All Manufacturers, Suppliers, Distributors and Exporters of Bendamustine Hydrochloride with approved Medicines Control Council in South Africa of Finished Dosage Form listed on PharmaCompass.com

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Chemistry

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Also known as: 3543-75-7, Bendamustine hcl, Treanda, Ribomustin, Cytostasan, Sdx-105
Molecular Formula
C16H22Cl3N3O2
Molecular Weight
394.7  g/mol
InChI Key
ZHSKUOZOLHMKEA-UHFFFAOYSA-N
FDA UNII
981Y8SX18M

Bendamustine Hydrochloride
A nitrogen mustard compound that functions as an ALKYLATING ANTINEOPLASTIC AGENT and is used in the treatment of CHRONIC LYMPHOCYTIC LEUKEMIA and NON-HODGKIN'S LYMPHOMA.
1 2D Structure

Bendamustine Hydrochloride

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
4-[5-[bis(2-chloroethyl)amino]-1-methylbenzimidazol-2-yl]butanoic acid;hydrochloride
2.1.2 InChI
InChI=1S/C16H21Cl2N3O2.ClH/c1-20-14-6-5-12(21(9-7-17)10-8-18)11-13(14)19-15(20)3-2-4-16(22)23;/h5-6,11H,2-4,7-10H2,1H3,(H,22,23);1H
2.1.3 InChI Key
ZHSKUOZOLHMKEA-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CN1C2=C(C=C(C=C2)N(CCCl)CCCl)N=C1CCCC(=O)O.Cl
2.2 Other Identifiers
2.2.1 UNII
981Y8SX18M
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Bendamustin

2. Bendamustine

3. Cytostasan

4. Hydrochloride, Bendamustine

5. Imet 3393

6. Ribomustin

7. Treanda

8. Zimet 3393

2.3.2 Depositor-Supplied Synonyms

1. 3543-75-7

2. Bendamustine Hcl

3. Treanda

4. Ribomustin

5. Cytostasan

6. Sdx-105

7. Bendamustin Hydrochloride

8. Bendeka

9. Imet 3393

10. 4-(5-(bis(2-chloroethyl)amino)-1-methyl-1h-benzo[d]imidazol-2-yl)butanoic Acid Hydrochloride

11. Syb L-0501

12. Ribomustine

13. Treakisym

14. Bendamustine (hydrochloride)

15. 4-[5-[bis(2-chloroethyl)amino]-1-methylbenzimidazol-2-yl]butanoic Acid Hydrochloride

16. 97832-05-8

17. Nsc-138783

18. Sdx 105

19. 3543-75-7 (hcl)

20. Sybl-0501

21. 981y8sx18m

22. Levact

23. 4-(5-(bis(2-chloroethyl)amino)-1-methyl-1h-benzo-[d]imidazol-2-yl)butanoic Acid Hydrochloride

24. 4-[5-[bis(2-chloroethyl)amino]-1-methylbenzimidazol-2-yl]butanoic Acid;hydrochloride

25. Treanda (tn)

26. 1h-benzimidazole-2-butanoic Acid, 5-(bis(2-chloroethyl)amino)-1-methyl-, Monohydrochloride

27. Bendit

28. Ccris 1864

29. Nsc 138783

30. Cytostosan

31. Innomustine

32. Symbenda

33. Benda

34. Unii-981y8sx18m

35. Treanda Hcl

36. Zimet 33/93

37. Ribomustin (tn)

38. Bendamustine Hydrochloride Injection

39. Vivimusta

40. Inno-p08001

41. Gamma(1-methyl-5-bis(beta-chloraethyl)aminobenzimidazoyl-2)buttersaeurehydrochlorid [german]

42. Schembl18843

43. Mls006010156

44. Sdx-105 (cytostasane) Hcl

45. Chembl1201734

46. Dtxsid40188912

47. Bcpp000348

48. Bcp02107

49. Hy-b0077

50. Tox21_500623

51. Mfcd01658758

52. Nsc138783

53. S1212

54. Akos015951203

55. Ac-1619

56. Bcp9000390

57. Bendamustine Hydrochloride (jan/usan)

58. Bendamustine Hydrochloride [mi]

59. Bendamustine Hydrochloride [usan:jan]

60. Ccg-221927

61. Cs-1771

62. Ep-3101

63. Lp00623

64. Sb17462

65. 2-benzimidazolebutyric Acid, 5-(bis(2-chloroethyl)amino)-1-methyl-, Monohydrochloride

66. 2-benzimidazolinebutryric Acid, 1-methyl-5-bis(2-chloroethyl)amino-, Hydrochloride

67. Bendamustine Hydrochloride [jan]

68. Gamma(1-methyl-5-bis(beta-chloraethyl)aminobenzimidazoyl-2)buttersaeurehydrochlorid

69. Bendamustine Hydrochloride [usan]

70. Ncgc00261308-01

71. As-15856

72. Bb164239

73. Bendamustine Hydrochloride [mart.]

74. Bp-25399

75. Smr004234484

76. Bendamustine Hydrochloride [usp-rs]

77. Bendamustine Hydrochloride [who-dd]

78. Bendamustine Hcl (sdx-105, Cytostasane)

79. 2-benzimidazolinebutryric Acid, Hydrochloride

80. Am20090666

81. B4033

82. Ft-0650624

83. Ft-0696296

84. Sw219266-1

85. 2-benzimidazolebutyric Acid, Monohydrochloride

86. Bendamustine Hydrochloride [orange Book]

87. D07085

88. Wln: T56 Bn Dnj B1 C3vq Gn2g2g &gh

89. 543b757

90. Bendamustine Hydrochloride [usp Monograph]

91. Q27272066

92. Fmoc-(s)-3-amino-3-(3-trifluoromethyl-phenyl)-propionicacid

93. 4-(5-(bis(2-chloroethyl)amino)-1-methylbenzimidazol-2-yl)butanoic Acid Hcl

94. 4-(5-(bis(2-chloroethyl)amino)-1-methyl-1h-benzo[d]imidazol-2-yl)butanoicacidhydrochloride

95. 5-[bis(2-chloroethyl)amino]-1-methyl-1h-benzimidazole-2-butanoic Acid Hydrochloride

96. 5-[bis(2-chloroethyl)amino]-1-methylbenzimidazole-2-butyric Acid Hydrochloride

97. 1h-benzimidazole-2-butanoic Acid, 5-[bis(2-chloroethyl)amino]-1-methyl-, Hydrochloride (1:1)

98. 4-(5-(bis(2-chloroethyl)amino)-1-methyl-1h-benzimidazole-2-yl)butanoic Acid Monohydrochloride

99. 5-[bis(2-chloroethyl)-amino]-1-methyl-1h-benzimidazole-2-butanoic Acid Hydrochloride;ribomustin Hcl

2.4 Create Date
2005-08-08
3 Chemical and Physical Properties
Molecular Weight 394.7 g/mol
Molecular Formula C16H22Cl3N3O2
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count9
Exact Mass393.077760 g/mol
Monoisotopic Mass393.077760 g/mol
Topological Polar Surface Area58.4 Ų
Heavy Atom Count24
Formal Charge0
Complexity380
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Drug and Medication Information
4.1 Drug Information
1 of 4  
Drug NameBendamustine hydrochloride
PubMed HealthBendamustine (Injection)
Drug ClassesAntineoplastic Agent
Drug LabelTREANDA contains bendamustine hydrochloride, an alkylating drug, as the active ingredient. The chemical name of bendamustine hydrochloride is 1H-benzimidazole-2-butanoic acid, 5-[bis(2-chloroethyl)amino]-1 methyl-,monohydrochloride. Its empirical m...
Active IngredientBendamustine hydrochloride
Dosage FormInjectable
Routeinjection
Strength100mg
Market StatusTentative Approval
CompanyEagle Pharms

2 of 4  
Drug NameTreanda
Drug LabelTREANDA contains bendamustine hydrochloride, an alkylating drug, as the active ingredient. The chemical name of bendamustine hydrochloride is 1H-benzimidazole-2-butanoic acid, 5-[bis(2-chloroethyl)amino]-1 methyl-,monohydrochloride. Its empirical m...
Active IngredientBendamustine hydrochloride
Dosage FormPowder; Injectable; Solution
Routeinjection; Iv (infusion)
Strength25mg/vial; 180mg/2ml (90mg/ml); 45mg/0.5ml (90mg/ml); 100mg/vial; 100mg
Market StatusPrescription
CompanyCephalon

3 of 4  
Drug NameBendamustine hydrochloride
PubMed HealthBendamustine (Injection)
Drug ClassesAntineoplastic Agent
Drug LabelTREANDA contains bendamustine hydrochloride, an alkylating drug, as the active ingredient. The chemical name of bendamustine hydrochloride is 1H-benzimidazole-2-butanoic acid, 5-[bis(2-chloroethyl)amino]-1 methyl-,monohydrochloride. Its empirical m...
Active IngredientBendamustine hydrochloride
Dosage FormInjectable
Routeinjection
Strength100mg
Market StatusTentative Approval
CompanyEagle Pharms

4 of 4  
Drug NameTreanda
Drug LabelTREANDA contains bendamustine hydrochloride, an alkylating drug, as the active ingredient. The chemical name of bendamustine hydrochloride is 1H-benzimidazole-2-butanoic acid, 5-[bis(2-chloroethyl)amino]-1 methyl-,monohydrochloride. Its empirical m...
Active IngredientBendamustine hydrochloride
Dosage FormPowder; Injectable; Solution
Routeinjection; Iv (infusion)
Strength25mg/vial; 180mg/2ml (90mg/ml); 45mg/0.5ml (90mg/ml); 100mg/vial; 100mg
Market StatusPrescription
CompanyCephalon

5 Pharmacology and Biochemistry
5.1 MeSH Pharmacological Classification

Antineoplastic Agents, Alkylating

A class of drugs that differs from other alkylating agents used clinically in that they are monofunctional and thus unable to cross-link cellular macromolecules. Among their common properties are a requirement for metabolic activation to intermediates with antitumor efficacy and the presence in their chemical structures of N-methyl groups, that after metabolism, can covalently modify cellular DNA. The precise mechanisms by which each of these drugs acts to kill tumor cells are not completely understood. (From AMA, Drug Evaluations Annual, 1994, p2026) (See all compounds classified as Antineoplastic Agents, Alkylating.)


5.2 FDA Pharmacological Classification
5.2.1 Pharmacological Classes
Alkylating Drug [EPC]; Alkylating Activity [MoA]

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NO. 100143","address":"ZYDUS TOWER, SARKHEJ-GANDHINAGAR,H","city":"AHMEDABAD,GUJARAT","supplier":"OLON S.P.A","supplierCountry":"ITALY","foreign_port":"N\/A","customer":"ZYDUS LIFESCIENCES LIMITED","customerCountry":"INDIA","quantity":"4.00","actualQuantity":"4","unit":"KGS","unitRateFc":"208939.5","totalValueFC":"838965.5","currency":"USD","unitRateINR":"17258402.8","date":"09-May-2023","totalValueINR":"69033611","totalValueInUsd":"838965.5","indian_port":"Ahmedabad-ZIPL-SEZ","hs_no":"29339990","bill_no":"1001953","productDescription":"API","marketType":"REGULATED MARKET","country":"ITALY","selfForZScoreResived":"Pharma Grade","supplierPort":"N\/A","supplierAddress":"DIREZIONE E UFFICI STR RIVOLTANA KM 6\/7, 20090 RODANO MI Italy","customerAddress":"ZYDUS TOWER, SARKHEJ-GANDHINAGAR,H"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q3","strtotime":1691346600,"product":"BENDAMUSTINE HYDROCHLORIDE MONOHYDRATE-4-5-BIS(2-CHLOROETHYL)AMINO-1-METHYLBENZIMIDAZOL-2-YLBUTANOIC ACID, HYDROCHLORIDE","address":"PLOT NO. 3, PHARMEZ, SEZ, SARKEHJ","city":"TAL- SANAND, DIST- AHMEDABAD","supplier":"XXRAEXX PRXXIOUXXMETXXS GXXH &XXO. XX","supplierCountry":"GERMANY","foreign_port":"FRANKFURT AM MAIN","customer":"ZYDUS LIFESCIENCES","customerCountry":"INDIA","quantity":"0.42","actualQuantity":"415","unit":"GMS","unitRateFc":"97.4","totalValueFC":"40650.9","currency":"USD","unitRateINR":"8143.1","date":"07-Aug-2023","totalValueINR":"3379405","totalValueInUsd":"40650.9","indian_port":"Ahmedabad-ZIPL-SEZ","hs_no":"29339990","bill_no":"1003327","productDescription":"API","marketType":"REGULATED MARKET","country":"GERMANY","selfForZScoreResived":"Pharma Grade","supplierPort":"FRANKFURT AM MAIN","supplierAddress":"N\/A","customerAddress":"PLOT NO. 3, PHARMEZ, SEZ, SARKEHJ"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q1","strtotime":1706121000,"product":"BENDAMUSTINE LOT NO.0023711516","address":"ZYDUS TOWER, SARKHEJ-GANDHINAGAR,H","city":"AHMEDABAD,GUJARAT","supplier":"OLON S.P.A","supplierCountry":"ITALY","foreign_port":"N\/A","customer":"ZYDUS LIFESCIENCES LIMITED","customerCountry":"INDIA","quantity":"4.00","actualQuantity":"4","unit":"KGS","unitRateFc":"176620.5","totalValueFC":"715477.1","currency":"USD","unitRateINR":"14853784","date":"25-Jan-2024","totalValueINR":"59415136","totalValueInUsd":"715477.1","indian_port":"Ahmedabad-ZIPL-SEZ","hs_no":"29339990","bill_no":"1000325","productDescription":"API","marketType":"REGULATED MARKET","country":"ITALY","selfForZScoreResived":"Pharma Grade","supplierPort":"N\/A","supplierAddress":"DIREZIONE E UFFICI: STR RIVOLTANA KM 6\/7 20090 RODANO (MI ) ITALY","customerAddress":"ZYDUS TOWER, SARKHEJ-GANDHINAGAR,H"}]
12-Jan-2021
02-Aug-2024
KGS
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Average Price (USD/KGS)

Number of Transactions

Total Quantity (KGS)

Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

Importing Country Total Quantity
(KGS)
Average Price
(USD/KGS)
Number of Transactions

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DRUG PRODUCT COMPOSITIONS

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DOSAGE - SOLUTION;INTRAVENOUS - 100MG/4ML (25...DOSAGE - SOLUTION;INTRAVENOUS - 100MG/4ML (25MG/ML)

USFDA APPLICATION NUMBER - 205580

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DOSAGE - SOLUTION;IV (INFUSION) - 100MG/4ML (...DOSAGE - SOLUTION;IV (INFUSION) - 100MG/4ML (25MG/ML)

USFDA APPLICATION NUMBER - 208194

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DOSAGE - SOLUTION;INTRAVENOUS - 100MG/4ML (25...DOSAGE - SOLUTION;INTRAVENOUS - 100MG/4ML (25MG/ML)

USFDA APPLICATION NUMBER - 215033

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01

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26th North American ISSX
Not Confirmed

CEPHALON

U.S.A
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Not Confirmed

BENDAMUSTINE HYDROCHLORIDE

US Patent Number : 9533955*PED

Drug Substance Claim :

Drug Product Claim :

Application Number : 22249

Patent Use Code :

Delist Requested :

Patent Use Description :

Patent Expiration Date : 2029-09-26

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02

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26th North American ISSX
Not Confirmed

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U.S.A
arrow
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Not Confirmed

BENDAMUSTINE HYDROCHLORIDE

US Patent Number : 8609863

Drug Substance Claim :

Drug Product Claim : Y

Application Number : 22249

Patent Use Code :

Delist Requested :

Patent Use Description :

Patent Expiration Date : 2026-01-12

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03

arrow
26th North American ISSX
Not Confirmed

CEPHALON

U.S.A
arrow
26th North American ISSX
Not Confirmed

BENDAMUSTINE HYDROCHLORIDE

US Patent Number : 8791270*PED

Drug Substance Claim :

Drug Product Claim :

Application Number : 22249

Patent Use Code :

Delist Requested :

Patent Use Description :

Patent Expiration Date : 2026-07-12

blank

04

arrow
26th North American ISSX
Not Confirmed

CEPHALON

U.S.A
arrow
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Not Confirmed

BENDAMUSTINE HYDROCHLORIDE

US Patent Number : 8791270

Drug Substance Claim :

Drug Product Claim : Y

Application Number : 22249

Patent Use Code : U-1542

Delist Requested :

Patent Use Description : FOR USE IN THE TREATME...

Patent Expiration Date : 2026-01-12

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05

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26th North American ISSX
Not Confirmed

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U.S.A
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26th North American ISSX
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BENDAMUSTINE HYDROCHLORIDE

US Patent Number : 8895756

Drug Substance Claim :

Drug Product Claim : Y

Application Number : 22249

Patent Use Code :

Delist Requested :

Patent Use Description :

Patent Expiration Date : 2026-01-12

blank

06

arrow
26th North American ISSX
Not Confirmed

CEPHALON

U.S.A
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26th North American ISSX
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BENDAMUSTINE HYDROCHLORIDE

US Patent Number : 9533955*PED

Drug Substance Claim :

Drug Product Claim :

Application Number : 22249

Patent Use Code :

Delist Requested :

Patent Use Description :

Patent Expiration Date : 2029-09-26

blank

07

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26th North American ISSX
Not Confirmed

CEPHALON

U.S.A
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US Patent Number : 8445524

Drug Substance Claim : Y

Drug Product Claim :

Application Number : 22249

Patent Use Code :

Delist Requested :

Patent Use Description :

Patent Expiration Date : 2029-03-26

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08

arrow
26th North American ISSX
Not Confirmed

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U.S.A
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US Patent Number : 9597397

Drug Substance Claim :

Drug Product Claim :

Application Number : 208194

Patent Use Code : U-1972

Delist Requested :

Patent Use Description :

Patent Expiration Date : 2033-03-15

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09

arrow
26th North American ISSX
Not Confirmed

EAGLE PHARMS

U.S.A
arrow
26th North American ISSX
Not Confirmed

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US Patent Number : 11844783

Drug Substance Claim :

Drug Product Claim :

Application Number : 208194

Patent Use Code : U-1971

Delist Requested :

Patent Use Description :

Patent Expiration Date : 2031-01-28

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10

arrow
26th North American ISSX
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US Patent Number : 8609707

Drug Substance Claim :

Drug Product Claim : Y

Application Number : 205580

Patent Use Code : U-1971

Delist Requested :

Patent Use Description :

Patent Expiration Date : 2031-08-11

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