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Chloroquine Phosphate

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ACTIVE PHARMA INGREDIENTS

18 API Suppliers, 6 USDMF, 1 CEP/COS, 6 EU WC, 4 NDC API, 12 Listed Suppliers, $ API Reference Price

18 API Suppliers
6 USDMF
1 CEP/COS
6 EU WC
4 NDC API
12 Listed Suppliers
$ API Reference Price

DEVELOPMENTS

3 Drugs in Development

3 Drugs in Development

INTERMEDIATES

1 Intermediates Suppliers

1 Intermediates Suppliers

FINISHED DOSAGE FORMULATIONS

51 FDF Dossiers, 16 FDA Orange Book, 5 Europe, 5 South Africa, 25 Listed Dossiers

51 FDF Dossiers
16 FDA Orange Book
5 Europe
5 South Africa
25 Listed Dossiers

RELATED EXCIPIENT COMPANIES

4 SPI Pharma, 2 Seqens, 3 DKSH, 1 Jai Radhe Sales, 4 Boai NKY Pharmaceuticals Ltd, 12 Gangwal Healthcare, 4 Nanjing Well Pharmaceutical, 1 ACG Worldwide, 5 Actylis, 1 Aeon Procare, 7 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd, 18 BASF, 1 Clariant, 10 Corel Pharma Chem, 5 DFE Pharma, 1 Finar, 11 Gangwal Chemicals, 5 Ideal Cures Pvt Ltd, 3 Ingredion Pharma Solutions, 29 Kerry, 3 Kima Chemical, 6 Lonza Capsugel, 13 Microlex e.U, 1 Nanjing Bold Chemical, 2 Nomisma Healthcare, 2 Novo Excipients, 3 Pharmatrans-Sanaq, 4 Pluviaendo, 3 Prachin Chemical, 1 Qianhao Chemical (Hebei) Co., Ltd, 1 Qualicaps, 18 Roquette, 13 Seppic, 6 Shanghai Shenmei Pharmaceutical Technology Co., Ltd, 1 Shanghai Welltone Material Technology Co., Ltd, 11 Sigachi Industries, 2 The Dow Chemical Company, 2 Ulanqab Kema New Material, 4 Vasa Pharmachem

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DIGITAL CONTENT

6 DATA COMPILATION #PharmaFlow, 1 STOCK RECAP #PipelineProspector, 74 NEWS #PharmaBuzz

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6 DATA COMPILATION #PharmaFlow
1 STOCK RECAP #PipelineProspector
74 NEWS #PharmaBuzz

GLOBAL SALES INFORMATION

1 US Medicaid Prescriptions, 1 Finished Drug Prices, 1 Annual Reports

globalSalesInformation
1 US Medicaid Prescriptions
1 Finished Drug Prices
1 Annual Reports

MARKET PLACE

23 APIs, 5 FDF Dossiers

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23 APIs
5 FDF Dossiers

REF. STANDARDS & IMPURITIES

1 EDQM , 6 USP , 6 Others

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1 EDQM
6 USP
6 Others

ANALYTICAL

1 Analytical Methods

otherMethods
1 Analytical Methods

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

$ 30

MARKET PLACE

API

FDF

1INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

3DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

653,430

Annual Reports (USD Million)

Finished Drug Prices

223 RELATED EXCIPIENT COMPANIES

376EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: Chloroquine diphosphate, 50-63-5, Resochin, Arechin, Aralen phosphate, Chingamin phosphate

Molecular Formula

C₁₈H₃₂ClN₃O₈P₂

Molecular Weight

515.9 g/mol

InChI Key

QKICWELGRMTQCR-UHFFFAOYSA-N

FDA UNII

6E17K3343P

Chloroquine Phosphate is the phosphate salt of chloroquine, a quinoline compound with antimalarial and anti-inflammatory properties. Chloroquine is the most widely used drug against malaria, except for those cases caused by chloroquine resistant Plasmodium falciparum. Although the mechanism of action is not fully understood, chloroquine is shown to inhibit the parasitic enzyme heme polymerase that converts the toxic heme into non-toxic hemazoin, thereby resulting in the accumulation of toxic heme within the parasite. Chloroquine may also interfere with the biosynthesis of nucleic acids.

1 2D Structure

Chloroquine Phosphate

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

4-N-(7-chloroquinolin-4-yl)-1-N,1-N-diethylpentane-1,4-diamine;phosphoric acid

2.1.2 InChI

InChI=1S/C18H26ClN3.2H3O4P/c1-4-22(5-2)12-6-7-14(3)21-17-10-11-20-18-13-15(19)8-9-16(17)18;2*1-5(2,3)4/h8-11,13-14H,4-7,12H2,1-3H3,(H,20,21);2*(H3,1,2,3,4)

2.1.3 InChI Key

QKICWELGRMTQCR-UHFFFAOYSA-N

2.1.4 Canonical SMILES

CCN(CC)CCCC(C)NC1=C2C=CC(=CC2=NC=C1)Cl.OP(=O)(O)O.OP(=O)(O)O

2.2 Other Identifiers

2.2.1 UNII

6E17K3343P

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Arechin

2. Chingamin Phosphate

3. Chloroquine Bis(dihydrogenphosphate) Dihydrate

4. Chloroquine Diphosphate

5. Chloroquine Diphosphate, (+)-isomer

6. Chloroquine Diphosphate, (+-)-isomer

7. Chloroquine Diphosphate, (-)-isomer

8. Delagil

9. Khingamin Phosphate

10. N(4)-(7-chloro-4-quinolinyl)-n(1),n(1)-diethyl-1,4-pentanediamine, Phosphate (1:2)

11. Resochin

12. Unspecified Phosphate Of Chloroquine Diphosphate

2.3.2 Depositor-Supplied Synonyms

1. Chloroquine Diphosphate

2. 50-63-5

3. Resochin

4. Arechin

5. Aralen Phosphate

6. Chingamin Phosphate

7. Chloroquine Bis(phosphate)

8. Chloroquine Diphosphate Salt

9. Avloclor

10. Delagil

11. Chloroquine (phosphate)

12. Khingamin

13. Miniquine

14. Tanakan

15. Tanakene

16. Aralen Diphosphate

17. Gontochin Phosphate

18. N4-(7-chloroquinolin-4-yl)-n1,n1-diethylpentane-1,4-diamine Bis(phosphate)

19. Chloroquin Diphosphate

20. Nsc 14050

21. Ipsen 225

22. Chloroquinediphosphate

23. Mfcd00069852

24. 3377 Rp

25. 50-63-5 (diphosphate)

26. Sn 7,618

27. Nsc-14050

28. 6e17k3343p

29. Sn-7618

30. Wr-1522

31. Chingaminum

32. Alermine

33. H-stadur

34. Dsstox_cid_24681

35. Dsstox_rid_80393

36. Dsstox_gsid_44681

37. 1,4-pentanediamine, N(sup 4)-(7-chloro-4-quinolinyl)-n(sup 1),n(sup 1)-diethyl-, Phosphate (1:2)

38. Chlorochin Diphosphate

39. Tanakan (antimalarial)

40. 4-n-(7-chloroquinolin-4-yl)-1-n,1-n-diethylpentane-1,4-diamine;phosphoric Acid

41. Dl-chloroquine Diphosphate

42. Ccris 1554

43. Sr-01000075548

44. Einecs 200-055-2

45. Wr 1522

46. Chloroquine Dihydrogen Phosphate (1:2)

47. Unikinon

48. Ai3-14952

49. Unii-6e17k3343p

50. Chloroquine Phosphate [usp:ban]

51. Chloroquindiphosphat

52. Chloroquini Phosphas

53. Prestwick_867

54. Aralen (tn)

55. Cas-50-63-5

56. Ncgc00015256-01

57. 7-chlor-4-(4-(diaethylamino)-1-methylbutylamino)-chinolindiphosphat [german]

58. 7-chloro-4-((4-(diethylamino)-1-methylbutyl)amino)quinoline Phosphate (1:2)

59. N4-(7-chloro-4-quinolinyl)-n1,n1-dimethyl-1,4-pentanediamine Diphosphate Salt

60. Chloroquine Diphosphate,(s)

61. 1,4-pentanediamine, N4-(7-chloro-4-quinolinyl)-n1,n1-diethyl-, Phosphate (1:2)

62. N(4)-(7-chloro-4-quinolinyl)-n(1),n(1)-diethyl-1,4-pentanediamine, Phosphate (1:2)

63. 1,4-diamine Bis(phosphate)

64. Chloroquine Phosphate (usp)

65. Schembl40827

66. Chembl58510

67. Spectrum1500179

68. Chloroquine Diphosphate, Sulfate

69. Dtxsid7044681

70. Hms501e06

71. Hms1569n17

72. Hms1920o05

73. Hms2091c16

74. Hms2096n17

75. Hms3260l14

76. Hms3713n17

77. Bcp31956

78. Chloroquine Diphosphate [mi]

79. Tox21_110115

80. Tox21_202838

81. Tox21_500296

82. 7-chlor-4-(4-(diaethylamino)-1-methylbutylamino)-chinolindiphosphat

83. Ccg-39643

84. Chloroquine Phosphate [vandf]

85. S4157

86. Chloroquine Phosphate [mart.]

87. Akos004910410

88. Chloroquine Phosphate [usp-rs]

89. Chloroquine Phosphate [who-dd]

90. Chloroquine Phosphate [who-ip]

91. N4-(7-chloro-4-quinolyl)-n1,n1-diethyl-pentane-1,4-diamine; Phosphoric Acid

92. Quinoline, 7-chloro-4-(4-diethylamino-1-methyl-butylamino)-, Diphosphate

93. Tox21_110115_1

94. Cs-3811

95. Dt-0015

96. Lp00296

97. 1,4-pentanediamine, N4-(7-chloro-4-quinolinyl)-n',n'-diethyl-, (+-)-, Phosphate (1:2)

98. Quinoline, 7-chloro-4-((4-(diethylamino)-1-methylbutyl)amino)-, Phosphate (1:2)

99. Ncgc00015256-12

100. Ncgc00093746-01

101. Ncgc00093746-02

102. Ncgc00093746-03

103. Ncgc00260384-01

104. Ncgc00260981-01

105. Ac-12463

106. Chloroquine Phosphate [green Book]

107. Hy-17589

108. Sy021941

109. Chloroquine Phosphate [orange Book]

110. Chloroquine Phosphate [ep Monograph]

111. Chloroquini Phosphas [who-ip Latin]

112. Db-051808

113. Chloroquine Diphosphate Salt, Solid, >=98%

114. Chloroquine Phosphate [usp Monograph]

115. Eu-0100296

116. Ft-0602804

117. C 6628

118. D02125

119. D70732

120. 069c852

121. A828213

122. N4-(7-chloroquinolin-4-yl)-n1,n1-diethylpentane-

123. Sr-01000075548-1

124. Sr-01000075548-3

125. Sr-01000075548-5

126. Q27264629

127. F2173-1139

128. 7-chloro-4-[[4-(diethylamino)-1-methylbutyl]amino]quinoline Phosphate

129. 7-chloro-4-[4-(diethylamino)-1-methylbutylamino]quinoline Bis(phosphate)

130. 7-chloro-4-[4-(diethylamino)-1-methylbutylamino]quinoline Diphosphate

131. Chloroquine Phosphate, United States Pharmacopeia (usp) Reference Standard

132. N4-(7-chloro-4-quinolyl)-n1,n1-diethyl-1,4-pentanediamine Diphosphate

133. 7-chloro-4-((4-(diethylamino)-1-methylbutyl)amino)quinoline Phosphate (1:2).

134. Chloroquine Phosphate, Pharmaceutical Secondary Standard; Certified Reference Material

135. Chloroquine Phosphate;aralen Phosphate;7-chloro-4-((4 Inverted Exclamation Mark -diethylamino-1-methylbutyl)amino)quinolinediphosphate

2.4 Create Date

2005-06-24

3 Chemical and Physical Properties

Molecular Formula	C₁₈H₃₂ClN₃O₈P₂
Molecular Weight	515.9 g/mol
Hydrogen Bond Donor Count	7
Hydrogen Bond Acceptor Count	11
Rotatable Bond Count	8
Exact Mass	515.1353167 g/mol
Monoisotopic Mass	515.1353167 g/mol
Topological Polar Surface Area	184 Å²
Heavy Atom Count	32
Formal Charge	0
Complexity	359
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	1
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	3

4 Drug and Medication Information

4.1 Drug Information

1 of 2
Drug Name	Chloroquine phosphate
Drug Label	Chloroquine phosphate, USP is a 4-aminoquinoline compound for oral administration. It is a white crystalline powder; odorless; has a bitter taste, and is discolored slowly on exposure to light. It is freely soluble in water, practically insoluble in...
Active Ingredient	Chloroquine phosphate
Dosage Form	Tablet
Route	Oral
Strength	eq 300mg base; eq 150mg base
Market Status	Prescription
Company	Ipca Labs; Natco Pharma; Hikma Pharms; Impax Labs

2 of 2
Drug Name	Chloroquine phosphate
Drug Label	Chloroquine phosphate, USP is a 4-aminoquinoline compound for oral administration. It is a white crystalline powder; odorless; has a bitter taste, and is discolored slowly on exposure to light. It is freely soluble in water, practically insoluble in...
Active Ingredient	Chloroquine phosphate
Dosage Form	Tablet
Route	Oral
Strength	eq 300mg base; eq 150mg base
Market Status	Prescription
Company	Ipca Labs; Natco Pharma; Hikma Pharms; Impax Labs

5 Pharmacology and Biochemistry

5.1 MeSH Pharmacological Classification

Anti-Inflammatory Agents, Non-Steroidal

Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects. (See all compounds classified as Anti-Inflammatory Agents, Non-Steroidal.)

Antimalarials

Agents used in the treatment of malaria. They are usually classified on the basis of their action against plasmodia at different stages in their life cycle in the human. (From AMA, Drug Evaluations Annual, 1992, p1585) (See all compounds classified as Antimalarials.)

Filaricides

Pharmacological agents destructive to nematodes in the superfamily Filarioidea. (See all compounds classified as Filaricides.)

5.2 FDA Pharmacological Classification

5.2.1 Pharmacological Classes

Antimalarial [EPC]

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Number of Transactions

Total Quantity (KGS)

Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

Importing Country	Total Quantity (KGS)	Average Price (USD/KGS)	Number of Transactions

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List of Suppliers' Coating Systems Additives Excipients Application used in Chloroquine Phosphate on PharmaCompass.com

Chloroquine Phosphate

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CHEMISTRY

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ACTIVE PHARMA INGREDIENTS

18 API Suppliers

6 USDMF

1 CEP/COS

6 EU WC

4 NDC API

12 Listed Suppliers

$ API Reference Price

DEVELOPMENTS

3 Drugs in Development

INTERMEDIATES

1 Intermediates Suppliers

FINISHED DOSAGE FORMULATIONS

51 FDF Dossiers

16 FDA Orange Book

5 Europe

5 South Africa

25 Listed Dossiers

RELATED EXCIPIENT COMPANIES

4 SPI Pharma

2 Seqens

3 DKSH

1 Jai Radhe Sales

4 Boai NKY Pharmaceuticals Ltd

12 Gangwal Healthcare

4 Nanjing Well Pharmaceutical

1 ACG Worldwide

5 Actylis

1 Aeon Procare

7 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd

18 BASF

1 Clariant

10 Corel Pharma Chem

5 DFE Pharma

1 Finar

11 Gangwal Chemicals

5 Ideal Cures Pvt Ltd

3 Ingredion Pharma Solutions

29 Kerry

3 Kima Chemical

6 Lonza Capsugel

13 Microlex e.U

1 Nanjing Bold Chemical

2 Nomisma Healthcare

2 Novo Excipients

3 Pharmatrans-Sanaq

4 Pluviaendo

3 Prachin Chemical

1 Qianhao Chemical (Hebei) Co., Ltd

1 Qualicaps

18 Roquette

13 Seppic

6 Shanghai Shenmei Pharmaceutical Technology Co., Ltd

1 Shanghai Welltone Material Technology Co., Ltd

11 Sigachi Industries

2 The Dow Chemical Company

2 Ulanqab Kema New Material

4 Vasa Pharmachem

EXCIPIENTS BY APPLICATIONS

67 Fillers, Diluents & Binders

45 Coating Systems & Additives

32 Direct Compression

28 Controlled & Modified Release

23 Solubilizers

22 Disintegrants & Superdisintegrants

22 Thickeners and Stabilizers

20 Lubricants & Glidants

18 Granulation

17 Co-Processed Excipients

12 Film Formers & Plasticizers

12 Topical

12 Parenteral

7 Taste Masking

7 Emulsifying Agents