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    Chemistry

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    Also known as: Tolterodine tartrate, 124937-52-6, Detrol la, Detrusitol, Tolterodine l-tartrate, Pnu-200583e
    Molecular Formula
    C26H37NO7
    Molecular Weight
    475.6  g/mol
    InChI Key
    TWHNMSJGYKMTRB-KXYUELECSA-N
    FDA UNII
    5T619TQR3R
    Tolterodine Tartrate
    An ANTIMUSCARINIC AGENT selective for the MUSCARINIC RECEPTORS of the BLADDER that is used in the treatment of URINARY INCONTINENCE and URINARY URGE INCONTINENCE.
    1 2D Structure

    Tolterodine Tartrate

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    (2R,3R)-2,3-dihydroxybutanedioic acid;2-[(1R)-3-[di(propan-2-yl)amino]-1-phenylpropyl]-4-methylphenol
    2.1.2 InChI
    InChI=1S/C22H31NO.C4H6O6/c1-16(2)23(17(3)4)14-13-20(19-9-7-6-8-10-19)21-15-18(5)11-12-22(21)24;5-1(3(7)8)2(6)4(9)10/h6-12,15-17,20,24H,13-14H2,1-5H3;1-2,5-6H,(H,7,8)(H,9,10)/t20-;1-,2-/m11/s1
    2.1.3 InChI Key
    TWHNMSJGYKMTRB-KXYUELECSA-N
    2.1.4 Canonical SMILES
    CC1=CC(=C(C=C1)O)C(CCN(C(C)C)C(C)C)C2=CC=CC=C2.C(C(C(=O)O)O)(C(=O)O)O
    2.1.5 Isomeric SMILES
    CC1=CC(=C(C=C1)O)[C@H](CCN(C(C)C)C(C)C)C2=CC=CC=C2.[C@@H]([C@H](C(=O)O)O)(C(=O)O)O
    2.2 Other Identifiers
    2.2.1 UNII
    5T619TQR3R
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Detrol La

    2. Detrusitol

    3. Pha 686464b

    4. Pha-686464b

    5. Pha686464b

    6. Tartrate, Tolterodine

    7. Tolterodine

    8. Tolterodine Tartrate

    9. Unidet

    10. Urotrol

    2.3.2 Depositor-Supplied Synonyms

    1. Tolterodine Tartrate

    2. 124937-52-6

    3. Detrol La

    4. Detrusitol

    5. Tolterodine L-tartrate

    6. Pnu-200583e

    7. (r)-2-(3-(diisopropylamino)-1-phenylpropyl)-4-methylphenol (2r,3r)-2,3-dihydroxysuccinate

    8. Tolterodine Tartrate [usan]

    9. Kabi-2234

    10. Urotrol

    11. 5t619tqr3r

    12. Pnu 200583e

    13. Tolterodine Tartrate (detrol La)

    14. 124937-52-6 (tartrate)

    15. Tolterodine (tartrate)

    16. (r)-2-(3-diisopropylamino-1-phenyl-propyl)-p-cresol L-tartrate

    17. (r)-2-(3-(bis(1-methylethyl)amino)-1-phenylpropyl)-4-methylphenol (r-(r*,r*))-2,3-dihydroxybutanedioate (1:1) (salt)

    18. (+)-(r)-2-(i-(2-(diisopropylamino)ethyl)benzyl)-p-cresol L-tartrate (1:1) (salt)

    19. Unii-5t619tqr3r

    20. (2r,3r)-2,3-dihydroxybutanedioic Acid;2-[(1r)-3-[di(propan-2-yl)amino]-1-phenylpropyl]-4-methylphenol

    21. Detrusitol Sr

    22. Mfcd07771985

    23. (r)-2-[3-(diisopropylamino)-1-phenylpropyl]-4-methylphenol L-tartrate

    24. Detrusitol (tn)

    25. Detrol (tn)

    26. Tolterodine, Tartrate

    27. (tolterodine Tartrate)

    28. Detrol La;kabi-2234;pnu-200583e

    29. Tolterodine Tartrate,(s)

    30. (r)-tolterodine L-tartrate

    31. Tolterodine Tartrate- Bio-x

    32. Mls003915640

    33. Schembl467372

    34. Chembl1200871

    35. Tolterodine Tartrate (jan/usp)

    36. Dtxsid80924972

    37. Tolterodine Tartrate [mi]

    38. Hms3715n08

    39. Hms3884j08

    40. Tolterodine Tartrate [jan]

    41. Tolterodine Tartrate [vandf]

    42. S2550

    43. Tolterodine Tartrate [mart.]

    44. Tolterodine Tartrate [usp-rs]

    45. Akos015961803

    46. Ac-2617

    47. Ccg-221263

    48. Cs-0441

    49. Ds-1398

    50. Tolterodine L-tartrate [who-dd]

    51. Tolterodine L-tartrate 124937-51-5

    52. (2r,3r)-2,3-dihydroxybutanedioic Acid,2-[(1r)-3-[di(propan-2-yl)amino]-1-phenylpropyl]-4-methylphenol

    53. As-35344

    54. Bt164484

    55. Hy-90010

    56. Phenol, 2-((1r)-3-(bis(1-methylethyl)amino)-1-phenylpropyl)-4-methyl-, (2r,3r)-2,3-dihydroxybutanedioate (1:1) (salt)

    57. Phenol, 2-(3-(bis(1-methylethyl)amino)-1-phenylpropyl)-4-methyl-, (r)-, (r-(r*,r*))-2,3-dihydroxybutanedioate (1:1) (salt)

    58. Smr002544692

    59. Tolterodine L-tartrate, >=98% (hplc)

    60. Tolterodine Tartrate [orange Book]

    61. Bcp0726000292

    62. Tolterodine Tartrate [ep Monograph]

    63. Tolterodine Tartrate [usp Monograph]

    64. Sw197495-2

    65. D01148

    66. (r)-2-(3-(diisopropylamino)-1-phenylpropyl)-

    67. 4-methylphenol (2r,3r)-2,3-dihydroxysuccinate

    68. 937t526

    69. A890340

    70. J-500064

    71. Q27114836

    72. (+)-(r)-2-(a-[2-(diisopropylamino)ethyl]benzyl)-p-cresol Tartrate

    73. (+)-r)-2-{a-(2-(diisopropylamino)ethyl)benzyl}-p-cresol Tartrate

    74. (r)-2-(3-(diisopropylamino)-1-phenylpropyl)-4-methylphenol(2r,3r)-2,3-dihydroxysuccinate

    75. (r)-2-(3-diisopropylamino-1-phenyl-propyl)-4-methyl-phenol L-tartrate

    76. 2-[(1r)-3-[bis(1-methylethyl)amino]-1-phenylpropyl]-4-methylphenol (2r,3r)-2,3-dihydroxybutanedioate

    2.4 Create Date
    2005-06-24
    3 Chemical and Physical Properties
    Molecular Weight 475.6 g/mol
    Molecular Formula C26H37NO7
    Hydrogen Bond Donor Count5
    Hydrogen Bond Acceptor Count8
    Rotatable Bond Count10
    Exact Mass475.25700252 g/mol
    Monoisotopic Mass475.25700252 g/mol
    Topological Polar Surface Area139 Ų
    Heavy Atom Count34
    Formal Charge0
    Complexity474
    Isotope Atom Count0
    Defined Atom Stereocenter Count3
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 6  
    Drug NameDetrol
    PubMed HealthTolterodine (By mouth)
    Drug ClassesUrinary Antispasmodic
    Drug LabelDETROL Tablets contain tolterodine tartrate. The active moiety, tolterodine, is a muscarinic receptor antagonist. The chemical name of tolterodine tartrate is (R)-2-[3-[bis(1-methylethyl)-amino]1-phenylpropyl]-4-methylphenol [R-(R*,R*)]-2,3dihydroxyb...
    Active IngredientTolterodine tartrate
    Dosage FormTablet
    RouteOral
    Strength2mg; 1mg
    Market StatusPrescription
    CompanyPharmacia And Upjohn

    2 of 6  
    Drug NameDetrol la
    Drug LabelDETROL LA Capsules contain tolterodine tartrate. The active moiety, tolterodine, is a muscarinic receptor antagonist. The chemical name of tolterodine tartrate is (R)-N,N-diisopropyl-3-(2-hydroxy-5-methylphenyl)-3-phenylpropanamine L-hydrogen tartrat...
    Active IngredientTolterodine tartrate
    Dosage FormCapsule, extended release
    RouteOral
    Strength4mg; 2mg
    Market StatusPrescription
    CompanyPharmacia And Upjohn

    3 of 6  
    Drug NameTolterodine tartrate
    PubMed HealthTolterodine (By mouth)
    Drug ClassesUrinary Antispasmodic
    Drug LabelTolterodine tartrate tablets contain tolterodine tartrate. The active moiety, tolterodine, is a muscarinic receptor antagonist. The chemical name of tolterodine tartrate is (+)-(R)-2-[I-[2-(Diisopropylamino)ethyl]benzyl]-p-cresol L-tartrate (1:1) (sa...
    Active IngredientTolterodine tartrate
    Dosage FormTablet; Capsule, extended release
    Routeoral; Oral
    Strength1mg; 4mg; 2mg
    Market StatusTentative Approval; Prescription
    CompanyMylan Pharms; Apotex; Sandoz

    4 of 6  
    Drug NameDetrol
    PubMed HealthTolterodine (By mouth)
    Drug ClassesUrinary Antispasmodic
    Drug LabelDETROL Tablets contain tolterodine tartrate. The active moiety, tolterodine, is a muscarinic receptor antagonist. The chemical name of tolterodine tartrate is (R)-2-[3-[bis(1-methylethyl)-amino]1-phenylpropyl]-4-methylphenol [R-(R*,R*)]-2,3dihydroxyb...
    Active IngredientTolterodine tartrate
    Dosage FormTablet
    RouteOral
    Strength2mg; 1mg
    Market StatusPrescription
    CompanyPharmacia And Upjohn

    5 of 6  
    Drug NameDetrol la
    Drug LabelDETROL LA Capsules contain tolterodine tartrate. The active moiety, tolterodine, is a muscarinic receptor antagonist. The chemical name of tolterodine tartrate is (R)-N,N-diisopropyl-3-(2-hydroxy-5-methylphenyl)-3-phenylpropanamine L-hydrogen tartrat...
    Active IngredientTolterodine tartrate
    Dosage FormCapsule, extended release
    RouteOral
    Strength4mg; 2mg
    Market StatusPrescription
    CompanyPharmacia And Upjohn

    6 of 6  
    Drug NameTolterodine tartrate
    PubMed HealthTolterodine (By mouth)
    Drug ClassesUrinary Antispasmodic
    Drug LabelTolterodine tartrate tablets contain tolterodine tartrate. The active moiety, tolterodine, is a muscarinic receptor antagonist. The chemical name of tolterodine tartrate is (+)-(R)-2-[I-[2-(Diisopropylamino)ethyl]benzyl]-p-cresol L-tartrate (1:1) (sa...
    Active IngredientTolterodine tartrate
    Dosage FormTablet; Capsule, extended release
    Routeoral; Oral
    Strength1mg; 4mg; 2mg
    Market StatusTentative Approval; Prescription
    CompanyMylan Pharms; Apotex; Sandoz

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Muscarinic Antagonists

    Drugs that bind to but do not activate MUSCARINIC RECEPTORS, thereby blocking the actions of endogenous ACETYLCHOLINE or exogenous agonists. Muscarinic antagonists have widespread effects including actions on the iris and ciliary muscle of the eye, the heart and blood vessels, secretions of the respiratory tract, GI system, and salivary glands, GI motility, urinary bladder tone, and the central nervous system. (See all compounds classified as Muscarinic Antagonists.)

    Urological Agents

    Drugs used in the treatment of urological conditions and diseases such as URINARY INCONTINENCE and URINARY TRACT INFECTIONS. (See all compounds classified as Urological Agents.)

    5.2 FDA Pharmacological Classification
    5.2.1 Pharmacological Classes
    Cholinergic Muscarinic Antagonists [MoA]; Cholinergic Muscarinic Antagonist [EPC]

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    16-Jan-2021
    10-Jul-2024
    KGS
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    Average Price (USD/KGS)

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    (USD/KGS)    		 Number of Transactions

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    DOSAGE - TABLET;ORAL - 1MG

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