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    Chemistry

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    Also known as: 104344-23-2, Zebeta, Bisoprolol hemifumarate, Bisoprolol monofumarate, Fondril, Maintate
    Molecular Formula
    C22H35NO8
    Molecular Weight
    441.5  g/mol
    InChI Key
    RZPZLFIUFMNCLY-WLHGVMLRSA-N
    FDA UNII
    U057CX04H0
    Bisoprolol Fumarate
    A cardioselective beta-1 adrenergic blocker. It is effective in the management of HYPERTENSION and ANGINA PECTORIS.
    1 2D Structure

    Bisoprolol Fumarate

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    (E)-but-2-enedioic acid;1-(propan-2-ylamino)-3-[4-(2-propan-2-yloxyethoxymethyl)phenoxy]propan-2-ol
    2.1.2 InChI
    InChI=1S/C18H31NO4.C4H4O4/c1-14(2)19-11-17(20)13-23-18-7-5-16(6-8-18)12-21-9-10-22-15(3)4;5-3(6)1-2-4(7)8/h5-8,14-15,17,19-20H,9-13H2,1-4H3;1-2H,(H,5,6)(H,7,8)/b;2-1+
    2.1.3 InChI Key
    RZPZLFIUFMNCLY-WLHGVMLRSA-N
    2.1.4 Canonical SMILES
    CC(C)NCC(COC1=CC=C(C=C1)COCCOC(C)C)O.C(=CC(=O)O)C(=O)O
    2.1.5 Isomeric SMILES
    CC(C)NCC(COC1=CC=C(C=C1)COCCOC(C)C)O.C(=C/C(=O)O)\C(=O)O
    2.2 Other Identifiers
    2.2.1 UNII
    U057CX04H0
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Bisoprolol

    2. Bisoprolol Fumarate (1:1) Salt, (+-)-isomer

    3. Bisoprolol Fumarate (2:1) Salt, (+-)-isomer

    4. Bisoprolol Hydrochloride

    5. Bisoprolol Methanesulfonate Salt

    6. Bisoprolol, (+-)-isomer

    7. Bisoprolol, (-)-isomer

    8. Bisoprolol, Fumarate (1:1) Salt

    9. Bisoprolol, Fumarate (2:1) Salt

    10. Cl 297939

    11. Cl-297939

    12. Cl297939

    13. Concor

    14. Emd 33512

    15. Emd-33512

    16. Emd33512

    17. Fumarate, Bisoprolol

    18. Hydrochloride, Bisoprolol

    2.3.2 Depositor-Supplied Synonyms

    1. 104344-23-2

    2. Zebeta

    3. Bisoprolol Hemifumarate

    4. Bisoprolol Monofumarate

    5. Fondril

    6. Maintate

    7. Concor

    8. 105878-43-1

    9. Bisoprolol (fumarate)

    10. Bisoprolol Hemifumarate Salt

    11. U057cx04h0

    12. Emd33512

    13. Ta-4708

    14. Cl-297939

    15. 1-[4-[[2-(1-methylethoxy)ethoxy]methyl]phenoxy]-3-[(1-methylethyl)amino]-2-propanol,(2e)-2-monobutenedioate

    16. 2-propanol, 1-(4-((2-(1-methylethoxy)ethoxy)methyl)phenoxy)-3-((1-methylethyl)amino)-, (2e)-2-butenedioate (1:1)

    17. 2-propanol, 1-(4-((2-(1-methylethoxy)ethoxy)methyl)phenoxy)-3-((1-methylethyl)amino)-, (2e)-2-butenedioate (1:1) (salt)

    18. 2-propanol, 1-(4-((2-(1-methylethoxy)ethoxy)methyl)phenoxy)-3-((1-methylethyl)amino)-, (e)-2-butenedioate (1:1) (salt)

    19. Smr000471619

    20. Emd-33512

    21. Bisocard

    22. Cardicor

    23. Congescor

    24. Sr-01000597980

    25. Bisoprololfumarate

    26. Concor Cor

    27. 66722-45-0

    28. Bisoprolol Fumarate (1:x)

    29. Schembl41419

    30. Mls001076669

    31. Mls001401436

    32. Unii-u057cx04h0

    33. Chembl1200708

    34. Bcpp000331

    35. Hms1569a21

    36. Hms2051i16

    37. Hms2094o19

    38. Hms2233f12

    39. Hms3884o05

    40. Pharmakon1600-01505704

    41. Nsc759181

    42. S1206

    43. Akos005267174

    44. Ac-5016

    45. Bcp9000419

    46. Ccg-100883

    47. Ccg-213520

    48. Nc00133

    49. Nsc-759181

    50. Hy-120829

    51. B3994

    52. Cs-0079270

    53. Sw197151-3

    54. 104b232

    55. Q-200729

    56. Sr-01000597980-4

    57. Q27290514

    58. 1-(4-((2-isopropoxyethoxy)methyl)phenoxy)-3-(isopropylamino)propan-2-ol Hemi-fumarate

    59. 1-{4-[(2-isopropoxyethoxy)methyl]phenoxy}-3-(isopropylamino)-2-propanol Fumaric Acid Salt

    2.4 Create Date
    2006-07-28
    3 Chemical and Physical Properties
    Molecular Weight 441.5 g/mol
    Molecular Formula C22H35NO8
    Hydrogen Bond Donor Count4
    Hydrogen Bond Acceptor Count9
    Rotatable Bond Count14
    Exact Mass441.23626707 g/mol
    Monoisotopic Mass441.23626707 g/mol
    Topological Polar Surface Area135 Ų
    Heavy Atom Count31
    Formal Charge0
    Complexity397
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count1
    Defined Bond Stereocenter Count1
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 4  
    Drug NameBisoprolol fumarate
    Drug LabelBisoprolol fumarate is a synthetic, beta1-selective (cardioselective) adrenoceptor blocking agent. The chemical name for bisoprolol fumarate is ()-1-[4-[[2-(1-Methylethoxy)ethoxy]methyl]phenoxy]-3-[(1-methylethyl)amino]-2-propanol(E)-2-butenedioate...
    Active IngredientBisoprolol fumarate
    Dosage FormTablet
    RouteOral
    Strength5mg; 10mg
    Market StatusPrescription
    CompanyTeva Pharms; Unichem Pharms (usa); Aurobindo Pharma; Sandoz; Mylan

    2 of 4  
    Drug NameZebeta
    PubMed HealthBisoprolol (By mouth)
    Drug ClassesAntianginal, Antihypertensive, Cardiovascular Agent
    Drug LabelZEBETA (bisoprolol fumarate) is a synthetic, beta1-selective (cardioselective) adrenoceptor blocking agent. The chemical name for bisoprolol fumarate is ()-1-[4-[[2-(1-Methylethoxy)ethoxy]methyl]phenoxy]-3-[(1-methylethyl)amino]-2-propanol(E)-2-but...
    Active IngredientBisoprolol fumarate
    Dosage FormTablet
    RouteOral
    Strength5mg; 10mg
    Market StatusPrescription
    CompanyTeva Womens

    3 of 4  
    Drug NameBisoprolol fumarate
    Drug LabelBisoprolol fumarate is a synthetic, beta1-selective (cardioselective) adrenoceptor blocking agent. The chemical name for bisoprolol fumarate is ()-1-[4-[[2-(1-Methylethoxy)ethoxy]methyl]phenoxy]-3-[(1-methylethyl)amino]-2-propanol(E)-2-butenedioate...
    Active IngredientBisoprolol fumarate
    Dosage FormTablet
    RouteOral
    Strength5mg; 10mg
    Market StatusPrescription
    CompanyTeva Pharms; Unichem Pharms (usa); Aurobindo Pharma; Sandoz; Mylan

    4 of 4  
    Drug NameZebeta
    PubMed HealthBisoprolol (By mouth)
    Drug ClassesAntianginal, Antihypertensive, Cardiovascular Agent
    Drug LabelZEBETA (bisoprolol fumarate) is a synthetic, beta1-selective (cardioselective) adrenoceptor blocking agent. The chemical name for bisoprolol fumarate is ()-1-[4-[[2-(1-Methylethoxy)ethoxy]methyl]phenoxy]-3-[(1-methylethyl)amino]-2-propanol(E)-2-but...
    Active IngredientBisoprolol fumarate
    Dosage FormTablet
    RouteOral
    Strength5mg; 10mg
    Market StatusPrescription
    CompanyTeva Womens

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Adrenergic beta-1 Receptor Antagonists

    Drugs that bind to and block the activation of ADRENERGIC BETA-1 RECEPTORS. (See all compounds classified as Adrenergic beta-1 Receptor Antagonists.)

    Antihypertensive Agents

    Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS. (See all compounds classified as Antihypertensive Agents.)

    Sympatholytics

    Drugs that inhibit the actions of the sympathetic nervous system by any mechanism. The most common of these are the ADRENERGIC ANTAGONISTS and drugs that deplete norepinephrine or reduce the release of transmitters from adrenergic postganglionic terminals (see ADRENERGIC AGENTS). Drugs that act in the central nervous system to reduce sympathetic activity (e.g., centrally acting alpha-2 adrenergic agonists, see ADRENERGIC ALPHA-AGONISTS) are included here. (See all compounds classified as Sympatholytics.)

    5.2 FDA Pharmacological Classification
    5.2.1 Pharmacological Classes
    beta-Adrenergic Blocker [EPC]; Adrenergic beta-Antagonists [MoA]

    API Reference Price

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    11-Jan-2021
    31-Aug-2024
    KGS
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    Average Price (USD/KGS)

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    DOSAGE - TABLET;ORAL - 10MG **Federal Registe...DOSAGE - TABLET;ORAL - 10MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

    USFDA APPLICATION NUMBER - 19982

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    DOSAGE - TABLET;ORAL - 5MG **Federal Register...DOSAGE - TABLET;ORAL - 5MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

    USFDA APPLICATION NUMBER - 19982

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