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    ACTIVE PHARMA INGREDIENTS

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    Synopsis

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    Chemistry

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    Also known as:
    Molecular Formula
    C28H38N6O11S
    Molecular Weight
    666.7  g/mol
    InChI Key
    DEIYFTQMQPDXOT-UHFFFAOYSA-N
    Sildenafil Citrate
    1 2D Structure

    Sildenafil Citrate

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    5-[2-ethoxy-5-(4-methylpiperazin-1-yl)sulfonylphenyl]-1-methyl-3-propyl-4H-pyrazolo[4,3-d]pyrimidin-7-one;2-hydroxypropane-1,2,3-tricarboxylic acid
    2.1.2 InChI
    InChI=1S/C22H30N6O4S.C6H8O7/c1-5-7-17-19-20(27(4)25-17)22(29)24-21(23-19)16-14-15(8-9-18(16)32-6-2)33(30,31)28-12-10-26(3)11-13-28;7-3(8)1-6(13,5(11)12)2-4(9)10/h8-9,14H,5-7,10-13H2,1-4H3,(H,23,24,29);13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)
    2.1.3 InChI Key
    DEIYFTQMQPDXOT-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CCCC1=NN(C2=C1NC(=NC2=O)C3=C(C=CC(=C3)S(=O)(=O)N4CCN(CC4)C)OCC)C.C(C(=O)O)C(CC(=O)O)(C(=O)O)O
    2.1.5 Isomeric SMILES
    CCCC1=NN(C2=C1NC(=NC2=O)C3=C(C=CC(=C3)S(=O)(=O)N4CCN(CC4)C)OCC)C.C(C(=O)O)C(CC(=O)O)(C(=O)O)O
    2.2 Create Date
    2005-06-24
    3 Chemical and Physical Properties
    Molecular Weight 666.7 g/mol
    Molecular Formula C28H38N6O11S
    Hydrogen Bond Donor Count5
    Hydrogen Bond Acceptor Count14
    Rotatable Bond Count12
    Exact Mass666.23192722 g/mol
    Monoisotopic Mass666.23192722 g/mol
    Topological Polar Surface Area250 A^2
    Heavy Atom Count46
    Formal Charge0
    Complexity1070
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 8  
    Drug NameRevatio
    PubMed HealthSildenafil
    Drug ClassesAntihypertensive, Peripheral Vasodilator, Erectile Dysfunction Agent, Vasodilator
    Drug LabelREVATIO, phosphodiesterase-5 (PDE-5) inhibitor, is the citrate salt of sildenafil, a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type-5 (PDE-5). Sildenafil is also marketed as VIAGRA for erectile dysfunct...
    Active IngredientSildenafil citrate
    Dosage FormTablet; Solution; For suspension
    RouteOral; Intravenous
    Strengtheq 20mg base; eq 10mg base/ml; eq 10mg base/12.5ml (eq 0.8mg base/ml)
    Market StatusPrescription
    CompanyPfizer

    2 of 8  
    Drug NameSildenafil citrate
    Drug LabelVIAGRA, an oral therapy for erectile dysfunction, is the citrate salt of sildenafil, a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5).Sildenafil citrate is designated chemically as 1-[[3-(6,7-d...
    Active IngredientSildenafil citrate
    Dosage FormTablet
    Routeoral
    Strength25mg; 100mg; 50mg
    Market StatusTentative Approval
    CompanyMacleods Pharma

    3 of 8  
    Drug NameSildenafil citrate
    PubMed HealthSildenafil
    Drug ClassesAntihypertensive, Peripheral Vasodilator, Erectile Dysfunction Agent, Vasodilator
    Drug LabelVIAGRA, an oral therapy for erectile dysfunction, is the citrate salt of sildenafil, a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5).Sildenafil citrate is designated chemically as 1-[[3-(6,7-d...
    Active IngredientSildenafil citrate
    Dosage FormTablet
    Routeoral; Oral
    Strengtheq 100mg base; 25mg; eq 50mg base; eq 20mg base; 100mg; 50mg; eq 25mg base
    Market StatusTentative Approval; Prescription
    CompanyAmneal Pharms; Mylan Pharms; Hetero Labs Ltd V; Mylan Pharma; Actavis Pharma; Apotex; Torrent Pharms; Watson Labs; Actavis Grp Ptc; Teva Pharms; Macleods Pharms; Dr Reddys Labs

    4 of 8  
    Drug NameViagra
    Drug LabelVIAGRA, an oral therapy for erectile dysfunction, is the citrate salt of sildenafil, a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5).Sildenafil citrate is designated chemically as 1-[[3-(6,7-d...
    Active IngredientSildenafil citrate
    Dosage FormTablet
    RouteOral
    Strengtheq 100mg base; eq 50mg base; eq 25mg base
    Market StatusPrescription
    CompanyPfizer Ireland

    5 of 8  
    Drug NameRevatio
    PubMed HealthSildenafil
    Drug ClassesAntihypertensive, Peripheral Vasodilator, Erectile Dysfunction Agent, Vasodilator
    Drug LabelREVATIO, phosphodiesterase-5 (PDE-5) inhibitor, is the citrate salt of sildenafil, a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type-5 (PDE-5). Sildenafil is also marketed as VIAGRA for erectile dysfunct...
    Active IngredientSildenafil citrate
    Dosage FormTablet; Solution; For suspension
    RouteOral; Intravenous
    Strengtheq 20mg base; eq 10mg base/ml; eq 10mg base/12.5ml (eq 0.8mg base/ml)
    Market StatusPrescription
    CompanyPfizer

    6 of 8  
    Drug NameSildenafil citrate
    Drug LabelVIAGRA, an oral therapy for erectile dysfunction, is the citrate salt of sildenafil, a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5).Sildenafil citrate is designated chemically as 1-[[3-(6,7-d...
    Active IngredientSildenafil citrate
    Dosage FormTablet
    Routeoral
    Strength25mg; 100mg; 50mg
    Market StatusTentative Approval
    CompanyMacleods Pharma

    7 of 8  
    Drug NameSildenafil citrate
    PubMed HealthSildenafil
    Drug ClassesAntihypertensive, Peripheral Vasodilator, Erectile Dysfunction Agent, Vasodilator
    Drug LabelVIAGRA, an oral therapy for erectile dysfunction, is the citrate salt of sildenafil, a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5).Sildenafil citrate is designated chemically as 1-[[3-(6,7-d...
    Active IngredientSildenafil citrate
    Dosage FormTablet
    Routeoral; Oral
    Strengtheq 100mg base; 25mg; eq 50mg base; eq 20mg base; 100mg; 50mg; eq 25mg base
    Market StatusTentative Approval; Prescription
    CompanyAmneal Pharms; Mylan Pharms; Hetero Labs Ltd V; Mylan Pharma; Actavis Pharma; Apotex; Torrent Pharms; Watson Labs; Actavis Grp Ptc; Teva Pharms; Macleods Pharms; Dr Reddys Labs

    8 of 8  
    Drug NameViagra
    Drug LabelVIAGRA, an oral therapy for erectile dysfunction, is the citrate salt of sildenafil, a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5).Sildenafil citrate is designated chemically as 1-[[3-(6,7-d...
    Active IngredientSildenafil citrate
    Dosage FormTablet
    RouteOral
    Strengtheq 100mg base; eq 50mg base; eq 25mg base
    Market StatusPrescription
    CompanyPfizer Ireland

    API Reference Price

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    01-Aug-2023
    31-Aug-2024
    KGS
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    Average Price (USD/KGS)

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    USFDA APPLICATION NUMBER - 203109

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