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Chemistry

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Also known as: (+)-pseudoephedrine, D-pseudoephedrine, Isoephedrine, Trans-ephedrine, D-isoephedrine, Psi-ephedrin
Molecular Formula
C10H15NO
Molecular Weight
165.23  g/mol
InChI Key
KWGRBVOPPLSCSI-WCBMZHEXSA-N
FDA UNII
7CUC9DDI9F

Pseudoephedrine
A phenethylamine that is an isomer of EPHEDRINE which has less central nervous system effects and usage is mainly for respiratory tract decongestion.
Pseudoephedrine is an alpha-Adrenergic Agonist. The mechanism of action of pseudoephedrine is as an Adrenergic alpha-Agonist.
1 2D Structure

Pseudoephedrine

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(1S,2S)-2-(methylamino)-1-phenylpropan-1-ol
2.1.2 InChI
InChI=1S/C10H15NO/c1-8(11-2)10(12)9-6-4-3-5-7-9/h3-8,10-12H,1-2H3/t8-,10+/m0/s1
2.1.3 InChI Key
KWGRBVOPPLSCSI-WCBMZHEXSA-N
2.1.4 Canonical SMILES
CC(C(C1=CC=CC=C1)O)NC
2.1.5 Isomeric SMILES
C[C@@H]([C@H](C1=CC=CC=C1)O)NC
2.2 Other Identifiers
2.2.1 UNII
7CUC9DDI9F
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Ephedrine Threo Isomer

2. Isoephedrine

3. Pseudoephedrine Hcl

4. Pseudoephedrine Hydrochloride

5. Sudafed

6. Threo Isomer Of Ephedrine

2.3.2 Depositor-Supplied Synonyms

1. (+)-pseudoephedrine

2. D-pseudoephedrine

3. Isoephedrine

4. Trans-ephedrine

5. D-isoephedrine

6. Psi-ephedrin

7. Sudafed

8. Psi-ephedrine

9. (+)-threo-ephedrine

10. D-psi-ephedrine

11. 90-82-4

12. L(+)-psi-ephedrine

13. L-(+)-pseudoephedrine

14. (+)-psi-ephedrine

15. Pseudoefedrina

16. Pseudoephedrinum

17. Besan

18. (+)-(1s,2s)-pseudoephedrine

19. (1s,2s)-2-(methylamino)-1-phenylpropan-1-ol

20. Pseudoephedrine D-form

21. (1s,2s)-pseudoephedrine

22. (1s,2s)-(+)-pseudoephedrine

23. Neodurasina

24. Acunaso

25. D-psi-2-methylamino-1-phenyl-1-propanol

26. Pseudoephedrine, (+)-

27. Isoephedrine, D-

28. Pseudoephedrine (inn)

29. 7cuc9ddi9f

30. Chebi:51209

31. Pseudoephedrine, L-(+)-

32. Alpha-(1-(methylamino)ethyl)benzyl Alcohol

33. Pseudoephedrine (d)

34. Benzenemethanol, Alpha-((1s)-1-(methylamino)ethyl)-, (alpha-s)-

35. Benzenemethanol, .alpha.-[(1s)-1-(methylamino)ethyl]-, (.alpha.s)-

36. Pseudoefedrina [inn-spanish]

37. Pseudoephedrinum [inn-latin]

38. (+) Threo-2-(methylamino)-1-phenyl-1-propanol

39. Pseudoephedrine [inn]

40. Pseudoephedrine [inn:ban]

41. Pseudoephedrine Ephedrine

42. Psi-ephedrine, (+)-

43. 2-(methylamino)-1-phenyl-1-propanol

44. Neodurasina (tn)

45. Acunaso (tn)

46. Pseudophedrine Sulphate

47. Hsdb 3177

48. Pseudoephedrine Polistirex

49. Einecs 202-018-6

50. Unii-7cuc9ddi9f

51. Benzenemethanol, .alpha.-((1s)-1-(methylamino)ethyl)-, (.alpha.s)-

52. (i)-ephedrin

53. Ephedrine-(racemic)

54. (+) Pseudoephedrine

55. D-pseudoephedrine Base

56. Spectrum_000878

57. Benzenemethanol, Alpha-(1-(methylamino)ethyl)-, (s-(r*,r*))-

58. Spectrum2_001303

59. Spectrum3_001771

60. Spectrum4_001162

61. Spectrum5_000650

62. Lopac-e-3250

63. (1s,2s) Pseudoephedrine

64. (1s,2s)-2-methylamino-1-phenylpropan-1-ol

65. (1s, 2s) Pseudoephedrine

66. Ec 202-018-6

67. Schembl4368

68. Chembl1590

69. Pseudoephedrine [mi]

70. (1s,2s)-2-(methylamino)-1-phenyl-propan-1-ol

71. Bspbio_003261

72. Kbiogr_001763

73. Kbioss_001358

74. Bidd:gt0817

75. Divk1c_000451

76. Pseudoephedrine [hsdb]

77. Spbio_001365

78. Pseudoephedrine [vandf]

79. Gtpl7286

80. Pseudoephedrine [mart.]

81. Benzenemethanol, .alpha.-(1-(methylamino)ethyl)-, (s-(r*,r*))-

82. Dtxsid0023537

83. Pseudoephedrine [who-dd]

84. Kbio1_000451

85. Kbio2_001358

86. Kbio2_003926

87. Kbio2_006494

88. Kbio3_002762

89. Zinc20259

90. (1s, 2s)-(+)-pseudoephedrine

91. Ninds_000451

92. Benzenemethanol, Alpha-((1s)-1-(methylamino)ethyl)-, (alphas)-

93. Pdsp1_001347

94. Akos025401512

95. Db00852

96. Idi1_000451

97. (1s,2s)-(+)-pseudoephedrine, 98%

98. Ncgc00015408-01

99. Ncgc00178180-01

100. Nci60_002955

101. Sbi-0051498.p003

102. 1-(s),2-(r)-erythro-(+)-ephedrine

103. C02765

104. D08449

105. 064p256

106. Q263958

107. Brd-k84175871-003-02-2

108. Ephedrine Hydrochloride Impurity B [ep Impurity]

109. (.alpha.s)-.alpha.-((1r)-1-(methylamino)ethyl)benzenemethanol

110. (s,s)-(+)-pseudoephedrine Solution, 1.0 Mg/ml In Methanol, Ampule Of 1 Ml, Certified Reference Material

2.4 Create Date
2005-06-24
3 Chemical and Physical Properties
Molecular Weight 165.23 g/mol
Molecular Formula C10H15NO
XLogP30.9
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count2
Rotatable Bond Count3
Exact Mass165.115364102 g/mol
Monoisotopic Mass165.115364102 g/mol
Topological Polar Surface Area32.3 Ų
Heavy Atom Count12
Formal Charge0
Complexity121
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Information
1 of 2  
Drug NameAfrinol
Active IngredientPseudoephedrine sulfate
Dosage FormTablet, extended release
RouteOral
Strength120mg
Market StatusOver the Counter
CompanySchering Plough

2 of 2  
Drug NameAfrinol
Active IngredientPseudoephedrine sulfate
Dosage FormTablet, extended release
RouteOral
Strength120mg
Market StatusOver the Counter
CompanySchering Plough

4.2 Therapeutic Uses

The Combat Methamphetamine Epidemic Act of 2005 has been incorporated into the Patriot Act signed by President Bush on March 9, 2006. The act bans over-the-counter sales of cold medicines that contain the ingredient pseudoephedrine, which is commonly used to make methamphetamine. The sale of cold medicine containing pseudoephedrine is limited to behind the counter. The amount of pseudoephedrine that an individual can purchase each month is limited and individuals are required to present photo identification to purchase products containing pseudoephedrine. In addition, stores are required to keep personal information about purchasers for at least two years.

FDA, Center for Drug Evaluation and Research (CDER); Legal Requirements for the Sale and Purchase of Drug Products Containing Pseudoephedrine, Ephedrine, and Phenylpropanolamine (May 8, 2006). Available from, as of March 12, 2007: https://www.fda.gov/cder/news/methamphetamine.htm


Pseudoephedrine is indicated for temporary relief of congestion associated with acute coryza, acute eustachian salpingitis, serous otitis media with eustachian tube congestion, vasomotor rhinitis, and aerotitis (barotitis) media. Pseudoephedrine also be indicated as an adjunct to analgesics, antihistamines, antibiotics, antitussive, or expectorants for optimum results in allergic rhinitis, croup, acute and subacute sinusitis, acute otitis medica and acute tracheobronchitis. /Included in US product labeling/

Thomson/Micromedex. Drug Information for the Health Care Professional. Volume 1, Greenwood Village, CO. 2007., p. 2452


Although pseudoephedrine has been used in the symptomatic treatment of bronchial asthma and reversible bronchospasm, the drug appear to be ineffective as a bronchodilator.

McEvoy, G.K. (ed.). American Hospital Formulary Service. AHFS Drug Information. American Society of Health-System Pharmacists, Bethesda, MD. 2007., p. 1354


/This study assessed whether/ pseudoephedrine hydrochloride is effective in decreasing the risk for earache ... in chlidren traveling by air. ... Children aged 6 months to 6 years were included in this study. Pseudoephedrine hydrochloride (1 mg/kg body weight) or placebo was administered 30 to 60 minutes prior to departure on commercial air flights. Caregivers noted historical details and the degree of apparent ear pain, drowsiness, and excitability with ascent and descent. Ninety-one flights involving 50 children were studied, with ear pain being reported in 13 (14%) of flights. Ear pain was not associated with a history of air travel-associated ear pain, recent ear infection, or recent upper airway symptoms. Pseudoephedrine use was not associated with a decrease in ear pain during either ascent (4% with pseudoephedrine vs 5% with placebo; P approximately 1.00) or descent (12% with pseudoephedrine vs. 13% with placebo; P approximately 1.00). Pseudoephedrine use was, however, linked to drowsiness at takeoff (60% with pseudoephedrine vs. 27% with placebo; P = .003) but not at landing (P = .39). Treatment was not associated with excitability at takeoff (P = .09) or landing (P approximately 1.00). Ear pain is not uncommon in children traveling by commercial aircraft. The predeparture use of pseudoephedrine does not decrease the risk for in-flight ear pain in children but is associated with drowsiness. /Pseudoephedrine Hydrochloride/

PMID:10323625 Buchanan BJ et al; Arch Pediatr Adolesc Med 153 (5): 466-8 (1999)


For more Therapeutic Uses (Complete) data for PSEUDOEPHEDRINE (6 total), please visit the HSDB record page.


4.3 Drug Warning

Maternal Medication usually Compatible with Breast-Feeding: Pseudoephedrine: Reported Sign or Symptom in Infant or Effect on Lactation: None. /from Table 6/

Report of the American Academy of Pediatrics Committee on Drugs in Pediatrics 93 (1): 141 (1994)


Pseudoephedrine may cause mild CNS stimulation, especially in patients who are hypersensitive to the effects of sympathomimetic drugs. Nervousness, excitability, restlessness, dizziness, weakness, and insomnia may occur. Headache and drowsiness also have been reported.

McEvoy, G.K. (ed.). American Hospital Formulary Service. AHFS Drug Information. American Society of Health-System Pharmacists, Bethesda, MD. 2007., p. 1355


As with other sympathomimetic drugs, pseudoephedrine should not be used for self-medication in patients with hyperthyroidism, diabetes mellitus, hypertension, ischemic heart disease, or difficulty urinating secondary to prostatic hypertrophy without consulting a clinician. The drug should be used cautiously, and may be contraindicated, in patients who are hypersensitive to the effects of other sympathomimetic drugs. Pseudoephedrine is contraindicated in patients with severe hypertension, severe coronary artery disease, angle-closure glaucoma, or urinary retention.

McEvoy, G.K. (ed.). American Hospital Formulary Service. AHFS Drug Information. American Society of Health-System Pharmacists, Bethesda, MD. 2007., p. 1355


Geriatric patients may be especially sensitive to the effects of sympathomimetic amines. Overdosage of sympathomimetic amines in patients older than 60 years of age may cause hallucinations, CNS depression, seizures, and death. Extended-release preparations containing pseudoephedrine therefore should not be administered to these patients until safety has been established by administration of a short-acting preparation.

McEvoy, G.K. (ed.). American Hospital Formulary Service. AHFS Drug Information. American Society of Health-System Pharmacists, Bethesda, MD. 2007., p. 1355


For more Drug Warnings (Complete) data for PSEUDOEPHEDRINE (22 total), please visit the HSDB record page.


4.4 Drug Indication

Pseudoephedrine is a sympathomimetic amine used for its decongestant activity.


5 Pharmacology and Biochemistry
5.1 Pharmacology

Pseudoephedrine causes vasoconstriction which leads to a decongestant effect. It has a short duration of action unless formulated as an extended release product. Patients should be counselled regarding the risk of central nervous system stimulation.


5.2 MeSH Pharmacological Classification

Nasal Decongestants

Drugs designed to treat inflammation of the nasal passages, generally the result of an infection (more often than not the common cold) or an allergy related condition, e.g., hay fever. The inflammation involves swelling of the mucous membrane that lines the nasal passages and results in inordinate mucus production. The primary class of nasal decongestants are vasoconstrictor agents. (From PharmAssist, The Family Guide to Health and Medicine, 1993) (See all compounds classified as Nasal Decongestants.)


Bronchodilator Agents

Agents that cause an increase in the expansion of a bronchus or bronchial tubes. (See all compounds classified as Bronchodilator Agents.)


5.3 FDA Pharmacological Classification
5.3.1 Active Moiety
PSEUDOEPHEDRINE
5.3.2 FDA UNII
7CUC9DDI9F
5.3.3 Pharmacological Classes
Established Pharmacologic Class [EPC] - alpha-Adrenergic Agonist
5.4 ATC Code

R01BA02

S76 | LUXPHARMA | Pharmaceuticals Marketed in Luxembourg | Pharmaceuticals marketed in Luxembourg, as published by d'Gesondheetskeess (CNS, la caisse nationale de sante, www.cns.lu), mapped by name to structures using CompTox by R. Singh et al. (in prep.). List downloaded from https://cns.public.lu/en/legislations/textes-coordonnes/liste-med-comm.html. Dataset DOI:10.5281/zenodo.4587355


R - Respiratory system

R01 - Nasal preparations

R01B - Nasal decongestants for systemic use

R01BA - Sympathomimetics

R01BA02 - Pseudoephedrine


5.5 Absorption, Distribution and Excretion

Absorption

A 240mg oral dose of pseudoephedrine reaches a Cmax of 246.310.5ng/mL fed and 272.513.4ng/mL fasted, with a Tmax of 6.601.38h fed and 11.870.72h fasted, with an AUC of 6862.0334.1ng\*h/mL fed and 7535.1333.0ng\*h/mL fasted.


Route of Elimination

55-75% of an oral dose is detected in the urine as unchanged pseudoephedrine.


Volume of Distribution

The apparent volume of distribution of pseudoephedrin is 2.6-3.3L/kg.


Clearance

A 60mg oral dose of pseudoephedrine has a clearance of 5.91.7mL/min/kg.


Elimination: Renal. About 55 to 75% of a dose is excreted unchange. The rate of excretion is accelerated in acidic urine.

Thomson/Micromedex. Drug Information for the Health Care Professional. Volume 1, Greenwood Village, CO. 2007., p. 2452


Oral capsules containing 100 mg pseudoephedrine hydrochloride and different grades of sodium alginate were prepared and studied to determine drug dissolution, the penetration of dissolution medium into the capsules, and the bioavailability of the formulations in 16 healthy subjects (ages 19-24 yr) using a randomized crossover design. At pH 1.2, there was no difference in dissolution between the formulations. At pH 7.2, release rates correlated with the viscosity grade of sodium alginate. Bioavailability tests confirmed that capsules containing high viscosity grades of alginate led to slow release, with a time to reach peak concn of 6.5 hr, and no loss of amount of drug absorbed. It was concluded that controlled release pseudoephedrine capsules can be prepared with high viscosity grades of sodium alginate. /Pseudoephedrine hydrochloride/

Veski P et al; Int J Pharm 111: 171-79 (1994)


The release of pseudoephedrine hydrochloride from beadlets coated with different levels of Eudragit S-100 and Eudragit RS was studied. In vitro dissolution studies indicated that the coating levels types of resins and types of plasticizers in the film played a major role in determining drug release rate profiles. Drug release appeared to follow first order kinetics. A coating of 2% Eudragit S-100 eliminated the formation of soft lumps which are commonly seen with Eudragit RS coated beadlets. Eudragit S-100 coating also contributed to retarding drug release in dissolution media at pH 1.2-6.5. It was concluded that pseudoephedrine release from coated beadlets depended on coating levels types of resins and types of plasticizers used. /Pseudoephedrine hydrochloride/

Li SP et al; Drug Dev Ind Pharm 17 (12): 1655-83 (1991)


Only three drugs are commonly used as oral decongestants: phenylpropanolamine (PPA), pseudoephedrine (PDE), and phenylephrine (PE). They are all chiral drugs that exist as stereoisomers. It is possible that each enantiomer can reflect significant enantioselective differences with regard to both pharmacokinetic and pharmacodynamic effects. Both PPA and PDE are readily and completely absorbed, whereas PE, with a bioavailability of only approximately 38%, is subject to gut wall metabolism and is thought to be absorbed erratically. Peak concn are reached between 0.5 and 2 hr after admin. All three drugs are extensively distributed into extravascular sites (apparent volume of distribution between 2.6 and 5.0 L/kg). No protein binding data in humans are available. Whereas PPA and PDE are not substantially metabolized, PE undergoes extensive biotransformation in the gut wall and the liver. Elimination of PPA and PDE is predominantly renal, with urinary excretion being pH dependent. Half-lives are relatively short, approximately 2.5 hr for PE, 4 hr for PPA, and 6 hr for PDE. Elimination of PPA and PDE may be rapid in children, and the agents should be used with caution in patients with renal impairment. In addition, PPA incr caffeine plasma levels and decr theophylline clearance. Reduced metabolism of PE occurs with concurrent admin of monoamine oxidase inhibitors. No direct relationship between nasal decongestant effect and plasma concentration has been established.

Kanfer I et al; 13 (6 Pt 2): 116S-28S (1993)


For more Absorption, Distribution and Excretion (Complete) data for PSEUDOEPHEDRINE (13 total), please visit the HSDB record page.


5.6 Metabolism/Metabolites

Pseudoephedrine is <1% N-demethylated to an inactive metabolite. The majority of pseudoephedrine is eliminated unmetabolized in the urine.


Pseudoephedrine is incompletely metabolized (less than 1%) in the liver by N-demethylation to an inactive metabolite. The drug and its metabolite are excreted in urine; 55-96% of a dose is excreted unchanged.

McEvoy, G.K. (ed.). American Hospital Formulary Service. AHFS Drug Information. American Society of Health-System Pharmacists, Bethesda, MD. 2007., p. 1356


D-PSEUDOEPHEDRINE YIELDS D-NORPSEUDOEPHEDRINE & L-PSEUDOEPHEDRINE YIELDS L-NORPSEUDOEPHEDRINE IN RABBIT: DANN, RE ET AL, EUR J PHARMAC, 16, 233 (1971). /FROM TABLE/

Goodwin, B.L. Handbook of Intermediary Metabolism of Aromatic Compounds. New York: Wiley, 1976., p. 43


Ephedrine (EPH), pseudoephedrine (PEPH), phenylpropanolamine (PPA), methylephedrine (MEPH) and cathine are sympathomimetic amines. ... Excretion studies of the ephedrine-related drugs have been performed to better understand the metabolic yields of ephedrines in urine. After consuming a single clinical dose of each of these drugs, urine samples from volunteers (n=3 for each drug) were subjected to tert-butyl-methyl-ether (TBME) extraction and trifluoroacetic acid (TFAA) derivatization before gas chromatography-mass spectrometry (GC-MS) analysis. Most ephedrines were excreted unchanged in urine, including EPH (40.9%), PEPH (72.2%), and PPA (59.3%). However, only a relatively small amount of MEPH (15.5%) was excreted unchanged in urine. In addition, a trace amount of PPA (1.6%) and cathine (0.7%) was found to be the metabolites of EPH and PEPH, respectively. Urinary EPH, PEPH, and PPA reached peaks at 2-6 hr and disappeared in urine at approximately 24-48 hr post-administration. ...

PMID:15885945 Tseng YL et al; Forensic Sci Int 157 (2-3): 149-55 (2006)


5.7 Biological Half-Life

The mean elimination half life of pseudoephedrine is 6.0h.


In two sequential double-blind, parallel-group, single-dose studies, 21 children received either pseudoephedrine, 30 or 60 mg, or placebo, and 20 children received either phenylpropanolamine, 20 or 37.5 mg, or placebo. Before dosing and at intervals up to 7 hours after dosing, serum pseudoephedrine or phenylpropanolamine concentrations were measured, and pulse and blood pressure were recorded. In two children receiving each drug, these tests were also performed at 12 and 24 hours, and urine was collected from 0 to 12 and from 12 to 24 hours. In children, the mean (+/-SEM) terminal elimination half-life values for pseudoephedrine, 3.1 +/- 0.5 hours, and for phenylpropanolamine, 2.6 +/- 0.6 hours, were significantly shorter than those found by other investigators in adults. Pharmacokinetics were not dose dependent in the dose ranges studied.

PMID:8917241 Simons FE et al; J Pediatr 129 (5): 729-34 (1996)


Urinary pH can affect the elimination half-life of pseudoephedrine, prolonging it when alkaline (pH 8) and reducing it when acidic (pH 5). The elimination half-life of pseudoephedrine ranges from 3-6 or 9-16 hours when urinary pH is 5 or 8, respectively, while when urinary pH is 5.8, the elimination half-life of the drug ranges from 5-8 hours. In one study in children 6-12 years of age, the elimination half-life of pseudoephedrine averaged about 3 hours when urinary pH was 6.5.

McEvoy, G.K. (ed.). American Hospital Formulary Service. AHFS Drug Information. American Society of Health-System Pharmacists, Bethesda, MD. 2007., p. 1356


5.8 Mechanism of Action

Pseudoephedrine acts mainly as an agonist of alpha adrenergic receptors and less strongly as an agonist of beta adrenergic receptors. This agonism of adrenergic receptors produces vasoconstriction which is used as a decongestant and as a treatment of priapism. Pseudoephedrine is also an inhibitor of norepinephrine, dopamine, and serotonin transporters. The sympathomimetic effects of pseudoephedrine include an increase in mean arterial pressure, heart rate, and chronotropic response of the right atria. Pseudoephedrine is also a partial agonist of the anococcygeal muscle. Pseudoephedrine also inhibits NF-kappa-B, NFAT, and AP-1.


THESE AGENTS /BRONCHODILATORS/ ACT ON BETA-2 RECEPTORS TO RELAX BRONCHIAL SMOOTH MUSCLE & PERIPHERAL VASCULATURE, APPARENTLY BY STIMULATING PRODN OF CYCLIC ADENOSINE-3.5-MONOPHOSPHATE (CAMP)...

American Medical Association, AMA Department of Drugs, AMA Drug Evaluations. 3rd ed. Littleton, Massachusetts: PSG Publishing Co., Inc., 1977., p. 627


Pseudoephedrine acts on alpha-adrenergic receptors in the mucosa of the respiratory tract, producing vasoconstriction. The medication shrinks swollen nasal mucous membranes; reduces tissue hyperemia, edema, and nasal congestion; and increases nasal airway patency. Also, drainage of sinus secretions may be increased and obstructed eustachian ostia may be opened.

Thomson/Micromedex. Drug Information for the Health Care Professional. Volume 1, Greenwood Village, CO. 2007., p. 2452


The pharmacological properties of the ephedrine derivative pseudoephedrine were investigated at the nuclear level. Following intraperitoneal injection of Sprague Dawley rats with pseudoephedrine, Fos induction was measured in various brain areas by Western blots and immunocytochemistry. Pseudoephedrine induced Fos-like immunoreactivity in the nucleus accumbens and striatum in a time and concentration-dependent manner with maximal effect at 60 mg/kg 2 hr after injection. Immunocytochemical studies confirmed that the majority of the signal was detectable in the nucleus accumbens and striatum. Pre-injection with the D1 dopamine receptor antagonist SCH23390 partially and completely blocked pseudoephedrine-induced Fos-like immunoreactivity in the striatum and nucleus accumbens, respectively, suggesting that the action of pseudoephedrine is mediated via dopamine release and results in the activation of D1 dopamine receptors. With the exception of the higher doses required, the actions of pseudoephedrine were similar to those previously described for the psychostimulant amphetamine.

PMID:10471092 Kumarnsit E et al; Neuropharmacology 38 (9): 1381-7 (1999)


API Reference Price

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01-Aug-2023
31-Aug-2024
KGS
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Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

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