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    Chemistry

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    Also known as: 242478-38-2, Vesicare, Solifenacin (succinate), Solifenacin succinate [usan], Ym-905, Ym 905
    Molecular Formula
    C27H32N2O6
    Molecular Weight
    480.6  g/mol
    InChI Key
    RXZMMZZRUPYENV-VROPFNGYSA-N
    FDA UNII
    KKA5DLD701
    Solifenacin Succinate
    A quinuclidine and tetrahydroisoquinoline derivative and selective M3 MUSCARINIC ANTAGONIST. It is used as a UROLOGIC AGENT in the treatment of URINARY INCONTINENCE.
    1 2D Structure

    Solifenacin Succinate

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    [(3R)-1-azabicyclo[2.2.2]octan-3-yl] (1S)-1-phenyl-3,4-dihydro-1H-isoquinoline-2-carboxylate;butanedioic acid
    2.1.2 InChI
    InChI=1S/C23H26N2O2.C4H6O4/c26-23(27-21-16-24-13-10-18(21)11-14-24)25-15-12-17-6-4-5-9-20(17)22(25)19-7-2-1-3-8-19;5-3(6)1-2-4(7)8/h1-9,18,21-22H,10-16H2;1-2H2,(H,5,6)(H,7,8)/t21-,22-;/m0./s1
    2.1.3 InChI Key
    RXZMMZZRUPYENV-VROPFNGYSA-N
    2.1.4 Canonical SMILES
    C1CN2CCC1C(C2)OC(=O)N3CCC4=CC=CC=C4C3C5=CC=CC=C5.C(CC(=O)O)C(=O)O
    2.1.5 Isomeric SMILES
    C1CN2CCC1[C@H](C2)OC(=O)N3CCC4=CC=CC=C4[C@@H]3C5=CC=CC=C5.C(CC(=O)O)C(=O)O
    2.2 Other Identifiers
    2.2.1 UNII
    KKA5DLD701
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. 2(1h)-isoquinolinecarboxylic Acid, 3,4-dihydro-1-phenyl-,1- Azabicyclo(2.2.2)oct-3-yl Ester, (r-(r*,s*))-

    2. 905, Ym

    3. Quinuclidin-3'-yl-1-phenyl-1,2,3,4-tetrahydroisoquinoline-2-carboxylate Monosuccinate

    4. Solifenacin

    5. Succinate, Solifenacin

    6. Vesicare

    7. Ym 905

    8. Ym905

    2.3.2 Depositor-Supplied Synonyms

    1. 242478-38-2

    2. Vesicare

    3. Solifenacin (succinate)

    4. Solifenacin Succinate [usan]

    5. Ym-905

    6. Ym 905

    7. Ym905

    8. 1-azabicyclo[2.2.2]octan-8-yl (1s)-1-phenyl-3,4-dihydro-1h-isoquinoline-2-carboxylate Butanedioic Acid

    9. Ym67905

    10. Kka5dld701

    11. Ym-67905

    12. [(3r)-1-azabicyclo[2.2.2]octan-3-yl] (1s)-1-phenyl-3,4-dihydro-1h-isoquinoline-2-carboxylate;butanedioic Acid

    13. Vesikur

    14. (s)-(r)-quinuclidin-3-yl 1-phenyl-3,4-dihydroisoquinoline-2(1h)-carboxylate Succinate

    15. Chembl1200803

    16. Solifenacin Succinate Salt

    17. Unii-kka5dld701

    18. Vesicare Od

    19. Vesicare (tn)

    20. Isoprenalinoe Sulfate

    21. Vesicare Ls

    22. Solifenacin Succinate- Bio-x

    23. Mls006010416

    24. Schembl109333

    25. Chebi:32151

    26. Dtxsid30947075

    27. Hms3887a13

    28. Solifenacin Succinate [mi]

    29. Solifenacin Succinate [jan]

    30. Ex-a4170

    31. Hy-a0002

    32. Mfcd00954234

    33. S3048

    34. Solifenacin Succinate [vandf]

    35. Solifenacin Succinate [mart.]

    36. Akos015994745

    37. Solifenacin Succinate [usp-rs]

    38. Solifenacin Succinate [who-dd]

    39. Am84825

    40. Ccg-269551

    41. Cs-0371

    42. Ks-1286

    43. Solifenacin Succinate (jan/usan/inn)

    44. Solifenacin Succinate, >=98% (hplc)

    45. [(3r)-1-azabicyclo[2.2.2]octan-3-yl] (1s)-1-phenyl-3,4-dihydro-1h-isoquinoline-2-carboxylate; Butanedioic Acid

    46. 2(1h)-isoquinolinecarboxylic Acid, 3,4-dihydro-1-phenyl-, (3r)-1-azabicyclo(2.2.2)oct-3-yl Ester, (1s)-, Butanedioate (1:1)

    47. As-35288

    48. Bs164410

    49. Butanedioic Acid, Cmpd. With (1s)-(3r)-1-azabicyclo(2.2.2)oct-3-yl 3,4-dihydro-1-phenyl-2(1h)-isoquinolinecarboxylate (1:1)

    50. Butanedioic Acid, Compd With (1s)-(3r)-1-azabicyclo(2.2.2)oct-3-yl 3,4-dihydro-1-phenyl-2(1h)-isoquinolinecarboxylate (1:1)

    51. Smr004701445

    52. Ym-53705

    53. Solifenacin Succinate [orange Book]

    54. Solifenacin Succinate [ep Monograph]

    55. S0944

    56. Sw219141-1

    57. D01269

    58. A819262

    59. A881133

    60. Q374826

    61. Solifenacin Succinate, Europepharmacopoeia (ep) Reference Standard

    62. Solifenacin Succinate, United States Pharmacopeia (usp) Reference Standard

    63. (r)-quinuclidin-3-yl (s)-1-phenyl-3,4-dihydroisoquinoline-2(1h)-carboxylate

    64. (s)-(r)-quinuclidin-3-yl1-phenyl-3,4-dihydroisoquinoline-2(1h)-carboxylatesuccinate

    65. Quinuclidin-3'-yl-1-phenyl-1,2,3,4-tetrahydroisoquinoline-2-carboxylatemonosuccinate

    66. Solifenacin For System Suitability, Europepharmacopoeia (ep) Reference Standard

    67. (1s)-(3r)-1-azabicyclo[2.2.2]oct-3-yl-3,4-dihydro-1-phenyl-2(1h)-isoquinolinecarboxylate Succinate

    68. 1-azabicyclo[2.2.2]octan-8-yl (1s)-1-phenyl-3,4-dihydro-1h-isoquinoline-2-carboxylate Butanedioic Acid (solifenacin?succinate)

    69. Butanedioic Acid--1-azabicyclo[2.2.2]octan-3-yl 1-phenyl-3,4-dihydroisoquinoline-2(1h)-carboxylate (1/1)

    70. Butanedioic Acid; (1s)-1-phenyl-3,4-dihydro-1h-isoquinoline-2-carboxylic Acid [(3r)-1-azabicyclo[2.2.2]octan-3-yl] Ester

    2.4 Create Date
    2005-08-09
    3 Chemical and Physical Properties
    Molecular Weight 480.6 g/mol
    Molecular Formula C27H32N2O6
    Hydrogen Bond Donor Count2
    Hydrogen Bond Acceptor Count7
    Rotatable Bond Count6
    Exact Mass480.22603674 g/mol
    Monoisotopic Mass480.22603674 g/mol
    Topological Polar Surface Area107 Ų
    Heavy Atom Count35
    Formal Charge0
    Complexity617
    Isotope Atom Count0
    Defined Atom Stereocenter Count2
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 4  
    Drug NameSolifenacin succinate
    Drug LabelVESIcare (solifenacin succinate) is a muscarinic receptor antagonist. Chemically, solifenacin succinate is butanedioic acid, compounded with (1S)-(3R)-1-azabicyclo[2.2.2]oct-3-yl 3,4-dihydro-1-phenyl-2(1H)-iso-quinolinecarboxylate (1:1) having an e...
    Active IngredientSolifenacin succinate
    Dosage FormTablet
    RouteOral
    Strength5mg; 10mg
    Market StatusPrescription
    CompanyTeva Pharms Usa

    2 of 4  
    Drug NameVesicare
    PubMed HealthSolifenacin (By mouth)
    Drug ClassesUrinary Antispasmodic
    Drug LabelVESIcare (solifenacin succinate) is a muscarinic receptor antagonist. Chemically, solifenacin succinate is butanedioic acid, compounded with (1S)-(3R)-1-azabicyclo[2.2.2]oct-3-yl 3,4-dihydro-1-phenyl-2(1H)-iso-quinolinecarboxylate (1:1) having an e...
    Active IngredientSolifenacin succinate
    Dosage FormTablet
    RouteOral
    Strength5mg; 10mg
    Market StatusPrescription
    CompanyAstellas

    3 of 4  
    Drug NameSolifenacin succinate
    Drug LabelVESIcare (solifenacin succinate) is a muscarinic receptor antagonist. Chemically, solifenacin succinate is butanedioic acid, compounded with (1S)-(3R)-1-azabicyclo[2.2.2]oct-3-yl 3,4-dihydro-1-phenyl-2(1H)-iso-quinolinecarboxylate (1:1) having an e...
    Active IngredientSolifenacin succinate
    Dosage FormTablet
    RouteOral
    Strength5mg; 10mg
    Market StatusPrescription
    CompanyTeva Pharms Usa

    4 of 4  
    Drug NameVesicare
    PubMed HealthSolifenacin (By mouth)
    Drug ClassesUrinary Antispasmodic
    Drug LabelVESIcare (solifenacin succinate) is a muscarinic receptor antagonist. Chemically, solifenacin succinate is butanedioic acid, compounded with (1S)-(3R)-1-azabicyclo[2.2.2]oct-3-yl 3,4-dihydro-1-phenyl-2(1H)-iso-quinolinecarboxylate (1:1) having an e...
    Active IngredientSolifenacin succinate
    Dosage FormTablet
    RouteOral
    Strength5mg; 10mg
    Market StatusPrescription
    CompanyAstellas

    4.2 Drug Indication

    Treatment of neurogenic detrusor overactivity

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Urological Agents

    Drugs used in the treatment of urological conditions and diseases such as URINARY INCONTINENCE and URINARY TRACT INFECTIONS. (See all compounds classified as Urological Agents.)

    Muscarinic Antagonists

    Drugs that bind to but do not activate MUSCARINIC RECEPTORS, thereby blocking the actions of endogenous ACETYLCHOLINE or exogenous agonists. Muscarinic antagonists have widespread effects including actions on the iris and ciliary muscle of the eye, the heart and blood vessels, secretions of the respiratory tract, GI system, and salivary glands, GI motility, urinary bladder tone, and the central nervous system. (See all compounds classified as Muscarinic Antagonists.)

    5.2 FDA Pharmacological Classification
    5.2.1 Pharmacological Classes
    Cholinergic Muscarinic Antagonists [MoA]; Cholinergic Muscarinic Antagonist [EPC]

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    02-Jan-2021
    30-Aug-2024
    KGS
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    Average Price (USD/KGS)

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    DOSAGE - TABLET;ORAL - 10MG

    USFDA APPLICATION NUMBER - 21518

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    DOSAGE - TABLET;ORAL - 5MG

    USFDA APPLICATION NUMBER - 21518

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    ABOUT THIS PAGE

    Solifenacin Succinate Manufacturers | Traders | Suppliers

    Solifenacin Succinate Manufacturers, Traders, Suppliers 1
    28

    We have 24 companies offering Solifenacin Succinate

    Get in contact with the supplier of your choice:

    1. Interquim SA
    2. Minakem (formerly Delmar Chemicals)
    3. Polpharma
    4. Medichem S.A
    5. Megafine Pharma (P) Limited
    6. Alembic Pharmaceuticals Limited
    7. Amoli Organics
    8. Aurobindo Pharma Limited
    9. Cipla
    10. DONG BANG FUTURE TECH & LIFE CO., LTD
    11. Glenmark Life Sciences
    12. HEC Pharm
    13. Hetero Drugs
    14. Jubilant Generics
    15. Micro Labs Limited
    16. MSN Laboratories
    17. Optimus Pharma
    18. Qilu Pharmaceutical
    19. Sun Pharmaceutical Industries Limited
    20. Teva Pharmaceutical Industries
    21. Tyche Industries Ltd
    22. Unichem Laboratories Limited
    23. UQUIFA
    24. Zhejiang Guobang Pharmaceutical
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