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    Chemistry

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    Also known as: 33386-08-2, Buspar, Buspirone hcl, Narol, Buspimen, Buspirone (hydrochloride)
    Molecular Formula
    C21H32ClN5O2
    Molecular Weight
    422.0  g/mol
    InChI Key
    RICLFGYGYQXUFH-UHFFFAOYSA-N
    FDA UNII
    207LT9J9OC
    Buspirone Hydrochloride
    An anxiolytic agent and serotonin receptor agonist belonging to the azaspirodecanedione class of compounds. Its structure is unrelated to those of the BENZODIAZAPINES, but it has an efficacy comparable to DIAZEPAM.
    1 2D Structure

    Buspirone Hydrochloride

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    8-[4-(4-pyrimidin-2-ylpiperazin-1-yl)butyl]-8-azaspiro[4.5]decane-7,9-dione;hydrochloride
    2.1.2 InChI
    InChI=1S/C21H31N5O2.ClH/c27-18-16-21(6-1-2-7-21)17-19(28)26(18)11-4-3-10-24-12-14-25(15-13-24)20-22-8-5-9-23-20;/h5,8-9H,1-4,6-7,10-17H2;1H
    2.1.3 InChI Key
    RICLFGYGYQXUFH-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    C1CCC2(C1)CC(=O)N(C(=O)C2)CCCCN3CCN(CC3)C4=NC=CC=N4.Cl
    2.2 Other Identifiers
    2.2.1 UNII
    207LT9J9OC
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Anxut

    2. Apo Buspirone

    3. Apo-buspirone

    4. Bespar

    5. Busp

    6. Buspar

    7. Buspirone

    8. Gen Buspirone

    9. Gen-buspirone

    10. Hydrochloride, Buspirone

    11. Lin Buspirone

    12. Lin-buspirone

    13. Mj 9022 1

    14. Mj-9022-1

    15. Mj90221

    16. N-(4-(4-(2-pyrimidinyl)-1-piperazinyl)butyl)-1-cyclopentanediacetamide

    17. Neurosine

    18. Novo Buspirone

    19. Novo-buspirone

    20. Nu Buspirone

    21. Nu-buspirone

    22. Pms Buspirone

    23. Pms-buspirone

    24. Ratio Buspirone

    25. Ratio-buspirone

    2.3.2 Depositor-Supplied Synonyms

    1. 33386-08-2

    2. Buspar

    3. Buspirone Hcl

    4. Narol

    5. Buspimen

    6. Buspirone (hydrochloride)

    7. Mj 9022-1

    8. 8-(4-(4-(pyrimidin-2-yl)piperazin-1-yl)butyl)-8-azaspiro[4.5]decane-7,9-dione Hydrochloride

    9. Nsc-751138

    10. Nsc-759571

    11. Mj-9022-1

    12. Mls000069796

    13. N-(4-(4-(2-pyrimidinyl)-1-piperazinyl)butyl)-1,1-cyclopentanediacetamide Monohydrochloride

    14. 207lt9j9oc

    15. Apd405

    16. Chebi:3224

    17. Apd-405

    18. Ansitec

    19. Anxinil

    20. Anxiolan

    21. Busirone

    22. Buspinol

    23. Censpar

    24. Effiplen

    25. Establix

    26. Kallmiren

    27. Lucelan

    28. Mabuson

    29. Normaton

    30. Smr000058186

    31. Spamilan

    32. Barpil

    33. Bespar

    34. Itagil

    35. Nerbet

    36. Sburol

    37. Travin

    38. Tutran

    39. Biron

    40. Relac

    41. 33386-08-2 (hcl)

    42. Apo-buspirone

    43. 8-[4-(4-pyrimidin-2-ylpiperazin-1-yl)butyl]-8-azaspiro[4.5]decane-7,9-dione;hydrochloride

    44. 8-azaspiro(4,5)decane-7,9-dione, 8-(4-(4-(2-pyrimidinyl)-1-piperazinyl)butyl)-, Monohydrochloride

    45. 8-[4-(4-pyrimidin-2-ylpiperazin-1-yl)butyl]-8-azaspiro[4.5]decane-7,9-dione Hydrochloride

    46. 8-{4-[4-(pyrimidin-2-yl)piperazin-1-yl]butyl}-8-azaspiro[4.5]decane-7,9-dione Hydrochloride

    47. Buspirone Hydrochloride [usan]

    48. Sr-01000075541

    49. Einecs 251-489-4

    50. Unii-207lt9j9oc

    51. C21h31n5o2.hcl

    52. Prestwick_711

    53. Buspirone Hydrochloride [usan:usp]

    54. Buspar (tn)

    55. Mfcd00078569

    56. Opera_id_707

    57. 1,1-cyclopentanediacetimide, N-(4-(4-(2-pyrimidinyl)-1-piperazinyl)butyl)-, Hydrochloride

    58. 8-(4-(4-(2-pyrimidinyl)-1-piperazinyl)butyl)-8-azaspiro(4.5)decane-7,9-dione Hydrochloride

    59. Schembl41495

    60. Mls001076085

    61. Mls002548862

    62. Buspirone Hydrochloride (usp)

    63. Buspirone Hydrochloride Solution

    64. Buspirone For System Suitability

    65. Chembl1200399

    66. Dtxsid1037193

    67. Hms1569i19

    68. Hms3750o03

    69. Pharmakon1600-02300173

    70. Apc-6002

    71. Apc-6003

    72. Bcp28463

    73. Hy-b1115

    74. Buspirone Hydrochloride [mi]

    75. Tox21_500223

    76. Buspirone Hydrochloride [jan]

    77. Nsc751138

    78. Nsc759571

    79. S4256

    80. Akos015962019

    81. Ac-1905

    82. Buspirone Hydrochloride [mart.]

    83. Buspirone Hydrochloride [vandf]

    84. Ccg-213652

    85. Cs-4714

    86. H05b847

    87. Ks-5163

    88. Lp00223

    89. Nc00673

    90. Nsc 751138

    91. Nsc 759571

    92. Buspirone Hydrochloride [usp-rs]

    93. Buspirone Hydrochloride [who-dd]

    94. Ncgc00093692-01

    95. Ncgc00093692-02

    96. Ncgc00260908-01

    97. 8-(4-(4-(2-pyrimidinyl)-1-piperazinyl)butyl)-8-azaspiro(4.5)decane-7,9-dione Monohydrochloride

    98. Buspirone Hydrochloride [orange Book]

    99. Eu-0100223

    100. Sw155073-5

    101. Buspirone Hydrochloride [ep Monograph]

    102. B 7148

    103. Buspirone Hydrochloride [usp Monograph]

    104. D00702

    105. D96810

    106. Q-200768

    107. Sr-01000075541-1

    108. Sr-01000075541-3

    109. Sr-01000075541-7

    110. Q27105997

    111. Buspirone Hydrochloride 1.0 Mg/ml In Methanol (as Free Base)

    112. Buspirone Hydrochloride, European Pharmacopoeia (ep) Reference Standard

    113. Buspirone Hydrochloride, United States Pharmacopeia (usp) Reference Standard

    114. 8-azaspiro[4.5]decane-7, 8-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-, Monohydrochloride

    115. Buspirone For System Suitability, European Pharmacopoeia (ep) Reference Standard

    116. Buspirone Hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material

    117. 1-[4-(7,9-dioxo-8-azaspiro[4.5]decan-8-yl)butyl]-4-(pyrimidin-2-yl)piperazin-1-ium Chloride

    118. 8-[4-[4-(2-pyrimidinyl)-1-pipirazin Yl]butyl]-8-azaspiro[4,5]decane-7,9-dione Hydrochloride

    119. 8-[4-[4-(2-pyrimidinyl)-1-pipirazinyl]butyl]-8-azaspiro[4,5]decane-7,9-dione Hydrochloride

    120. 8-[4-[4-(pyrimidine-2-yl)-piperazine-1-yl]-butyl]-8-aza-spiro[4.5]decane-7,9-dione Hydrochloride

    121. 8-azaspiro[4.5]decane-7,9-dione, 8-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-, Hydrochloride (1:1)

    122. Buspirone Hcl Pound>>mj 9022 1 Pound>> Mj-9022-1 Pound>>mj90221 Pound>>mj9022 1 Pound>>mj9022-1

    123. Buspirone Hydrochloride Solution, 1.0 Mg/ml In Methanol (as Free Base), Ampule Of 1 Ml, Certified Reference Material

    2.4 Create Date
    2005-06-24
    3 Chemical and Physical Properties
    Molecular Weight 422.0 g/mol
    Molecular Formula C21H32ClN5O2
    Hydrogen Bond Donor Count1
    Hydrogen Bond Acceptor Count6
    Rotatable Bond Count6
    Exact Mass421.2244530 g/mol
    Monoisotopic Mass421.2244530 g/mol
    Topological Polar Surface Area69.6 Ų
    Heavy Atom Count29
    Formal Charge0
    Complexity529
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 2  
    Drug NameBuspirone hydrochloride
    Drug LabelBuspirone hydrochloride tablets USP are an antianxiety agent that is not chemically or pharmacologically related to the benzodiazepines, barbiturates, or other sedative/anxiolytic drugs.Buspirone hydrochloride is a white crystalline, water soluble co...
    Active IngredientBuspirone hydrochloride
    Dosage FormTablet
    RouteOral
    Strength5mg; 7.5mg; 30mg; 10mg; 15mg
    Market StatusPrescription
    CompanyWatson Labs; Teva; Zydus Pharms Usa; Strides Arcolab; Dr Reddys Labs; Prosam Labs; Mylan

    2 of 2  
    Drug NameBuspirone hydrochloride
    Drug LabelBuspirone hydrochloride tablets USP are an antianxiety agent that is not chemically or pharmacologically related to the benzodiazepines, barbiturates, or other sedative/anxiolytic drugs.Buspirone hydrochloride is a white crystalline, water soluble co...
    Active IngredientBuspirone hydrochloride
    Dosage FormTablet
    RouteOral
    Strength5mg; 7.5mg; 30mg; 10mg; 15mg
    Market StatusPrescription
    CompanyWatson Labs; Teva; Zydus Pharms Usa; Strides Arcolab; Dr Reddys Labs; Prosam Labs; Mylan

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Anti-Anxiety Agents

    Agents that alleviate ANXIETY, tension, and ANXIETY DISORDERS, promote sedation, and have a calming effect without affecting clarity of consciousness or neurologic conditions. ADRENERGIC BETA-ANTAGONISTS are commonly used in the symptomatic treatment of anxiety but are not included here. (See all compounds classified as Anti-Anxiety Agents.)

    Serotonin Receptor Agonists

    Endogenous compounds and drugs that bind to and activate SEROTONIN RECEPTORS. Many serotonin receptor agonists are used as ANTIDEPRESSANTS; ANXIOLYTICS; and in the treatment of MIGRAINE DISORDERS. (See all compounds classified as Serotonin Receptor Agonists.)

    API Reference Price

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    27-Jan-2021
    21-Aug-2024
    KGS
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    BUSPIRONE HCL Manufacturers | Traders | Suppliers

    BUSPIRONE HCL Manufacturers, Traders, Suppliers 1
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    7. Aspire Lifesciences Pvt Ltd
    8. Cyclo Industries
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    10. Hiray Pharma Solutions
    11. Industriale Chimica
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    14. Medilux Laboratories
    15. R L Fine Chem
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