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    Chemistry

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    Also known as: 532-03-6, Robaxin, Lumirelax, Metocarbamol, Parabaxin, Delaxin
    Molecular Formula
    C11H15NO5
    Molecular Weight
    241.24  g/mol
    InChI Key
    GNXFOGHNGIVQEH-UHFFFAOYSA-N
    FDA UNII
    125OD7737X
    Methocarbamol
    A centrally acting muscle relaxant whose mode of action has not been established. It is used as an adjunct in the symptomatic treatment of musculoskeletal conditions associated with painful muscle spasm. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1206)
    Methocarbamol is a Muscle Relaxant. The physiologic effect of methocarbamol is by means of Centrally-mediated Muscle Relaxation.
    1 2D Structure

    Methocarbamol

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    [2-hydroxy-3-(2-methoxyphenoxy)propyl] carbamate
    2.1.2 InChI
    InChI=1S/C11H15NO5/c1-15-9-4-2-3-5-10(9)16-6-8(13)7-17-11(12)14/h2-5,8,13H,6-7H2,1H3,(H2,12,14)
    2.1.3 InChI Key
    GNXFOGHNGIVQEH-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    COC1=CC=CC=C1OCC(COC(=O)N)O
    2.2 Other Identifiers
    2.2.1 UNII
    125OD7737X
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Carbamate, Guaiphenesin

    2. Guaiphenesin Carbamate

    3. Lumirelax

    4. Ortoton

    5. Parabaxin

    6. Robaxin

    2.3.2 Depositor-Supplied Synonyms

    1. 532-03-6

    2. Robaxin

    3. Lumirelax

    4. Metocarbamol

    5. Parabaxin

    6. Delaxin

    7. Perilax

    8. Metocarbamolo

    9. Etroflex

    10. Methocal

    11. Metofenia

    12. Miolaxene

    13. Miorilas

    14. Myolaxene

    15. Neuraxin

    16. Reflexyn

    17. Relestrid

    18. Romethocarb

    19. Surquetil

    20. Tresortil

    21. Avetil

    22. Miowas

    23. Robinax

    24. Metofenina

    25. Forbaxin

    26. Guaiacol Glyceryl Ether Carbamate

    27. Guaiphenesine Carbamate

    28. 2-hydroxy-3-(2-methoxyphenoxy)propyl Carbamate

    29. Glycerylguaiacolate Carbamate

    30. Glycerylguajacol-carbamat

    31. Ahr 85

    32. Methocarbamolum

    33. Robaxan

    34. Robaxine

    35. Robaxon

    36. Guiacol-gliceriletere Monocarbammato

    37. [2-hydroxy-3-(2-methoxyphenoxy)propyl] Carbamate

    38. 1,2-propanediol, 3-(2-methoxyphenoxy)-, 1-carbamate

    39. 3-(o-methoxyphenoxy)-2-hydroxypropyl Carbamate

    40. 3-(o-methoxyphenoxy)-1,2-propanediol 1-carbamate

    41. 3-(2-methoxyphenoxy)-1-glyceryl Carbamate

    42. Nsc 170960

    43. 2-hydroxy-3-(o-methoxyphenoxy)propyl 1-carbamate

    44. Methocarbamol (robaxin)

    45. Nsc-170960

    46. Guaiphenesin Carbamate

    47. 1,2-propanediol, 3-(o-methoxyphenoxy)-, 1-carbamate

    48. Mls000028610

    49. Carbamic Acid, 2-hydroxy-3-(o-methoxyphenoxy)propyl Ester

    50. Chebi:77498

    51. 125od7737x

    52. Robamol

    53. Smr000058719

    54. Traumacut

    55. Dsstox_cid_3286

    56. Dsstox_rid_76958

    57. Dsstox_gsid_23286

    58. Methyocarbamol

    59. Metocarbamolo [dcit]

    60. Robaxisol

    61. Robaxin-750

    62. Metocarbamol [inn-spanish]

    63. Methocarbamolum [inn-latin]

    64. Hsdb 3122

    65. Sr-01000000240

    66. Einecs 208-524-3

    67. 2-hydroxy-3-{[2-(methyloxy)phenyl]oxy}propyl Carbamate

    68. Brn 1884446

    69. Methacarbamol

    70. Unii-125od7737x

    71. Ncgc00016492-01

    72. Methocarbamol,(s)

    73. Cas-532-03-6

    74. Methocarbamol [usp:inn:ban:jan]

    75. Prestwick_614

    76. Delaxin (tn)

    77. Robaxin (tn)

    78. Mfcd00057662

    79. Robaxisol (salt/mix)

    80. Spectrum_000997

    81. Opera_id_1471

    82. Prestwick0_000184

    83. Prestwick1_000184

    84. Prestwick2_000184

    85. Prestwick3_000184

    86. Spectrum2_001272

    87. Spectrum3_000496

    88. Spectrum4_000049

    89. Spectrum5_000956

    90. Methocarbamol [mi]

    91. 2-hydroxy-3-(o-methoxyphenoxy)propyl Carbamate

    92. Methocarbamol [inn]

    93. Methocarbamol [jan]

    94. Methocarbamol [hsdb]

    95. Schembl34365

    96. Bspbio_000107

    97. Bspbio_001991

    98. Kbiogr_000517

    99. Kbioss_001477

    100. Methocarbamol [vandf]

    101. 3-(2-methoxyphenoxy)-1,2-propanediol 1-carbamate

    102. Mls001148605

    103. Divk1c_000434

    104. Methocarbamol [mart.]

    105. Spectrum1500397

    106. Wln: Zvo1yq1or Bo1

    107. Spbio_001264

    108. Spbio_002028

    109. Methocarbamol [usp-rs]

    110. Methocarbamol [who-dd]

    111. Bpbio1_000119

    112. Gtpl6829

    113. Methocarbamol (jan/usp/inn)

    114. (+-)-3-(o-methoxyphenoxy)-1,2-propanediol 1-carbamate

    115. Chembl1201117

    116. Dtxsid6023286

    117. Hms501f16

    118. Kbio1_000434

    119. Kbio2_001477

    120. Kbio2_004045

    121. Kbio2_006613

    122. Kbio3_001491

    123. Ninds_000434

    124. Hms1568f09

    125. Hms1920l19

    126. Hms2091d14

    127. Hms2095f09

    128. Hms2233g18

    129. Hms3259m17

    130. Hms3369b17

    131. Hms3655o06

    132. Hms3712f09

    133. Methocarbamol [green Book]

    134. Pharmakon1600-01500397

    135. Methocarbamol [orange Book]

    136. Bcp13801

    137. Hy-b0262

    138. Tox21_110454

    139. Ccg-39655

    140. Methocarbamol [usp Monograph]

    141. Nsc170960

    142. Nsc757112

    143. S1736

    144. Akos015960743

    145. Tox21_110454_1

    146. Db00423

    147. Nc00509

    148. Nsc-757112

    149. Idi1_000434

    150. Robaxisal Component Methocarbamol

    151. Ncgc00018257-02

    152. Ncgc00018257-03

    153. Ncgc00018257-04

    154. Ncgc00018257-07

    155. Ncgc00018257-08

    156. Ncgc00018257-16

    157. Ncgc00089805-02

    158. Ncgc00089805-03

    159. 1, 3-(o-methoxyphenoxy)-, 1-carbamate

    160. Ac-12037

    161. As-11691

    162. 1, 3-(2-methoxyphenoxy)-, 1-carbamate

    163. Methocarbamol Component Of Robaxisal

    164. Sbi-0051442.p003

    165. 3-o-(2-methoxyphenyl)-1-glyceryl Carbamate

    166. Ab00052040

    167. Ft-0628302

    168. Ft-0671053

    169. M2254

    170. Sw196781-3

    171. D00402

    172. D70323

    173. Ab00052040-15

    174. Ab00052040_16

    175. Ab00052040_17

    176. 2-hydroxy-3-(2-methoxyphenoxy)propyl Carbamate #

    177. A829442

    178. Q411456

    179. Sr-01000000240-2

    180. Sr-01000000240-3

    181. (rs)-2-hydroxy-3-(2-methoxyphenoxy)propyl Carbamate

    182. Brd-a31521121-001-05-8

    183. Guaiacol Glyceryl Ether Carbamate, Analytical Standard

    184. (+/-)-3-( O-methoxyphenoxy)-1,2-propanediol 1-carbamate

    185. Carbamic Acid 2-hydroxy-3-(2-methoxyphenoxy)propyl Ester

    186. Carbamic Acid [2-hydroxy-3-(2-methoxy-phenoxy)-propyl] Ester

    187. (+/-)-3-(o-methoxyphenoxy)-1,2-propanediol 1-carbamate

    188. Methocarbamol, United States Pharmacopeia (usp) Reference Standard

    189. 1,2-propanediol, 3-(2-methoxyphenoxy)-, 1-carbamate, (+/-)-

    190. Methocarbamol, Pharmaceutical Secondary Standard; Certified Reference Material

    191. 3967-43-9

    2.4 Create Date
    2005-03-25
    3 Chemical and Physical Properties
    Molecular Weight 241.24 g/mol
    Molecular Formula C11H15NO5
    XLogP30.6
    Hydrogen Bond Donor Count2
    Hydrogen Bond Acceptor Count5
    Rotatable Bond Count7
    Exact Mass241.09502258 g/mol
    Monoisotopic Mass241.09502258 g/mol
    Topological Polar Surface Area91 Ų
    Heavy Atom Count17
    Formal Charge0
    Complexity236
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count1
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 6  
    Drug NameMethocarbamol
    PubMed HealthMethocarbamol
    Drug ClassesSkeletal Muscle Relaxant, Centrally Acting
    Drug Labelrobaxin/robaxin-750 (methocarbamol tablets, USP), a carbamate derivative of guaifenesin, is a central nervous system (CNS) depressant with sedative and musculoskeletal relaxant properties.The chemical name of methocarbamol is 3-(2-methoxyphenoxy)...
    Active IngredientMethocarbamol
    Dosage FormTablet
    RouteOral
    Strength500mg; 750mg
    Market StatusPrescription
    CompanyHikma Intl Pharms; Vintage Pharms; Hetero Labs Ltd Iii; Sandoz; Prinston; Lannett Holdings; Watson Labs; Austarpharma

    2 of 6  
    Drug NameRobaxin
    PubMed HealthMethocarbamol
    Drug ClassesSkeletal Muscle Relaxant, Centrally Acting
    Drug Labelrobaxin/robaxin-750 (methocarbamol tablets, USP), a carbamate derivative of guaifenesin, is a central nervous system (CNS) depressant with sedative and musculoskeletal relaxant properties.The chemical name of methocarbamol is 3-(2-methoxyphenoxy)...
    Active IngredientMethocarbamol
    Dosage FormTablet; Injectable
    RouteInjection; Oral
    Strength500mg; 100mg/ml
    Market StatusPrescription
    CompanyAuxilium Pharms; Hikma Maple

    3 of 6  
    Drug NameRobaxin-750
    PubMed HealthMethocarbamol (By mouth)
    Drug ClassesSkeletal Muscle Relaxant, Centrally Acting
    Active IngredientMethocarbamol
    Dosage FormTablet
    RouteOral
    Strength750mg
    Market StatusPrescription
    CompanyAuxilium Pharms

    4 of 6  
    Drug NameMethocarbamol
    PubMed HealthMethocarbamol
    Drug ClassesSkeletal Muscle Relaxant, Centrally Acting
    Drug Labelrobaxin/robaxin-750 (methocarbamol tablets, USP), a carbamate derivative of guaifenesin, is a central nervous system (CNS) depressant with sedative and musculoskeletal relaxant properties.The chemical name of methocarbamol is 3-(2-methoxyphenoxy)...
    Active IngredientMethocarbamol
    Dosage FormTablet
    RouteOral
    Strength500mg; 750mg
    Market StatusPrescription
    CompanyHikma Intl Pharms; Vintage Pharms; Hetero Labs Ltd Iii; Sandoz; Prinston; Lannett Holdings; Watson Labs; Austarpharma

    5 of 6  
    Drug NameRobaxin
    PubMed HealthMethocarbamol
    Drug ClassesSkeletal Muscle Relaxant, Centrally Acting
    Drug Labelrobaxin/robaxin-750 (methocarbamol tablets, USP), a carbamate derivative of guaifenesin, is a central nervous system (CNS) depressant with sedative and musculoskeletal relaxant properties.The chemical name of methocarbamol is 3-(2-methoxyphenoxy)...
    Active IngredientMethocarbamol
    Dosage FormTablet; Injectable
    RouteInjection; Oral
    Strength500mg; 100mg/ml
    Market StatusPrescription
    CompanyAuxilium Pharms; Hikma Maple

    6 of 6  
    Drug NameRobaxin-750
    PubMed HealthMethocarbamol (By mouth)
    Drug ClassesSkeletal Muscle Relaxant, Centrally Acting
    Active IngredientMethocarbamol
    Dosage FormTablet
    RouteOral
    Strength750mg
    Market StatusPrescription
    CompanyAuxilium Pharms

    4.2 Therapeutic Uses

    Muscle Relaxants, Central

    National Library of Medicine's Medical Subject Headings online file (MeSH, 1999)

    Skeletal muscle relaxants are indicated as adjunts to other measures, such as rest and physical therapy, for the relief of muscle spasm associated with acute, painful musculoskeletal conditions. /Included in US product label/

    Thomson/Micromedex. Drug Information for the Health Care Professional. Volume 1, Greenwood Village, CO. 2007., p. 2625

    Methcarbamol is also FDA-approved for control of the neuromuscular manifestations of tetanus. However it has largely been replaced in the treatment of tetanus by diazepam, or, in severe cases a neuromuscular blocking agent such as pancuronium. Such therapy is used as an adjunct to other measures, such as debridement, tetanus antitoxin, penicillin, tracheotomy, fluid and electrolyte replacement, and supportive treatment.

    Thomson/Micromedex. Drug Information for the Health Care Professional. Volume 1, Greenwood Village, CO. 2007., p. 2625

    VET: In dogs, cats, and horses, methocarbamol is indicated as adjunct therapy of acute inflammatory and traumatic conditions of skeletal muscle and to reduce muscle spasms.

    Kahn, C.M. (Ed.); The Merck Veterinary Manual 9th ed. Merck & Co. Whitehouse Station, NJ. 2005, p. 2017

    For more Therapeutic Uses (Complete) data for METHOCARBAMOL (6 total), please visit the HSDB record page.

    4.3 Drug Warning

    The most frequent adverse effects of methocarbamol are drowsiness, dizziness, and lightheadedness. Blurred vision, headache, fever, and nausea may occur after oral, IM, or IV administration of the drug. Anorexia has been reported after oral administration. Adynamic ileus occurred in one patient who received a total of 10 g of methocarbamol orally. Metallic taste, GI upset, nystagmus, diplopia, flushing, vertigo, mild muscular incoordination, syncope, hypotension, and bradycardia have occurred in patients receiving the drug IM or IV.

    McEvoy, G.K. (ed.). American Hospital Formulary Service. AHFS Drug Information. American Society of Health-System Pharmacists, Bethesda, MD. 2007.

    Allergic reactions such as urticaria, pruritus, rash, skin eruptions, and conjunctivitis with nasal congestion may occur in patients receiving methocarbamol. Anaphylactic reactions have occurred following IM or IV administration of the drug. Although most patients with methocarbamol-induced syncope recover with supportive treatment, epinephrine, corticosteroids, and/or antihistamines have been used to increase the rate of recovery in some of these patients.

    McEvoy, G.K. (ed.). American Hospital Formulary Service. AHFS Drug Information. American Society of Health-System Pharmacists, Bethesda, MD. 2007.

    When methocarbamol is administered IV, thrombophlebitis, sloughing, and pain at the injection site may result from extravasation. IM injection of the drug may also cause local irritation. IV injection of methocarbamol may cause a small amount of hemolysis and increased hemoglobin and red blood cells in the urine. Leukopenia may occur rarely.

    McEvoy, G.K. (ed.). American Hospital Formulary Service. AHFS Drug Information. American Society of Health-System Pharmacists, Bethesda, MD. 2007.

    Parenteral dosage forms should be used with caution in patients with epilepsy.

    Thomson/Micromedex. Drug Information for the Health Care Professional. Volume 1, Greenwood Village, CO. 2007., p. 2629

    For more Drug Warnings (Complete) data for METHOCARBAMOL (14 total), please visit the HSDB record page.

    4.4 Drug Indication

    Methocarbamol tablets and intramuscular injections are indicated in the United States as an adjunct to rest, physical therapy, and other measures for the relief of discomforts associated with acute, painful musculoskeletal conditions. Oral methocarbamol in America may be given up to 1500mg 4 times daily for 2-3 days. In Canada, methocarbamol containing oral formulations are sold over the counter for pain associated with muscle spasm. However, if these combination formulations include codeine, they are prescription only.

    FDA Label

    5 Pharmacology and Biochemistry
    5.1 Pharmacology

    Methacarbamol is a skeletal muscle relaxant with an unknown mechanism of action. Methacarbamol has been shown to block spinal polysynaptic reflexes, decrease nerve transmission in spinal and supraspinal polysynaptic pathways, and prolong the refractory period of muscle cells. Methocarbamol does not act as a local anesthetic upon injection. In animal studies, methocarbamol also prevents convulsions after electric shock.

    5.2 MeSH Pharmacological Classification

    Muscle Relaxants, Central

    A heterogeneous group of drugs used to produce muscle relaxation, excepting the neuromuscular blocking agents. They have their primary clinical and therapeutic uses in the treatment of muscle spasm and immobility associated with strains, sprains, and injuries of the back and, to a lesser degree, injuries to the neck. They have been used also for the treatment of a variety of clinical conditions that have in common only the presence of skeletal muscle hyperactivity, for example, the muscle spasms that can occur in MULTIPLE SCLEROSIS. (From Smith and Reynard, Textbook of Pharmacology, 1991, p358) (See all compounds classified as Muscle Relaxants, Central.)

    5.3 FDA Pharmacological Classification
    5.3.1 Active Moiety
    METHOCARBAMOL
    5.3.2 FDA UNII
    125OD7737X
    5.3.3 Pharmacological Classes
    Muscle Relaxant [EPC]; Centrally-mediated Muscle Relaxation [PE]
    5.4 ATC Code

    M - Musculo-skeletal system

    M03 - Muscle relaxants

    M03B - Muscle relaxants, centrally acting agents

    M03BA - Carbamic acid esters

    M03BA03 - Methocarbamol

    5.5 Absorption, Distribution and Excretion

    Absorption

    The time to maximum concentration is 1.1 hours for both healthy patients and those on hemodialysis. The maximum plasma concentration is 21.3mg/L for healthy patients and 28.7mg/L in hemodialysis patients. The area under the curve for healthy patients is 52.5mg/L\*hr and 87.1mg/L*hr in hemodialysis patients. AUC% based on terminal elimination half life is 2% for healthy patients and 4% for hemodialysis patients. Older studies report maximum plasma concentrations in 0.5 hours.

    Route of Elimination

    In humans the majority of the dose is eliminated in the urine. In dogs, 88.85% of the dose is eliminated in urine and 2.14% in the feces. In rats, 84.5-92.5% of the dose is eliminated in the urine and 0-13.3% is eliminated in the feces.

    Volume of Distribution

    Volume of distribution data in humans is scarce. In horses, the volume of distribution is 515-942mL/kg at steady state or 724-1130mL/kg.

    Clearance

    0.2-0.8L/h/kg.

    Methocarbamol is rapidly and almost completely absorbed from the GI tract. Blood or serum concentrations of methocarbamol required for sedative, skeletal muscle relaxant, or toxic effects are not known.

    McEvoy, G.K. (ed.). American Hospital Formulary Service. AHFS Drug Information. American Society of Health-System Pharmacists, Bethesda, MD. 2007.

    Following oral administration of a single dose of methocarbamol, peak blood or serum concentrations of the drug appear to be attained in approximately 1-2 hours; the onset of action is usually within 30 minutes. Data from an unpublished study indicate that peak blood concentrations (measured as total carbamates and expressed in terms of methocarbamol) average 16.5 mcg/mL following a single 2-g oral dose, while data from a published study (using an assay relatively specific for methocarbamol) indicate that peak serum concentrations average 29.8 mcg/mL following the same dose. Data from the unpublished study also indicate that after IV administration of 1 g of methocarbamol at a rate of 300 mg/minute, blood concentrations of 19 mcg/mL are attained immediately and that the onset of action is almost immediate.

    McEvoy, G.K. (ed.). American Hospital Formulary Service. AHFS Drug Information. American Society of Health-System Pharmacists, Bethesda, MD. 2007.

    In dogs, methocarbamol is widely distributed, with highest concentrations attained in the kidney and liver; lower concentrations are attained in the lungs, brain, and spleen, and low concentrations are attained in heart and skeletal muscle.

    McEvoy, G.K. (ed.). American Hospital Formulary Service. AHFS Drug Information. American Society of Health-System Pharmacists, Bethesda, MD. 2007.

    The drug and/or its metabolites cross the placenta in dogs. It is not known if methocarbamol is distributed into milk in humans.

    McEvoy, G.K. (ed.). American Hospital Formulary Service. AHFS Drug Information. American Society of Health-System Pharmacists, Bethesda, MD. 2007.

    For more Absorption, Distribution and Excretion (Complete) data for METHOCARBAMOL (8 total), please visit the HSDB record page.

    5.6 Metabolism/Metabolites

    Methocarbamol is metabolized in the liver by demethylation to 3-(2-hydroxyphenoxy)-1,2-propanediol-1-carbamate or hydroxylation to 3-(4-hydroxy-2-methoxyphenoxy)-1,2-propanediol-1-carbamate. Methocarbamol and its metabolites are conjugated through glucuronidation or sulfation.

    Methocarbamol is extensively metabolized, presumably in the liver, by dealkylation and hydroxylation.

    McEvoy, G.K. (ed.). American Hospital Formulary Service. AHFS Drug Information. American Society of Health-System Pharmacists, Bethesda, MD. 2007.

    Based on limited data, about 10-15% of a single oral dose is excreted in urine as unchanged drug, about 40-50% as the glucuronide and sulfate conjugates of 3-(2-hydroxyphenoxy)-1,2-propanediol-1-carbamate and 3-(4-hydroxy-2-methoxyphenoxy)-1,2-propanediol-1-carbamate, and the remainder as unidentified metabolites.

    McEvoy, G.K. (ed.). American Hospital Formulary Service. AHFS Drug Information. American Society of Health-System Pharmacists, Bethesda, MD. 2007.

    In dogs, rats and in man, methocarbamol gave p-hydroxymethocarbamol and o-demethylation product. All three substances were excreted in urine as glucuronic acid and ester sulfate conjugates.

    The Chemical Society. Foreign Compound Metabolism in Mammals. Volume 2: A Review of the Literature Published Between 1970 and 1971. London: The Chemical Society, 1972., p. 206

    Permethylation and g.l.c.-mass spectrometric analysis of bile from an isolated rat liver perfusion to which methocarmol was added showed seven components not present in control bile: methocarbamol, glucuronides of methocarbamol and desmethyl-methocarbamol, and four glucuronides of hydroxylated methocarbamol metabolites. 2. An interesting rearrangement of a methyl group has been found in the mass spectrum of 3-(2-methoxyphenyloxy)-1,2-dimethoxypropane, the permethylation product from methocarbamol.

    PMID:1166662 Thompson RM, Gerber N et al; Xenobiotica 5 (3): 145-53 (1975)

    5.7 Biological Half-Life

    The elimination half life is 1.14 hours in healthy subjects and 1.24 hours in subjects with renal insufficiency. Older studies report half lives of 1.6-2.15 hours.

    Methocarbamol has a serum half-life of 0.9-1.8 hours.

    McEvoy, G.K. (ed.). American Hospital Formulary Service. AHFS Drug Information. American Society of Health-System Pharmacists, Bethesda, MD. 2007.

    ... Pharmacokinetics of methocarbamol were studied in eight healthy, adult horses after intravenous (iv) and oral administration of large dosages. ... Plasma methocarbamol concentration declined very rapidly during the initial or rapid disposition phase after iv administration; the terminal elimination half-life ranged from 59 to 90 mins. ...

    PMID:9109959 Muir W, Sams R et al; Equine Vet J Suppl (11): 41-4 (1992)

    /Investigators/ determined plasma methocarbamol concentrations over 24 hr following a 1.5 g methocarbamol dose (off-dialysis day) to 8 chronic hemodialysis patients and compared these results to those from 17 healthy male volunteers. The harmonic mean elimination half-life was similar between the two groups, 1.24 and 1.14 hr, respectively. ...

    PMID:2253675 Sica D, Comstock T et al; Eur J Clin Pharmacol 39 (2): 193-4 (1990)

    ... Pharmacokinetics of methocarbamol were studied in eight healthy, adult horses after intravenous (iv) and oral administration of large dosages. ... Plasma methocarbamol concentration declined very rapidly during the initial or rapid disposition phase after iv administration; the terminal elimination half-life ranged from 59 to 90 mins. ...

    PMID:9109959 Muir W, Sams R et al; Equine Vet J Suppl (11): 41-4 (1992)

    5.8 Mechanism of Action

    The mechanism of action of methocarbamol is thought to be dependant on its central nervous system depressant activity. This action may be mediated through blocking spinal polysynaptic reflexes, decreasing nerve transmission in spinal and supraspinal polysynaptic pathways, and prolonging the refractory period of muscle cells. Methocarbamol has been found to have no effect on contraction of muscle fibres, motor end plates, or nerve fibres.

    Precise mechanism of action has not been determined. These agents act in the central nervous system (CNS) rather than directly on skeletal muscle. Several of these medications have been shown to depress polysynaptic reflexes preferentially. The muscle relaxant effects of most of these agents may be related to their CNS depressant (sedative) effects. /Skeletal Muscle Relaxants/

    Thomson/Micromedex. Drug Information for the Health Care Professional. Volume 1, Greenwood Village, CO. 2007., p. 2625

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OF","selfForZScoreResived":"Pharma Grade","supplierPort":"HO CHI MINH CITY","supplierAddress":"COMPANY 27 NGUYEN CHI THANH STREETWARD 9 TRA VINH CITY TRA VINH PROVINCE VIETNAM, DEMOCRATIC REP.","customerAddress":"Shop No.L-9, Durvas CHS,Yashwant Viva Township,"}]
    20-Jan-2021
    12-Aug-2024
    KGS
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    DOSAGE - TABLET;ORAL - 500MG **Federal Regist...DOSAGE - TABLET;ORAL - 500MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

    USFDA APPLICATION NUMBER - 11011

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    DOSAGE - TABLET;ORAL - 750MG **Federal Regist...DOSAGE - TABLET;ORAL - 750MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

    USFDA APPLICATION NUMBER - 11011

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