl)-2-phenyl-

23. Oed8fv75py

24. 4-isopropyl-1,5-dimethyl-2-phenyl-1,2-dihydro-pyrazol-3-one

25. 2,3-dimethyl-4-isopropyl-1-phenyl-3h-pyrazolin-5-one

26. 3-pyrazolin-5-one, 2,3-dimethyl-4-isopropyl-1-phenyl-

27. 3-pyrazolin-5-one, 4-isopropyl-2,3-dimethyl-1-phenyl-

28. 1,5-dimethyl-2-phenyl-4-(propan-2-yl)-1,2-dihydro-3h-pyrazol-3-one

29. Propyphenazone (4-isopropylantipyrine)

30. 4-isopropylantipyrine;isopropylphenazone

31. Propyphenazone (inn)

32. 4-isopropyl-1,5-dimethyl-2-phenyl-1h-pyrazol-3(2h)-one

33. Ncgc00164612-01

34. Isopropchin

35. Propifenazone

36. 4-isopropyl-1,5-dimethyl-2-phenyl-1,2-dihydro-3h-pyrazol-3-one

37. Dsstox_cid_3529

38. Dsstox_rid_77065

39. Propyphenazone [inn]

40. 4-isopropyl-2,3-dimethyl-1-phenyl-5-pyrazolone

41. Dsstox_gsid_23529

42. Propifenazone [dcit]

43. Causyth

44. Propifenazona [inn-spanish]

45. Propyphenazonum [inn-latin]

46. Cas-479-92-5

47. 4-isopropylphenazone

48. Ccris 6716

49. Propyphenazone [inn:ban:dcf]

50. Einecs 207-539-2

51. Unii-oed8fv75py

52. Brn 0204533

53. Yoshipyrin (tn)

54. 5-pyrazolone, 1-phenyl-2,3-dimethyl-4-isopropyl-

55. Propyphenazone,(s)

56. Chemdiv2_002457

57. Epitope Id:124928

58. Propyphenazone [mi]

59. Isopropylantipyrine (jp17)

60. Schembl23393

61. 5-24-01-00408 (beilstein Handbook Reference)

62. Mls004773970

63. Chembl28318

64. Propyphenazone [mart.]

65. Propyphenazone [who-dd]

66. Dtxsid6023529

67. Isopropylantipyrine [jan]

68. Pxwlvjlkjgvoke-uhfffaoysa-

69. Zinc49151

70. Hms1375p15

71. Hy-a0273

72. Tox21_112233

73. Mfcd00053368

74. Propyphenazone [ep Monograph]

75. S5309

76. Stk766727

77. 1,5-dimethyl-4-(1-methylethyl)-2-phenyl-1,2-dihydro-3h-pyrazol-3-one

78. Akos001725335

79. Tox21_112233_1

80. Ccg-266797

81. Cs-5533

82. Db13524

83. Ncgc00164612-02

84. Ac-12099

85. Bs-16890

86. Propyphenazone 1.0 Mg/ml In Acetonitrile

87. Propyphenazone 100 Microg/ml In Methanol

88. Smr001495368

89. Ft-0654525

90. I0656

91. D01380

92. D91192

93. Q425111

94. Sr-01000536454

95. 4-isopropylantipyrine, Analytical Reference Material

96. Sr-01000536454-1

97. W-106059

98. 4-isopropyl-1,5-dimethyl-2-phenyl-3-pyrazolone

99. Propyphenazone, European Pharmacopoeia (ep) Reference Standard

100. 4-isopropyl-1,5-dimethyl-2-phenyl-1,2-dihydro-3h-pyrazol-3-one #

101. Propyphenazone, Pharmaceutical Secondary Standard; Certified Reference Material

2.4 Create Date

2005-03-25

3 Chemical and Physical Properties

Molecular Formula	C₁₄H₁₈N₂O
Molecular Weight	230.31 g/mol
XLogP3	1.7
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	2
Exact Mass	230.141913202 g/mol
Monoisotopic Mass	230.141913202 g/mol
Topological Polar Surface Area	23.6 Å²
Heavy Atom Count	17
Formal Charge	0
Complexity	340
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

4 Pharmacology and Biochemistry

4.1 MeSH Pharmacological Classification

Anti-Inflammatory Agents, Non-Steroidal

Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects. (See all compounds classified as Anti-Inflammatory Agents, Non-Steroidal.)

4.2 ATC Code

N - Nervous system

N02 - Analgesics

N02B - Other analgesics and antipyretics

N02BB - Pyrazolones

N02BB04 - Propyphenazone

API SUPPLIERS

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CEP/COS

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JDMF

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EU WC

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Listed Suppliers

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API Reference Price

[{"dataSource":"API Export","activeIngredients":"PROPYPHENAZONE","year":"2021","qtr":"Q1","strtotime":1615746600,"product":"PROPYPHENAZONE - BP BATCH NO.FABB21029","address":"NO.456,1A AND 1B,INDUSTRIAL AREAJIGANI,","city":"BANGALORE,KARNATAKA","supplier":"STELLENCE PHARMSCIENCE","supplierCountry":"INDIA","foreign_port":"ISTANBUL","customer":"BERKO PHARMACEUTICALS","customerCountry":"TURKEY","quantity":"5.00","actualQuantity":"5","unit":"KGS","unitRateFc":"34.1","totalValueFC":"168.6","currency":"USD","unitRateINR":2454.8000000000002,"date":"15-Mar-2021","totalValueINR":"12274","totalValueInUsd":"168.6","indian_port":"BANGALORE AIR","hs_no":"29331100","bill_no":"9370616","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"TURKEY","selfForZScoreResived":"Pharma Grade","supplierPort":"BANGALORE AIR","supplierAddress":"NO.456,1A AND 1B,INDUSTRIAL AREAJIGANI,, BANGALORE,KARNATAKA","customerAddress":""},{"dataSource":"API Export","activeIngredients":"PROPYPHENAZONE","year":"2021","qtr":"Q2","strtotime":1619375400,"product":"PROPYPHENAZONE BP (MATERIAL CODE:R0910) BATCH NO:FABB21091 FABB21092 FABB21093","address":"NO.456,1A AND 1B,INDUSTRIAL AREAJIGANI,","city":"BANGALORE,KARNATAKA","supplier":"STELLENCE PHARMSCIENCE","supplierCountry":"INDIA","foreign_port":"JAKARTA","customer":"P.T TEMPO SCAN ","customerCountry":"INDONESIA","quantity":"1400.00","actualQuantity":"1400","unit":"KGS","unitRateFc":"18.6","totalValueFC":"25200.3","currency":"USD","unitRateINR":1340.0999999999999,"date":"26-Apr-2021","totalValueINR":"1876140","totalValueInUsd":"25200.3","indian_port":"BANGALORE ICD","hs_no":"29331100","bill_no":"1369991","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"INDONESIA","selfForZScoreResived":"Pharma Grade","supplierPort":"BANGALORE ICD","supplierAddress":"NO.456,1A AND 1B,INDUSTRIAL AREAJIGANI,, BANGALORE,KARNATAKA","customerAddress":""},{"dataSource":"API Export","activeIngredients":"PROPYPHENAZONE","year":"2021","qtr":"Q2","strtotime":1620153000,"product":"PROPYPHENAZONE","address":"105 AATISH ANNEXIE GULBAI TEKRAOFF. 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