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    Chemistry

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    Also known as: Sodium risedronate, 115436-72-1, Actonel, Atelvia, Risedronate (sodium), Ne 58095
    Molecular Formula
    C7H10NNaO7P2
    Molecular Weight
    305.09  g/mol
    InChI Key
    DRFDPXKCEWYIAW-UHFFFAOYSA-M
    FDA UNII
    OFG5EXG60L
    Risedronate Sodium
    A pyridine and diphosphonic acid derivative that acts as a CALCIUM CHANNEL BLOCKER and inhibits BONE RESORPTION.
    1 2D Structure

    Risedronate Sodium

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    sodium;hydroxy-(1-hydroxy-1-phosphono-2-pyridin-3-ylethyl)phosphinate
    2.1.2 InChI
    InChI=1S/C7H11NO7P2.Na/c9-7(16(10,11)12,17(13,14)15)4-6-2-1-3-8-5-6;/h1-3,5,9H,4H2,(H2,10,11,12)(H2,13,14,15);/q;+1/p-1
    2.1.3 InChI Key
    DRFDPXKCEWYIAW-UHFFFAOYSA-M
    2.1.4 Canonical SMILES
    C1=CC(=CN=C1)CC(O)(P(=O)(O)O)P(=O)(O)[O-].[Na+]
    2.2 Other Identifiers
    2.2.1 UNII
    OFG5EXG60L
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. 1-hydroxy-2-(3-pyridyl)ethylidene Diphosphonate

    2. 2-(3-pyridinyl)-1-hydroxyethylidene-bisphosphonate

    3. 2-(3-pyridinyl)-1-hydroxyethylidenebisphosphonate

    4. Actonel

    5. Atelvia

    6. Bisphosphonate Risedronate Sodium

    7. Risedronate

    8. Risedronate Sodium, Bisphosphonate

    9. Risedronic Acid

    10. Risedronic Acid, Monosodium Salt

    11. Sodium, Bisphosphonate Risedronate

    2.3.2 Depositor-Supplied Synonyms

    1. Sodium Risedronate

    2. 115436-72-1

    3. Actonel

    4. Atelvia

    5. Risedronate (sodium)

    6. Ne 58095

    7. Risedronic Acid Monosodium Salt

    8. Risedronate Monosodium

    9. Ofg5exg60l

    10. Risedronate Sodium Anhydrous

    11. Ne-58095 Anhydrous

    12. Sodium Trihydrogen (1-hydroxy-2-(3-pyridyl)ethylidene)diphosphonate

    13. 115436-72-1 (sodium)

    14. Risedronic Acid Sodium

    15. Benet

    16. Nsc-722598

    17. Nsc-759280

    18. Actonel (tn)

    19. Phosphonic Acid, (1-hydroxy-2-(3-pyridinyl)ethylidene)bis-, Monosodium Salt

    20. Sodium Hydrogen (1-hydroxy-1-phosphono-2-(pyridin-3-yl)ethyl)phosphonate

    21. Risedronate Sodium [usan]

    22. Risedronic Acid Sodium Salt

    23. Mfcd00867080

    24. 122458-82-6

    25. Unii-ofg5exg60l

    26. Optinate

    27. Acrel

    28. Risedronate Sodium [usan:usp]

    29. Sodium Hydrogen [1-hydroxy-1-phosphono-2-(pyridin-3-yl)ethyl]phosphonate

    30. Optinate Septimum

    31. Monosodium Risedronate

    32. Monosodium (1-hydroxy-2-(3-pyridinyl)ethylidene)bisphosphonate

    33. Ne 58095 Sodium

    34. Risedronate Sodium (usp)

    35. Chembl1654

    36. Schembl18377

    37. Risedronate Sodium, Min 97%

    38. Chebi:8868

    39. Dtxsid20924178

    40. Risedronate Sodium [vandf]

    41. Risedronate Sodium [mart.]

    42. Act03362

    43. Bcp22742

    44. Hy-b0119

    45. Risedronate Sodium [usp-rs]

    46. Risedronate Sodium [who-dd]

    47. Ac-732

    48. Mfcd01706268

    49. S1428

    50. Akos015833432

    51. Ab09807

    52. Ccg-213235

    53. Cs-1883

    54. Nsc 722598

    55. Nsc 759280

    56. Risedronate Sodium [orange Book]

    57. Ncgc00346521-01

    58. Ac-20120

    59. As-13309

    60. Risedronate Sodium [usp Monograph]

    61. Ft-0631078

    62. M2289

    63. Risedronic Acid Monosodium Salt [mi]

    64. D00942

    65. H11438

    66. Ab01274790-01

    67. Q-201723

    68. Q27285633

    69. 2-(3-pyridinyl)-2-hydroxyethylidene-1,1-bisphosphonate

    70. Monosodium 1-hydroxy-2-(3-pyridyl)ethylidene-1,1-diphosphonate

    71. 1-hydroxy-2-(3-pyridinyl) Ethylidene Bis-phosphonic Acid Monosodium Salt

    72. Hydrogen [1-hydroxy-1-phosphono-2-(pyridin-3-yl)ethyl]phosphonate (na+)

    73. P,p'-[1-hydroxy-2-(3-pyridonyl)ethylidene]bis-phosphonic Acid Sodium Salt

    74. Phosphonic Acid, (1-hydroxy-2-(3-pyridinyl)ethylidene)bis-, Disodium Salt

    75. Phosphonic Acid, (2-hydroxy-2-(3-pyridinyl)ethylidene)bis-, Disodium Salt

    76. Risedronate Sodium, United States Pharmacopeia (usp) Reference Standard

    77. Risedronate Sodium;risedronic Acid Sodium;ne-58095; Ne 58095; Ne58095

    78. Sodium Hydrogen-1-hydroxy-1-phosphono-2-(pyridin-3-yl)ethylphosphonate

    79. Sodium;hydroxy-(1-hydroxy-1-phosphono-2-pyridin-3-ylethyl)phosphinate

    80. (1-hydroxy-2-(pyridin-3-yl)ethane-1,1-diyl)bis(phosphonic Acid) Sodium Salt

    81. Risedronate Sodium 2.5-hydrate, European Pharmacopoeia (ep) Reference Standard

    82. Risedronate Sodium, Pharmaceutical Secondary Standard; Certified Reference Material

    83. 934544-85-1

    2.4 Create Date
    2005-09-13
    3 Chemical and Physical Properties
    Molecular Weight 305.09 g/mol
    Molecular Formula C7H10NNaO7P2
    Hydrogen Bond Donor Count4
    Hydrogen Bond Acceptor Count8
    Rotatable Bond Count4
    Exact Mass304.98301994 g/mol
    Monoisotopic Mass304.98301994 g/mol
    Topological Polar Surface Area151 Ų
    Heavy Atom Count18
    Formal Charge0
    Complexity375
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count1
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 6  
    Drug NameActonel
    PubMed HealthAntacid, Calcium Containing (By mouth)
    Drug ClassesAntacid, Aluminum Containing, Antacid, Aluminum/Calcium/Magnesium Containing, Antacid, Calcium Containing, Antacid, Magnesium Containing, Antiflatulent, Calcium Supplement
    Drug LabelACTONEL (risedronate sodium) tablets is a pyridinyl bisphosphonate that inhibits osteoclast-mediated bone resorption and modulates bone metabolism. Each ACTONEL tablet for oral administration contains the equivalent of 5, 30, 35, 75, or 150 mg of anh...
    Active IngredientRisedronate sodium
    Dosage FormTablet
    RouteOral
    Strength5mg; 30mg; 150mg; 35mg
    Market StatusPrescription
    CompanyWarner Chilcott

    2 of 6  
    Drug NameAtelvia
    Drug LabelAtelvia (risedronate sodium) delayed-release tablets contain a pH-sensitive enteric coating and a chelating agent (EDTA). Risedronate is a pyridinyl bisphosphonate that inhibits osteoclast-mediated bone resorption and modulates bone metabolism. Each...
    Active IngredientRisedronate sodium
    Dosage FormTablet, delayed release
    RouteOral
    Strength35mg
    Market StatusPrescription
    CompanyWarner Chilcott

    3 of 6  
    Drug NameRisedronate sodium
    PubMed HealthRisedronate (By mouth)
    Drug ClassesCalcium Regulator
    Drug LabelACTONEL (risedronate sodium) tablets is a pyridinyl bisphosphonate that inhibits osteoclast-mediated bone resorption and modulates bone metabolism. Each ACTONEL tablet for oral administration contains the equivalent of 5, 30, 35, 75, or 150 mg of anh...
    Active IngredientRisedronate sodium
    Dosage FormTablet
    Routeoral; Oral
    Strength30mg; 150mg; 75mg; 5mg; 35mg
    Market StatusTentative Approval; Prescription
    CompanyMylan Pharms; Apotex; Aurobindo Pharma; Teva Pharms Usa; Sun Pharma Global; Teva Pharms

    4 of 6  
    Drug NameActonel
    PubMed HealthAntacid, Calcium Containing (By mouth)
    Drug ClassesAntacid, Aluminum Containing, Antacid, Aluminum/Calcium/Magnesium Containing, Antacid, Calcium Containing, Antacid, Magnesium Containing, Antiflatulent, Calcium Supplement
    Drug LabelACTONEL (risedronate sodium) tablets is a pyridinyl bisphosphonate that inhibits osteoclast-mediated bone resorption and modulates bone metabolism. Each ACTONEL tablet for oral administration contains the equivalent of 5, 30, 35, 75, or 150 mg of anh...
    Active IngredientRisedronate sodium
    Dosage FormTablet
    RouteOral
    Strength5mg; 30mg; 150mg; 35mg
    Market StatusPrescription
    CompanyWarner Chilcott

    5 of 6  
    Drug NameAtelvia
    Drug LabelAtelvia (risedronate sodium) delayed-release tablets contain a pH-sensitive enteric coating and a chelating agent (EDTA). Risedronate is a pyridinyl bisphosphonate that inhibits osteoclast-mediated bone resorption and modulates bone metabolism. Each...
    Active IngredientRisedronate sodium
    Dosage FormTablet, delayed release
    RouteOral
    Strength35mg
    Market StatusPrescription
    CompanyWarner Chilcott

    6 of 6  
    Drug NameRisedronate sodium
    PubMed HealthRisedronate (By mouth)
    Drug ClassesCalcium Regulator
    Drug LabelACTONEL (risedronate sodium) tablets is a pyridinyl bisphosphonate that inhibits osteoclast-mediated bone resorption and modulates bone metabolism. Each ACTONEL tablet for oral administration contains the equivalent of 5, 30, 35, 75, or 150 mg of anh...
    Active IngredientRisedronate sodium
    Dosage FormTablet
    Routeoral; Oral
    Strength30mg; 150mg; 75mg; 5mg; 35mg
    Market StatusTentative Approval; Prescription
    CompanyMylan Pharms; Apotex; Aurobindo Pharma; Teva Pharms Usa; Sun Pharma Global; Teva Pharms

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Bone Density Conservation Agents

    Agents that inhibit BONE RESORPTION and/or favor BONE MINERALIZATION and BONE REGENERATION. They are used to heal BONE FRACTURES and to treat METABOLIC BONE DISEASES such as OSTEOPOROSIS. (See all compounds classified as Bone Density Conservation Agents.)

    Calcium Channel Blockers

    A class of drugs that act by selective inhibition of calcium influx through cellular membranes. (See all compounds classified as Calcium Channel Blockers.)

    5.2 FDA Pharmacological Classification
    5.2.1 Pharmacological Classes
    Bisphosphonate [EPC]; Diphosphonates [CS]; Bisphosphonate [EPC]

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    04-Jan-2021
    23-Aug-2024
    KGS
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    Average Price (USD/KGS)

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    Quantity (KGS) & Unit rate (USD/KGS) over time

    API Imports and Exports

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    (KGS)    		 Average Price
    (USD/KGS)    		 Number of Transactions

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    DOSAGE - TABLET;ORAL - 150MG

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    DOSAGE - TABLET;ORAL - 75MG **Federal Registe...DOSAGE - TABLET;ORAL - 75MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

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    DOSAGE - TABLET, DELAYED RELEASE;ORAL - 35MG

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    Risedronate Sodium API Manufacturers | Traders | Suppliers

    Risedronate Sodium API Manufacturers, Traders, Suppliers 1
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    We have 9 companies offering Risedronate Sodium API

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    1. Polpharma
    2. Alchymars ICM SM
    3. Aurobindo Pharma Limited
    4. Cipla
    5. Divis Laboratories
    6. Hetero Drugs
    7. Jubilant Pharmova
    8. Pliva Hrvatska
    9. Viatris
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