List of Suppliers' Topical Excipients Application used in Prestwick3_000325 on PharmaCompass.com

Prestwick3_000325

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ACTIVE PHARMA INGREDIENTS

55 API Suppliers, 9 USDMF, 8 CEP/COS, 14 JDMF, 5 EU WC, 6 KDMF, 6 NDC API, 35 Listed Suppliers, $ API Reference Price

55 API Suppliers
9 USDMF
8 CEP/COS
14 JDMF
5 EU WC
6 KDMF
6 NDC API
35 Listed Suppliers
$ API Reference Price

DEVELOPMENTS

15 Drugs in Development

15 Drugs in Development

FINISHED DOSAGE FORMULATIONS

291 FDF Dossiers, 20 FDA Orange Book, 53 Europe, 9 Canada, 65 South Africa, 144 Listed Dossiers

291 FDF Dossiers
20 FDA Orange Book
53 Europe
9 Canada
65 South Africa
144 Listed Dossiers

DRUG PRODUCT COMPOSITIONS

FOR SOLUTION;INTRAVENOUS - 80MG/VIAL;0.02MG/VIAL;0.001MG/VIAL;5MG/VIAL;0.01MG/VIAL;0.14MG/VIAL;17MG/VIAL;0.2MG/VIAL;1MG/VIAL;1.4MG/VIAL;EQ 1.2MG BASE/VIAL;0.7MG/VIAL;7MG/VIAL, SOLUTION;INTRAVENOUS - 25,000MG/50ML (500MG/ML), SOLUTION;INTRAVENOUS - 2 IU/ML;40MG/ML;12MCG/ML;40 IU/ML;1MCG/ML;3MG/ML;120MCG/ML;8MG/ML;1.2MG/ML;0.72MG/ML;1.2MG/ML;660 IU/ML;0.03MG/ML, SOLUTION;INTRAVENOUS - 2 IU/ML;40MG/ML;12MCG/ML;40 IU/ML;1MCG/ML;3MG/ML;120MCG/ML;8MG/ML;1.2MG/ML;0.72MG/ML;1.2MG/ML;660 IU/ML;30MCG/ML, INJECTABLE;INTRAVENOUS - 200MG/VIAL;0.06MG/VIAL;0.005MG/VIAL;15MG/VIAL;0.005MG/VIAL;0.6MG/VIAL;40MG/VIAL;6MG/VIAL;3.6MG/VIAL;6MG/VIAL;1MG/VIAL;10MG/VIAL;0.15MG/VIAL, INJECTABLE;INJECTION - 20MG/ML;0.006MG/ML;0.05MCG/ML;1.5MG/ML;0.0005MG/ML;0.06MG/ML;4MG/ML;0.6MG/ML;0.36MG/ML;0.6MG/ML;0.1MG/ML;1MG/ML

drugProductComposition
FOR SOLUTION;INTRAVENOUS - 80MG/VIAL;0.02MG/VIAL;0.001MG/VIAL;5MG/VIAL;0.01MG/VIAL;0.14MG/VIAL;17MG/VIAL;0.2MG/VIAL;1MG/VIAL;1.4MG/VIAL;EQ 1.2MG BASE/VIAL;0.7MG/VIAL;7MG/VIAL
SOLUTION;INTRAVENOUS - 25,000MG/50ML (500MG/ML)
SOLUTION;INTRAVENOUS - 2 IU/ML;40MG/ML;12MCG/ML;40 IU/ML;1MCG/ML;3MG/ML;120MCG/ML;8MG/ML;1.2MG/ML;0.72MG/ML;1.2MG/ML;660 IU/ML;0.03MG/ML
SOLUTION;INTRAVENOUS - 2 IU/ML;40MG/ML;12MCG/ML;40 IU/ML;1MCG/ML;3MG/ML;120MCG/ML;8MG/ML;1.2MG/ML;0.72MG/ML;1.2MG/ML;660 IU/ML;30MCG/ML
INJECTABLE;INTRAVENOUS - 200MG/VIAL;0.06MG/VIAL;0.005MG/VIAL;15MG/VIAL;0.005MG/VIAL;0.6MG/VIAL;40MG/VIAL;6MG/VIAL;3.6MG/VIAL;6MG/VIAL;1MG/VIAL;10MG/VIAL;0.15MG/VIAL
INJECTABLE;INJECTION - 20MG/ML;0.006MG/ML;0.05MCG/ML;1.5MG/ML;0.0005MG/ML;0.06MG/ML;4MG/ML;0.6MG/ML;0.36MG/ML;0.6MG/ML;0.1MG/ML;1MG/ML

RELATED EXCIPIENT COMPANIES

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relatedExcipients
2 Evonik
14 Rochem International Inc
22 SPI Pharma
2 Seqens
26 DKSH
2 Jai Radhe Sales
2 Pharm-RX Chemical
8 Boai NKY Pharmaceuticals Ltd
14 Gangwal Healthcare
2 Kewpie Corporation
12 Nanjing Well Pharmaceutical
2 Pfanstiehl
4 ACG Worldwide
16 Actylis
2 Aeon Procare
1 Alcedo Pharmachem
9 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd
1 Avesta Pharma
36 BASF
2 Bioplus Life Sciences
2 Clariant
13 Corel Pharma Chem
5 DFE Pharma
3 Doshion Polyscience
2 Finar
13 Gangwal Chemicals
7 Ideal Cures Pvt Ltd
4 Ingredion Pharma Solutions
34 Kerry
5 Kima Chemical
6 Lonza Capsugel
22 Microlex e.U
1 Nanjing Bold Chemical
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4 Novo Excipients
3 Pharmatrans-Sanaq
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2 Qualicaps
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1 Shanghai Welltone Material Technology Co., Ltd
3 Shijiazhuang Huaxu Pharmaceutical
11 Sigachi Industries
4 The Dow Chemical Company
3 Ulanqab Kema New Material
2 Valens Pharmachem
4 Vasa Pharmachem
2 Zhejiang Huakang Pharmaceutical

EXCIPIENTS BY APPLICATIONS

120 Fillers, Diluents & Binders, 63 Coating Systems & Additives, 51 Direct Compression, 50 Thickeners and Stabilizers, 45 Taste Masking, 44 Solubilizers, 40 Parenteral, 38 Controlled & Modified Release, 35 Disintegrants & Superdisintegrants, 32 Granulation, 30 Topical, 29 Film Formers & Plasticizers, 25 Lubricants & Glidants, 23 Chewable & Orodispersible Aids, 21 Co-Processed Excipients, 16 Emulsifying Agents, 13 Rheology Modifiers, 11 API Stability Enhancers, 9 Empty Capsules, 7 Surfactant & Foaming Agents, 5 Coloring Agents, 4 Vegetarian Capsules, 1 Soft Gelatin

DIGITAL CONTENT

1 DATA COMPILATION #PharmaFlow, 25 NEWS #PharmaBuzz

media
1 DATA COMPILATION #PharmaFlow
25 NEWS #PharmaBuzz

GLOBAL SALES INFORMATION

1 US Medicaid Prescriptions, 28 Finished Drug Prices

globalSalesInformation
1 US Medicaid Prescriptions
28 Finished Drug Prices

MARKET PLACE

172 APIs, 34 FDF Dossiers, 13 EXCIPIENTS

marketPlace
172 APIs
34 FDF Dossiers
13 EXCIPIENTS

PATENTS & EXCLUSIVITIES

12 US Patents, 1 US Exclusivities

patents
12 US Patents
1 US Exclusivities

REF. STANDARDS & IMPURITIES

5 EDQM , 2 USP , 3 JP , 6 Others

otherSolutions
5 EDQM
2 USP
3 JP
6 Others

ANALYTICAL

11 Analytical Methods

otherMethods
11 Analytical Methods

Ascorbic Acid

Synopsis

Chemistry

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Also known as: L-ascorbic acid, Vitamin c, 50-81-7, L-ascorbate, L(+)-ascorbic acid, Ascorbate

Molecular Formula

C₆H₈O₆

Molecular Weight

176.12 g/mol

InChI Key

CIWBSHSKHKDKBQ-JLAZNSOCSA-N

FDA UNII

PQ6CK8PD0R

A six carbon compound related to glucose. It is found naturally in citrus fruits and many vegetables. Ascorbic acid is an essential nutrient in human diets, and necessary to maintain connective tissue and bone. Its biologically active form, vitamin C, functions as a reducing agent and coenzyme in several metabolic pathways. Vitamin C is considered an antioxidant.

Ascorbic acid is a Vitamin C.

1 2D Structure

Ascorbic Acid

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

(2R)-2-[(1S)-1,2-dihydroxyethyl]-3,4-dihydroxy-2H-furan-5-one

2.1.2 InChI

InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-10H,1H2/t2-,5+/m0/s1

2.1.3 InChI Key

CIWBSHSKHKDKBQ-JLAZNSOCSA-N

2.1.4 Canonical SMILES

C(C(C1C(=C(C(=O)O1)O)O)O)O

2.1.5 Isomeric SMILES

C([C@@H]([C@@H]1C(=C(C(=O)O1)O)O)O)O

2.2 Other Identifiers

2.2.1 UNII

PQ6CK8PD0R

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Acid, Ascorbic

2. Acid, L-ascorbic

3. Ascorbate, Ferrous

4. Ascorbate, Magnesium

5. Ascorbate, Sodium

6. Ascorbic Acid, Monosodium Salt

7. Di-l-ascorbate, Magnesium

8. Ferrous Ascorbate

9. Hybrin

10. L Ascorbic Acid

11. L-ascorbic Acid

12. Magnesium Ascorbate

13. Magnesium Ascorbicum

14. Magnesium Di L Ascorbate

15. Magnesium Di-l-ascorbate

16. Magnorbin

17. Sodium Ascorbate

18. Vitamin C

2.3.2 Depositor-Supplied Synonyms

1. L-ascorbic Acid

2. Vitamin C

3. 50-81-7

4. L-ascorbate

5. L(+)-ascorbic Acid

6. Ascorbate

7. Ascoltin

8. Ascorbicap

9. Cevitamic Acid

10. Cenolate

11. Natrascorb

12. Hybrin

13. Allercorb

14. Ascorbajen

15. Ascorbutina

16. Ascorteal

17. Cescorbat

18. Cetemican

19. Cevitamin

20. Citriscorb

21. Laroscorbine

22. Lemascorb

23. Proscorbin

24. Roscorbic

25. Secorbate

26. Testascorbic

27. Vitacimin

28. Vitamisin

29. Vitascorbol

30. Ascorin

31. Ascorvit

32. Cantaxin

33. Cebicure

34. Cebione

35. Cegiolan

36. Ceglion

37. Celaskon

38. Cemagyl

39. Cenetone

40. Cergona

41. Cetamid

42. Cevatine

43. Cevimin

44. Cevital

45. Cevitan

46. Cevitex

47. Colascor

48. Concemin

49. Redoxon

50. Vicelat

51. Viforcit

52. Viscorin

53. Vitacee

54. Vitacin

55. Adenex

56. Ascorb

57. Cantan

58. Cebid

59. Cebion

60. Cecon

61. Cemill

62. Cereon

63. Cevex

64. Ciamin

65. Cipca

66. Hicee

67. Ribena

68. Vitace

69. Xitix

70. Davitamon C

71. Arco-cee

72. Planavit C

73. Catavin C

74. Ce Lent

75. Liqui-cee

76. Vicomin C

77. Cee-vite

78. Cevi-bid

79. Scorbu-c

80. C-level

81. C-vimin

82. Cetane-caps Td

83. Duoscorb

84. Scorbacid

85. Cewin

86. Antiscorbic Vitamin

87. C-long

88. C-quin

89. C-span

90. Meri-c

91. Cee-caps Td

92. L-lyxoascorbic Acid

93. L-xyloascorbic Acid

94. Cevalin

95. Antiscorbutic Vitamin

96. Cetane-caps Tc

97. 3-oxo-l-gulofuranolactone

98. 3-keto-l-gulofuranolactone

99. Ce-mi-lin

100. Ido-c

101. Natrascorb Injectable

102. Acidum Ascorbicum

103. L-(+)-ascorbic Acid

104. Ce-vi-sol

105. Ferrous Ascorbate

106. Acidum Ascorbinicum

107. Ascor-b.i.d.

108. (r)-5-((s)-1,2-dihydroxyethyl)-3,4-dihydroxyfuran-2(5h)-one

109. Celin

110. Dora-c-500

111. Kyselina Askorbova

112. Cortalex

113. Ferancee

114. Stuartinic

115. Tolfrinic

116. Acido Ascorbico

117. L-threoascorbic Acid

118. Acide Ascorbique

119. L-3-ketothreohexuronic Acid Lactone

120. Chromagen

121. Kyselina Askorbova [czech]

122. Caswell No. 061b

123. Fema No. 2109

124. Acide Ascorbique [inn-french]

125. Acido Ascorbico [inn-spanish]

126. Acidum Ascorbicum [inn-latin]

127. Sodascorbate

128. Ascorbicin

129. Nci-c54808

130. L-threo-hex-2-enonic Acid, Gamma-lactone

131. L-threo-ascorbic Acid

132. 3-oxo-l-gulofuranolactone (enol Form)

133. Ascor

134. Ascorbicum Acidum

135. Ascorbic Acid, L-

136. Cetebe

137. Ascorbin

138. (+)-ascorbic Acid

139. Hex-2-enonic Acid Gamma-lactone, L-threo-

140. Mfcd00064328

141. Iron(ii) Ascorbate

142. Pq6ck8pd0r

143. Component Of E And C-level

144. Component Of Endoglobin Forte

145. Vitamin C (as Ascorbic Acid)

146. Vasc

147. Ins No.300

148. Ascorbicab

149. E-300

150. Chebi:29073

151. Ins-300

152. Ccris 57

153. Nsc-33832

154. Component Of Cortalex

155. Component Of Ferancee

156. Hsdb 818

157. Nsc-218455

158. 6730-29-6

159. Antiscorbutic Factor

160. Ncgc00164357-01

161. E300

162. Ester-c

163. (2r)-2-[(1s)-1,2-dihydroxyethyl]-3,4-dihydroxy-2h-furan-5-one

164. (5r)-5-[(1s)-1,2-dihydroxyethyl]-3,4-dihydroxyfuran-2(5h)-one

165. Dsstox_cid_106

166. Hex-1-enofuranos-3-ulose

167. (5r)-5-[(1s)-1,2-dihydroxyethyl]-3,4-dihydroxy-2,5-dihydrofuran-2-one

168. Iron-ascorbic Acid Complexes

169. L-ascorbic Acid 1000 Microg/ml In Acetonitrile

170. Dsstox_rid_75370

171. Dsstox_gsid_20106

172. Kangbingfeng

173. Chewcee

174. Citrovit

175. Juvamine

176. Ceklin

177. Rovimix C

178. Scorbu C

179. Ascorbinsaeure

180. Parentrovite

181. Cell C

182. Viscorin 100m

183. Ronotec 100

184. Suncoat Vc 40

185. Rontex 100

186. Ascorbicap (tn)

187. Xyloascorbic Acid, L-

188. Ascoltin (tn)

189. [14c]ascorbic Acid

190. Ascorbic Acid [ban:inn:jan]

191. Vitamin C (ascorbic Acid)

192. [14c]-ascorbic Acid

193. Ascorbic Acid (vit C)

194. L-ascorbic Acid, Meets Usp Testing Specifications

195. 2-(1,2-dihydroxyethyl)-4,5-dihydroxyfuran-3-one

196. Einecs 200-066-2

197. Unii-pq6ck8pd0r

198. Nsc 33832

199. Cevitamate

200. L-lyxoascorbate

201. L-xyloascorbate

202. .ascorbinsaure

203. (5r)-5-((1s)-1,2-dihydroxyethyl)-3,4-dihydroxyfuran-2(5h)-one

204. Vitamin B Mixture With Vitamin C

205. 3eka

206. Ester C

207. (+)-ascorbate

208. L(+)-ascorbate

209. L-threo-hex-2-enono-1,4-lactone

210. L-ascorbic Acid, Free Radical Form

211. L-(+)-ascorbate

212. Ascorbic Acid [usp:inn:ban:jan]

213. Ascorbic Acid Mixture With Vitamin B

214. Vitamin C,(s)

215. E 300

216. Ascorbic Acid Dc97sf

217. (2r)-2-[(1s)-1,2-dihydroxyethyl]-4,5-dihydroxyfuran-3-one

218. Prestwick3_000325

219. L-ascorbic Acid, 99%

220. Ascorbic Acid Mixture With Vitamin B Complex

221. Ascor (tn)

222. Schembl785

223. Bmse000182

224. Vitamin C [vandf]

225. Ascorbic Acid [ii]

226. Ascorbic Acid [mi]

227. Schembl4430

228. Ascorbic Acid [fcc]

229. Ascorbic Acid [inn]

230. Ascorbic Acid [jan]

231. L-ascorbic Acid, Fcc, Fg

232. L-ascorbic Acid, Free Acid

233. Ascorbic Acid [fhfi]

234. Ascorbic Acid [hsdb]

235. Ascorbic Acid [inci]

236. Bspbio_000329

237. (r)-5-(1,2-dihydroxy-ethyl)-3,4-dihydroxy-5h-furan-2-one

238. Mls002153776

239. Ascorbic Acid [vandf]

240. Chembl40274

241. L-ascorbic Acid, Cell Culture

242. Ascorbic Acid [mart.]

243. Bpbio1_000363

244. Gtpl4532

245. Gtpl4781

246. L-ascorbic Acid, Reagent Grade

247. Ascorbic Acid [usp-rs]

248. Ascorbic Acid [who-dd]

249. Ascorbic Acid [who-ip]

250. Dtxsid5020106

251. L-ascorbic Acid, >=99.0%

252. Dtxsid50986567

253. Ascorbic Acid (jp17/usp/inn)

254. Hms2096a11

255. Hms2231n16

256. Hms3713a11

257. L-ascorbic Acid Acs Reagent Grade

258. (2r)-2-[(1s)-1,2-dihydroxyethyl]-4,5-dihydroxy-furan-3-one

259. Ascorbic Acid [orange Book]

260. Bcp27915

261. Hy-b0166

262. Tox21_110315

263. Tox21_112104

264. Tox21_202127

265. Tox21_302958

266. Ascorbic Acid [ep Monograph]

267. Gamma-lactone L-threo-hex-2-enonate

268. L-ascorbic Acid, Analytical Standard

269. L-ascorbic Acid, Ar, >=99.5%

270. S3114

271. Ascorbic Acid [usp Monograph]

272. Akos016843589

273. Tox21_112104_1

274. Zinc100006770

275. Zinc100019304

276. Ccg-207946

277. Db00126

278. L-ascorbic Acid, Mixt. With Vitamin B

279. Nsc 218455

280. Acidum Ascorbicum [who-ip Latin]

281. Gamma-lactone L-threo-hex-2-enonic Acid

282. L-ascorbic Acid, Acs Reagent, >=99%

283. Ncgc00091517-01

284. Ncgc00091517-02

285. Ncgc00091517-03

286. Ncgc00091517-06

287. Ncgc00188972-01

288. Ncgc00256504-01

289. Ncgc00259676-01

290. 53262-66-1

291. Bp-12831

292. Smr001233160

293. L-ascorbic Acid, Plant Cell Culture Tested

294. L-ascorbic Acid, Reagent Grade, Crystalline

295. A0537

296. A8158

297. Ab00376923

298. Ascorbic Acid (l-ascorbic Acid; Vitamin C)

299. Sw198791-2

300. L-ascorbic Acid, Bioultra, >=99.5% (rt)

301. L-ascorbic Acid, Tested According To Ph.eur.

302. C 1000

303. C00072

304. D00018

305. E80759

306. L-ascorbic Acid, P.a., Acs Reagent, 99.0%

307. 2,3-dehydro-l-threo-hexono-1,4-lactone

308. Ab00376923_04

309. Ab00376923_05

310. L-ascorbic Acid, Jis Special Grade, >=99.0%

311. L-ascorbic Acid, Vetec(tm) Reagent Grade, 99%

312. L-ascorbic Acid, Bioxtra, >=99.0%, Crystalline

313. Q199678

314. L-ascorbic Acid, Puriss. P.a., >=99.0% (rt)

315. Q27101942

316. 47a605f0-4187-47a8-b0ce-f9e7da1b0076

317. L-ascorbic Acid, P.a., Acs Reagent, Reag. Iso, 99.7%

318. Ascorbic Acid, British Pharmacopoeia (bp) Reference Standard

319. Ascorbic Acid, European Pharmacopoeia (ep) Reference Standard

320. L-ascorbic Acid, Certified Reference Material, Tracecert(r)

321. L-ascorbic Acid, Powder, Cell Culture Tested, Gamma-irradiated

322. 3,4-dihydroxy-5beta-[(s)-1,2-dihydroxyethyl]furan-2(5h)-one

323. Ascorbic Acid, United States Pharmacopeia (usp) Reference Standard

324. (2r)-2-[(1s)-1,2-dihydroxyethyl]-4,5-dihydroxy-2,3-dihydrofuran-3-one

325. 4-((e)-2-[(2-hydroxyethyl)sulfanyl]diazenyl)benzenecarboxylicacid

326. (5r)-5-[(1s)-1,2-dihydroxyethyl]-3,4-dihydroxyfuran-2(5h)-one (non-preferred Name)

327. L-ascorbic Acid Solution, 1.0 Mg/ml In Acetonitrile: Water, Certified Reference Material

328. L-ascorbic Acid, Anhydrous, Free-flowing, Redi-dri(tm), Acs Reagent, >=99%

329. L-ascorbic Acid, Suitable For Cell Culture, Suitable For Plant Cell Culture, >=98%

330. L-ascorbic Acid (vitamin C)-13c6 Solution, 500 Mug/ml In Acetonitrile: Water, Certified Reference Material, Ampule Of 1 Ml

331. L-ascorbic Acid, Puriss. P.a., Acs Reagent, Reag. Iso, Reag. Ph. Eur., 99.7-100.5% (oxidimetric)

332. Valeryl Fentanyl Hydrochloride Solution, 100 Mug/ml In Methanol (as A Free Base), Certified Reference Material, Ampule Of 0.5 Ml

2.4 Create Date

2011-12-26

3 Chemical and Physical Properties

Molecular Formula	C₆H₈O₆
Molecular Weight	176.12 g/mol
XLogP3	-1.6
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	2
Exact Mass	176.03208797 g/mol
Monoisotopic Mass	176.03208797 g/mol
Topological Polar Surface Area	107 Å²
Heavy Atom Count	12
Formal Charge	0
Complexity	232
Isotope Atom Count	0
Defined Atom Stereocenter Count	2
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

4 Drug and Medication Information

4.1 Therapeutic Uses

Antioxidants; Free Radical Scavengers

National Library of Medicine's Medical Subject Headings online file (MeSH, 1999)

Prophylaxis and treatment of scurvy

Gilman, A. G., L. S. Goodman, and A. Gilman. (eds.). Goodman and Gilman's The Pharmacological Basis of Therapeutics. 6th ed. New York: Macmillan Publishing Co., Inc. 1980., p. 1579

Ascorbic acid 100 to 200 mg daily may be given with desferrioxamine in the treatment of patients with thalassemia, to improve the chelating action of desferrioxamine, thereby increasing the excretion of iron.

Sweetman SC (ed), Martindale: The Complete Drug Reference. London: Pharmaceutical Press (2009), p.1985.

In iron deficiency states ascorbic acid may increase gastrointestinal iron absorption and ascorbic acid or ascorbate salts are therefore included in some oral iron preparations.

Sweetman SC (ed), Martindale: The Complete Drug Reference. London: Pharmaceutical Press (2009), p.1985.

For more Therapeutic Uses (Complete) data for L-Ascorbic Acid (30 total), please visit the HSDB record page.

4.2 Drug Warning

Large doses are reported to cause diarrhea and other gastrointestinal disturbances. It has also been stated that large doses may result in hyperoxaluria and the formation of renal calcium oxalate calculi, and ascorbic acid should therefore be given with care to patients with hyperoxaluria. Tolerance may be induced with prolonged use of large doses, resulting in symptoms of deficiency when intake is reduced to normal. Prolonged or excessive use of chewable vitamin C preparations may cause erosion of tooth enamel.

Sweetman SC (ed), Martindale: The Complete Drug Reference. London: Pharmaceutical Press (2009), p.1984.

Large doses of ascorbic acid have resulted in hemolysis in patients with G6PD deficiency.

Sweetman SC (ed), Martindale: The Complete Drug Reference. London: Pharmaceutical Press (2009), p.1984.

Vitamin C intakes of 250 mg/day or higher have been associated with false-negative results for detecting stool and gastric occult blood. Therefore, high dose vitamin C supplements should be discontinued at least two weeks before physical exams to avoid interference with blood and urine tests.

Otten JJ, Hellwig JP, Meyers LD, eds; Dietary Reference Intakes: The Essential Guide to Nutrient Requirements, Washington, DC: The National Academies Press, 2006, p.208

Supplemental vitamin C may reduce the effectiveness of cancer chemotherapy, and its effectiveness in reducing risk from cancer and related death is unclear.

PDR Network, LLC. PDR for Nonprescription Drugs, Dietary Supplements, and Herbs. 31st Ed. PDR Network, LLC, Montvale, NJ. 2010 p. 603

For more Drug Warnings (Complete) data for L-Ascorbic Acid (25 total), please visit the HSDB record page.

4.3 Minimum/Potential Fatal Human Dose

1(?) = Practically non-toxic: probable oral lethal dose (human) above 15 g/kg, more than 1 qt for 70 kg person (150 lb). Human poisonings are unknown and even reliable estimates of lethal dose in animals are rare.

Gosselin, R.E., R.P. Smith, H.C. Hodge. Clinical Toxicology of Commercial Products. 5th ed. Baltimore: Williams and Wilkins, 1984., p. II-266

4.4 Drug Indication

Used to treat vitamin C deficiency, scurvy, delayed wound and bone healing, urine acidification, and in general as an antioxidant. It has also been suggested to be an effective antiviral agent.

5 Pharmacology and Biochemistry

5.1 Pharmacology

Ascorbic Acid (vitamin C) is a water-soluble vitamin indicated for the prevention and treatment of scurvy, as ascorbic acid deficiency results in scurvy. Collagenous structures are primarily affected, and lesions develop in bones and blood vessels. Administration of ascorbic acid completely reverses the symptoms of ascorbic acid deficiency.

5.2 MeSH Pharmacological Classification

Antioxidants

Naturally occurring or synthetic substances that inhibit or retard oxidation reactions. They counteract the damaging effects of oxidation in animal tissues. (See all compounds classified as Antioxidants.)

Vitamins

Organic substances that are required in small amounts for maintenance and growth, but which cannot be manufactured by the human body. (See all compounds classified as Vitamins.)

5.3 FDA Pharmacological Classification

5.3.1 Active Moiety

ASCORBIC ACID

5.3.2 FDA UNII

PQ6CK8PD0R

5.3.3 Pharmacological Classes

Vitamin C [EPC]; Ascorbic Acid [CS]

5.4 ATC Code

A - Alimentary tract and metabolism

A11 - Vitamins

A11G - Ascorbic acid (vitamin c), incl. combinations

A11GA - Ascorbic acid (vitamin c), plain

A11GA01 - Ascorbic acid (vit C)

B - Blood and blood forming organs

B03 - Antianemic preparations

B03A - Iron preparations

B03AA - Iron bivalent, oral preparations

B03AA10 - Ferrous ascorbate

G - Genito urinary system and sex hormones

G01 - Gynecological antiinfectives and antiseptics

G01A - Antiinfectives and antiseptics, excl. combinations with corticosteroids

G01AD - Organic acids

G01AD03 - Ascorbic acid

S - Sensory organs

S01 - Ophthalmologicals

S01X - Other ophthalmologicals

S01XA - Other ophthalmologicals

S01XA15 - Ascorbic acid

5.5 Absorption, Distribution and Excretion

Absorption

70% to 90%

Ascorbic acid is readily absorbed from the gastrointestinal tract and is widely distributed in the body tissues. Plasma concentrations of ascorbic acid rise as the dose ingested is increased until a plateau is reached with doses of about 90 to 150 mg daily. Body stores of ascorbic acid in health are about 1.5 g although more may be stored at intakes above 200 mg daily. The concentration is higher in leucocytes and platelets than in erythrocytes and plasma. In deficiency states the concentration in leucocytes declines later and at a slower rate, and has been considered to be a better criterion for the evaluation of deficiency than the concentration in plasma.

Sweetman SC (ed), Martindale: The Complete Drug Reference. London: Pharmaceutical Press (2009), p.1984.

Ascorbic acid is reversibly oxidized to dehydroascorbic acid; some is metabolized to ascorbate-2-sulfate, which is inactive, and oxalic acid which are excreted in the urine. Ascorbic acid in excess of the body's needs is also rapidly eliminated unchanged in the urine; this generally occurs with intakes exceeding 100 mg daily.

Sweetman SC (ed), Martindale: The Complete Drug Reference. London: Pharmaceutical Press (2009), p.1984.

Ascorbic acid crosses the placenta and is distributed into breast milk. It is removed by hemodialysis.

Sweetman SC (ed), Martindale: The Complete Drug Reference. London: Pharmaceutical Press (2009), p.1984.

The renal threshold for ascorbic acid is approx 14 ug/mL, but this level varies among individuals. When the body is saturated with ascorbic acid and blood concentrations exceed the threshold, unchanged ascorbic acid is excreted in the urine. When tissue saturation and blood concentrations of ascorbic acid are low, administration of the vitamin results in little or no urinary excretion of ascorbic acid. Inactive metabolites of ascorbic acid such as ascorbic acid-2-sulfate and oxalic acid are excreted in the urine ... Ascorbic acid is also excreted in the bile but there is no evidence for enterohepatic circulation ...

IPCS; Poisons Information Monograph 046: Ascorbic acid (2006). Available from, as of March 9, 2010: https://www.inchem.org/pages/pims.html

For more Absorption, Distribution and Excretion (Complete) data for L-Ascorbic Acid (29 total), please visit the HSDB record page.

5.6 Metabolism/Metabolites

Hepatic. Ascorbic acid is reversibly oxidised (by removal of the hydrogen from the enediol group of ascorbic acid) to dehydroascorbic acid. The two forms found in body fluids are physiologically active. Some ascorbic acid is metabolized to inactive compounds including ascorbic acid-2-sulfate and oxalic acid.

Ascorbic acid-2-sulfate has ... been identified as metabolite of Vitamin C in human urine.

Gilman, A.G., T.W. Rall, A.S. Nies and P. Taylor (eds.). Goodman and Gilman's The Pharmacological Basis of Therapeutics. 8th ed. New York, NY. Pergamon Press, 1990., p. 1548

Ascorbate is oxidized to CO2 in rats and guinea pigs, but considerably less conversion can be detected in man. One route of metabolism of the vitamin in man involves its conversion to oxalate and eventual excretion in the urine; dehydroascorbate is presumably an intermediate.

Gilman, A.G., T.W. Rall, A.S. Nies and P. Taylor (eds.). Goodman and Gilman's The Pharmacological Basis of Therapeutics. 8th ed. New York, NY. Pergamon Press, 1990., p. 1548

... Young male guinea pigs /were fed/ diets containing either 2 g/kg (18 control animals) or 86 g/kg (29 treatment animals) of ascorbic acid for 275 days. The average weight gain was significantly higher in the control group. Eight control and eight treatment animals, chosen to maintain comparable weights between the groups, were then given a totally deficient ascorbic acid diet 24 hr before a metabolic study was initiated. In the metabolic study, (14)C-labeled L-ascorbic acid (628 g) was then injected intraperitoneally into both treatment and control guinea pigs to study the catabolism and excretion of the ascorbic acid. Catabolism of the labeled ascorbic acid to respiratory (14)CO2 was increased in treatment guinea pigs. The control and treatment animals were then divided into two groups. One group received 3 mg/kg ascorbic acid (chronic deficiency) for 68 days. The other received a diet devoid of ascorbic acid (acute deficiency) for 44 days. Four control and three treatment animals from the chronic deficiency group and three control and four treatment animals from the acute deficiency group were given a totally deficient ascorbic acid diet 24 hr before a second metabolic study was initiated. (14)C-labeled L-ascorbic acid (628 g) was injected intraperitoneally as above. Treatment animals in the chronic deficiency and the acute deficiency groups had increased catabolism of the labeled ascorbic acid to respiratory (14)CO2 compared to control animals in the chronic and acute deficiency groups. The amount of radioactivity recovered in the urine and feces was similar for both groups except for an increased urinary excretion of the label in treated animals exposed to the totally deficient diet. The treatment animals maintained higher tissue stores of ascorbic acid than the control animals. However, this difference was significant only in the testes. When subjected to a totally deficient diet the treatment animals were depleted of ascorbic acid at a faster rate than the control animals. The accelerated catabolism was not reversible by subnormal intakes of the vitamin ...

Cosmetic Ingredient Review Expert Panel; Int J Toxicol 24 (Suppl 2): 51-111 (2005).

... Hartley guinea pigs approximately 30 days pregnant /were divided/ into a control group receiving 25 mg ascorbic acid and a treated group receiving 300 mg/kg/day ascorbic acid daily. All animals were fed a 0.05% ascorbic acid diet. The groups were maintained for 10 days on their respective diets. Pups (both sexes) were randomly chosen on either day 5 or day 10 for the metabolic study. L-l-(14)C-Ascorbic Acid (10 uCi/mM) was injected intraperitoneally into the pups and they were placed in a metabolic chamber for five hours to collect expired (14)CO2. From day 11 all pups were caged individually and weaned to a diet containing only traces of ascorbic acid. Every third day the animals were examined for physical signs of scurvy. Once signs appeared, the animals were examined daily until death. Necropsies were performed on all animals. Pups from the treated group demonstrated a marked increase in (14)CO2 excretion following the intraperitoneal injection. Signs of scurvy appeared 4 days earlier in the treated group and mortality of the treated pups occurred approximately one week earlier. When excretion of labeled CO2 in both groups was correlated with the day of onset of scurvy signs, a linear correlation was found between the two parameters, suggesting that the earlier appearance of signs of scurvy on the experimental pups is secondary to an increased rate of ascorbic acid catabolism ...

Cosmetic Ingredient Review Expert Panel; Int J Toxicol 24 (Suppl 2): 51-111 (2005).

For more Metabolism/Metabolites (Complete) data for L-Ascorbic Acid (10 total), please visit the HSDB record page.

Ascorbic acid has known human metabolites that include Ascorbic acid-2-sulfate.

S73 | METXBIODB | Metabolite Reaction Database from BioTransformer | DOI:10.5281/zenodo.4056560

5.7 Biological Half-Life

16 days (3.4 hours in people who have excess levels of vitamin C)

The plasma half-life is reported to be 16 days in humans. This is different in people who have excess levels of vitamin C where the half-life is 3.4 hours

IPCS; Poisons Information Monograph 046: Ascorbic acid (2006). Available from, as of March 9, 2010: https://www.inchem.org/pages/pims.html

Vitamin C has a 96 hr half-life in guinea pigs.

Rossoff, I.S. Handbook of Veterinary Drugs. New York: Springer Publishing Company, 1974., p. 651

Due to homeostatic regulation, the biological half-life of ascorbate varies widely from 8 to 40 days and is inversely related to the ascorbate body pool.

NAS, Food and Nutrition Board, Institute of Medicine; Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids. National Academy Press, Washington, D.C., pg. 100, 2000. Available from, as of March 4, 2010: https://www.nap.edu/catalog/9810.html

5.8 Mechanism of Action

In humans, an exogenous source of ascorbic acid is required for collagen formation and tissue repair by acting as a cofactor in the posttranslational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins. Ascorbic acid is reversibly oxidized to dehydroascorbic acid in the body. These two forms of the vitamin are believed to be important in oxidation-reduction reactions. The vitamin is involved in tyrosine metabolism, conversion of folic acid to folinic acid, carbohydrate metabolism, synthesis of lipids and proteins, iron metabolism, resistance to infections, and cellular respiration.

Ascorbic Acid reducing potential and conversion to AFR (ascorbate free radical) are key to its biological activity, including its free radical scavenging and its relationship to the oxidation of transition metals such as iron and copper at enzyme active sites and in food.

Cosmetic Ingredient Review Expert Panel; Int J Toxicol 24 (Suppl 2): 51-111 (2005).

Vitamin C is known to be an electron donor for eight human enzymes. Three participate in collagen hydroxylation; two in carnitine biosynthesis; and three in hormone and amino acid biosynthesis. The three enzymes that participate in hormone and amino acid biosynthesis are dopamine-beta-hydroxylase, necessary for the biosynthesis of the catecholamines norepinephrine and epinephrine; peptidyl-glycine monooxygenase, necessary for amidation of peptide hormones; and 4-hydroxyphenylpyruvatedioxygenase, involved in tyrosine metabolism. Ascorbate's action with these enzymes involves either monooxygenase or dioxygenase activities.

NAS, Food and Nutrition Board, Institute of Medicine; Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids. National Academy Press, Washington, D.C., pg. 96-97, 2000. Available from, as of March 4, 2010: https://www.nap.edu/catalog/9810.html

As a cofactor for hydroxylase and oxygenase metalloenzymes, ascorbic acid is believed to work by reducing the active metal site, resulting in reactivation of the metal-enzyme complex, or by acting as a co-substrate involved in the reduction of molecular oxygen. The best known of these reactions is the posttranslational hydroxylation of peptide-bound proline and lysine residues during formation of mature collagen. In these reactions, ascorbate is believed to reactivate the enzymes by reducing the metal sites of prolyl (iron) and lysyl (copper) hydroxylases.

NAS, Food and Nutrition Board, Institute of Medicine; Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids. National Academy Press, Washington, D.C., pg. 97-98, 2000. Available from, as of March 4, 2010: https://www.nap.edu/catalog/9810.html

Evidence also suggests that ascorbate plays a role in or influences collagen gene expression, cellular procollagen secretion, and the biosynthesis of other connective tissue components besides collagen, including elastin, fibronectin, proteoglycans, bone matrix, and elastin-associated fibrillin. The primary physical symptoms of ascorbic acid's clinical deficiency disease, scurvy, which involves deterioration of elastic tissue, illustrate the important role of ascorbate in connective tissue synthesis.

NAS, Food and Nutrition Board, Institute of Medicine; Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids. National Academy Press, Washington, D.C., pg. 98, 2000. Available from, as of March 4, 2010: https://www.nap.edu/catalog/9810.html

For more Mechanism of Action (Complete) data for L-Ascorbic Acid (11 total), please visit the HSDB record page.

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A6, VEERA"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1721154600,"product":"VITAMIN C(ASCORBIC ACID)(25KG\/BAG)(LOT NO:815110624D772)","address":"NO.21\/10A, 1ST FLOOR,JYOTHI","city":"KANAKAPURA ROAD, BANGALORE","supplier":"BEIJING JINKANGPU FOOD SCIENCE & TECHNOLOGY CO LTD","supplierCountry":"CHINA","foreign_port":"BEIJING","customer":"PRARAS BIO - SCIENCES PRIVATE LIMITED","customerCountry":"INDIA","quantity":"100.00","actualQuantity":"100","unit":"KGS","unitRateFc":"9","totalValueFC":"910.2","currency":"USD","unitRateINR":"755.8","date":"17-Jul-2024","totalValueINR":"75582.75","totalValueInUsd":"910.2","indian_port":"Bangalore Air","hs_no":"29362700","bill_no":"4548382","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"BEIJING","supplierAddress":"ROOM NO 410,BLOCK 1,NO.8HANGFENG ROAD,FENGTAI SCIENCE CITYFENGTAI CHINA","customerAddress":"NO.21\/10A, 1ST FLOOR,JYOTHI"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1721413800,"product":"3-O-ETHYL-L-ASCORBIC ACID CAS: (86404-04-8)","address":"403-404, B WING, DELPHI,,HIRANANDA","city":"MUMBAI,MAHARASHTRA","supplier":"NANJING HABO MEDICAL TECHNOLOGY CO.,LTD","supplierCountry":"CHINA","foreign_port":"BEIJING","customer":"THERMO FISHER SCIENTIFIC","customerCountry":"INDIA","quantity":"50.20","actualQuantity":"50.2","unit":"KGS","unitRateFc":"77.5","totalValueFC":"3961.1","currency":"USD","unitRateINR":"6552.6","date":"20-Jul-2024","totalValueINR":"328941.78","totalValueInUsd":"3961.1","indian_port":"Hyderabad Air","hs_no":"29322090","bill_no":"4607250","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"BEIJING","supplierAddress":"NO.9,WEIDI ROAD,XIANLIN UNIVERSITY,QIXIA DISTRICT,NANJING,JIANGSU, CHINA CHINA","customerAddress":"403-404, B WING, DELPHI,,HIRANANDA"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1721845800,"product":"SODIUM ASCORBATE IP","address":"218\/219, 2ND FLOOR,KAILASH PLAZA,","city":"GHATKOPAR EAST,MUMBAI, MAHARASTHRA","supplier":"BRILLIANT PHARMACEUTICAL LIMITED","supplierCountry":"CHINA","foreign_port":"SHANGHAI","customer":"AQUATIC REMEDIES PVT LTD","customerCountry":"INDIA","quantity":"5000.00","actualQuantity":"5000","unit":"KGS","unitRateFc":"4.5","totalValueFC":"23121.1","currency":"USD","unitRateINR":"384","date":"25-Jul-2024","totalValueINR":"1920041.08","totalValueInUsd":"23121.1","indian_port":"JNPT","hs_no":"29362990","bill_no":"4685018","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"SHANGHAI","supplierAddress":"OFFICE F, 32\/F, PLAZA 88 NO, 88 YEUNG UK ROAD TSUEN WAN, NT HONG KONGTSUEN, , HONG KONG HONG KONG","customerAddress":"218\/219, 2ND FLOOR,KAILASH PLAZA,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1722364200,"product":"ASCORBIC ACID PH- (MEDICAL USE) UNITED KINGDOM","address":"401 4TH FL WINDSOR HOUSE CST RD","city":"MUMBAI, MAHARASHTRA.","supplier":"ROYAL DSM","supplierCountry":"UNITED KINGDOM","foreign_port":"AMSTERDAM, SCHIPHOL","customer":"ROYAL DSM","customerCountry":"INDIA","quantity":"75.00","actualQuantity":"75","unit":"KGS","unitRateFc":"1269.2","totalValueFC":"1146.3","currency":"INR","unitRateINR":"1269.2","date":"31-Jul-2024","totalValueINR":"95187.75","totalValueInUsd":"1146.3","indian_port":"Bombay Air","hs_no":"29362700","bill_no":"4800118","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED KINGDOM","selfForZScoreResived":"Pharma Grade","supplierPort":"AMSTERDAM, SCHIPHOL","supplierAddress":"30 PASIR PANJANG ROAD #13-31, MAPLETREE BUSINESS CITY, Singapore - 117440, , Singapore Singapore","customerAddress":"401 4TH FL WINDSOR HOUSE CST RD"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1722450600,"product":"ASCORBIC ACID API CSPC_EP (CEP) CRYST (FOR R&D PURPOS ONLY)","address":"34TH KM TUMKUR ROAD,TEPPADA BEGUR","city":"BANGALORE,KARNATAKA","supplier":"HELM PORTUGAL","supplierCountry":"CHINA","foreign_port":"LISBON","customer":"RECIPHARM AB","customerCountry":"INDIA","quantity":"275.00","actualQuantity":"275","unit":"KGS","unitRateFc":"24.5","totalValueFC":"7521","currency":"EUR","unitRateINR":"2271.2","date":"01-Aug-2024","totalValueINR":"624566.25","totalValueInUsd":"7521","indian_port":"Bangalore Air","hs_no":"29362990","bill_no":"4820428","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"LISBON","supplierAddress":"AV. VITOR FIGUEIREDO N4. 1 2790-255CARNAXIDE Portugal, , PortugalSDNF Portugal","customerAddress":"34TH KM TUMKUR ROAD,TEPPADA BEGUR"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1722537000,"product":"MASTER:7485 (VITAMIN C\/PLEXUSPHARMACO), PRODUCTION LOT: 9675(VITAMIN C\/PLEXUSPHARMA) (LIPOSOMAL FLUID FOOD SUPPLEMENT)(","address":"RJD-1,18 MAHAVIR ENCLAVE,CHARPHOOL ,SINGH MARKET,PALM DASRI ROAD","city":"DELHI,DELHI","supplier":"PLANTACORP GMBH","supplierCountry":"GERMANY","foreign_port":"HAMBURG - FUHLSBUETT","customer":"PARVATI GRAMODYOG HARBAL PRODUCTS","customerCountry":"INDIA","quantity":"15.00","actualQuantity":"15","unit":"LTR","unitRateFc":"3.3","totalValueFC":"66.6","currency":"EUR","unitRateINR":"368.7","date":"02-Aug-2024","totalValueINR":"5531.02","totalValueInUsd":"66.6","indian_port":"Delhi Air","hs_no":"29369000","bill_no":"4834642","productDescription":"API","marketType":"REGULATED MARKET","country":"GERMANY","selfForZScoreResived":"Pharma Grade","supplierPort":"HAMBURG - FUHLSBUETT","supplierAddress":"Fangdieckstr. 66 22547 HamburgSDNFSDNF Germany","customerAddress":"RJD-1,18 MAHAVIR ENCLAVE,CHARPHOOL ,SINGH MARKET,PALM DASRI ROAD"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1722882600,"product":"ASCORBIC ACID IP","address":"42,MAHANT ROAD,3,VILE PARLE","city":"MUMBAI,MAHARASHTRA","supplier":"SINOBRIGHT PHARMACEUTICAL COMPANY LTD","supplierCountry":"CHINA","foreign_port":"SHENZHEN","customer":"PRATISTHA PHARMA","customerCountry":"INDIA","quantity":"6000.00","actualQuantity":"6000","unit":"KGS","unitRateFc":"3.3","totalValueFC":"20454.6","currency":"USD","unitRateINR":"283.1","date":"06-Aug-2024","totalValueINR":"1698603.48","totalValueInUsd":"20454.6","indian_port":"JNPT","hs_no":"29362700","bill_no":"4900813","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"SHENZHEN","supplierAddress":"OFFICE F,32\/F,PLAZA 88 NO.88 YEUNGUK ROAD,TSUEN WAN,NT,HONG KONG,CHINA ., , CHINA CHINA","customerAddress":"42,MAHANT ROAD,3,VILE PARLE"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1723401000,"product":"VITAMIN C COATED ( ASCORBIC ACID COATED) (97)","address":"NO.10-1\/A HOODI VILLAGE","city":"BANGALORE","supplier":"HENAN WEIHE BIOLOGICAL ENGINEERING CO.LTD","supplierCountry":"CHINA","foreign_port":"SHANGHAI","customer":"BIOPLUS LIFE SCIENCES","customerCountry":"INDIA","quantity":"1000.00","actualQuantity":"1000","unit":"KGS","unitRateFc":"4.9","totalValueFC":"4941","currency":"USD","unitRateINR":"410.3","date":"12-Aug-2024","totalValueINR":"410310","totalValueInUsd":"4941","indian_port":"Madras Sea","hs_no":"29362700","bill_no":"5012803","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"SHANGHAI","supplierAddress":"GEENLAND HUBIN INTERNATIONAL CITYSOUTH UNIVERSITY ROAD,ZHENGZHOU,HENAN,CHINA CHINA","customerAddress":"NO.10-1\/A HOODI VILLAGE"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1724005800,"product":"ASCORBIC ACID IP","address":"42,MAHANT ROAD,3,VILE PARLE","city":"MUMBAI,MAHARASHTRA","supplier":"SINOBRIGHT PHARMACEUTICAL COMPANY LTD","supplierCountry":"CHINA","foreign_port":"SHENZHEN","customer":"PRATISTHA PHARMA","customerCountry":"INDIA","quantity":"6000.00","actualQuantity":"6000","unit":"KGS","unitRateFc":"3.3","totalValueFC":"20329","currency":"USD","unitRateINR":"281.4","date":"19-Aug-2024","totalValueINR":"1688172.04","totalValueInUsd":"20329","indian_port":"JNPT","hs_no":"29362700","bill_no":"5134815","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"SHENZHEN","supplierAddress":"S LIMITED OFFICE F, 32\/F , PLAZA 88NO.88 YEUNG UK ROAD, TSUEN WAN, NT,HONG KONG, CHINA","customerAddress":"42,MAHANT ROAD,3,VILE PARLE"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1724437800,"product":"VITAMIN C COATED","address":"NO.10-1\/A HOODI VILLAGE","city":"BANGALORE","supplier":"HANGZHOU STARSHINE PHARMACEUTICAL ","supplierCountry":"CHINA","foreign_port":"SHANGHAI","customer":"BIOPLUS LIFE SCIENCES","customerCountry":"INDIA","quantity":"5000.00","actualQuantity":"5000","unit":"KGS","unitRateFc":"4.6","totalValueFC":"23602.7","currency":"USD","unitRateINR":"392","date":"24-Aug-2024","totalValueINR":"1960035","totalValueInUsd":"23602.7","indian_port":"Madras Sea","hs_no":"29362700","bill_no":"5233053","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"SHANGHAI","supplierAddress":"ROOM 1005,BUILDING8,DONGYE CANAL FORTUNE CENTER,NO 99 SHENHUA RD,GONGSHU,HANGZHOU CHINA","customerAddress":"NO.10-1\/A HOODI VILLAGE"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1724869800,"product":"ASCORBIC ACID IP","address":"606 6TH FL ARUN CHAMBERS","city":"TARDEO MUMBAI ,MAHARASHTRA","supplier":"BRILLIANT PHARMACEUTICAL LIMITED.","supplierCountry":"CHINA","foreign_port":"SHENZHEN","customer":"DILIPKUMAR & CO.","customerCountry":"INDIA","quantity":"40000.00","actualQuantity":"40000","unit":"KGS","unitRateFc":"3.3","totalValueFC":"137031.8","currency":"USD","unitRateINR":"284.5","date":"29-Aug-2024","totalValueINR":"11379489.59","totalValueInUsd":"137031.8","indian_port":"JNPT","hs_no":"29362700","bill_no":"5307629","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"SHENZHEN","supplierAddress":"OFFICE F,32\/F,PLAZA 88 NO.88 YEUNGUK ROAD. TSUEN WAN, NT,HONG KONG,CHINA China","customerAddress":"606 6TH FL ARUN CHAMBERS"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1724956200,"product":"PROMACARE EAA (ETHYL ASCORBIC ACID) (RAW MATERIAL FOR COSMETIC USE)","address":"509,SHAH NIHAR (WORLI) INDL.ESTAT","city":"WORLI, MUMBAI, MAHARASHTRA.","supplier":"DEUTSCHE TECH LIMITED","supplierCountry":"CHINA","foreign_port":"SHANGHAI - PU DONG","customer":"VALUETREE INGREDIENTS PRIVATE LIMITED","customerCountry":"INDIA","quantity":"275.00","actualQuantity":"275","unit":"KGS","unitRateFc":"75","totalValueFC":"21921.6","currency":"USD","unitRateINR":"6619.8","date":"30-Aug-2024","totalValueINR":"1820431.99","totalValueInUsd":"21921.6","indian_port":"Bombay Air","hs_no":"29224990","bill_no":"5324625","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"SHANGHAI - PU DONG","supplierAddress":"9-405,231 GREENLAND AVENUE,HUAQIAO,KUNSHAN,SUZHOU,JIANGSU 215332SDNF CHINA","customerAddress":"509,SHAH NIHAR (WORLI) INDL.ESTAT"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1725042600,"product":"PROMACARE EAA (ETHYL ASCORBIC ACID) (RAW MATERIAL FOR COSMETIC USE)","address":"509,SHAH NIHAR (WORLI) INDL.ESTAT","city":"WORLI, MUMBAI, MAHARASHTRA.","supplier":"DEUTSCHE TECH LIMITED","supplierCountry":"CHINA","foreign_port":"SHANGHAI","customer":"VALUETREE INGREDIENTS PRIVATE LIMITED","customerCountry":"INDIA","quantity":"400.00","actualQuantity":"400","unit":"KGS","unitRateFc":"75","totalValueFC":"30696.7","currency":"USD","unitRateINR":"6372.8","date":"31-Aug-2024","totalValueINR":"2549134.88","totalValueInUsd":"30696.7","indian_port":"JNPT","hs_no":"29224990","bill_no":"5359486","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"SHANGHAI","supplierAddress":"9-405,231 GREENLAND AVENUE,HUAQIAO,KUNSHAN,SUZHOU,JIANGSU 215332SDNF CHINA","customerAddress":"509,SHAH NIHAR (WORLI) INDL.ESTAT"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1725042600,"product":"ASCORBIC ACID IP.","address":"48, CHANDRA GUPTA ESTATE,","city":"MUMBAI, MAHARASHTRA.","supplier":"BRILLIANT PHARMACEUTICAL LIMITED.","supplierCountry":"CHINA","foreign_port":"SHEKOU","customer":"GORANG INTERNATIONAL","customerCountry":"INDIA","quantity":"32058.38","actualQuantity":"32058.38","unit":"KGS","unitRateFc":"3.4","totalValueFC":"111370.7","currency":"USD","unitRateINR":"288.5","date":"31-Aug-2024","totalValueINR":"9248522.05","totalValueInUsd":"111370.7","indian_port":"JNPT","hs_no":"29362700","bill_no":"5343926","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"SHEKOU","supplierAddress":"OFFICE F, 32\/F, PLAZA 88 NO.88 YEUNG UK ROAD, TSUEN WAN NT, HONG KONGCHINA ., ., China China","customerAddress":"48, CHANDRA GUPTA ESTATE,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1725042600,"product":"ASCORBIC ACID IP","address":"42,MAHANT ROAD,3,VILE PARLE","city":"MUMBAI,MAHARASHTRA","supplier":"SINOBRIGHT PHARMACEUTICAL COMPANY LTD","supplierCountry":"CHINA","foreign_port":"SHENZHEN","customer":"PRATISTHA PHARMA","customerCountry":"INDIA","quantity":"7000.00","actualQuantity":"7000","unit":"KGS","unitRateFc":"3.3","totalValueFC":"23684.3","currency":"USD","unitRateINR":"281","date":"31-Aug-2024","totalValueINR":"1966810.78","totalValueInUsd":"23684.3","indian_port":"JNPT","hs_no":"29362700","bill_no":"5357753","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"SHENZHEN","supplierAddress":"OFFICE F,32\/F,PLAZA 88 NO.88 YEUNGUK ROAD,TSUEN WAN,NT,HONG KONG,CHINA ., , CHINA CHINA","customerAddress":"42,MAHANT ROAD,3,VILE PARLE"}]

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Total Quantity (KGS)

Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

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Importing Country	Total Quantity (KGS)	Average Price (USD/KGS)	Number of Transactions

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DOSAGE - FOR SOLUTION;INTRAVENOUS - 80MG/VIAL...DOSAGE - FOR SOLUTION;INTRAVENOUS - 80MG/VIAL;0.02MG/VIAL;0.001MG/VIAL;5MG/VIAL;0.01MG/VIAL;0.14MG/VIAL;17MG/VIAL;0.2MG/VIAL;1MG/VIAL;1.4MG/VIAL;EQ 1.2MG BASE/VIAL;0.7MG/VIAL;7MG/VIAL

USFDA APPLICATION NUMBER - 18920

DOSAGE - SOLUTION;INTRAVENOUS - 25,000MG/50ML...DOSAGE - SOLUTION;INTRAVENOUS - 25,000MG/50ML (500MG/ML)

USFDA APPLICATION NUMBER - 209112

DOSAGE - SOLUTION;INTRAVENOUS - 2 IU/ML;40MG/...DOSAGE - SOLUTION;INTRAVENOUS - 2 IU/ML;40MG/ML;12MCG/ML;40 IU/ML;1MCG/ML;3MG/ML;120MCG/ML;8MG/ML;1.2MG/ML;0.72MG/ML;1.2MG/ML;660 IU/ML;0.03MG/ML

USFDA APPLICATION NUMBER - 21163

DOSAGE - SOLUTION;INTRAVENOUS - 2 IU/ML;40MG/...DOSAGE - SOLUTION;INTRAVENOUS - 2 IU/ML;40MG/ML;12MCG/ML;40 IU/ML;1MCG/ML;3MG/ML;120MCG/ML;8MG/ML;1.2MG/ML;0.72MG/ML;1.2MG/ML;660 IU/ML;30MCG/ML

USFDA APPLICATION NUMBER - 21163

DOSAGE - INJECTABLE;INTRAVENOUS - 200MG/VIAL;...DOSAGE - INJECTABLE;INTRAVENOUS - 200MG/VIAL;0.06MG/VIAL;0.005MG/VIAL;15MG/VIAL;0.005MG/VIAL;0.6MG/VIAL;40MG/VIAL;6MG/VIAL;3.6MG/VIAL;6MG/VIAL;1MG/VIAL;10MG/VIAL;0.15MG/VIAL

USFDA APPLICATION NUMBER - 21625

DOSAGE - INJECTABLE;INJECTION - 20MG/ML;0.006...DOSAGE - INJECTABLE;INJECTION - 20MG/ML;0.006MG/ML;0.05MCG/ML;1.5MG/ML;0.0005MG/ML;0.06MG/ML;4MG/ML;0.6MG/ML;0.36MG/ML;0.6MG/ML;0.1MG/ML;1MG/ML

USFDA APPLICATION NUMBER - 8809

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List of Suppliers' Topical Excipients Application used in Prestwick3_000325 on PharmaCompass.com

Prestwick3_000325

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ACTIVE PHARMA INGREDIENTS

55 API Suppliers

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8 CEP/COS

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5 EU WC

6 KDMF

6 NDC API

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65 South Africa

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DRUG PRODUCT COMPOSITIONS

FOR SOLUTION;INTRAVENOUS - 80MG/VIAL;0.02MG/VIAL;0.001MG/VIAL;5MG/VIAL;0.01MG/VIAL;0.14MG/VIAL;17MG/VIAL;0.2MG/VIAL;1MG/VIAL;1.4MG/VIAL;EQ 1.2MG BASE/VIAL;0.7MG/VIAL;7MG/VIAL

SOLUTION;INTRAVENOUS - 25,000MG/50ML (500MG/ML)

SOLUTION;INTRAVENOUS - 2 IU/ML;40MG/ML;12MCG/ML;40 IU/ML;1MCG/ML;3MG/ML;120MCG/ML;8MG/ML;1.2MG/ML;0.72MG/ML;1.2MG/ML;660 IU/ML;0.03MG/ML

SOLUTION;INTRAVENOUS - 2 IU/ML;40MG/ML;12MCG/ML;40 IU/ML;1MCG/ML;3MG/ML;120MCG/ML;8MG/ML;1.2MG/ML;0.72MG/ML;1.2MG/ML;660 IU/ML;30MCG/ML

INJECTABLE;INTRAVENOUS - 200MG/VIAL;0.06MG/VIAL;0.005MG/VIAL;15MG/VIAL;0.005MG/VIAL;0.6MG/VIAL;40MG/VIAL;6MG/VIAL;3.6MG/VIAL;6MG/VIAL;1MG/VIAL;10MG/VIAL;0.15MG/VIAL

INJECTABLE;INJECTION - 20MG/ML;0.006MG/ML;0.05MCG/ML;1.5MG/ML;0.0005MG/ML;0.06MG/ML;4MG/ML;0.6MG/ML;0.36MG/ML;0.6MG/ML;0.1MG/ML;1MG/ML

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2 Seqens

26 DKSH

2 Jai Radhe Sales

2 Pharm-RX Chemical

8 Boai NKY Pharmaceuticals Ltd

14 Gangwal Healthcare

2 Kewpie Corporation

12 Nanjing Well Pharmaceutical

2 Pfanstiehl

4 ACG Worldwide

16 Actylis

2 Aeon Procare

1 Alcedo Pharmachem

9 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd

1 Avesta Pharma

36 BASF

2 Bioplus Life Sciences

2 Clariant

13 Corel Pharma Chem

5 DFE Pharma

3 Doshion Polyscience

2 Finar

13 Gangwal Chemicals

7 Ideal Cures Pvt Ltd

4 Ingredion Pharma Solutions

34 Kerry

5 Kima Chemical

6 Lonza Capsugel

22 Microlex e.U

1 Nanjing Bold Chemical

2 Nomisma Healthcare

4 Novo Excipients

3 Pharmatrans-Sanaq

13 Pluviaendo

3 Prachin Chemical

1 Qianhao Chemical (Hebei) Co., Ltd

2 Qualicaps

39 Roquette

16 Seppic

8 Shanghai Shenmei Pharmaceutical Technology Co., Ltd

1 Shanghai Welltone Material Technology Co., Ltd

3 Shijiazhuang Huaxu Pharmaceutical

11 Sigachi Industries

4 The Dow Chemical Company