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Chemistry

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Also known as: Fluphenazine dihydrochloride, 146-56-5, Prolixin, Anatensol, Permitil, Fluphenazine (dihydrochloride)
Molecular Formula
C22H28Cl2F3N3OS
Molecular Weight
510.4  g/mol
InChI Key
MBHNWCYEGXQEIT-UHFFFAOYSA-N
FDA UNII
ZOU145W1XL

Fluphenazine
A phenothiazine used in the treatment of PSYCHOSES. Its properties and uses are generally similar to those of CHLORPROMAZINE.
1 2D Structure

Fluphenazine

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
2-[4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]piperazin-1-yl]ethanol;dihydrochloride
2.1.2 InChI
InChI=1S/C22H26F3N3OS.2ClH/c23-22(24,25)17-6-7-21-19(16-17)28(18-4-1-2-5-20(18)30-21)9-3-8-26-10-12-27(13-11-26)14-15-29;;/h1-2,4-7,16,29H,3,8-15H2;2*1H
2.1.3 InChI Key
MBHNWCYEGXQEIT-UHFFFAOYSA-N
2.1.4 Canonical SMILES
C1CN(CCN1CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)C(F)(F)F)CCO.Cl.Cl
2.2 Other Identifiers
2.2.1 UNII
ZOU145W1XL
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Flufenazin

2. Fluphenazine

3. Hydrochloride, Fluphenazine

4. Lyogen

5. Prolixin

2.3.2 Depositor-Supplied Synonyms

1. Fluphenazine Dihydrochloride

2. 146-56-5

3. Prolixin

4. Anatensol

5. Permitil

6. Fluphenazine (dihydrochloride)

7. Tensofin

8. Moditen

9. Squibb 4918

10. Dapotum

11. Omca

12. Fluphenazine Hcl

13. Calmansial

14. Flufenazin

15. Lyorodin

16. Liogen

17. Fluphenazine Chloride

18. Fluphenazine Dihcl

19. Fluorophenazine Dihydrochloride

20. Zou145w1xl

21. Valamina

22. 1-(2-hydroxyethyl)-4-(3-(2-trifluoromethyl-10-phenothiazinylpropyl)piperazine Dihydrochloride

23. 1-piperazineethanol, 4-(3-(2-(trifluoromethyl)-10h-phenothiazin-10-yl)propyl)-, Dihydrochloride

24. 4-(3-(2-(trifluoromethyl)phenothiazin-10-yl)propyl)-1-piperazineethanol Dihydrochloride

25. Nsc-179197

26. Trancin

27. A 4077

28. 2-[4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]piperazin-1-yl]ethanol;dihydrochloride

29. Permitil Hydrochloride

30. 10-(3-(4-(2-hydroxyethyl)piperazinyl)propyl)-2-trifluoromethylphenothiazine Dihydrochloride

31. 1-piperazineethanol, 4-[3-[2-(trifluoromethyl)-10h-phenothiazin-10-yl]propyl]-, Dihydrochloride

32. 2-(4-(3-(2-(trifluoromethyl)-10h-phenothiazin-10-yl)propyl)piperazin-1-yl)ethanol Dihydrochloride

33. Ccris 4032

34. Nsc 62323

35. Sr-01000003048

36. Einecs 205-674-1

37. Unii-zou145w1xl

38. Nsc 179197

39. Siqualone

40. Fluphenazine 2hcl

41. Prolixin (tn)

42. 2-(4-(3-(2-(trifluoromethyl)-10h-phenothiazin-10-yl)propyl)piperazin-1-yl)ethan-1-ol Dihydrochloride

43. 2-(4-{3-[2-(trifluoromethyl)-10h-phenothiazin-10-yl]propyl}piperazin-1-yl)ethan-1-ol Dihydrochloride

44. Prestwick_225

45. Fluphenazine Hydrochloride [usp:ban:jan]

46. Schembl41634

47. Spectrum1500994

48. Chebi:5126

49. Flufenazine Hydrochloride

50. Chembl1448187

51. Dtxsid00892922

52. Hms1568p22

53. Hms1921o14

54. Bcp18079

55. Hy-a0081

56. Tox21_500555

57. S4569

58. Fluphenazine Hydrochloride (jan/usp)

59. Akos015960787

60. Ccg-212902

61. Cs-4290

62. Lp00555

63. 1-piperazineethanol, 4-(3-(2-(trifluoromethyl)phenothiazin-10-yl)propyl)-, Dihydrochloride

64. Fluphenazine Hydrochloride [jan]

65. Fluphenazine Dihydrochloride [mi]

66. Ncgc00093941-01

67. Ncgc00093941-02

68. Ncgc00093941-03

69. Ncgc00261240-01

70. Ac-12201

71. Bs-15804

72. Fluphenazine Hydrochloride [mart.]

73. Fluphenazine Hydrochloride [vandf]

74. S4569 Fluphenazine (dihydrochloride).cd

75. Fluphenazine Hydrochloride [usp-rs]

76. Fluphenazine Hydrochloride [who-dd]

77. Fluphenazine Hydrochloride [who-ip]

78. Eu-0100555

79. F1240

80. Ft-0668755

81. C72785

82. D00791

83. F 4765

84. Fluphenazine Hydrochloride [orange Book]

85. Fluphenazine Hydrochloride [usp Impurity]

86. Fluphenazine Hydrochloride [usp Monograph]

87. Fluphenazini Hydrochloridum [who-ip Latin]

88. Sr-01000003048-2

89. Sr-01000003048-9

90. W-108125

91. Fluphenazine Dihydrochloride 100 Microg/ml In Methanol

92. Q27295826

93. Z2784093501

94. Fluphenazine Dihydrochloride 1.0 Mg/ml In Methanol (as Free Base)

95. Fluphenazine Dihydrochloride, European Pharmacopoeia (ep) Reference Standard

96. Fluphenazine Hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material

97. Fluphenazine Hydrochloride, United States Pharmacopeia (usp) Reference Standard

98. 2-(4-(3-(2-(trifluoromethyl)-10h-phenothiazin-10-yl)propyl)piperazin-1-yl)ethanoldihydrochloride

99. 2-(4-{3-[2-(trifluoromethyl)-10h-phenothiazin-10-yl]propyl}-1-piperazinyl)ethanol Dihydrochloride

100. 2-[4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]piperazin-1-yl]ethanol,dihydrochloride

101. Fluphenazine Dihydrochloride Solution, 1.0 Mg/ml In Methanol (as Free Base), Ampule Of 1 Ml, Certified Reference Material

2.4 Create Date
2005-03-27
3 Chemical and Physical Properties
Molecular Weight 510.4 g/mol
Molecular Formula C22H28Cl2F3N3OS
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count8
Rotatable Bond Count6
Exact Mass509.1282236 g/mol
Monoisotopic Mass509.1282236 g/mol
Topological Polar Surface Area55.2 Ų
Heavy Atom Count32
Formal Charge0
Complexity544
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count3
4 Drug and Medication Information
4.1 Drug Information
1 of 2  
Drug NameFluphenazine hydrochloride
PubMed HealthFluphenazine Hydrochloride (By mouth)
Drug ClassesAnalgesic, Antipsychotic
Drug LabelFluphenazine hydrochloride is a trifluoromethyl phenothiazine derivative intended for the management of schizophrenia. Chemically it is 4-[3-[2-(Trifluoromethyl) phenothiazin-10-yl]propyl]-1-piperazineethanol dihydrochloride which may be represented...
Active IngredientFluphenazine hydrochloride
Dosage FormElixir; Tablet; Concentrate; Injectable
RouteInjection; Oral
Strength2.5mg; 1mg; 2.5mg/ml; 2.5mg/5ml; 5mg; 5mg/ml; 10mg
Market StatusPrescription
CompanyPharm Assoc; Sandoz; Fresenius Kabi Usa; Lannett; Mylan

2 of 2  
Drug NameFluphenazine hydrochloride
PubMed HealthFluphenazine Hydrochloride (By mouth)
Drug ClassesAnalgesic, Antipsychotic
Drug LabelFluphenazine hydrochloride is a trifluoromethyl phenothiazine derivative intended for the management of schizophrenia. Chemically it is 4-[3-[2-(Trifluoromethyl) phenothiazin-10-yl]propyl]-1-piperazineethanol dihydrochloride which may be represented...
Active IngredientFluphenazine hydrochloride
Dosage FormElixir; Tablet; Concentrate; Injectable
RouteInjection; Oral
Strength2.5mg; 1mg; 2.5mg/ml; 2.5mg/5ml; 5mg; 5mg/ml; 10mg
Market StatusPrescription
CompanyPharm Assoc; Sandoz; Fresenius Kabi Usa; Lannett; Mylan

5 Pharmacology and Biochemistry
5.1 MeSH Pharmacological Classification

Antipsychotic Agents

Agents that control agitated psychotic behavior, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect. They are used in SCHIZOPHRENIA; senile dementia; transient psychosis following surgery; or MYOCARDIAL INFARCTION; etc. These drugs are often referred to as neuroleptics alluding to the tendency to produce neurological side effects, but not all antipsychotics are likely to produce such effects. Many of these drugs may also be effective against nausea, emesis, and pruritus. (See all compounds classified as Antipsychotic Agents.)


Dopamine Antagonists

Drugs that bind to but do not activate DOPAMINE RECEPTORS, thereby blocking the actions of dopamine or exogenous agonists. Many drugs used in the treatment of psychotic disorders (ANTIPSYCHOTIC AGENTS) are dopamine antagonists, although their therapeutic effects may be due to long-term adjustments of the brain rather than to the acute effects of blocking dopamine receptors. Dopamine antagonists have been used for several other clinical purposes including as ANTIEMETICS, in the treatment of Tourette syndrome, and for hiccup. Dopamine receptor blockade is associated with NEUROLEPTIC MALIGNANT SYNDROME. (See all compounds classified as Dopamine Antagonists.)


5.2 FDA Pharmacological Classification
5.2.1 Pharmacological Classes
Phenothiazines [CS]; Phenothiazine [EPC]

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BATCH NO.: FLU-CL\/248 MFG DATE: 02\/2021 EXP\/RETEST DATE: 02\/2026","address":"ZYDUS TOWER, SARKHEJ-GANDHINAGAR","city":"AHMEDABAD\/GUJRAT","supplier":"TRIFARMA","supplierCountry":"ITALY","foreign_port":"N\/A","customer":"ZYDUS LIFESCIENCES","customerCountry":"INDIA","quantity":"25.00","actualQuantity":"25","unit":"KGS","unitRateFc":"2975","totalValueFC":"75611","currency":"USD","unitRateINR":"224315","date":"04-Aug-2021","totalValueINR":"5607875","totalValueInUsd":"75611","indian_port":"Ahmedabad-ZIPL-SEZ","hs_no":"29343000","bill_no":"1003039","productDescription":"API","marketType":"REGULATED MARKET","country":"ITALY","selfForZScoreResived":"Pharma Grade","supplierPort":"N\/A","supplierAddress":"VIA GUIDO GUARINI MATTEUCCI, 1, 201 62 MILANO, Italy","customerAddress":"ZYDUS TOWER, SARKHEJ-GANDHINAGAR"},{"dataSource":"API Import","activeIngredients":"","year":"2021","qtr":"Q4","strtotime":1633285800,"product":"FLUPHENAZINE DEC USP","address":"PLOT NO.2, MAITHRIVIHAR AMEERPET,","city":"HYDERABAD","supplier":"ASPEN API","supplierCountry":"SOUTH AFRICA","foreign_port":"NA","customer":"EUGIA PHARMA SPECIALITIES ","customerCountry":"INDIA","quantity":"1.32","actualQuantity":"1.32","unit":"KGS","unitRateFc":"65000","totalValueFC":"85213.6","currency":"USD","unitRateINR":"4836000","date":"04-Oct-2021","totalValueINR":"6383520","totalValueInUsd":"85213.6","indian_port":"HYDERABAD AIR","hs_no":"29343000","bill_no":"5699847","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"SOUTH AFRICA","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"PLOT NO.2, MAITHRIVIHAR AMEERPET,"},{"dataSource":"API Import","activeIngredients":"","year":"2022","qtr":"Q1","strtotime":1643653800,"product":"FLUPHENAZINE DEC USP","address":"OLD NO.1\/63, NEW NO.1\/58 PUDUPAKKAM","city":"","supplier":"ASPEN API","supplierCountry":"SOUTH AFRICA","foreign_port":"CAPE TOWN","customer":"PAR PHARMACEUTICAL","customerCountry":"INDIA","quantity":"8.00","actualQuantity":"8","unit":"KGS","unitRateFc":"65000","totalValueFC":"522380.2","currency":"USD","unitRateINR":"4894500","date":"01-Feb-2022","totalValueINR":"39156000","totalValueInUsd":"522380.2","indian_port":"Indore-EPZ\/SEZ","hs_no":"29343000","bill_no":"1000698","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"SOUTH AFRICA","selfForZScoreResived":"Pharma Grade","supplierPort":"CAPE TOWN","supplierAddress":"N\/A","customerAddress":"OLD NO.1\/63, NEW NO.1\/58 PUDUPAKKAM"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q2","strtotime":1680805800,"product":"PF5105 FLUPHENAZINE HYDROCHLORIDE (BATCH NO.FLU-CL\/254\/L)(MATERIAL CODE:1003246)","address":"98, GOVT.INDUSTRIAL AREA,","city":"MUMBAI.","supplier":"TRIFARMA","supplierCountry":"ITALY","foreign_port":"N\/A","customer":"AJANTA PHARMA LIMITED","customerCountry":"INDIA","quantity":"21.00","actualQuantity":"21","unit":"KGS","unitRateFc":"3283.7","totalValueFC":"69710.8","currency":"USD","unitRateINR":"272050.7","date":"07-Apr-2023","totalValueINR":"5713065","totalValueInUsd":"69710.8","indian_port":"Dahez-SEZ","hs_no":"29343000","bill_no":"1001186","productDescription":"API","marketType":"REGULATED MARKET","country":"ITALY","selfForZScoreResived":"Pharma Grade","supplierPort":"N\/A","supplierAddress":"VIA GUIDO GUARINI MATTEUCCI,1 20162 MILANO - 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BOX 253 EPPINDUST 7475 South Africa","customerAddress":"564\/A\/22, ROAD NO.92"}]
05-Jan-2021
17-Aug-2024
KGS
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Quantity (KGS) & Unit rate (USD/KGS) over time

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