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    Chemistry

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    Also known as: 29110-48-3, Guanfacine hcl, Tenex, Intuniv, Guanfacine (hydrochloride), N-carbamimidoyl-2-(2,6-dichlorophenyl)acetamide hydrochloride
    Molecular Formula
    C9H10Cl3N3O
    Molecular Weight
    282.5  g/mol
    InChI Key
    DGFYECXYGUIODH-UHFFFAOYSA-N
    FDA UNII
    PML56A160O
    Guanfacine
    A centrally acting antihypertensive agent with specificity towards ADRENERGIC ALPHA-2 RECEPTORS.
    1 2D Structure

    Guanfacine

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    N-(diaminomethylidene)-2-(2,6-dichlorophenyl)acetamide;hydrochloride
    2.1.2 InChI
    InChI=1S/C9H9Cl2N3O.ClH/c10-6-2-1-3-7(11)5(6)4-8(15)14-9(12)13;/h1-3H,4H2,(H4,12,13,14,15);1H
    2.1.3 InChI Key
    DGFYECXYGUIODH-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    C1=CC(=C(C(=C1)Cl)CC(=O)N=C(N)N)Cl.Cl
    2.2 Other Identifiers
    2.2.1 UNII
    PML56A160O
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Bs 100 141

    2. Bs-100-141

    3. Bs100141

    4. Estulic

    5. Guanfacine

    6. Guanfacine Monohydrochloride

    7. Hydrochloride, Guanfacine

    8. Lon798

    9. Monohydrochloride, Guanfacine

    10. Tenex

    2.3.2 Depositor-Supplied Synonyms

    1. 29110-48-3

    2. Guanfacine Hcl

    3. Tenex

    4. Intuniv

    5. Guanfacine (hydrochloride)

    6. N-carbamimidoyl-2-(2,6-dichlorophenyl)acetamide Hydrochloride

    7. Estulic

    8. Bs 100-141

    9. 29520-14-7

    10. N-(aminoiminomethyl)-2,6-dichlorobenzeneacetamide Hydrochloride

    11. Spd503

    12. N-amidino-2-(2,6-dichlorophenyl)acetamide Hydrochloride

    13. N-amidino-2-(2,6-dichlorophenyl)acetamide Monohydrochloride

    14. Guafacine Hydrochloride

    15. Bs-100-141

    16. Benzeneacetamide, N-(aminoiminomethyl)-2,6-dichloro-, Monohydrochloride

    17. Spd 503

    18. Mls000069745

    19. Pml56a160o

    20. Smr000058453

    21. 29110-48-3 (hcl)

    22. Dsstox_cid_25157

    23. Dsstox_rid_80708

    24. Dsstox_gsid_45157

    25. Connexyn

    26. Lon 798

    27. N-(diaminomethylidene)-2-(2,6-dichlorophenyl)acetamide;hydrochloride

    28. Cas-29520-14-7

    29. Guanfacinehcl

    30. Tenex (tn)

    31. Guanfacinehydrochloride

    32. Sr-01000075893

    33. Ncgc00015469-05

    34. Einecs 249-443-3

    35. N-(aminoiminomethyl)-2,6-dichlorophenylacetamide Monohydrochloride

    36. Unii-pml56a160o

    37. Spd-503

    38. Prestwick_740

    39. Guanfacine Hydrochloride (jan/usp)

    40. Intuniv (tn)

    41. Mfcd00798230

    42. Guanfacine Hydrochloride [usan:usp:jan]

    43. Opera_id_1928

    44. N-(diaminomethylidene)-2-(2,6-dichlorophenyl)acetamide Hydrochloride

    45. Benzeneacetamide, N-(aminoiminomethyl)-2,6-dichloro-, Hydrochloride (1:1)

    46. G 1043

    47. Schembl41681

    48. Mls001077329

    49. Mls002222252

    50. [(2,6-dichlorophenyl)acetyl]guanidine Hydrochloride

    51. Chebi:5559

    52. Chembl1200494

    53. Dtxsid2045157

    54. Schembl15603414

    55. Hms1569c19

    56. Hms3747e15

    57. Pharmakon1600-01505435

    58. Bcp21710

    59. N-(aminoiminomethyl)-2,6-dichloro-benzeneacetamide Hydrochloride

    60. Tox21_110159

    61. Tox21_500519

    62. Guanfacine Hydrochloride [mi]

    63. Nsc759121

    64. S4693

    65. Guanfacine Hydrochloride [jan]

    66. Akos015966858

    67. Akos030242245

    68. Tox21_110159_1

    69. Ccg-213439

    70. Ccg-220339

    71. Cs-1254

    72. Guanfacine Hydrochloride [usan]

    73. Lp00519

    74. Guanfacine Hydrochloride [mart.]

    75. Guanfacine Hydrochloride [vandf]

    76. Guanfacine Hydrochloride [usp-rs]

    77. Guanfacine Hydrochloride [who-dd]

    78. Ncgc00015469-09

    79. Ncgc00093914-01

    80. Ncgc00093914-02

    81. Ncgc00180965-01

    82. Ncgc00261204-01

    83. As-12253

    84. Hy-17416

    85. Guanfacine Hydrochloride, >=98% (hplc)

    86. Bs100-141

    87. Db-047525

    88. Eu-0100519

    89. Ft-0630546

    90. Ft-0698181

    91. G0414

    92. Guanfacine Hydrochloride [orange Book]

    93. D00606

    94. Guanfacine Hydrochloride [usp Monograph]

    95. T72238

    96. A826918

    97. J-017395

    98. S-877503

    99. Sr-01000075893-1

    100. Sr-01000075893-3

    101. Sr-01000075893-6

    102. Q27286641

    103. N-carbamimidoyl-2-(2,6-dichlorophenyl)-acetamide Hydrochloride

    104. Guanfacine Hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material

    105. Guanfacine Hydrochloride, United States Pharmacopeia (usp) Reference Standard

    106. N-[bis(azanyl)methylidene]-2-[2,6-bis(chloranyl)phenyl]ethanamide Hydrochloride

    2.4 Create Date
    2005-06-24
    3 Chemical and Physical Properties
    Molecular Weight 282.5 g/mol
    Molecular Formula C9H10Cl3N3O
    Hydrogen Bond Donor Count3
    Hydrogen Bond Acceptor Count1
    Rotatable Bond Count2
    Exact Mass280.988945 g/mol
    Monoisotopic Mass280.988945 g/mol
    Topological Polar Surface Area81.5 Ų
    Heavy Atom Count16
    Formal Charge0
    Complexity256
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 4  
    Drug NameGuanfacine hydrochloride
    Drug LabelTenex (guanfacine hydrochloride) is a centrally acting antihypertensive with 2-adrenoceptor agonist properties in tablet form for oral administration. The chemical name of Tenex (guanfacine hydrochloride) is N-amidino- 2-(2,6-dichlorophenyl) acetam...
    Active IngredientGuanfacine hydrochloride
    Dosage FormTablet, extended release; Tablet
    Routeoral; Oral
    Strengtheq 4mg base; eq 2mg base; 1mg; eq 1mg base; eq 3mg base; 4mg; 2mg; 3mg
    Market StatusTentative Approval; Prescription
    CompanyTwi Pharms; Epic Pharma; Teva Pharms Usa; Sandoz; Watson Labs; Actavis Elizabeth; Amneal Pharm; Mylan

    2 of 4  
    Drug NameTenex
    PubMed HealthGuanfacine (By mouth)
    Drug ClassesAntihypertensive, Cardiovascular Agent, Central Nervous System Agent
    Drug LabelTenex (guanfacine hydrochloride) is a centrally acting antihypertensive with 2-adrenoceptor agonist properties in tablet form for oral administration. The chemical name of Tenex (guanfacine hydrochloride) is N-amidino- 2-(2,6-dichlorophenyl) acetam...
    Active IngredientGuanfacine hydrochloride
    Dosage FormTablet
    RouteOral
    Strengtheq 2mg base; eq 1mg base
    Market StatusPrescription
    CompanyPromius Pharma

    3 of 4  
    Drug NameGuanfacine hydrochloride
    Drug LabelTenex (guanfacine hydrochloride) is a centrally acting antihypertensive with 2-adrenoceptor agonist properties in tablet form for oral administration. The chemical name of Tenex (guanfacine hydrochloride) is N-amidino- 2-(2,6-dichlorophenyl) acetam...
    Active IngredientGuanfacine hydrochloride
    Dosage FormTablet, extended release; Tablet
    Routeoral; Oral
    Strengtheq 4mg base; eq 2mg base; 1mg; eq 1mg base; eq 3mg base; 4mg; 2mg; 3mg
    Market StatusTentative Approval; Prescription
    CompanyTwi Pharms; Epic Pharma; Teva Pharms Usa; Sandoz; Watson Labs; Actavis Elizabeth; Amneal Pharm; Mylan

    4 of 4  
    Drug NameTenex
    PubMed HealthGuanfacine (By mouth)
    Drug ClassesAntihypertensive, Cardiovascular Agent, Central Nervous System Agent
    Drug LabelTenex (guanfacine hydrochloride) is a centrally acting antihypertensive with 2-adrenoceptor agonist properties in tablet form for oral administration. The chemical name of Tenex (guanfacine hydrochloride) is N-amidino- 2-(2,6-dichlorophenyl) acetam...
    Active IngredientGuanfacine hydrochloride
    Dosage FormTablet
    RouteOral
    Strengtheq 2mg base; eq 1mg base
    Market StatusPrescription
    CompanyPromius Pharma

    4.2 Drug Indication

    Intuniv is indicated for the treatment of attention deficit hyperactivity disorder (ADHD) in children and adolescents 6 17 years old for whom stimulants are not suitable, not tolerated or have been shown to be ineffective.

    Intuniv must be used as a part of a comprehensive ADHD treatment programme, typically including psychological, educational and social measures.

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Adrenergic alpha-2 Receptor Agonists

    Compounds that bind to and activate ADRENERGIC ALPHA-2 RECEPTORS. (See all compounds classified as Adrenergic alpha-2 Receptor Agonists.)

    Antihypertensive Agents

    Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS. (See all compounds classified as Antihypertensive Agents.)

    5.2 FDA Pharmacological Classification
    5.2.1 Pharmacological Classes
    Central alpha-2 Adrenergic Agonist [EPC]; Adrenergic alpha2-Agonists [MoA]
    5.3 ATC Code

    C02AC02

    API Reference Price

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    17-Mar-2021
    11-Jul-2024
    KGS
    overview
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    Average Price (USD/KGS)

    Number of Transactions

    Total Quantity (KGS)

    Total Value (USD)

    Quantity (KGS) & Unit rate (USD/KGS) over time

    API Imports and Exports

    Importing Country Total Quantity
    (KGS)    		 Average Price
    (USD/KGS)    		 Number of Transactions

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    Fillers, Diluents & Binders

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