List of Related Excipient Companies and Suppliers of NCGC00024902-01 on PharmaCompass.com

PharmaCompass

Synopsis

Synopsis

ACTIVE PHARMA INGREDIENTS

0

API Suppliers

API Suppliers

0

USDMF

US DMFs Filed

0

CEP/COS

CEP/COS Certifications

0

JDMF

JDMFs Filed

0

EU WC

EU WC

0

KDMF

KDMF

0

NDC API

NDC API

0

VMF

NDC API

0

Listed Suppliers

Other Suppliers

API REF. PRICE (USD/KG)

MARKET PLACE

0

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

0

FDF Dossiers

FDF Dossiers

0

FDA Orange Book

FDA (Orange Book)

0

Europe

Europe

0

Canada

Canada

0

Australia

Australia

0

South Africa

South Africa

0

Listed Dossiers

Listed Dossiers

0 DRUGS IN DEVELOPMENT

FDF Dossiers

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

0

EDQM

0

USP

0

JP

0

Others

PATENTS & EXCLUSIVITIES

0

US Patents

0

US Exclusivities

0

Health Canada Patents

DIGITAL CONTENT

0

Data Compilation #PharmaFlow

0

Stock Recap #PipelineProspector

0

Weekly News Recap #Phispers

0

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid

NA

Annual Reports

NA

Finished Drug Prices

NA

4 RELATED EXCIPIENT COMPANIES

7EXCIPIENTS BY APPLICATIONS

Chemistry

Click the arrow to open the dropdown
read-moreClick the button for full data set
Also known as: 71-44-3, Musculamine, Neuridine, Gerontine, Spermin, 4,9-diaza-1,12-dodecanediamine
Molecular Formula
C10H26N4
Molecular Weight
202.34  g/mol
InChI Key
PFNFFQXMRSDOHW-UHFFFAOYSA-N
FDA UNII
2FZ7Y3VOQX

Spermine
A biogenic polyamine formed from spermidine. It is found in a wide variety of organisms and tissues and is an essential growth factor in some bacteria. It is found as a polycation at all pH values. Spermine is associated with nucleic acids, particularly in viruses, and is thought to stabilize the helical structure.
1 2D Structure

Spermine

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
N,N'-bis(3-aminopropyl)butane-1,4-diamine
2.1.2 InChI
InChI=1S/C10H26N4/c11-5-3-9-13-7-1-2-8-14-10-4-6-12/h13-14H,1-12H2
2.1.3 InChI Key
PFNFFQXMRSDOHW-UHFFFAOYSA-N
2.1.4 Canonical SMILES
C(CCNCCCN)CNCCCN
2.2 Other Identifiers
2.2.1 UNII
2FZ7Y3VOQX
2.3 Synonyms
2.3.1 Depositor-Supplied Synonyms

1. 71-44-3

2. Musculamine

3. Neuridine

4. Gerontine

5. Spermin

6. 4,9-diaza-1,12-dodecanediamine

7. N,n'-bis(3-aminopropyl)-1,4-butanediamine

8. Diaminopropyltetramethylenediamine

9. Spermine, Puriss

10. 1,4-butanediamine, N,n'-bis(3-aminopropyl)-

11. 4,9-diazadodecamethylenediamine

12. N,n'-bis(3-aminopropyl)butane-1,4-diamine

13. 1,4-bis(aminopropyl)butanediamine

14. Gerotine

15. 4,9-diazadodecane-1,12-diamine

16. 68956-56-9

17. Polyspermine

18. Nsc 268508

19. 1,4-bis(aminopropyl) Butanediamine

20. N1,n1'-(butane-1,4-diyl)bis(propane-1,3-diamine)

21. Spermine Free Base

22. Actilip Sp-91

23. 1,4-diaminobutane, N,n'-bis(3-aminopropyl)-

24. Brn 1750791

25. Ai3-26633

26. 1,5,10,14-tetraazatetradecane

27. 2fz7y3voqx

28. Nsc-268508

29. Nsc 268508; Neuridine

30. Chembl23194

31. Hydrocarbons, Terpene Processing By-products

32. 71052-31-8

33. Chebi:15746

34. N1,n4-bis(3-aminopropyl)-1,4-butanediamine

35. Nsc268508

36. 71-44-3 (free Base)

37. Spermidine 3hcl

38. 1,4-butanediamine, N1,n4-bis(3-aminopropyl)-

39. Spm

40. (3-aminopropyl)({4-[(3-aminopropyl)amino]butyl})amine

41. 1,4-butanediamine, N1,n4-bis(3-aminopropyl)-, Homopolymer

42. Spermina

43. Mls002472980

44. Diaminopropyl-tetramethylenediamine

45. Spermina [italian]

46. Smr001397086

47. Einecs 200-754-2

48. Unii-2fz7y3voqx

49. Mfcd00008215

50. Spermine Puriss

51. N,n'-bis(3-aminopropyl)-1,4-diaminobutane

52. Terpene Hydrocarbons, By Product

53. Einecs 273-309-3

54. 4,12-diamine

55. Spermine, >=97%

56. Tocris-0958

57. Gerotine [inci]

58. Spermine [mi]

59. Lopac-s-2876

60. Biomol-nt_000213

61. Bmse000117

62. Ec 273-309-3

63. Ncimech_000206

64. Spermine, Min. 98.0%

65. Lopac0_001077

66. Schembl14965

67. Wln: Z3m4m3z

68. Gtpl710

69. Spermine, Analytical Standard

70. 4-04-00-01301 (beilstein Handbook Reference)

71. Bpbio1_001086

72. Sperminetetrahydrochloride

73. Dtxsid9058781

74. Bdbm79403

75. Cid_5351186

76. 1, N,n'-bis(3-aminopropyl)-

77. Spermine, >=99.0% (gc)

78. Hy-b1777

79. Zinc1532734

80. Ccg-35276

81. Hsci1_000212

82. S3948

83. Akos024258603

84. Db00127

85. Sb38410

86. Sdccgsbi-0051047.p003

87. N1,n4-bis(3-aminopropyl)-butanediamine

88. Ncgc00015941-01

89. Ncgc00015941-02

90. Ncgc00015941-03

91. Ncgc00015941-04

92. Ncgc00015941-05

93. Ncgc00015941-10

94. Ncgc00024902-01

95. Ncgc00024902-02

96. Ncgc00024902-03

97. As-35114

98. Bp-21388

99. Nci60_035280

100. Db-055526

101. Cs-0013806

102. Ft-0625219

103. Ft-0631308

104. N,na?bis(3-aminopropyl)-1,4-diaminobutane

105. Spermine, Vetec(tm) Reagent Grade, >=97%

106. N,n''-bis(3-aminopropyl)butane-1,4-diamine

107. C00750

108. S-7400

109. Z-1049

110. 956s569

111. A866441

112. L001114

113. N1,n1'-(butane-1,4-diyl)dipropane-1,3-diamine

114. Q424597

115. N,n'-bis(3-aminopropyl)-1,4-tetramethylenediamine

116. N1,n1-(butane-1,4-diyl)bis(propane-1,3-diamine)

117. N1,n1'-(butane-1,4-diyl);bis(propane-1,3-diamine);

118. 2b445aed-6284-43e4-82fe-39598858d67f

119. 3-aminopropyl-[4-(3-aminopropylamino)butyl]amine;hydrochloride

120. N,n''''-bis(3-aminopropyl)butane-1,4-diamine;hydrochloride

121. N,n''''-bis(3-azanylpropyl)butane-1,4-diamine;hydrochloride

122. Spermine, Bioreagent, Amorphous Semi-solid, Suitable For Cell Culture

2.4 Create Date
2004-09-16
3 Chemical and Physical Properties
Molecular Weight 202.34 g/mol
Molecular Formula C10H26N4
XLogP3-1.1
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count4
Rotatable Bond Count11
Exact Mass202.21574685 g/mol
Monoisotopic Mass202.21574685 g/mol
Topological Polar Surface Area76.1 Ų
Heavy Atom Count14
Formal Charge0
Complexity86.1
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Indication

For nutritional supplementation, also for treating dietary shortage or imbalance


5 Pharmacology and Biochemistry
5.1 Pharmacology

Spermine is a polyamine. It is an organic molecule that is involved in cellular metabolism.


5.2 Mechanism of Action

Spermine is derived from spermidine by spermine synthase. Spermine is a polyamine, a small organic cations that is absolutely required for eukaryotic cell growth. Spermine, is normally found in millimolar concentrations in the nucleus. Spermine functions directly as a free radical scavenger, and forms a variety of adducts that prevent oxidative damage to DNA. Oxidative damage to DNA by reactive oxygen species is a continual problem that cells must guard against to survive. Hence, spermine is a major natural intracellular compound capable of protecting DNA from free radical attack. Spermine is also implicated in the regulation of gene expression, the stabilization of chromatin, and the prevention of endonuclease-mediated DNA fragmentation.


Related Excipient Companies

Upload your portfolio for free, ask us

Excipients by Applications

Click here to find the perfect excipient manufacturers by their capabilities

Parenteral

read-more
read-more

Film Formers & Plasticizers

read-more
read-more

Coating Systems & Additives

read-more
read-more

Topical

read-more
read-more

Controlled & Modified Release

read-more
read-more

Market Place

Do you need sourcing support? Ask us

ABOUT THIS PAGE

Ask Us for Pharmaceutical Supplier and Partner
Ask Us, Find A Supplier / Partner
No Commissions, No Strings Attached, Get Connected for FREE

What are you looking for?

How can we help you?

The request can't be empty

Please read our Privacy Policy carefully

You must agree to the privacy policy

The name can't be empty
The company can't be empty.
The email can't be empty Please enter a valid email.
The mobile can't be empty