All Manufacturers, Suppliers, Distributors and Exporters of Dihydrocodeine Bitartrate with Listed Dossiers of Finished Dosage Form listed on PharmaCompass.com

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Chemistry

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Also known as: 5965-13-9, Df 118, Codeine, dihydro-, tartrate (1:1), 8lxs95bsa9, Tuscodin, Dihydrocodeine bitartrate [usp]
Molecular Formula
C22H29NO9
Molecular Weight
451.5  g/mol
InChI Key
ZGSZBVAEVPSPFM-HYTSPMEMSA-N
FDA UNII
8LXS95BSA9

Dihydrocodeine Tartrate
Dihydrocodeine Bitartrate is a synthetic opioid analgesic. Dihydrocodeine bitartrate mimics the actions of the endogenous opioid peptides due to its agonistic effects on the opioid receptors. Stimulation of the mu receptors produces the typical narcotic effects of analgesia, miosis, euphoria, respiratory depression, sedation, physical dependence and bradycardia. Dihydrocodeine bitartrate is twice as potent as codeine and has one third of the potency of morphine. This analgesic is used for the relief of moderate to moderately severe pain.
1 2D Structure

Dihydrocodeine Tartrate

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(4R,4aR,7S,7aR,12bS)-9-methoxy-3-methyl-2,4,4a,5,6,7,7a,13-octahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-ol;(2R,3R)-2,3-dihydroxybutanedioic acid
2.1.2 InChI
InChI=1S/C18H23NO3.C4H6O6/c1-19-8-7-18-11-4-5-13(20)17(18)22-16-14(21-2)6-3-10(15(16)18)9-12(11)19;5-1(3(7)8)2(6)4(9)10/h3,6,11-13,17,20H,4-5,7-9H2,1-2H3;1-2,5-6H,(H,7,8)(H,9,10)/t11-,12+,13-,17-,18-;1-,2-/m01/s1
2.1.3 InChI Key
ZGSZBVAEVPSPFM-HYTSPMEMSA-N
2.1.4 Canonical SMILES
CN1CCC23C4C1CC5=C2C(=C(C=C5)OC)OC3C(CC4)O.C(C(C(=O)O)O)(C(=O)O)O
2.1.5 Isomeric SMILES
CN1CC[C@]23[C@@H]4[C@H]1CC5=C2C(=C(C=C5)OC)O[C@H]3[C@H](CC4)O.[C@@H]([C@H](C(=O)O)O)(C(=O)O)O
2.2 Other Identifiers
2.2.1 UNII
8LXS95BSA9
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Contugesic

2. Df 118

3. Dhc Continus

4. Dhc Mundipharma

5. Dicodin

6. Dihydrocodeine

7. Dihydrocodeine Acetate, (5alpha,6alpha)-isomer

8. Dihydrocodeine Hydrochloride, (5alpha,6alpha)-isomer

9. Dihydrocodeine Phosphate (1:1), (5alpha,6alpha)-isomer

10. Dihydrocodeine Tartrate (1:1), (5alpha,6alpha)-(r-(r*,r*))-isomer

11. Dihydrocodeine Tartrate (1:1), (5alpha,6beta)-(r-(r*,r*))-isomer

12. Dihydrocodeine, (5alpha,6alpha,14alpha)-isomer

13. Dihydrocodeine, (5alpha,6beta)-isomer

14. Dihydrocodeine, (5alpha,6beta,14alpha)-isomer

15. Dihydrocodeine, Thiocyanate Salt (5alpha,6alpha)-isomer

16. Paracodin

17. Paracodina

18. Paramol 118

19. Rikodeine

20. Tiamon

21. Tosidrin

2.3.2 Depositor-Supplied Synonyms

1. 5965-13-9

2. Df 118

3. Codeine, Dihydro-, Tartrate (1:1)

4. 8lxs95bsa9

5. Tuscodin

6. Dihydrocodeine Bitartrate [usp]

7. Paracodeine Bitartrate

8. Dihydrocodeine Tartrate

9. Dihydrocodeine Acid Tartrate

10. Dihydrocodeine Hydrogen Tartrate

11. Dihydrocodeine Bitartrate (usp)

12. Unii-8lxs95bsa9

13. Nsc-117857

14. (4r,4ar,7s,7ar,12bs)-9-methoxy-3-methyl-2,4,4a,5,6,7,7a,13-octahydro-1h-4,12-methanobenzofuro[3,2-e]isoquinoline-7-ol;(2r,3r)-2,3-dihydroxybutanedioic Acid

15. Einecs 227-747-7

16. Nsc 117857

17. Dtxsid00975047

18. Dihydrocodeine Tartrate [mi]

19. Dihydrocodeine Tartrate [mart.]

20. Dihydrocodeine Bitartrate [vandf]

21. Dihydrocodeine Bitartrate [usp-rs]

22. Dihydrocodeine Bitartrate [who-dd]

23. D03825

24. Dihydrocodeine Bitartrate [orange Book]

25. Dihydrocodeine Bitartrate [usp Monograph]

26. Trezix Component Dihydrocodeine Bitartrate

27. Dhc Plus Component Dihydrocodeine Bitartrate

28. Dihydrocodeine Bitartrate Component Of Dhc Plus

29. Dihydrocodeine Hydrogen Tartrate [ep Monograph]

30. Q27270730

31. Synalgos-dc Component Dihydrocodeine Bitartrate

32. Dihydrocodeine Bitartrate Component Of Synalgos-dc

33. Synalgos-dc-a Component Dihydrocodeine Bitartrate

34. Dihydrocodeine Bitartrate Component Of Synalgos-dc-a

35. 4,5.alpha.-epoxy-3-methoxy-17-methylmorphinan-6a-ol (+)-tartrate (salt)

36. 4,5alpha-epoxy-6alpha-hydroxy-3-methoxy-17-methylmorphinan Hydrogen (r-(r*,r*))-tartrate

37. Morphinan-6-alpha-ol, 4,5-alpha-epoxy-3-methoxy-17-methyl-, Tartrate (1:1)

38. Morphinan-6alpha-ol, 4,5alpha-epoxy-3-methoxy-17-methyl-, Tartrate (1:1) (salt)

39. (4r,4ar,7s,7ar,12bs)-9-methoxy-3-methyl-2,4,4a,5,6,7,7a,13-octahydro-1h-4,12-methanobenzofuro[3,2-e]isoquinolin-7-ol;(2r,3r)-2,3-dihydroxybutanedioic Acid

40. Morphinan-6-ol, 4,5-epoxy-3-methoxy-17-methyl-, (5.alpha.,6.alpha.)-2,3-dihydroxybutanedioate (1:1) (salt)

41. Morphinan-6-ol, 4,5-epoxy-3-methoxy-17-methyl-, (5alpha,6alpha)-, (r-(r*,r*))-2,3-dihydroxybutanedioate (1:1) (salt)

2.4 Create Date
2005-08-09
3 Chemical and Physical Properties
Molecular Weight 451.5 g/mol
Molecular Formula C22H29NO9
Hydrogen Bond Donor Count5
Hydrogen Bond Acceptor Count10
Rotatable Bond Count4
Exact Mass451.18423150 g/mol
Monoisotopic Mass451.18423150 g/mol
Topological Polar Surface Area157 Ų
Heavy Atom Count32
Formal Charge0
Complexity605
Isotope Atom Count0
Defined Atom Stereocenter Count7
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Analgesics, Opioid

Compounds with activity like OPIATE ALKALOIDS, acting at OPIOID RECEPTORS. Properties include induction of ANALGESIA or NARCOSIS. (See all compounds classified as Analgesics, Opioid.)


API SUPPLIERS

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01

Veranova

U.S.A

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

  • fda
  • EDQM
  • WHO-GMP

Virtual BoothVeranova: A CDMO that manages complexity with confidence.

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Veranova

02

Parand Darou Pharma

Iran

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

  • fda
  • EDQM
  • WHO-GMP

Virtual BoothParand Darou is a knowledge-based company, focused on the production of Narcotic APIs.

Flag Iran
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USDMF CEP/COS JDMF EU-WC NDC KDMF VMF Others AUDIT
Parand Darou Pharma

03

Mallinckrodt Pharmaceuticals

Ireland

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

BioProcess International
Not Confirmed
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Mallinckrodt Pharmaceuticals

Ireland

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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04

Chattem Chemicals, Inc

U.S.A

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

BioProcess International
Not Confirmed
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Chattem Chemicals, Inc

U.S.A

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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05

DMFs Not Supported

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06

Siegfried AG

Switzerland

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BioProcess International
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Siegfried AG

Switzerland

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07

Saneca Pharmaceuticals

Slovakia

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BioProcess International
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Saneca Pharmaceuticals

Slovakia

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08

Alkaloida Chemical Company Zrt

Hungary

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BioProcess International
Not Confirmed
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Alkaloida Chemical Company Zrt

Hungary

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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Not Confirmed
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09

Kimyagaran

Iran

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

BioProcess International
Not Confirmed
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10

SALARAS

Italy

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

BioProcess International
Not Confirmed
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SALARAS

Italy

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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API Reference Price

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[{"dataSource":"API Import","activeIngredients":"","year":"2022","qtr":"Q3","strtotime":1657650600,"product":"DIHYDROCODEINE TARTRATE(DIHYDROCODEINE BITARTRATE) (CBN CERTNO. IMP-81\/2022 DT.15.06.2022)","address":"SANOFI HOUSE,CTS NO.117-B, L&T BUSINESS PARK,SAKI VIHAR RD, POWAI","city":"MUMBAI","supplier":"WOOD & COMPANY FINANCIAL SERVICES","supplierCountry":"SLOVAKIA","foreign_port":"NA","customer":"SANOFI","customerCountry":"INDIA","quantity":"50.00","actualQuantity":"50","unit":"KGS","unitRateFc":"475","totalValueFC":"24536.6","currency":"EUR","unitRateINR":"39021.3","date":"13-Jul-2022","totalValueINR":"1951062.5","totalValueInUsd":"24536.6","indian_port":"BOMBAY AIR","hs_no":"29391100","bill_no":"9532683","productDescription":"API","marketType":"REGULATED MARKET","country":"SLOVAK REPUBLIC","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"SANOFI HOUSE,CTS NO.117-B, L&T BUSINESS PARK,SAKI VIHAR RD, POWAI"},{"dataSource":"API Import","activeIngredients":"","year":"2022","qtr":"Q4","strtotime":1666204200,"product":"DIHYDROCODEINE TARTRATE, CAS NO: 5965-13-9, B NO: 5080522, CBN NO N-IMP-115\/2022 DT 01\/08\/22, QUOTA NO ND-193\/2022 DT 06","address":"PLOT NO 58- D GOVT. INDUSTRIAL ESTA CHARKOP KANDIVALI","city":"MUMBAI","supplier":"WOOD & COMPANY FINANCIAL SERVICES","supplierCountry":"SLOVAKIA","foreign_port":"NA","customer":"RUSAN PHARMA","customerCountry":"INDIA","quantity":"0.50","actualQuantity":"0.5","unit":"KGS","unitRateFc":"485","totalValueFC":"242.8","currency":"EUR","unitRateINR":"39964","date":"20-Oct-2022","totalValueINR":"19982","totalValueInUsd":"242.8","indian_port":"BOMBAY AIR","hs_no":"29391100","bill_no":"2972013","productDescription":"API","marketType":"REGULATED MARKET","country":"SLOVAK REPUBLIC","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"PLOT NO 58- D GOVT. INDUSTRIAL ESTA CHARKOP KANDIVALI"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q3","strtotime":1691605800,"product":"DIHYDROCODEINE TARTRATE BATCH F23070071","address":"NEELAM CENTRE, B WING, 4TH FLOOR ,,HIND CYCLE ROAD, WORLI,","city":"MUMBAI","supplier":"WELDING GMBH CO","supplierCountry":"ITALY","foreign_port":"NA","customer":"J B CHEMICALS PHARMACEUTICALS LIMITED","customerCountry":"INDIA","quantity":"35.00","actualQuantity":"35","unit":"KGS","unitRateFc":"550","totalValueFC":"19319.6","currency":"USD","unitRateINR":"45429.2","date":"10-Aug-2023","totalValueINR":"1606081.4","totalValueInUsd":"19319.6","indian_port":"SAHAR AIR","hs_no":"29415000","bill_no":"0","productDescription":"API","marketType":"REGULATED MARKET","country":"ITALY","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"NEELAM CENTRE, B WING, 4TH FLOOR ,,HIND CYCLE ROAD, WORLI,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1723141800,"product":"DIHYDROCODEINE TARTRATE (CBN CERTIFICATE NO. IMP-84\/2024 DT24\/06\/2024)","address":"A-802, CRESCENZO, C\/38-39,,G-BLOCK","city":"MUMBAI,MAHARASHTRA","supplier":"WOOD & COMPANY FINANCIAL SERVICES","supplierCountry":"SLOVAKIA","foreign_port":"BRATISLAVA","customer":"ZENTIVA","customerCountry":"INDIA","quantity":"67.60","actualQuantity":"67.6","unit":"KGS","unitRateFc":"580","totalValueFC":"43555.2","currency":"EUR","unitRateINR":"53505","date":"09-Aug-2024","totalValueINR":"3616938","totalValueInUsd":"43555.2","indian_port":"Bombay Air","hs_no":"29391100","bill_no":"4966775","productDescription":"API","marketType":"REGULATED MARKET","country":"SLOVAKIA","selfForZScoreResived":"Pharma Grade","supplierPort":"BRATISLAVA","supplierAddress":"NITRINSKA 100 920 27 HLOHOVEC Hlohovec, , SLOVAK REPUBLICSDNF SLOVAK REPUBLIC","customerAddress":"A-802, CRESCENZO, C\/38-39,,G-BLOCK"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1723141800,"product":"DIHYDROCODEINE TARTRATE (CBN CERTIFICATE NO. IMP-84\/2024 DT24\/06\/2024)","address":"A-802, CRESCENZO, C\/38-39,,G-BLOCK","city":"MUMBAI,MAHARASHTRA","supplier":"WOOD & COMPANY FINANCIAL SERVICES","supplierCountry":"SLOVAKIA","foreign_port":"BRATISLAVA","customer":"ZENTIVA","customerCountry":"INDIA","quantity":"269.00","actualQuantity":"269","unit":"KGS","unitRateFc":"580","totalValueFC":"173318.6","currency":"EUR","unitRateINR":"53505","date":"09-Aug-2024","totalValueINR":"14392845","totalValueInUsd":"173318.6","indian_port":"Bombay Air","hs_no":"29391100","bill_no":"4966775","productDescription":"API","marketType":"REGULATED MARKET","country":"SLOVAKIA","selfForZScoreResived":"Pharma Grade","supplierPort":"BRATISLAVA","supplierAddress":"NITRINSKA 100 920 27 HLOHOVEC Hlohovec, , SLOVAK REPUBLICSDNF SLOVAK REPUBLIC","customerAddress":"A-802, CRESCENZO, C\/38-39,,G-BLOCK"}]
13-Jul-2022
09-Aug-2024
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