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26 API Suppliers, 6 USDMF, 5 EU WC, 2 KDMF, 4 NDC API, 20 Listed Suppliers, $ API Reference Price

26 API Suppliers
6 USDMF
5 EU WC
2 KDMF
4 NDC API
20 Listed Suppliers
$ API Reference Price

DEVELOPMENTS

35 Drugs in Development

35 Drugs in Development

INTERMEDIATES

19 Intermediates Suppliers

19 Intermediates Suppliers

FINISHED DOSAGE FORMULATIONS

40 FDF Dossiers, 6 FDA Orange Book, 22 Europe, 2 Canada, 4 Australia, 2 South Africa, 4 Listed Dossiers

40 FDF Dossiers
6 FDA Orange Book
22 Europe
2 Canada
4 Australia
2 South Africa
4 Listed Dossiers

RELATED EXCIPIENT COMPANIES

1 SPI Pharma, 2 DKSH, 1 Jai Radhe Sales, 9 Gangwal Healthcare, 1 Nanjing Well Pharmaceutical, 4 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd, 1 BASF, 5 DFE Pharma, 4 Gangwal Chemicals, 1 Ideal Cures Pvt Ltd, 1 Ingredion Pharma Solutions, 17 Kerry, 9 Microlex e.U, 1 Pharmatrans-Sanaq, 3 Pluviaendo, 3 Prachin Chemical, 10 Roquette, 3 Shanghai Shenmei Pharmaceutical Technology Co., Ltd, 10 Sigachi Industries, 3 Vasa Pharmachem

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excipientsByApplications
41 Fillers, Diluents & Binders
19 Direct Compression
14 Disintegrants & Superdisintegrants
11 Co-Processed Excipients
10 Granulation
10 Lubricants & Glidants
10 Thickeners and Stabilizers
7 Coating Systems & Additives
4 Film Formers & Plasticizers
4 Controlled & Modified Release
3 Taste Masking
2 Coloring Agents
2 Rheology Modifiers
2 Chewable & Orodispersible Aids
1 Emulsifying Agents
1 Parenteral

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2 DATA COMPILATION #PharmaFlow, 70 NEWS #PharmaBuzz

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2 DATA COMPILATION #PharmaFlow
70 NEWS #PharmaBuzz

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1 US Medicaid Prescriptions, 15 Finished Drug Prices, 1 Annual Reports

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1 US Medicaid Prescriptions
15 Finished Drug Prices
1 Annual Reports

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6 APIs

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6 APIs

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patents
16 US Patents
8 Health Canada Patents

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1 Others

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1 Others

Synopsis

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JDMF

EU WC

KDMF

NDC API

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Listed Suppliers

API REF. PRICE (USD/KG)

$ 453,498

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API

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19INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

35DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

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US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

417,577,746

Annual Reports (USD Million)

1,036

Finished Drug Prices

89 RELATED EXCIPIENT COMPANIES

141EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: 319460-85-0, Ag-013736, Inlyta, Ag 013736, (e)-n-methyl-2-((3-(2-(pyridin-2-yl)vinyl)-1h-indazol-6-yl)thio)benzamide, Ag-13736

Molecular Formula

C₂₂H₁₈N₄OS

Molecular Weight

386.5 g/mol

InChI Key

RITAVMQDGBJQJZ-FMIVXFBMSA-N

FDA UNII

C9LVQ0YUXG

A benzamide and indazole derivative that acts as a TYROSINE KINASE inhibitor of the VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR. It is used in the treatment of advanced RENAL CELL CARCINOMA.

Axitinib is a Kinase Inhibitor. The mechanism of action of axitinib is as a Receptor Tyrosine Kinase Inhibitor.

1 2D Structure

Axitinib

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

N-methyl-2-[[3-[(E)-2-pyridin-2-ylethenyl]-1H-indazol-6-yl]sulfanyl]benzamide

2.1.2 InChI

InChI=1S/C22H18N4OS/c1-23-22(27)18-7-2-3-8-21(18)28-16-10-11-17-19(25-26-20(17)14-16)12-9-15-6-4-5-13-24-15/h2-14H,1H3,(H,23,27)(H,25,26)/b12-9+

2.1.3 InChI Key

RITAVMQDGBJQJZ-FMIVXFBMSA-N

2.1.4 Canonical SMILES

CNC(=O)C1=CC=CC=C1SC2=CC3=C(C=C2)C(=NN3)C=CC4=CC=CC=N4

2.1.5 Isomeric SMILES

CNC(=O)C1=CC=CC=C1SC2=CC3=C(C=C2)C(=NN3)/C=C/C4=CC=CC=N4

2.2 Other Identifiers

2.2.1 UNII

C9LVQ0YUXG

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Ag 013736

2. Ag-013736

3. Ag013736

4. Inlyta

2.3.2 Depositor-Supplied Synonyms

1. 319460-85-0

2. Ag-013736

3. Inlyta

4. Ag 013736

5. (e)-n-methyl-2-((3-(2-(pyridin-2-yl)vinyl)-1h-indazol-6-yl)thio)benzamide

6. Ag-13736

7. Ag013736

8. C9lvq0yuxg

9. N-methyl-2-((3-((1e)-2-(pyridin-2-yl)ethenyl)-1h-indazol-6-yl)sulfanyl)benzamide

10. Nsc-757441

11. Chebi:66910

12. (e)-n-methyl-2-(3-(2-(pyridin-2-yl)vinyl)-1h-indazol-6-ylthio)benzamide

13. N-methyl-2-[[3-[(e)-2-pyridin-2-ylethenyl]-1h-indazol-6-yl]sulfanyl]benzamide

14. Nsc757441

15. N-methyl-2-({3-[(e)-2-(pyridin-2-yl)ethenyl]-1h-indazol-6-yl}sulfanyl)benzamide

16. Ncgc00241108-01

17. S1005

18. Dsstox_cid_28975

19. Dsstox_rid_83240

20. Dsstox_gsid_49049

21. Axitinib (ag 013736)

22. N-methyl-2-({3-[(e)-2-(pyridin-2-yl)vinyl]-1h-indazol-6-yl}sulfanyl)benzamide

23. N-methyl-2-(3-((e)-2-pyridin-2-yl-vinyl)-1h-indazol-6-ylsulfanyl)-benzamide

24. Axitinib [usan]

25. Cas-319460-85-0

26. Unii-c9lvq0yuxg

27. Axitinibum

28. Axitinib [usan:inn:jan]

29. 4agc

30. Benzamide, N-methyl-2-((3-((1e)-2-(2-pyridinyl)ethenyl)-1h-indazol-6-yl)thio)-

31. Benzamide, N-methyl-2-[[3-[(1e)-2-(2-pyridinyl)ethenyl]-1h-indazol-6-yl]thio]-

32. Inlyta (tn)

33. Mfcd09837898

34. Ag13736

35. 4ag8

36. Axitinib (jan/usan)

37. Axitinib [inn]

38. Axitinib [jan]

39. Axitinib [mi]

40. Axitinib [vandf]

41. Axitinib [mart.]

42. Ag-013736;axitinib

43. Axitinib [who-dd]

44. Axitinib,ag-013736

45. Mls006010164

46. Schembl172918

47. Axitinib [orange Book]

48. Gtpl5659

49. Axitinib, >=98% (hplc)

50. Chembl1289926

51. Dtxsid3049049

52. N-methyl-2-[[3-[2-(2-pyridinyl)ethenyl]-1h-indazol-6-yl]thio]benzamide

53. Schembl22930506

54. Bdbm25117

55. Chebi:94568

56. Ex-a337

57. Bcpp000372

58. Bcp01371

59. Zinc3816287

60. Tox21_113597

61. Nsc799341

62. Akos015902898

63. Tox21_113597_1

64. Ac-1539

65. Bcp9000345

66. Ccg-264772

67. Cs-0116

68. Db06626

69. Ks-1448

70. Nsc 757441

71. Nsc-799341

72. Benzamide, N-methyl-2-((3-((e)-2-(2-pyridinyl)ethenyl)-1h-indazol-6-yl)thio)-

73. Ncgc00241108-04

74. Ncgc00241108-06

75. Hy-10065

76. Smr002530046

77. Am20090673

78. Sw219464-1

79. D03218

80. Ab01274739-01

81. Ab01274739_02

82. 460a850

83. Sr-01000941566

84. J-502064

85. Q-200662

86. Q4830631

87. Sr-01000941566-1

88. Brd-k29905972-001-01-4

89. Brd-k29905972-001-02-2

90. Benzamide, N-methyl-2-((3-((1e)-2-(2-pyridinyl)ethenyl)-1h-indazo)-6-yl)thio)-

91. N-methyl-[[3[(1e)-2-(2-pyridinyl)ethenyl]-1h-indazol-6-yl]thio]-benzamide

92. N-methyl-2((3-((1e0-2-(pyridin-2-yl)ethenyl)-1h-inazol-6-ylsufanyl)benzamide

93. N-methyl-2-({3-[(e)-2-pyridin-2-ylethenyl]-2h-indazol-6-yl}sulfanyl)benzamide

2.4 Create Date

2006-04-29

3 Chemical and Physical Properties

Molecular Formula	C₂₂H₁₈N₄OS
Molecular Weight	386.5 g/mol
XLogP3	4.2
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	5
Exact Mass	386.12013238 g/mol
Monoisotopic Mass	386.12013238 g/mol
Topological Polar Surface Area	96 Å²
Heavy Atom Count	28
Formal Charge	0
Complexity	557
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	1
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

4 Drug and Medication Information

4.1 Drug Information

1 of 2
Drug Name	Inlyta
PubMed Health	Axitinib (By mouth)
Drug Classes	Antineoplastic Agent
Drug Label	INLYTA (axitinib) is a kinase inhibitor. Axitinib has the chemical name N-methyl-2-[3-((E)-2-pyridin-2-yl-vinyl)-1H-indazol-6-ylsulfanyl]-benzamide. The molecular formula is C22H18N4OS and the molecular weight is 386.47 Daltons. The chemical structur...
Active Ingredient	Axitinib
Dosage Form	Tablet
Route	Oral
Strength	1mg; 5mg
Market Status	Prescription
Company	Pfizer

2 of 2
Drug Name	Inlyta
PubMed Health	Axitinib (By mouth)
Drug Classes	Antineoplastic Agent
Drug Label	INLYTA (axitinib) is a kinase inhibitor. Axitinib has the chemical name N-methyl-2-[3-((E)-2-pyridin-2-yl-vinyl)-1H-indazol-6-ylsulfanyl]-benzamide. The molecular formula is C22H18N4OS and the molecular weight is 386.47 Daltons. The chemical structur...
Active Ingredient	Axitinib
Dosage Form	Tablet
Route	Oral
Strength	1mg; 5mg
Market Status	Prescription
Company	Pfizer

4.2 Drug Indication

Used in kidney cell cancer and investigated for use/treatment in pancreatic and thyroid cancer.

FDA Label

Inlyta is indicated for the treatment of adult patients with advanced renal cell carcinoma (RCC) after failure of prior treatment with sunitinib or a cytokine.

5 Pharmacology and Biochemistry

5.1 Pharmacology

Axitinib prevents the progression of cancer by inhibiting angiogenesis and blocking tumor growth.

5.2 MeSH Pharmacological Classification

Antineoplastic Agents

Substances that inhibit or prevent the proliferation of NEOPLASMS. (See all compounds classified as Antineoplastic Agents.)

Protein Kinase Inhibitors

Agents that inhibit PROTEIN KINASES. (See all compounds classified as Protein Kinase Inhibitors.)

5.3 FDA Pharmacological Classification

5.3.1 Active Moiety

AXITINIB

5.3.2 FDA UNII

C9LVQ0YUXG

5.3.3 Pharmacological Classes

Receptor Tyrosine Kinase Inhibitors [MoA]; Kinase Inhibitor [EPC]

5.4 ATC Code

L01EK01

L01XE17

S76 | LUXPHARMA | Pharmaceuticals Marketed in Luxembourg | Pharmaceuticals marketed in Luxembourg, as published by d'Gesondheetskeess (CNS, la caisse nationale de sante, www.cns.lu), mapped by name to structures using CompTox by R. Singh et al. (in prep.). List downloaded from https://cns.public.lu/en/legislations/textes-coordonnes/liste-med-comm.html. Dataset DOI:10.5281/zenodo.4587355

L - Antineoplastic and immunomodulating agents

L01 - Antineoplastic agents

L01E - Protein kinase inhibitors

L01EK - Vascular endothelial growth factor receptor (vegfr) tyrosine kinase inhibitors

L01EK01 - Axitinib

5.5 Absorption, Distribution and Excretion

Absorption

After one 5 mg dose of axitinib, it takes about 2.5 to 4.1 hours to reach maximum plasma concentration.

Route of Elimination

Axitinib is mainly eliminated unchanged in the feces (41%) with 12% of the original dose as unchanged axitinib. There is also 23% eliminated in the urine, most of which are metabolites.

Volume of Distribution

The volume of distribution is 160 L.

Clearance

The average clearance of axitinib is 38 L/h.

5.6 Metabolism/Metabolites

Axitinib undergoes mainly hepatic metabolism. CYP3A4 and CYP3A5 are the main hepatic enzymes while CYP1A2, CYP2C19, and UGT1A1 enzymes are secondary.

5.7 Biological Half-Life

Axitinib has a half life of 2.5 to 6.1 hours.

5.8 Mechanism of Action

Axitinib selectively blocks the tyrosine kinase receptors VEGFR-1 (vascular endothelial growth factor receptor), VEGFR-2, and VEGFR-3.

API SUPPLIERS

01

LGM Pharma

U.S.A

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Contract Pharma 2024

Booth #134

LGM Pharma accelerates & optimizes the new product pathway from early development through commercialization.

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USDMF CEP/COS JDMF EU-WC NDC KDMF VMF Others AUDIT

02

Shilpa Medicare

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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01

Alembic Pharmaceuticals Limited

India

India

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API Reference Price

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Number of Transactions

Total Quantity (KGS)

Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

Importing Country	Total Quantity (KGS)	Average Price (USD/KGS)	Number of Transactions

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List of Related Excipient Companies and Suppliers of DSSTox_CID_28975 by Anhui Sunhere Pharmaceutical Excipients Coltd on PharmaCompass.com

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ACTIVE PHARMA INGREDIENTS

26 API Suppliers

6 USDMF

5 EU WC

2 KDMF

4 NDC API

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$ API Reference Price

DEVELOPMENTS

35 Drugs in Development

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RELATED EXCIPIENT COMPANIES

1 SPI Pharma

2 DKSH

1 Jai Radhe Sales

9 Gangwal Healthcare

1 Nanjing Well Pharmaceutical

4 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd

1 BASF

5 DFE Pharma

4 Gangwal Chemicals

1 Ideal Cures Pvt Ltd

1 Ingredion Pharma Solutions

17 Kerry

9 Microlex e.U

1 Pharmatrans-Sanaq

3 Pluviaendo

3 Prachin Chemical

10 Roquette

3 Shanghai Shenmei Pharmaceutical Technology Co., Ltd

10 Sigachi Industries

3 Vasa Pharmachem

EXCIPIENTS BY APPLICATIONS

41 Fillers, Diluents & Binders

19 Direct Compression

14 Disintegrants & Superdisintegrants

11 Co-Processed Excipients

10 Granulation

10 Lubricants & Glidants

10 Thickeners and Stabilizers

7 Coating Systems & Additives

4 Film Formers & Plasticizers

4 Controlled & Modified Release

3 Taste Masking

2 Coloring Agents

2 Rheology Modifiers

2 Chewable & Orodispersible Aids

1 Emulsifying Agents

1 Parenteral

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70 NEWS #PharmaBuzz

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1 US Medicaid Prescriptions

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1 Annual Reports

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6 APIs

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16 US Patents

8 Health Canada Patents

REF. STANDARDS & IMPURITIES

1 Others

ACTIVE PHARMA INGREDIENTS

API REF. PRICE (USD/KG)

$ 453,498