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MolPort-002-052-059

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14 API Suppliers, 1 JDMF, 13 Listed Suppliers, $ API Reference Price

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2 Evonik, 14 Rochem International Inc, 20 SPI Pharma, 2 Seqens, 25 DKSH, 2 Jai Radhe Sales, 2 Pharm-RX Chemical, 8 Boai NKY Pharmaceuticals Ltd, 14 Gangwal Healthcare, 2 Kewpie Corporation, 10 Nanjing Well Pharmaceutical, 2 Pfanstiehl, 4 ACG Worldwide, 13 Actylis, 2 Aeon Procare, 1 Alcedo Pharmachem, 9 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd, 1 Avesta Pharma, 36 BASF, 1 Bioplus Life Sciences, 2 Clariant, 13 Corel Pharma Chem, 5 DFE Pharma, 3 Doshion Polyscience, 2 Finar, 13 Gangwal Chemicals, 7 Ideal Cures Pvt Ltd, 4 Ingredion Pharma Solutions, 34 Kerry, 5 Kima Chemical, 6 Lonza Capsugel, 22 Microlex e.U, 1 Nanjing Bold Chemical, 2 Nomisma Healthcare, 4 Novo Excipients, 3 Pharmatrans-Sanaq, 11 Pluviaendo, 3 Prachin Chemical, 1 Qianhao Chemical (Hebei) Co., Ltd, 2 Qualicaps, 35 Roquette, 16 Seppic, 8 Shanghai Shenmei Pharmaceutical Technology Co., Ltd, 1 Shanghai Welltone Material Technology Co., Ltd, 3 Shijiazhuang Huaxu Pharmaceutical, 11 Sigachi Industries, 4 The Dow Chemical Company, 3 Ulanqab Kema New Material, 2 Valens Pharmachem, 4 Vasa Pharmachem, 2 Zhejiang Huakang Pharmaceutical

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2 Pharm-RX Chemical
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14 Gangwal Healthcare
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4 ACG Worldwide
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36 BASF
1 Bioplus Life Sciences
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22 Microlex e.U
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3 Prachin Chemical
1 Qianhao Chemical (Hebei) Co., Ltd
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1 Shanghai Welltone Material Technology Co., Ltd
3 Shijiazhuang Huaxu Pharmaceutical
11 Sigachi Industries
4 The Dow Chemical Company
3 Ulanqab Kema New Material
2 Valens Pharmachem
4 Vasa Pharmachem
2 Zhejiang Huakang Pharmaceutical

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40 APIs, 7 FDF Dossiers, 1 EXCIPIENTS

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1 EDQM , 6 JP , 2 Others

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Synopsis

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Chemistry

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Also known as: Thiamin, Vitamin b1, Aneurin, Thiamine ion, Antiberiberi factor, Thiadoxine

Molecular Formula

C₁₂H₁₇N₄OS+

Molecular Weight

265.36 g/mol

InChI Key

JZRWCGZRTZMZEH-UHFFFAOYSA-N

FDA UNII

4ABT0J945J

3-((4-Amino-2-methyl-5-pyrimidinyl)methyl)-5-(2- hydroxyethyl)-4-methylthiazolium chloride.

1 2D Structure

Vitamin B1

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

2-[3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-1,3-thiazol-3-ium-5-yl]ethanol

2.1.2 InChI

InChI=1S/C12H17N4OS/c1-8-11(3-4-17)18-7-16(8)6-10-5-14-9(2)15-12(10)13/h5,7,17H,3-4,6H2,1-2H3,(H2,13,14,15)/q+1

2.1.3 InChI Key

JZRWCGZRTZMZEH-UHFFFAOYSA-N

2.1.4 Canonical SMILES

CC1=C(SC=[N+]1CC2=CN=C(N=C2N)C)CCO

2.2 Other Identifiers

2.2.1 UNII

4ABT0J945J

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Aneurin

2. Mononitrate, Thiamine

3. Thiamin

4. Thiamine Mononitrate

5. Vitamin B 1

6. Vitamin B1

2.3.2 Depositor-Supplied Synonyms

1. Thiamin

2. Vitamin B1

3. Aneurin

4. Thiamine Ion

5. Antiberiberi Factor

6. Thiadoxine

7. Betaxin

8. 70-16-6

9. Biamine

10. Bequin

11. Thiaminium

12. Thiamine(1+)

13. Thiamine(1+) Ion

14. 3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-5-(2-hydroxyethyl)-4-methyl-1,3-thiazol-3-ium

15. 2-[3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-1,3-thiazol-3-ium-5-yl]ethanol

16. Thiamine (vit B1)

17. 4abt0j945j

18. Chebi:18385

19. 3-(4-amino-2-methyl-pyrimidin-5-ylmethyl)-5-(2-hydroxy-ethyl)-4-methyl-thiazol-3-ium

20. Vib

21. Thd

22. 3-((4-amino-2-methylpyrimidin-5-yl)methyl)-5-(2-hydroxyethyl)-4-methylthiazol-3-ium

23. Thiazolium, 3-((4-amino-2-methyl-5-pyrimidinyl)methyl)-5-(2-hydroxyethyl)-4-methyl-

24. [3h]thiamine

25. [3h]-thiamine

26. Vitamin B 1

27. Nsc36226

28. [3h]vitamin B1

29. 1sbr

30. 3rlb

31. Thoh

32. Prestwick0_000631

33. Prestwick1_000631

34. Prestwick2_000631

35. Prestwick3_000631

36. Bmse000274

37. Timtec1_000613

38. Chembl1547

39. Thiamin; Vitamin B1

40. Unii-4abt0j945j

41. Schembl10075

42. Bspbio_000622

43. Spbio_002841

44. Bpbio1_000686

45. Gtpl4628

46. Gtpl4629

47. Schembl22129283

48. Zinc49153

49. Dtxsid50220251

50. Bdbm50373877

51. Stl301841

52. Akos000668650

53. Db00152

54. 2-[3-[(4-amino-2-methyl-pyrimidin-5-yl)methyl]-4-methyl-thiazol-3-ium-5-yl]ethanol

55. 3[(4-amino-2-methyl-5-pyrimidinyl)-methyl]-5-(2-hydroxyethyl)-4-methylthiazolium Chloride

56. Smp1_000084

57. Ncgc00017013-06

58. Ncgc00188957-01

59. Ncgc00188957-02

60. C00378

61. Q83187

62. 3-(2-methyl-4-aminopyrimidine-5-ylmethyl)-4-methylthiazolium-5-ethanol

2.4 Create Date

2004-09-16

3 Chemical and Physical Properties

Molecular Formula	C₁₂H₁₇N₄OS+
Molecular Weight	265.36 g/mol
XLogP3	1
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	4
Exact Mass	265.11230735 g/mol
Monoisotopic Mass	265.11230735 g/mol
Topological Polar Surface Area	104 Å²
Heavy Atom Count	18
Formal Charge	1
Complexity	269
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

4 Drug and Medication Information

4.1 Therapeutic Uses

Thiamine is used to prevent and to treat thiamine deficiency syndromes including beriberi, Wernicke's encephalopathy syndrome, delirium, and peripheral neuritis associated with pellagra or neuritis of pregnancy (if associated with severe vomiting).

American Society of Health System Pharmacists; AHFS Drug Information 2009. Bethesda, MD. (2009)

Although thiamine has not been shown by well-controlled trials to have any therapeutic value, the drug has been used for the management of poor appetite, ulcerative colitis, chronic diarrhea, other GI disorders, and the cerebellar syndrome. Thiamine has also been used orally as an insect repellent, but there is a lack of adequate evidence to establish the efficacy of thiamine for this use.

American Society of Health System Pharmacists; AHFS Drug Information 2009. Bethesda, MD. (2009)

Low plasma thiamine concentrations have been found in patients with type 1 and type 2 diabetes mellitus. In a small placebo-controlled study, benfotiamine /a related vitamin B1 substance/ 100 mg given four times daily by mouth significantly improved neuropathic pain in patients with diabetic polyneuropathy. /Benfotiamine/

Sweetman SC (ed), Martindale: The Complete Drug Reference. London: Pharmaceutical Press (2009), p.1976-7.

/This study assessed/ the effect of thiamine repletion on thiamine status, functional capacity, and left ventricular ejection fraction (LVEF) in patients with moderate to severe congestive heart failure (CHF) who had received furosemide in doses of 80 mg/d or more for at least 3 months. PATIENTS AND METHODS: Thirty patients were randomized to 1 week of double-blind inpatient therapy with either iv thiamine 200 mg/d or placebo (n = 15 each). All previous drugs were continued. Following discharge, all 30 patients received oral thiamine 200 mg/d as outpatients for 6 weeks. Thiamine status was determined by the erythrocyte thiamine-pyrophosphate effect (TPPE). LVEF was determined by echocardiography. RESULTS: TPPE, diuresis, and LVEF were unchanged with iv placebo. After iv thiamine, TPPE decreased (11.7% +/- 6.5% to 5.4% +/- 3.2%; P < 0.01). LVEF increased (0.28 +/- 0.11 to 0.32 +/- 0.09; P < 0.05), as did diuresis (1,731 +/- 800 mL/d to 2,389 +/- 752 mL/d; P < 0.02), and sodium excretion (84 +/- 52 mEq/d to 116 +/- 83 mEq/d, P < 0.05). In the 27 patients completing the full 7-week intervention, LVEF rose by 22% (0.27 +/- 0.10 to 0.33 +/- 0.11, P < 0.01). CONCLUSIONS: Thiamine repletion can improve left ventricular function and biochemical evidence of thiamine deficiency in some patients with moderate-to-severe CHF who are receiving longterm furosemide therapy.

PMID:7733128 Shimon I et al; Am J Med 98 (5): 485-90 (1995).

For more Therapeutic Uses (Complete) data for Vitamin B1 (11 total), please visit the HSDB record page.

4.2 Drug Warning

Serious hypersensitivity/anaphylactic reactions can occur, especially after repeated administration. Deaths have resulted from IV or IM administration of thiamine.

Novak, K.M. (ed.). Drug Facts and Comparisons2008 Edition. Wolters Kluwer Health. St. Louis, Missouri 2008., p. 18

Anaphylaxis as an adverse systemic reaction to thiamine (vitamin B1) has been described in the literature since 1938. Although its precise mechanism is still uncertain, the reaction appears to involve immediate type hypersensitivity and to be exclusively related to parenteral administration...

PMID:9846348 Morinville V et al; Schweiz Med Wochenschr 128 (44): 1743-4 (1998).

Anaphylaxis. There have been occasional reports of serious and even fatal responses to the parenteral administration of thiamin. The clinical characteristics have strongly suggested an anaphylactic reaction. Symptoms associated with thiamin-induced anaphylaxis include anxiety, pruritus, respiratory distress, nausea, abdominal pain, and shock, sometimes progressing to death.

NAS, Food and Nutrition Board, Institute of Medicine; Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline. National Academy Press, Washington, D.C., pg. 81, 1998. Available from, as of March 2, 2010: https://www.nap.edu/catalog/6015.html

Adverse reactions with thiamine are rare, but hypersensitivity reactions have occurred, mainly after parenteral doses. These reactions have ranged in severity from very mild to, very rarely, fatal anaphylactic shock ... The UK Committee on Safety of Medicines had received, between 1970 and July, 1988, 90 reports of adverse reactions associated with the use of an injection containing high doses of vitamins B and C. The most frequent reactions were anaphylaxis (41 cases, including 2 fatalities), dyspnea or bronchospasm (13 cases), and rash or flushing (22 cases); 78 of the reactions occurred during, or shortly after, intravenous injection and the other 12 after intramuscular injectdion. They recommended that parenteral treatment be used only when essential, and that, when given, facilities for treating anaphylaxis should be available. They also recommended that, when the intravenous route was used, the injection be given slowly (over 10 minutes). Various authors have noted that parenteral treatment is essential for the prophylaxis and treatment of Wernicke's encephalopathy. However, further reports of anaphylaxis to parenteral thiamine have since been described, including one with a fatal outcome.

Sweetman SC (ed), Martindale: The Complete Drug Reference. London: Pharmaceutical Press (2009), p.1976.

For more Drug Warnings (Complete) data for Vitamin B1 (15 total), please visit the HSDB record page.

4.3 Drug Indication

For the treatment of thiamine and niacin deficiency states, Korsakov's alcoholic psychosis, Wernicke-Korsakov syndrome, delirium, and peripheral neuritis.

5 Pharmacology and Biochemistry

5.1 Pharmacology

Thiamine is a vitamin with antioxidant, erythropoietic, cognition-and mood-modulatory, antiatherosclerotic, putative ergogenic, and detoxification activities. Thiamine has been found to protect against lead-induced lipid peroxidation in rat liver and kidney. Thiamine deficiency results in selective neuronal death in animal models. The neuronal death is associated with increased free radical production, suggesting that oxidative stress may play an important early role in brain damage associated with thiamine deficiency. Thiamine plays a key role in intracellular glucose metabolism and it is thought that thiamine inhibits the effect of glucose and insulin on arterial smooth muscle cell proliferation. Inhibition of endothelial cell proliferation may also promote atherosclerosis. Endothelial cells in culture have been found to have a decreased proliferative rate and delayed migration in response to hyperglycemic conditions. Thiamine has been shown to inhibit this effect of glucose on endothelial cells.

5.2 MeSH Pharmacological Classification

Vitamin B Complex

A group of water-soluble vitamins, some of which are COENZYMES. (See all compounds classified as Vitamin B Complex.)

5.3 ATC Code

A - Alimentary tract and metabolism

A11 - Vitamins

A11D - Vitamin b1, plain and in combination with vitamin b6 and b12

A11DA - Vitamin b1, plain

A11DA01 - Thiamine (vit B1)

5.4 Absorption, Distribution and Excretion

Absorption

Absorbed mainly from duodenum, by both active and passive processes

Absorption of thiamin occurs mainly in the jejunum. At low concentrations of thiamin, absorption occurs by an active transport system that involves phosphyrylation; at higher concentrations, absorption occurs by passive diffusion. Only a small percentage of a high dose of thiamin is absorbed, and elevated serum values result in active urinary excretion of the vitamin.

Otten JJ, Hellwig JP, Meyers LD, eds; Dietary Reference Intakes: The Essential Guide to Nutrient Requirements, Washington, DC: The National Academies Press, 2006, p. 281

Thiamin is transported in blood in both erythrocytes and plasma and is excreted in the urine.

Otten JJ, Hellwig JP, Meyers LD, eds; Dietary Reference Intakes: The Essential Guide to Nutrient Requirements, Washington, DC: The National Academies Press, 2006, p.281

Thiamine is absorbed from the small intestine and is phosphorylated in the intestinal mucosa.

Furia, T.E. (ed.). CRC Handbook of Food Additives. 2nd ed. Cleveland: The Chemical Rubber Co., 1972., p. 89

The B vitamins are readily absorbed from the gastrointestinal tract, except in malabsorption syndromes. Thiamine is absorbed mainly in the duodenum.

USP Convention. USPDI-Drug Information for the Health Care Professional. 14th ed. Volume I. Rockville, MD: United States Pharmacopeial Convention, Inc., 1994. (Plus Updates)., p. 2647

For more Absorption, Distribution and Excretion (Complete) data for Vitamin B1 (8 total), please visit the HSDB record page.

5.5 Metabolism/Metabolites

Hepatic

Converted in vivo to thiamine diphosphate, a coenzyme in the decarboxylation of alpha-keto acids.

O'Neil, M.J. (ed.). The Merck Index - An Encyclopedia of Chemicals, Drugs, and Biologicals. Whitehouse Station, NJ: Merck and Co., Inc., 2006., p. 1598

Compound 3-(2'-methyl-4'-amino-5'-pyrimidylmethyl)-4-methylthiazole-5-acetic acid, ie thiamine acetic acid, 2-methyl-4-amino-5-formylaminomethylpyrimidine, and 5-(2-hydroxyethyl)-4-methylthiazole have been identified as important metabolites of thiamine, vitamin B1.

The Chemical Society. Foreign Compound Metabolism in Mammals. Volume 2: A Review of the Literature Published Between 1970 and 1971. London: The Chemical Society, 1972., p. 248

Biotransformation of thiamine in mammals is generally supposed to /yield/ thiochrome, thiamine disulfide, 5-(2-hydroxyethyl)-4-methyl-thiazole, and some form corresponding to pyrimidine residue of thiamine.

The Chemical Society. Foreign Compound Metabolism in Mammals. Volume 1: A Review of the Literature Published Between 1960 and 1969. London: The Chemical Society, 1970., p. 229

Thiamine is metabolized in the liver of animals. Several urinary metabolites of thiamine have been identified in humans. Little or no unchanged thiamine is excreted in urine following administration of physiologic doses; however, following administration of larger doses, both unchanged thiamine and metabolites are excreted after tissue stores become saturated.

American Society of Health System Pharmacists; AHFS Drug Information 2009. Bethesda, MD. (2009)

5.6 Biological Half-Life

The biological half-life of the vitamin is in the range of 9-18 days.

Otten JJ, Hellwig JP, Meyers LD, eds; Dietary Reference Intakes: The Essential Guide to Nutrient Requirements, Washington, DC: The National Academies Press, 2006, p.281

With higher pharmacological levels, namely repetitive 250-mg amounts taken orally and 500 mg given intramuscularly, nearly 1 week was required for steady state plasma concentrations to be reached; a mean elimination half-life of 1.8 days was estimated.

NAS, Food and Nutrition Board, Institute of Medicine; Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline. National Academy Press, Washington, D.C., pg. 59, 1998. Available from, as of March 2, 2010: https://www.nap.edu/catalog/6015.html

Total thiamin content of the adult human has been estimated to be approximately 30 mg, and the biological half-life of the vitamin is probably in the range of 9 to 18 days.

NAS, Food and Nutrition Board, Institute of Medicine; Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline. National Academy Press, Washington, D.C., pg. 59, 1998. Available from, as of March 2, 2010: https://www.nap.edu/catalog/6015.html

5.7 Mechanism of Action

It is thought that the mechanism of action of thiamine on endothelial cells is related to a reduction in intracellular protein glycation by redirecting the glycolytic flux. Thiamine is mainly the transport form of the vitamin, while the active forms are phosphorylated thiamine derivatives. Natural derivatives of thiamine phosphate, such as thiamine monophosphate (ThMP), thiamine diphosphate (ThDP), also sometimes called thiamine pyrophosphate (TPP), thiamine triphosphate (ThTP), and thiamine triphosphate (AThTP), that act as coenzymes in addition to their each unique biological functions.

Metabolic control analysis predicts that stimulators of transketolase enzyme synthesis such as thiamin (vitamin B-1) support a high rate of nucleic acid ribose synthesis necessary for tumor cell survival, chemotherapy resistance, and proliferation. Metabolic control analysis also predicts that transketolase inhibitor drugs will have the opposite effect on tumor cells. This may have important implications in the nutrition and future treatment of patients with cancer.

PMID:10890024 Cascante M et al; Nutr Cancer 36 (2): 150-4 (2000).

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API Reference Price

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DSM","customerCountry":"INDIA","quantity":"2.00","actualQuantity":"2","unit":"KGS","unitRateFc":"975276.5","totalValueFC":"23488.6","currency":"INR","unitRateINR":"975276.5","date":"10-Aug-2024","totalValueINR":"1950553.06","totalValueInUsd":"23488.6","indian_port":"Bombay Air","hs_no":"29362610","bill_no":"4979471","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"AMSTERDAM, SCHIPHOL","supplierAddress":"30 PASIR PANJANG ROAD #13-31, MAPLETREE BUSINESS CITY, Singapore - 117440, , Singapore Singapore","customerAddress":"401 4TH FL WINDSOR HOUSE CST RD"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1723573800,"product":"THIAMINE MONONITRATE 98% FEED GRADE (VITAMIN B1) - (NOT FORHUMAN\/MEDICINAL USE,FOR USE IN ANIMAL FEED ONLY)","address":"IS.40 KHB INDUSTRIAL AREA","city":"BANGALORE ,KARNATAKA","supplier":"CARGILL INTERNATIONAL SA","supplierCountry":"CHINA","foreign_port":"SHANGHAI","customer":"PROVIMI ANIMAL NUTRITION ","customerCountry":"INDIA","quantity":"600.00","actualQuantity":"600","unit":"KGS","unitRateFc":"19","totalValueFC":"11783.9","currency":"USD","unitRateINR":"1630.9","date":"14-Aug-2024","totalValueINR":"978568.2","totalValueInUsd":"11783.9","indian_port":"Madras Sea","hs_no":"29362210","bill_no":"5063217","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"SHANGHAI","supplierAddress":"ESPLANADE DE PONT-ROUGE 4 ,CH-1212 GRAND-LANCYGENEVE CH","customerAddress":"IS.40 KHB INDUSTRIAL AREA"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1723573800,"product":"THIAMINE HYDROCHLORIDE ( VITAMIN B1 HCL ) BP \/USP\/EP","address":"21, AREX HOUSE , BOTWALA BLDG","city":"MUMBAI","supplier":"JIANGSU BROTHER VITAMINS CO; 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PU DONG APT","customer":"DEL TRADE INTERNATIONAL ","customerCountry":"INDIA","quantity":"3000.00","actualQuantity":"3000","unit":"KGS","unitRateFc":"21.5","totalValueFC":"66650.3","currency":"USD","unitRateINR":"1844.9","date":"16-Aug-2024","totalValueINR":"5534817","totalValueInUsd":"66650.3","indian_port":"Delhi PPG ICD","hs_no":"29362290","bill_no":"5085028","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"SHANGHAI PU DONG APT","supplierAddress":"OFFICE F 32\/F PLAZA 88 NO. 88 YEUNGUK ROAD TSUEN WAN NT HONG KONG CHINA HONG KONG, , CHINA CHINA","customerAddress":"BEETAL HOUSE, 99, MADANGIR"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1724265000,"product":"VITAMIN B12 IP (CYANOCOBALAMIN) VITAMIN B12 IP (CYANOCOBALAMIN)","address":"301 CEEJAY HOUSE LEVEL 3 SHIVSAGAR","city":"MUMBAI,MAHARASHTRA","supplier":"SINOBRIGHT PHARMACEUTICAL COMPANY 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,MAHARASHTRA","supplier":"BRILLIANT PHARMACEUTICAL LIMITED.","supplierCountry":"CHINA","foreign_port":"SHANGHAI","customer":"DILIPKUMAR & CO.","customerCountry":"INDIA","quantity":"2000.00","actualQuantity":"2000","unit":"KGS","unitRateFc":"32","totalValueFC":"65594.4","currency":"USD","unitRateINR":"2723.6","date":"23-Aug-2024","totalValueINR":"5447132.35","totalValueInUsd":"65594.4","indian_port":"JNPT","hs_no":"29362210","bill_no":"5213004","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"SHANGHAI","supplierAddress":"OFFICE F 32\/F, PLAZA 88,NO.88 YEUNGUK ROAD,TSUEN WAN,NT,HONG KONG,CHI China","customerAddress":"606 6TH FL ARUN CHAMBERS"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1724351400,"product":"THIAMINE MONONITRATE (VITAMIN B1 MONONITRATE ) IP","address":"606 6TH FL ARUN CHAMBERS","city":"TARDEO MUMBAI ,MAHARASHTRA","supplier":"BRILLIANT PHARMACEUTICAL LIMITED.","supplierCountry":"CHINA","foreign_port":"SHANGHAI","customer":"DILIPKUMAR & CO.","customerCountry":"INDIA","quantity":"3000.00","actualQuantity":"3000","unit":"KGS","unitRateFc":"22","totalValueFC":"67644.2","currency":"USD","unitRateINR":"1872.5","date":"23-Aug-2024","totalValueINR":"5617355.24","totalValueInUsd":"67644.2","indian_port":"JNPT","hs_no":"29362210","bill_no":"5213004","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"SHANGHAI","supplierAddress":"OFFICE F 32\/F, PLAZA 88,NO.88 YEUNGUK ROAD,TSUEN WAN,NT,HONG KONG,CHI China","customerAddress":"606 6TH FL ARUN CHAMBERS"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1724351400,"product":"THIAMINE HYDROCHLORIDE ( VITAMIN B1 HCL ) BP \/USP\/EP","address":"21, AREX HOUSE , BOTWALA BLDG","city":"MUMBAI","supplier":"JIANGSU BROTHER VITAMINS CO; LTD","supplierCountry":"CHINA","foreign_port":"SHANGHAI","customer":"BIOXERA PHARMA","customerCountry":"INDIA","quantity":"55.00","actualQuantity":"55","unit":"KGS","unitRateFc":"30.7","totalValueFC":"1725.2","currency":"USD","unitRateINR":"2604.9","date":"23-Aug-2024","totalValueINR":"143269.23","totalValueInUsd":"1725.2","indian_port":"JNPT","hs_no":"29362210","bill_no":"5199824","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"SHANGHAI","supplierAddress":"SOUTH OF WEI ER ROAD , SOUTHERN AREA OCEAN ECONOMICS DEVELOPMENT ZONEDAFENG DISTRICT , YANCHENG CITY JIA China","customerAddress":"21, AREX HOUSE , BOTWALA BLDG"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1724351400,"product":"THIAMINE HYDROCHLORIDE ( VITAMIN B1 HCL ) BP \/USP\/EP","address":"21, AREX HOUSE , BOTWALA BLDG","city":"MUMBAI","supplier":"JIANGSU BROTHER VITAMINS CO; LTD","supplierCountry":"CHINA","foreign_port":"SHANGHAI","customer":"BIOXERA PHARMA","customerCountry":"INDIA","quantity":"7945.00","actualQuantity":"7945","unit":"KGS","unitRateFc":"30.7","totalValueFC":"249219.9","currency":"USD","unitRateINR":"2604.9","date":"23-Aug-2024","totalValueINR":"20695890.78","totalValueInUsd":"249219.9","indian_port":"JNPT","hs_no":"29362210","bill_no":"5199824","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"SHANGHAI","supplierAddress":"SOUTH OF WEI ER ROAD , SOUTHERN AREA OCEAN ECONOMICS DEVELOPMENT ZONEDAFENG DISTRICT , YANCHENG CITY JIA China","customerAddress":"21, AREX HOUSE , BOTWALA BLDG"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1724351400,"product":"THIAMINE MONONITRATE (VITAMIN B1 MONONITRATE) IP","address":"2 FLR.PRESTIGE PLAZA","city":"AKOTA BARODA","supplier":"SINOBRIGHT PHARMACEUTICAL COMPANY LTD","supplierCountry":"CHINA","foreign_port":"SHANGHAI","customer":"AMI LIFESCIENCES PRIVATE LIMITED","customerCountry":"INDIA","quantity":"5000.00","actualQuantity":"5000","unit":"KGS","unitRateFc":"21.3","totalValueFC":"108971.1","currency":"USD","unitRateINR":"1809.9","date":"23-Aug-2024","totalValueINR":"9049252.5","totalValueInUsd":"108971.1","indian_port":"JNPT","hs_no":"29362210","bill_no":"5207691","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"SHANGHAI","supplierAddress":"S LIMITED OFFICE F,32\/F, PLAZA 88 NO.88 YEUNG UK ROAD, TSUEN WAN, NT,HONG KONG CHINA","customerAddress":"2 FLR.PRESTIGE PLAZA"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1724437800,"product":"VITAMIN B1 (THIAMINE MONOITRATE) (NOT FOR MEDICINAL USE) CAS- 532-43-4","address":"No 56 and 57 Ponappa Chetty Street","city":"Chennai","supplier":"A.H.A INTERNATIONAL","supplierCountry":"CHINA","foreign_port":"SHANGHAI","customer":"RAKSH BIO SCIENCE ","customerCountry":"INDIA","quantity":"5000.00","actualQuantity":"5000","unit":"KGS","unitRateFc":"21.1","totalValueFC":"107918.7","currency":"USD","unitRateINR":"1792.4","date":"24-Aug-2024","totalValueINR":"8961861.22","totalValueInUsd":"107918.7","indian_port":"Madras Sea","hs_no":"29362210","bill_no":"5231737","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Non Pharma","supplierPort":"SHANGHAI","supplierAddress":"JINAN MANSION,306 TUNXI ROAD,HEFEI,ANHUI,CHINA CHINA","customerAddress":"No 56 and 57 Ponappa Chetty Street"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1724610600,"product":"THIAMINE HYDROCHLORIDE PH 20 KG BOX ALU","address":"7\/1,CORPORATE PARK,SION-TROMBAY","city":"MUMBAI","supplier":"XXM NXXRITXXNALXXRODXXTS XXDIAXXVT.XXD","supplierCountry":"GERMANY","foreign_port":"ROTTERDAM","customer":"FLAMINGO PHARMACEUTICALS LIMITED","customerCountry":"INDIA","quantity":"500.00","actualQuantity":"500","unit":"KGS","unitRateFc":"61.6","totalValueFC":"31483.8","currency":"USD","unitRateINR":"5229","date":"26-Aug-2024","totalValueINR":"2614500","totalValueInUsd":"31483.8","indian_port":"MIDC SEZ\/Nanded","hs_no":"29362290","bill_no":"1000048","productDescription":"API","marketType":"REGULATED MARKET","country":"GERMANY","selfForZScoreResived":"Pharma Grade","supplierPort":"ROTTERDAM","supplierAddress":"N\/A","customerAddress":"7\/1,CORPORATE PARK,SION-TROMBAY"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1724783400,"product":"THIAMINE MONONITRATE (VITAMIN B1 MONONITRATE)IP.-(INV NO.SJ24N00537\/0399-1-INV DT. 09.08.2024.)","address":"48, CHANDRA GUPTA ESTATE,","city":"MUMBAI, MAHARASHTRA.","supplier":"BRILLIANT PHARMACEUTICAL LIMITED.","supplierCountry":"CHINA","foreign_port":"SHANGHAI","customer":"GORANG INTERNATIONAL","customerCountry":"INDIA","quantity":"2200.00","actualQuantity":"2200","unit":"KGS","unitRateFc":"22","totalValueFC":"49548.3","currency":"USD","unitRateINR":"1870.3","date":"28-Aug-2024","totalValueINR":"4114626.28","totalValueInUsd":"49548.3","indian_port":"JNPT","hs_no":"29362210","bill_no":"5287098","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"SHANGHAI","supplierAddress":"OFFICE F, 32\/F, PLAZA 88 NO.88 YEUNG UK ROAD, TSUEN WAN NT, HONG KONGCHINA ., ., China China","customerAddress":"48, CHANDRA GUPTA ESTATE,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1724783400,"product":"VITAMIN B12 (CYANOCOBALAMIN )IP","address":"AGARWAL B2B CENTRE, 604 KANCHPADA","city":"MUMBAI","supplier":"BRILLIANT PHARMACEUTICAL LIMITED","supplierCountry":"CHINA","foreign_port":"NANNING","customer":"SUN RISE ENTERPRISES","customerCountry":"INDIA","quantity":"50.00","actualQuantity":"50","unit":"KGS","unitRateFc":"1400","totalValueFC":"71523.5","currency":"USD","unitRateINR":"118790","date":"28-Aug-2024","totalValueINR":"5939500","totalValueInUsd":"71523.5","indian_port":"Bombay Air","hs_no":"29362610","bill_no":"5291515","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"NANNING","supplierAddress":"OFFICE F,32\/F, PLAZA 88 NO.88 YEUNGUK ROAD, TSUEN WAN, NT,HONG KONG, CN","customerAddress":"AGARWAL B2B CENTRE, 604 KANCHPADA"}]

Number of Transactions

Total Quantity (KGS)

Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

Importing Country	Total Quantity (KGS)	Average Price (USD/KGS)	Number of Transactions

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List of Suppliers' Chewable Orodispersible Aids Excipients Application used in MolPort-002-052-059 on PharmaCompass.com

MolPort-002-052-059

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CHEMISTRY

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ACTIVE PHARMA INGREDIENTS

14 API Suppliers

1 JDMF

13 Listed Suppliers

$ API Reference Price

INTERMEDIATES

1 Intermediates Suppliers

FINISHED DOSAGE FORMULATIONS

200 FDF Dossiers

4 FDA Orange Book

22 Europe

4 Australia

99 South Africa

71 Listed Dossiers

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EXCIPIENTS BY APPLICATIONS

118 Fillers, Diluents & Binders

63 Coating Systems & Additives

50 Direct Compression

49 Thickeners and Stabilizers

44 Taste Masking

44 Solubilizers

38 Controlled & Modified Release