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ACTIVE PHARMA INGREDIENTS

14 API Suppliers, 6 USDMF, 3 CEP/COS, 2 JDMF, 1 EU WC, 7 Listed Suppliers, $ API Reference Price

14 API Suppliers
6 USDMF
3 CEP/COS
2 JDMF
1 EU WC
7 Listed Suppliers
$ API Reference Price

FINISHED DOSAGE FORMULATIONS

4 FDF Dossiers, 3 FDA Orange Book, 1 Listed Dossiers

4 FDF Dossiers
3 FDA Orange Book
1 Listed Dossiers

DRUG PRODUCT COMPOSITIONS

CREAM;TOPICAL - 10%, LOTION;TOPICAL - 10%

drugProductComposition
CREAM;TOPICAL - 10%
LOTION;TOPICAL - 10%

RELATED EXCIPIENT COMPANIES

1 SPI Pharma, 1 DKSH, 1 Nanjing Well Pharmaceutical, 1 Aeon Procare, 3 BASF, 1 Corel Pharma Chem, 1 Finar, 1 Gangwal Chemicals, 5 Kerry, 2 Lubrizol Life Science Health, 1 Valens Pharmachem

relatedExcipients
1 SPI Pharma
1 DKSH
1 Nanjing Well Pharmaceutical
1 Aeon Procare
3 BASF
1 Corel Pharma Chem
1 Finar
1 Gangwal Chemicals
5 Kerry
2 Lubrizol Life Science Health
1 Valens Pharmachem

EXCIPIENTS BY APPLICATIONS

9 Topical, 5 Co-Processed Excipients, 5 Solubilizers, 3 Thickeners and Stabilizers, 2 Direct Compression, 2 Film Formers & Plasticizers, 1 Controlled & Modified Release, 1 Lubricants & Glidants, 1 Rheology Modifiers, 1 Coating Systems & Additives, 1 Emulsifying Agents, 1 API Stability Enhancers, 1 Parenteral

excipientsByApplications
9 Topical
5 Co-Processed Excipients
5 Solubilizers
3 Thickeners and Stabilizers
2 Direct Compression
2 Film Formers & Plasticizers
1 Controlled & Modified Release
1 Lubricants & Glidants
1 Rheology Modifiers
1 Coating Systems & Additives
1 Emulsifying Agents
1 API Stability Enhancers
1 Parenteral

DIGITAL CONTENT

1 NEWS #PharmaBuzz

media
1 NEWS #PharmaBuzz

GLOBAL SALES INFORMATION

1 US Medicaid Prescriptions

globalSalesInformation
1 US Medicaid Prescriptions

MARKET PLACE

16 APIs, 1 FDF Dossiers

marketPlace
16 APIs
1 FDF Dossiers

REF. STANDARDS & IMPURITIES

2 EDQM , 1 USP , 1 Others

otherSolutions
2 EDQM
1 USP
1 Others

Transopharm Crotamiton

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

$ 46

MARKET PLACE

API

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

0 DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

1,428,065

Annual Reports (USD Million)

Finished Drug Prices

18 RELATED EXCIPIENT COMPANIES

33EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: 483-63-6, N-ethyl-o-crotonotoluidide, Trans-crotamiton, Crotamitone, Eurax, Crotalgin

Molecular Formula

C₁₃H₁₇NO

Molecular Weight

203.28 g/mol

InChI Key

DNTGGZPQPQTDQF-XBXARRHUSA-N

FDA UNII

2EEH27851Y

1 2D Structure

Crotamiton

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

(E)-N-ethyl-N-(2-methylphenyl)but-2-enamide

2.1.2 InChI

InChI=1S/C13H17NO/c1-4-8-13(15)14(5-2)12-10-7-6-9-11(12)3/h4,6-10H,5H2,1-3H3/b8-4+

2.1.3 InChI Key

DNTGGZPQPQTDQF-XBXARRHUSA-N

2.1.4 Canonical SMILES

CCN(C1=CC=CC=C1C)C(=O)C=CC

2.1.5 Isomeric SMILES

CCN(C1=CC=CC=C1C)C(=O)/C=C/C

2.2 Other Identifiers

2.2.1 UNII

2EEH27851Y

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Eurax

2.3.2 Depositor-Supplied Synonyms

1. 483-63-6

2. N-ethyl-o-crotonotoluidide

3. Trans-crotamiton

4. Crotamitone

5. Eurax

6. Crotalgin

7. 124236-29-9

8. Veteusan

9. Crotamitex

10. Eurasil

11. Euraxil

12. Crotamitonum

13. Crotonyl-n-ethyl-o-toluidine

14. Crotamiton, (e)-

15. 2-butenamide, N-ethyl-n-(2-methylphenyl)-

16. (e)-n-ethyl-n-(2-methylphenyl)but-2-enamide

17. (e)-n-ethyl-n-(o-tolyl)but-2-enamide

18. O-crotonotoluidide, N-ethyl-

19. (2e)-n-ethyl-n-(2-methylphenyl)but-2-enamide

20. 2eeh27851y

21. 2-butenamide, N-ethyl-n-(2-methylphenyl)-, (e)-

22. Mfcd00026989

23. 2-butenamide, N-ethyl-n-(2-methylphenyl)-, (2e)-

24. Nsc-758951

25. Crotan

26. Caswell No. 431b

27. Bestloid

28. Crotamitonum [inn-latin]

29. Smr000059145

30. N-ethyl-n-(2-methylphenyl)but-2-enamide

31. Sr-01000759366

32. Einecs 207-596-3

33. Unii-d6s4o4xd0h

34. Epa Pesticide Chemical Code 055701

35. Chebi:31439

36. Brn 3275497

37. N-ethyl-n-(2-methylphenyl)-2-butenamide

38. Unii-2eeh27851y

39. Ai3-17732

40. N-crotonyl-n-ethyl-o-toluidine

41. (e)-crotamiton

42. Crotamiton [usp:inn:ban:jan]

43. Eurax (tn)

44. Prestwick2_000951

45. Prestwick3_000951

46. N-ethylcrotono-o-toluidide

47. N-ethyl-o-crotonotoluidine

48. G 7857

49. N-ethyl- O-crotonotoluidide

50. D6s4o4xd0h

51. Schembl32934

52. Bspbio_000942

53. Bspbio_002722

54. Crotamiton (jan/usp/inn)

55. 3-12-00-01856 (beilstein Handbook Reference)

56. Mls000759489

57. Mls001424003

58. Mls002222307

59. Mls002695895

60. N-ethyl-ortho-crotonotoluidide

61. Spectrum1505271

62. Bpbio1_001038

63. Component Of Eurax (salt/mix)

64. Chembl1200709

65. Gtpl11165

66. Zinc56427

67. N-ethyl-o-crotonotoluidide, 97%

68. Dtxsid101256463

69. Hms1570p04

70. Hms1922p21

71. Hms2051e10

72. Hms2090a10

73. Hms2093o12

74. Hms2097p04

75. Hms2234e16

76. Hms3714p04

77. Pharmakon1600-01505271

78. Bcp13315

79. Hy-b1177

80. N-ethyl-n-(o-tolyl)but-2-enamide

81. Nsc78382

82. Ccg-39402

83. Nsc-78382

84. Nsc758951

85. S1711

86. (e)-n-ethyl-n-o-tolylbut-2-enamide

87. Akos015892746

88. Cs-4730

89. Nc00107

90. Nsc 758951

91. Ncgc00094571-01

92. Ncgc00094571-02

93. Ncgc00094571-03

94. Ncgc00094571-04

95. Ncgc00094571-05

96. As-11641

97. Trans-n-ethyl-n-(o-tolyl)-2-butenamide

98. Sbi-0206763.p001

99. Ab00513973

100. E0814

101. N-ethyl-n-(2-methylphenyl)-2-butenamide #

102. D01381

103. D70888

104. (2e)-n-ethyl-n-(2-methylphenyl)-2-butenamide

105. Ab00513973-09

106. Ab00513973_10

107. 483c636

108. A827519

109. Q-200893

110. Q2439845

111. Sr-01000759366-4

112. Sr-01000759366-6

113. Brd-k13240564-001-01-8

114. Brd-k57179821-001-05-5

115. Brd-k57179821-001-08-9

116. Crotamiton, British Pharmacopoeia (bp) Reference Standard

117. Crotamiton, European Pharmacopoeia (ep) Reference Standard

118. Crotamiton, United States Pharmacopeia (usp) Reference Standard

119. N-ethyl-o-crotonotoluidide; Crotamitone; Crotalgin; Eurasil; Euraxil

2.4 Create Date

2005-03-25

3 Chemical and Physical Properties

Molecular Formula	C₁₃H₁₇NO
Molecular Weight	203.28 g/mol
XLogP3	2.8
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	1
Rotatable Bond Count	3
Exact Mass	203.131014166 g/mol
Monoisotopic Mass	203.131014166 g/mol
Topological Polar Surface Area	20.3 Å²
Heavy Atom Count	15
Formal Charge	0
Complexity	235
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	1
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

4 Drug and Medication Information

4.1 Drug Information

1 of 4
Drug Name	Crotan
PubMed Health	Crotamiton (On the skin)
Drug Classes	Scabicide
Drug Label	Eurax (crotamiton USP) is a scabicidal and antipruritic agent available as a cream or lotion for topical use only. Eurax provides 10% (w/w) of the synthetic, crotamiton USP, in a vanishing-cream or emollient-lotion base containing: carbomer-934, cety...
Active Ingredient	Crotamiton
Dosage Form	Lotion
Route	Topical
Strength	10%
Market Status	Prescription
Company	Summers

2 of 4
Drug Name	Eurax
Active Ingredient	Crotamiton
Dosage Form	Lotion; Cream
Route	Topical
Strength	10%
Market Status	Prescription
Company	Ranbaxy

3 of 4
Drug Name	Crotan
PubMed Health	Crotamiton (On the skin)
Drug Classes	Scabicide
Drug Label	Eurax (crotamiton USP) is a scabicidal and antipruritic agent available as a cream or lotion for topical use only. Eurax provides 10% (w/w) of the synthetic, crotamiton USP, in a vanishing-cream or emollient-lotion base containing: carbomer-934, cety...
Active Ingredient	Crotamiton
Dosage Form	Lotion
Route	Topical
Strength	10%
Market Status	Prescription
Company	Summers

4 of 4
Drug Name	Eurax
Active Ingredient	Crotamiton
Dosage Form	Lotion; Cream
Route	Topical
Strength	10%
Market Status	Prescription
Company	Ranbaxy

5 Pharmacology and Biochemistry

5.1 MeSH Pharmacological Classification

Pesticides

Chemicals used to destroy pests of any sort. The concept includes fungicides (FUNGICIDES, INDUSTRIAL); INSECTICIDES; RODENTICIDES; etc. (See all compounds classified as Pesticides.)

API SUPPLIERS

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USDMF

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CEP/COS

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JDMF

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EU WC

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Listed Suppliers

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API Reference Price

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Number of Transactions

Total Quantity (KGS)

Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

Importing Country	Total Quantity (KGS)	Average Price (USD/KGS)	Number of Transactions

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DOSAGE - CREAM;TOPICAL - 10%

USFDA APPLICATION NUMBER - 6927

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