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    Chemistry

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    Also known as: 161735-79-1, Azilect, Rasagiline mesilate, Tvp-1012, Agilect, (r)-n-(prop-2-yn-1-yl)-2,3-dihydro-1h-inden-1-amine methanesulfonate
    Molecular Formula
    C13H17NO3S
    Molecular Weight
    267.35  g/mol
    InChI Key
    JDBJJCWRXSVHOQ-UTONKHPSSA-N
    FDA UNII
    LH8C2JI290
    Rasagiline Mesylate
    1 2D Structure

    Rasagiline Mesylate

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    methanesulfonic acid;(1R)-N-prop-2-ynyl-2,3-dihydro-1H-inden-1-amine
    2.1.2 InChI
    InChI=1S/C12H13N.CH4O3S/c1-2-9-13-12-8-7-10-5-3-4-6-11(10)12;1-5(2,3)4/h1,3-6,12-13H,7-9H2;1H3,(H,2,3,4)/t12-;/m1./s1
    2.1.3 InChI Key
    JDBJJCWRXSVHOQ-UTONKHPSSA-N
    2.1.4 Canonical SMILES
    CS(=O)(=O)O.C#CCNC1CCC2=CC=CC=C12
    2.1.5 Isomeric SMILES
    CS(=O)(=O)O.C#CCN[C@@H]1CCC2=CC=CC=C12
    2.2 Other Identifiers
    2.2.1 UNII
    LH8C2JI290
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. 2,3-dihydro-n-2-propynyl-1h-inden-1-amine-(1r)-hydrochloride

    2. Agn 1135

    3. Agn-1135

    4. Azilect

    5. N-2-propynyl-1-indanamine

    6. N-propargyl-1-aminoindan Mesylate

    7. Rasagiline

    8. Rasagiline Hydrochloride

    9. Tvp 101

    10. Tvp 1022

    11. Tvp-101

    12. Tvp-1022

    13. Tvp1022

    2.3.2 Depositor-Supplied Synonyms

    1. 161735-79-1

    2. Azilect

    3. Rasagiline Mesilate

    4. Tvp-1012

    5. Agilect

    6. (r)-n-(prop-2-yn-1-yl)-2,3-dihydro-1h-inden-1-amine Methanesulfonate

    7. Rasagiline Methanesulfonate

    8. Rasagiline Mesylate [usan]

    9. Rasagiline (mesylate)

    10. Rasagline Ratiopharm

    11. Rasagiline (as Mesilate)

    12. Lh8c2ji290

    13. (r)-n-2-propynyl-1-indanamine Methanesulfonate

    14. 1h-inden-1-amine, 2,3-dihydro-n-2-propynyl-, (r)-, Methanesulfonate

    15. Methanesulfonic Acid;(1r)-n-prop-2-ynyl-2,3-dihydro-1h-inden-1-amine

    16. Ncgc00168774-01

    17. Azilect (tn)

    18. Mfcd08460604

    19. 1h-inden-1-amine, 2,3-dihydro-n-2-propynyl-, (1r)-, Methanesulfonate

    20. Rasagiline Mesilate (jan)

    21. Rasagiline Mesylate (usan)

    22. Dsstox_cid_27826

    23. Dsstox_rid_82589

    24. Dsstox_gsid_47848

    25. Rasagiline Mesilate [jan]

    26. Tvp1012

    27. Cas-161735-79-1

    28. Tvp 1012

    29. Unii-lh8c2ji290

    30. C12h13n.ch3so3h

    31. Schembl158439

    32. (1r)-2,3-dihydro-n-2-propynyl-1h-inden-1-amine Methanesulfonate

    33. (r)-2,3-dihydro-n-2-propynyl-1-indenamine Mesylate

    34. Chembl1201142

    35. Dtxsid8047848

    36. Hms3884d07

    37. Rasagiline Mesylate [vandf]

    38. (1r)-2,3-dihydro-n-2-propyn-1-yl-1h-inden-1-amine Mesylate

    39. Act06733

    40. Rasagiline Mesilate [mart.]

    41. Tox21_112635

    42. Ac-724

    43. Rasagiline Mesylate [who-dd]

    44. S2102

    45. Akos005145768

    46. Rasagiline Mesylate, >=98% (hplc)

    47. Tox21_112635_1

    48. Bs-1009

    49. Ccg-267122

    50. Tv 1012

    51. 1h-inden-1-amine, 2,3-dihydro-n-2-propyn-1-yl-, (1r)-, Methanesulfonate (1:1)

    52. Rasagiline Methanesulfonate [mi]

    53. Ncgc00168774-02

    54. Rasagiline Mesylate [orange Book]

    55. (+)-agn-1135

    56. Hy-14605

    57. R0213

    58. D02562

    59. 735r791

    60. Q-101873

    61. Q27282989

    62. (r)-n-2-propynyl-1-indanamine Methanesulphonate

    63. Z1820079046

    64. (1r)-2,3-dihydro-n-2-propynyl-1h-in Den-1-amine Methanesulfonate

    65. (r)-n-(prop-2-ynyl)-2,3-dihydro-1h-inden-1-amine Methanesulfonate

    66. (1r)-n-(prop-2-yn-1-yl)-2,3-dihydro-1h-inden-1-amine; Methanesulfonic Acid

    67. 1h-inden-1-amine, 2,3-dihydro-n-2-propynyl-, (r)-, Methanesulphonate

    2.4 Create Date
    2005-08-09
    3 Chemical and Physical Properties
    Molecular Weight 267.35 g/mol
    Molecular Formula C13H17NO3S
    Hydrogen Bond Donor Count2
    Hydrogen Bond Acceptor Count4
    Rotatable Bond Count2
    Exact Mass267.09291458 g/mol
    Monoisotopic Mass267.09291458 g/mol
    Topological Polar Surface Area74.8 Ų
    Heavy Atom Count18
    Formal Charge0
    Complexity305
    Isotope Atom Count0
    Defined Atom Stereocenter Count1
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 4  
    Drug NameAzilect
    Drug LabelAZILECT tablets contain rasagiline (as the mesylate), a propargylamine-based drug indicated for the treatment of idiopathic Parkinsons disease. It is designated chemically as: 1H-Inden-1-amine, 2, 3-dihydro-N-2-propynyl-, (1R)-, methanesulfonate...
    Active IngredientRasagiline mesylate
    Dosage FormTablet
    RouteOral
    Strengtheq 0.5mg base; eq 1mg base
    Market StatusPrescription
    CompanyTeva

    2 of 4  
    Drug NameRasagiline mesylate
    PubMed HealthRasagiline (By mouth)
    Drug ClassesAntiparkinsonian
    Drug LabelAZILECT tablets contain rasagiline (as the mesylate), a propargylamine-based drug indicated for the treatment of idiopathic Parkinsons disease. It is designated chemically as: 1H-Inden-1-amine, 2, 3-dihydro-N-2-propynyl-, (1R)-, methanesulfonate...
    Active IngredientRasagiline mesylate
    Dosage FormTablet
    Routeoral; Oral
    Strengtheq 0.5mg base; 0.5mg; 1mg; eq 1mg base
    Market StatusTentative Approval; Prescription
    CompanyMylan Pharma; Apotex

    3 of 4  
    Drug NameAzilect
    Drug LabelAZILECT tablets contain rasagiline (as the mesylate), a propargylamine-based drug indicated for the treatment of idiopathic Parkinsons disease. It is designated chemically as: 1H-Inden-1-amine, 2, 3-dihydro-N-2-propynyl-, (1R)-, methanesulfonate...
    Active IngredientRasagiline mesylate
    Dosage FormTablet
    RouteOral
    Strengtheq 0.5mg base; eq 1mg base
    Market StatusPrescription
    CompanyTeva

    4 of 4  
    Drug NameRasagiline mesylate
    PubMed HealthRasagiline (By mouth)
    Drug ClassesAntiparkinsonian
    Drug LabelAZILECT tablets contain rasagiline (as the mesylate), a propargylamine-based drug indicated for the treatment of idiopathic Parkinsons disease. It is designated chemically as: 1H-Inden-1-amine, 2, 3-dihydro-N-2-propynyl-, (1R)-, methanesulfonate...
    Active IngredientRasagiline mesylate
    Dosage FormTablet
    Routeoral; Oral
    Strengtheq 0.5mg base; 0.5mg; 1mg; eq 1mg base
    Market StatusTentative Approval; Prescription
    CompanyMylan Pharma; Apotex

    4.2 Drug Indication

    Azilect is indicated for the treatment of idiopathic Parkinson's disease (PD) as monotherapy (without levodopa) or as adjunct therapy (with levodopa) in patients with end-of-dose fluctuations.

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Monoamine Oxidase Inhibitors

    A chemically heterogeneous group of drugs that have in common the ability to block oxidative deamination of naturally occurring monoamines. (From Gilman, et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p414) (See all compounds classified as Monoamine Oxidase Inhibitors.)

    Neuroprotective Agents

    Drugs intended to prevent damage to the brain or spinal cord from ischemia, stroke, convulsions, or trauma. Some must be administered before the event, but others may be effective for some time after. They act by a variety of mechanisms, but often directly or indirectly minimize the damage produced by endogenous excitatory amino acids. (See all compounds classified as Neuroprotective Agents.)

    5.2 FDA Pharmacological Classification
    5.2.1 Pharmacological Classes
    Monoamine Oxidase Inhibitors [MoA]; Monoamine Oxidase Inhibitor [EPC]
    5.3 ATC Code

    N04BD02

    API Reference Price

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    05-Jan-2021
    30-Aug-2024
    KGS
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    Rasagiline Manufacturers | Traders | Suppliers

    Rasagiline Manufacturers, Traders, Suppliers 1
    34

    We have 20 companies offering Rasagiline

    Get in contact with the supplier of your choice:

    1. LGM Pharma
    2. Jai Radhe Sales
    3. Alkem Laboratories
    4. Amino Chemicals
    5. Beijing Mesochem Technology
    6. Biotechnica DWC
    7. CHEMO
    8. Dishman Carbogen Amcis
    9. Everlight Chemical
    10. Glenmark Pharmaceuticals
    11. Guangzhou Tosun Pharmaceutical
    12. Indoco Remedies Limited
    13. Maithili Life Sciences
    14. Micro Labs Limited
    15. Ningbo Zhenlei Chemical Co.,Ltd
    16. Optimus Pharma
    17. SGMR Pharmaceuticals
    18. Tai Heng Industry Co., Ltd
    19. ULKAR KIMYA SANAYII VE TICARET
    20. Viatris
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