List of Related Excipient Companies and Suppliers of NCGC00024357-07 by Roquette Corporate on PharmaCompass.com

NCGC00024357-07

Alchem Hyoscine Scopolamine Hydrobromide

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Phytex Scopolamine Hydrobromide

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xyz-pharma-m-2024-09-09

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Transo Pharm Handels GmbH

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Veranova: A CDMO that manages complexity with confidence.

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xyz-pharma-m-2024-09-09

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ACTIVE PHARMA INGREDIENTS

13 API Suppliers, 6 USDMF, 3 CEP/COS, 2 JDMF, 4 EU WC, 4 NDC API, 7 Listed Suppliers, $ API Reference Price

13 API Suppliers
6 USDMF
3 CEP/COS
2 JDMF
4 EU WC
4 NDC API
7 Listed Suppliers
$ API Reference Price

DEVELOPMENTS

5 Drugs in Development

5 Drugs in Development

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6 FDF Dossiers, 2 Europe, 2 Canada, 2 South Africa

6 FDF Dossiers
2 Europe
2 Canada
2 South Africa

RELATED EXCIPIENT COMPANIES

2 Rochem International Inc, 6 SPI Pharma, 4 DKSH, 11 Gangwal Healthcare, 2 Nanjing Well Pharmaceutical, 1 Pfanstiehl, 4 Actylis, 4 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd, 3 BASF, 3 Corel Pharma Chem, 5 DFE Pharma, 6 Gangwal Chemicals, 1 Ideal Cures Pvt Ltd, 2 Ingredion Pharma Solutions, 26 Kerry, 14 Microlex e.U, 1 Pharmatrans-Sanaq, 4 Pluviaendo, 2 Prachin Chemical, 24 Roquette, 1 Seppic, 4 Shanghai Shenmei Pharmaceutical Technology Co., Ltd, 1 Shijiazhuang Huaxu Pharmaceutical, 9 Sigachi Industries, 3 Vasa Pharmachem, 1 Zhejiang Huakang Pharmaceutical

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62 Fillers, Diluents & Binders, 28 Direct Compression, 18 Lubricants & Glidants, 16 Coating Systems & Additives, 15 Co-Processed Excipients, 15 Thickeners and Stabilizers, 13 Taste Masking, 12 Film Formers & Plasticizers, 11 Granulation, 9 Disintegrants & Superdisintegrants, 7 Parenteral, 7 Controlled & Modified Release, 7 Chewable & Orodispersible Aids, 3 Emulsifying Agents, 2 Topical, 2 Coloring Agents, 1 API Stability Enhancers, 1 Soft Gelatin, 1 Rheology Modifiers

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2 Finished Drug Prices

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2 EDQM , 1 USP , 11 JP , 2 Others

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2 Others

Scopolamine Hydrobromide

Synopsis

ACTIVE PHARMA INGREDIENTS

13

API Suppliers

6

USDMF

3

CEP/COS

CEP/COS Certifications

2

JDMF

4

EU WC

0

KDMF

4

NDC API

0

VMF

7

Listed Suppliers

API REF. PRICE (USD/KG)

$

$ 7,355

MARKET PLACE

5

API

0

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

6

FDF Dossiers

0

FDA Orange Book

FDA (Orange Book)

2

Europe

2

Canada

0

Australia

2

South Africa

0

Listed Dossiers

5DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

2

EDQM

1

USP

11

JP

2

Others

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Finished Drug Prices

144 RELATED EXCIPIENT COMPANIES

230EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: 114-49-8, Scopolamine hbr, Hyoscine hydrobromide, Scopos, (-)-scopolamine hydrobromide, Scopolamine (hydrobromide)

Molecular Formula

C₁₇H₂₂BrNO₄

Molecular Weight

384.3 g/mol

InChI Key

WTGQALLALWYDJH-WYHSTMEOSA-N

FDA UNII

R3K67DRL3J

Scopolamine Hydrobromide

An alkaloid from SOLANACEAE, especially DATURA and SCOPOLIA. Scopolamine and its quaternary derivatives act as antimuscarinics like ATROPINE, but may have more central nervous system effects. Its many uses include an anesthetic premedication, the treatment of URINARY INCONTINENCE and MOTION SICKNESS, an antispasmodic, and a mydriatic and cycloplegic.

1 2D Structure

Scopolamine Hydrobromide

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

[(1R,2R,4S,5S)-9-methyl-3-oxa-9-azatricyclo[3.3.1.02,4]nonan-7-yl] (2S)-3-hydroxy-2-phenylpropanoate;hydrobromide

2.1.2 InChI

InChI=1S/C17H21NO4.BrH/c1-18-13-7-11(8-14(18)16-15(13)22-16)21-17(20)12(9-19)10-5-3-2-4-6-10;/h2-6,11-16,19H,7-9H2,1H3;1H/t11?,12-,13-,14+,15-,16+;/m1./s1

2.1.3 InChI Key

WTGQALLALWYDJH-WYHSTMEOSA-N

2.1.4 Canonical SMILES

CN1C2CC(CC1C3C2O3)OC(=O)C(CO)C4=CC=CC=C4.Br

2.1.5 Isomeric SMILES

CN1[C@@H]2CC(C[C@H]1[C@H]3[C@@H]2O3)OC(=O)[C@H](CO)C4=CC=CC=C4.Br

2.2 Other Identifiers

2.2.1 UNII

R3K67DRL3J

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Boro Scopol

2. Boro-scopol

3. Hyoscine

4. Isopto Hyoscine

5. Kwells

6. Scoburen

7. Scopace

8. Scopoderm Tts

9. Scopolamine

10. Scopolamine Cooper

11. Transderm Scop

12. Transderm V

13. Transderm-v

14. Travacalm Ho

15. Vorigeno

2.3.2 Depositor-Supplied Synonyms

1. 114-49-8

2. Scopolamine Hbr

3. Hyoscine Hydrobromide

4. Scopos

5. (-)-scopolamine Hydrobromide

6. Scopolamine (hydrobromide)

7. Beldavrin

8. Scopamin

9. Tranaxine

10. Hyosol

11. Hyoscine Bromide

12. (-)-hyoscine Hydrobromide

13. Scopolaminium Bromide

14. Scopolammonium Bromide

15. Euscopol

16. Isoscopil

17. Hysco

18. Kwells

19. (-)-scopolamine Bromide

20. Scopolamine Bromide

21. Scopolamine Hydrobromide Anhydrous

22. R3k67drl3j

23. L-hyoscine Hydrobromide

24. Sereen

25. Mls000069527

26. L-scopolamine-hydrobromide

27. Chebi:61271

28. Smr000058594

29. Dsstox_cid_12029

30. Dsstox_rid_78902

31. Dsstox_gsid_32029

32. Cas-114-49-8

33. Unii-r3k67drl3j

34. Einecs 204-050-6

35. Nsc 61806

36. Nsc-61806

37. Opera_id_496

38. Ec 204-050-6

39. Hyoscine Bromide (anhydrous)

40. Schembl40627

41. Scopolamine Bromide (anhydrous)

42. Chembl3185877

43. Dtxsid0032029

44. Hy-n0296a

45. Scopolaminium Bromide (anhydrous)

46. Regid_for_cid_6603108

47. Scopolammonium Bromide (anhydrous)

48. 672-21-9

49. Scopolamine Hydrobromide (anhydrous)

50. Tox21_110035

51. Tox21_302019

52. (-)-scopolamine Bromide (anhydrous)

53. S2508

54. Scopolamine Hydrobromide [mi]

55. (-)-hyoscine Hydrobromide (anhydrous)

56. Akos015965267

57. Hyoscine Hydrobromide [who-dd]

58. Tox21_110035_1

59. Ac-3389

60. Ccg-268451

61. Cs-2000

62. 1alphah,5alphah-tropan-3-alpha-ol, 5beta,7beta-epoxy-, (-)-tropate (ester), Hydrobromide

63. Ncgc00013722-01

64. Ncgc00024357-07

65. Ncgc00255166-01

66. (-)-scopolamine Hydrobromide (anhydrous)

67. As-35324

68. N2570

69. Sw199343-2

70. 114s498

71. A935283

72. Sr-01000597758

73. Sr-01000597758-1

74. W-108599

75. Q27130957

76. (-)-scopolamine Hydrobromide;hyoscine Hydrobromide;scopine Hydrobromide

77. 1alphah,5alphah-tropan-3alpha-ol, 6beta,7beta-epoxy-, (-)-tropate (ester), Hydrobromide

78. (?,s)-?-(hydroxymethyl)benzeneacetic Acid (1?,2?,4?,5?,7?)-9-methyl-3-oxa-9-azatricyclo[3.3.1.02,4]non-7-yl Ester Hydrobromide

79. (1r,2r,4s,5s,7s)-9-methyl-3-oxa-9-azatricyclo[3.3.1.0(2,4)]non-7-yl (2s)-3-hydroxy-2-phenylpropanoate Hydrobromide

80. (1r,2r,4s,5s,7s,9s)-7-{[(2s)-3-hydroxy-2-phenylpropanoyl]oxy}-9-methyl-3-oxa-9-azoniatricyclo[3.3.1.0(2,4)]nonane Bromide

81. 1-alpha-h,5-alpha-h-tropan-3-alpha-ol, 6-beta,7-beta-epoxy-, (-)-tropate (ester), Hydrobromide

82. 6.beta.,7.beta.-epoxy-1.alpha.h,5.alpha.h-tropan-3.alpha.-ol (-)-tropate (ester) Hydrobromide

83. Benzeneacetic Acid, .alpha.-(hydroxymethyl)-, (1.alpha.,2.beta.,4.beta.,5.alpha.,7.beta.)-9-methyl-3-oxa-9-azatricyclo3.3.1.02,4non-7-yl Ester, (.alpha.s)- Hydrobromide

84. Benzeneacetic Acid, Alpha-(hydroxymethyl)-, (1alpha,2beta,4beta,5alpha,7beta)-9-methyl-3-oxa-9-azatricyclo(3.3.1.02,4)non-7-yl Ester, Hydrobromide (1:1), (alphas)-

85. Benzeneacetic Acid, Alpha-(hydroxymethyl)-, (1alpha,2beta,4beta,5alpha,7beta)-9-methyl-3-oxa-9-azatricyclo(3.3.1.02,4)non-7-yl Ester, Hydrobromide, (alphas)-

86. Benzeneacetic Acid, Alpha-(hydroxymethyl)-, 9-methyl-3-oxa-9-azatricyclo(3.3.1.02,4)non-7-yl Ester, Hydrobromide, (7(s)-(1alpha,2beta,4beta,5alpha,7beta))-

2.4 Create Date

2006-05-25

3 Chemical and Physical Properties

Molecular Formula	C₁₇H₂₂BrNO₄
Molecular Weight	384.3 g/mol
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	5
Exact Mass	383.07322 g/mol
Monoisotopic Mass	383.07322 g/mol
Topological Polar Surface Area	62.3 Å²
Heavy Atom Count	23
Formal Charge	0
Complexity	418
Isotope Atom Count	0
Defined Atom Stereocenter Count	5
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Pharmacology and Biochemistry

4.1 MeSH Pharmacological Classification

Adjuvants, Anesthesia

Agents that are administered in association with anesthetics to increase effectiveness, improve delivery, or decrease required dosage. (See all compounds classified as Adjuvants, Anesthesia.)

Antiemetics

Drugs used to prevent NAUSEA or VOMITING. (See all compounds classified as Antiemetics.)

Cholinergic Antagonists

Drugs that bind to but do not activate CHOLINERGIC RECEPTORS, thereby blocking the actions of ACETYLCHOLINE or cholinergic agonists. (See all compounds classified as Cholinergic Antagonists.)

Muscarinic Antagonists

Drugs that bind to but do not activate MUSCARINIC RECEPTORS, thereby blocking the actions of endogenous ACETYLCHOLINE or exogenous agonists. Muscarinic antagonists have widespread effects including actions on the iris and ciliary muscle of the eye, the heart and blood vessels, secretions of the respiratory tract, GI system, and salivary glands, GI motility, urinary bladder tone, and the central nervous system. (See all compounds classified as Muscarinic Antagonists.)

Mydriatics

Agents that dilate the pupil. They may be either sympathomimetics or parasympatholytics. (See all compounds classified as Mydriatics.)

API SUPPLIERS

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API Reference Price

[{"dataSource":"API Export","activeIngredients":"SCOPOLAMINE HYDROBROMIDE","year":"2021","qtr":"Q2","strtotime":1619548200,"product":"SCOPOLAMINE HYDROBROMIDE USP (SCOPOLAMIN","address":"8, BENTINCK STREET,","city":"KOLKATA, WEST BENGAL.","supplier":"ALKALOIDS CORPORATION","supplierCountry":"INDIA","foreign_port":"MILAN","customer":"TEVA PHARMACEUTICAL INDUSTRIES","customerCountry":"ITALY","quantity":"12.00","actualQuantity":"12","unit":"KGS","unitRateFc":"6000","totalValueFC":"71780.6","currency":"USD","unitRateINR":445333.33333333331,"date":"28-Apr-2021","totalValueINR":"5344000","totalValueInUsd":"71780.6","indian_port":"HYDERABAD AIR","hs_no":"29397990","bill_no":"1419685","productDescription":"API","marketType":"REGULATED MARKET","country":"ITALY","selfForZScoreResived":"Pharma Grade","supplierPort":"HYDERABAD AIR","supplierAddress":"8, BENTINCK STREET,, KOLKATA, WEST BENGAL.","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q2","strtotime":1715020200,"product":"ACTIVE PHARMACEUTICAL INGREDIENTS-OTHERORGANIC CHEMICAL COMPOUNDS:SCOPOLAMINE HYDROBROMIDE TRIHYDRATE BP, BATCH NO.HHBR","address":"SETHNA BUILDING, 4TH FLR,","city":"LINES, MUMBAI ,MAHARASHTRA","supplier":"MEGAFINE PHARMA (P) LIMITED","supplierCountry":"INDIA","foreign_port":"MONTEVIDEO -","customer":"TO THE ORDER OF","customerCountry":"URUGUAY","quantity":"0.50","actualQuantity":"0.5","unit":"KGS","unitRateFc":"7750","totalValueFC":"3648.4","currency":"USD","unitRateINR":605954,"date":"07-May-2024","totalValueINR":"302977","totalValueInUsd":"3648.4","indian_port":"Bombay Air","hs_no":"29391900","bill_no":"9699532","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"URUGAY","selfForZScoreResived":"Pharma Grade","supplierPort":"Bombay Air","supplierAddress":"SETHNA BUILDING, 4TH FLR,, LINES, MUMBAI ,MAHARASHTRA","customerAddress":""},{"dataSource":"API Import","activeIngredients":"","year":"2022","qtr":"Q1","strtotime":1642789800,"product":"SCOPOLAMINE HYDROBROMIDE TRIHYDRATE","address":"MSN HOUSE, PLOT NO. C-24,INDUSTRIAL HYDERABAD","city":"HYDERABAD","supplier":"ALKALOIDS OF AUSTRALIA","supplierCountry":"AUSTRIA","foreign_port":"#N\/A","customer":"MSN LABORATORIES","customerCountry":"INDIA","quantity":"1.00","actualQuantity":"1","unit":"KGS","unitRateFc":"1850","totalValueFC":"1870","currency":"USD","unitRateINR":"139305","date":"22-Jan-2022","totalValueINR":"139305","totalValueInUsd":"1870","indian_port":"MADRAS AIR","hs_no":"29021990","bill_no":"7184920","productDescription":"API","marketType":"REGULATED MARKET","country":"AUSTRIA","selfForZScoreResived":"Pharma Grade","supplierPort":"#N\/A","supplierAddress":"","customerAddress":"MSN HOUSE, PLOT NO. C-24,INDUSTRIAL HYDERABAD"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q2","strtotime":1682447400,"product":"SCOPOLAMINE HYDROBROMIDE (QTY:1 X 500 MG,VALUE:USD 265)(FOC)","address":"P.NO. D6 & D8, SY.NO. 234\/2,234\/3, ,235\/2 & 542\/2, IKP KNOWLEDGE PARK,","city":"TURKAPALLY-V SHAMIRPET HYDERABAD,TE","supplier":"USP","supplierCountry":"INDIA","foreign_port":"NA","customer":"UNITED STATES PHARMACOPEIA - INDIA PRIVATE LIMITED","customerCountry":"INDIA","quantity":"0.00","actualQuantity":"0.0005","unit":"KGS","unitRateFc":"530000","totalValueFC":"283.5","currency":"USD","unitRateINR":"46468340","date":"26-Apr-2023","totalValueINR":"23234.17","totalValueInUsd":"283.5","indian_port":"HYDERABAD AIR","hs_no":"29398000","bill_no":"5681755","productDescription":"Re-Import","marketType":"REGULATED MARKET","country":"INDIA","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"P.NO. D6 & D8, SY.NO. 234\/2,234\/3, ,235\/2 & 542\/2, IKP KNOWLEDGE PARK,"}]

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