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    ACTIVE PHARMA INGREDIENTS

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    Synopsis

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    Chemistry

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    Also known as:
    Molecular Formula
    C17H20N4S
    Molecular Weight
    312.4  g/mol
    InChI Key
    WXPNDRBBWZMPQG-UHFFFAOYSA-N
    Olanzapine
    1 2D Structure

    Olanzapine

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    2-methyl-4-(4-methylpiperazin-1-yl)-5H-thieno[3,2-c][1,5]benzodiazepine
    2.1.2 InChI
    InChI=1S/C17H20N4S/c1-12-11-13-16(21-9-7-20(2)8-10-21)18-14-5-3-4-6-15(14)19-17(13)22-12/h3-6,11,18H,7-10H2,1-2H3
    2.1.3 InChI Key
    WXPNDRBBWZMPQG-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CC1=CC2=C(NC3=CC=CC=C3N=C2S1)N4CCN(CC4)C
    2.1.5 Isomeric SMILES
    CC1=CC2=C(NC3=CC=CC=C3N=C2S1)N4CCN(CC4)C
    2.2 Create Date
    2005-03-25
    3 Chemical and Physical Properties
    Molecular Weight 312.4 g/mol
    Molecular Formula C17H20N4S
    XLogP32.8
    Hydrogen Bond Donor Count1
    Hydrogen Bond Acceptor Count5
    Rotatable Bond Count1
    Exact Mass312.14086783 g/mol
    Monoisotopic Mass312.14086783 g/mol
    Topological Polar Surface Area56.2 A^2
    Heavy Atom Count22
    Formal Charge0
    Complexity543
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 8  
    Drug NameOlanzapine
    PubMed HealthOlanzapine
    Drug ClassesAntipsychotic
    Drug LabelOlanzapine is an atypical antipsychotic that belongs to the thienobenzodiazepine class. The chemical designation is 2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b] [1,5]benzodiazepine. The molecular formula is C17H20N4S, which corresponds to a...
    Active IngredientOlanzapine
    Dosage FormTablet; Injectable; Tablet, orally disintegrating
    Routeoral; Oral; Intramuscular
    Strength2.5mg; 10mg/vial; 7.5mg; 15mg; 5mg; 10mg; 20mg
    Market StatusTentative Approval; Prescription
    CompanyMylan Pharms; Apotex; Aurobindo Pharma; Sun Pharm Inds; Torrent Pharms; Barr Labs; Sandoz; Par Pharm; Roxane; Teva Pharms; Macleods Pharms; Jubilant Generics; Luitpold; Dr Reddys Labs; Orchid Hlthcare; Mylan

    2 of 8  
    Drug NameSymbyax
    PubMed HealthOlanzapine/Fluoxetine (By mouth)
    Drug ClassesAntidepressant, Antipsychotic
    Active IngredientFluoxetine hydrochloride; olanzapine
    Dosage FormCapsule
    RouteOral
    Strengtheq 50mg base; eq 6mg base; eq 12mg base; eq 3mg base; eq 25mg base
    Market StatusPrescription
    CompanyLilly

    3 of 8  
    Drug NameZyprexa
    Drug LabelZYPREXA (olanzapine) is an atypical antipsychotic that belongs to the thienobenzodiazepine class. The chemical designation is 2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b] [1,5]benzodiazepine. The molecular formula is C17H20N4S, which corresp...
    Active IngredientOlanzapine
    Dosage FormTablet; Injectable
    RouteOral; Intramuscular
    Strength2.5mg; 10mg/vial; 7.5mg; 15mg; 5mg; 10mg; 20mg
    Market StatusPrescription
    CompanyLilly

    4 of 8  
    Drug NameZyprexa zydis
    Drug LabelZYPREXA (olanzapine) is an atypical antipsychotic that belongs to the thienobenzodiazepine class. The chemical designation is 2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b] [1,5]benzodiazepine. The molecular formula is C17H20N4S, which corresp...
    Active IngredientOlanzapine
    Dosage FormTablet, orally disintegrating
    RouteOral
    Strength15mg; 5mg; 10mg; 20mg
    Market StatusPrescription
    CompanyLilly

    5 of 8  
    Drug NameOlanzapine
    PubMed HealthOlanzapine
    Drug ClassesAntipsychotic
    Drug LabelOlanzapine is an atypical antipsychotic that belongs to the thienobenzodiazepine class. The chemical designation is 2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b] [1,5]benzodiazepine. The molecular formula is C17H20N4S, which corresponds to a...
    Active IngredientOlanzapine
    Dosage FormTablet; Injectable; Tablet, orally disintegrating
    Routeoral; Oral; Intramuscular
    Strength2.5mg; 10mg/vial; 7.5mg; 15mg; 5mg; 10mg; 20mg
    Market StatusTentative Approval; Prescription
    CompanyMylan Pharms; Apotex; Aurobindo Pharma; Sun Pharm Inds; Torrent Pharms; Barr Labs; Sandoz; Par Pharm; Roxane; Teva Pharms; Macleods Pharms; Jubilant Generics; Luitpold; Dr Reddys Labs; Orchid Hlthcare; Mylan

    6 of 8  
    Drug NameSymbyax
    PubMed HealthOlanzapine/Fluoxetine (By mouth)
    Drug ClassesAntidepressant, Antipsychotic
    Active IngredientFluoxetine hydrochloride; olanzapine
    Dosage FormCapsule
    RouteOral
    Strengtheq 50mg base; eq 6mg base; eq 12mg base; eq 3mg base; eq 25mg base
    Market StatusPrescription
    CompanyLilly

    7 of 8  
    Drug NameZyprexa
    Drug LabelZYPREXA (olanzapine) is an atypical antipsychotic that belongs to the thienobenzodiazepine class. The chemical designation is 2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b] [1,5]benzodiazepine. The molecular formula is C17H20N4S, which corresp...
    Active IngredientOlanzapine
    Dosage FormTablet; Injectable
    RouteOral; Intramuscular
    Strength2.5mg; 10mg/vial; 7.5mg; 15mg; 5mg; 10mg; 20mg
    Market StatusPrescription
    CompanyLilly

    8 of 8  
    Drug NameZyprexa zydis
    Drug LabelZYPREXA (olanzapine) is an atypical antipsychotic that belongs to the thienobenzodiazepine class. The chemical designation is 2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b] [1,5]benzodiazepine. The molecular formula is C17H20N4S, which corresp...
    Active IngredientOlanzapine
    Dosage FormTablet, orally disintegrating
    RouteOral
    Strength15mg; 5mg; 10mg; 20mg
    Market StatusPrescription
    CompanyLilly

    API Reference Price

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D6 & D8, SY.NO. 234\/2,234\/3, ,235\/2 & 542\/2, IKP KNOWLEDGE PARK,","city":"TURKAPALLY-V SHAMIRPET HYDERABAD,TE","supplier":"UNITED STATES PHARMACOPEIAL ","supplierCountry":"INDIA","foreign_port":"NA","customer":"UNITED STATES PHARMACOPEIA - INDIA PRIVATE LIMITED","customerCountry":"INDIA","quantity":"0.00","actualQuantity":"0.00025","unit":"KGS","unitRateFc":"397400","totalValueFC":"117","currency":"USD","unitRateINR":"37234640","date":"27-Aug-2022","totalValueINR":"9308.66","totalValueInUsd":"117","indian_port":"HYDERABAD AIR","hs_no":"29349990","bill_no":"2190162","productDescription":"Re-Import","marketType":"REGULATED MARKET","country":"INDIA","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"P.NO. D6 & D8, SY.NO. 234\/2,234\/3, ,235\/2 & 542\/2, IKP KNOWLEDGE PARK,"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q1","strtotime":1677522600,"product":"OLANZAPINE USP (TL NO: TL\/AZ\/22\/000230) FOR R & D PURPOSE NOT FOR SALE","address":"ZYDUS CORPORATE PARK, SCHEME NO 63, KHORAJ (GANDHINAGAR), NR. VAISHNODE","city":"AHMEDABAD","supplier":"INKE S.A","supplierCountry":"SPAIN","foreign_port":"NA","customer":"ZYDUS LIFESCIENCES LIMITED","customerCountry":"INDIA","quantity":"0.45","actualQuantity":"0.45","unit":"KGS","unitRateFc":"7500","totalValueFC":"3688","currency":"EUR","unitRateINR":"676875","date":"28-Feb-2023","totalValueINR":"304593.75","totalValueInUsd":"3688","indian_port":"BOMBAY AIR","hs_no":"29349990","bill_no":"4839180","productDescription":"API","marketType":"REGULATED MARKET","country":"SPAIN","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"ZYDUS CORPORATE PARK, SCHEME NO 63, KHORAJ (GANDHINAGAR), NR. VAISHNODE"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q2","strtotime":1680287400,"product":"OLANZAPINE USP (TEST LIC : TL\/AZ\/22\/000230) FOR R&D PURPOSENOT FOR SALE","address":"ZYDUS CORPORATE PARK, SCHEME NO 63, KHORAJ (GANDHINAGAR), NR. 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VAISHNODE"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q2","strtotime":1683657000,"product":"OLANZAPINE USP BATCH NO COLU220001 0000058933 COLU220005","address":"NO. 9,215, PUDUPAKKAM - VANDALLUR, MAIN ROAD PUDUPAKKAM","city":"KANCHIPURAM","supplier":"ENDO VENTURES LIMITED","supplierCountry":"UNITED STATES","foreign_port":"NEW YORK JOHN F K","customer":"PAR PHARMACEUTICAL","customerCountry":"INDIA","quantity":"24.50","actualQuantity":"24.498","unit":"KGS","unitRateFc":"4400","totalValueFC":"108762","currency":"USD","unitRateINR":"365311.3","date":"10-May-2023","totalValueINR":"8949396.12","totalValueInUsd":"108762","indian_port":"MADRAS AIR","hs_no":"29349990","bill_no":"0","productDescription":"API","marketType":"REGULATED MARKET","country":"United States","selfForZScoreResived":"Pharma Grade","supplierPort":"NEW YORK JOHN F K","supplierAddress":"","customerAddress":"NO. 9,215, PUDUPAKKAM - VANDALLUR, MAIN ROAD PUDUPAKKAM"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q3","strtotime":1688495400,"product":"OLANZAPINE PH.EUR RE-IMPORT GOODS VIDE SB NO-7147897\/30-12-2021 & EXP INV-SI3621122894\/25.12.2021","address":"7-2-A2, HETERO CORPORATE, INDUSTRIAL ESTATE, SANATHNAGAR, Con","city":"HYDERABAD","supplier":"GEDEON RICHTER","supplierCountry":"INDIA","foreign_port":"NA","customer":"HETERO DRUGS","customerCountry":"INDIA","quantity":"20.00","actualQuantity":"20","unit":"KGS","unitRateFc":"1800","totalValueFC":"37777.8","currency":"USD","unitRateINR":"155247","date":"05-Jul-2023","totalValueINR":"3104936.695","totalValueInUsd":"37777.8","indian_port":"HYDERABAD AIR","hs_no":"29349990","bill_no":"0","productDescription":"Re-Import","marketType":"REGULATED MARKET","country":"INDIA","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"7-2-A2, HETERO CORPORATE, INDUSTRIAL ESTATE, SANATHNAGAR, Con"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q1","strtotime":1711564200,"product":"(REJECTED AND RETURN) OLANZAPINE (FORM - 1) -PH EUR, MFG DT:JA N- 2024, RETEST DT:DEC-2024, BATCH NO: OZ P2401004.S\/B#78","address":"PLOT NO.1-A SEC-16A","city":"NOIDA (U.P) INDIA","supplier":"SANOFI","supplierCountry":"INDIA","foreign_port":"DUBAI","customer":"JUBILANT PHARMOVA","customerCountry":"INDIA","quantity":"17.90","actualQuantity":"17.9","unit":"KGS","unitRateFc":"1030","totalValueFC":"18649.5","currency":"USD","unitRateINR":"86520","date":"28-Mar-2024","totalValueINR":"1548708","totalValueInUsd":"18649.5","indian_port":"Bangalore Air","hs_no":"29349990","bill_no":"2789201","productDescription":"Re-Import","marketType":"REGULATED MARKET","country":"INDIA","selfForZScoreResived":"Pharma Grade","supplierPort":"DUBAI","supplierAddress":"ESENTEPE MAH. BUYUKDERE CAD, 193 APT NO:193\/14 SISLI ISTANBUL Istanbul, , Turkey Turkey","customerAddress":"PLOT NO.1-A SEC-16A"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q2","strtotime":1716575400,"product":"OLANZAPINE ( RE-IMPORT CARGO EXPORTED VIDE S.B. NO. 5884880DATE 08.12.2023 )","address":"NO.201, DEVAVRATA SECTOR 17,,VASHI","city":"NAVI MUMBAI,MAHARASHTRA","supplier":"JIM ROYAL TRADING CO. 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    05-Jan-2021
    31-Aug-2024
    KGS
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    Average Price (USD/KGS)

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    Total Quantity (KGS)

    Total Value (USD)

    Quantity (KGS) & Unit rate (USD/KGS) over time

    API Imports and Exports

    Importing Country Total Quantity
    (KGS)    		 Average Price
    (USD/KGS)    		 Number of Transactions

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    DOSAGE - TABLET;ORAL - 10MG

    USFDA APPLICATION NUMBER - 20592

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    DOSAGE - TABLET;ORAL - 15MG

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    DOSAGE - TABLET;ORAL - 2.5MG

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    DOSAGE - TABLET;ORAL - 20MG

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    DOSAGE - TABLET;ORAL - 5MG

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    DOSAGE - TABLET;ORAL - 7.5MG

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    DOSAGE - TABLET, ORALLY DISINTEGRATING;ORAL -...DOSAGE - TABLET, ORALLY DISINTEGRATING;ORAL - 10MG

    USFDA APPLICATION NUMBER - 21086

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    DOSAGE - TABLET, ORALLY DISINTEGRATING;ORAL -...DOSAGE - TABLET, ORALLY DISINTEGRATING;ORAL - 15MG

    USFDA APPLICATION NUMBER - 21086

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    DOSAGE - TABLET, ORALLY DISINTEGRATING;ORAL -...DOSAGE - TABLET, ORALLY DISINTEGRATING;ORAL - 20MG

    USFDA APPLICATION NUMBER - 21086

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    DOSAGE - TABLET, ORALLY DISINTEGRATING;ORAL -...DOSAGE - TABLET, ORALLY DISINTEGRATING;ORAL - 5MG

    USFDA APPLICATION NUMBER - 21086

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