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Anakinra

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CHEMISTRY
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DEVELOPMENTS

8 Drugs in Development

8 Drugs in Development

FINISHED DOSAGE FORMULATIONS

15 FDF Dossiers, 3 FDA Orange Book, 9 Europe, 1 Canada, 2 Australia

15 FDF Dossiers
3 FDA Orange Book
9 Europe
1 Canada
2 Australia

RELATED EXCIPIENT COMPANIES

1 Jai Radhe Sales, 2 Nanjing Well Pharmaceutical, 4 Actylis, 1 BASF, 3 Gangwal Chemicals, 1 Nanjing Bold Chemical, 6 Seppic

relatedExcipients
1 Jai Radhe Sales
2 Nanjing Well Pharmaceutical
4 Actylis
1 BASF
3 Gangwal Chemicals
1 Nanjing Bold Chemical
6 Seppic

EXCIPIENTS BY APPLICATIONS

10 Solubilizers, 8 Parenteral, 3 Topical, 3 Emulsifying Agents, 2 Thickeners and Stabilizers, 2 Film Formers & Plasticizers, 2 Surfactant & Foaming Agents, 1 Co-Processed Excipients, 1 Direct Compression, 1 Rheology Modifiers, 1 API Stability Enhancers

excipientsByApplications
10 Solubilizers
8 Parenteral
3 Topical
3 Emulsifying Agents
2 Thickeners and Stabilizers
2 Film Formers & Plasticizers
2 Surfactant & Foaming Agents
1 Co-Processed Excipients
1 Direct Compression
1 Rheology Modifiers
1 API Stability Enhancers

DIGITAL CONTENT

1 DATA COMPILATION #PharmaFlow, 13 NEWS #PharmaBuzz

media
1 DATA COMPILATION #PharmaFlow
13 NEWS #PharmaBuzz

GLOBAL SALES INFORMATION

1 US Medicaid Prescriptions, 6 Finished Drug Prices, 5 Annual Reports

globalSalesInformation
1 US Medicaid Prescriptions
6 Finished Drug Prices
5 Annual Reports

MARKET PLACE

3 APIs, 2 FDF Dossiers

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3 APIs
2 FDF Dossiers

PATENTS & EXCLUSIVITIES

2 Health Canada Patents

patents
2 Health Canada Patents

Synopsis

ACTIVE PHARMA INGREDIENTS

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API Suppliers

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USDMF

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CEP/COS

CEP/COS Certifications

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JDMF

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EU WC

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KDMF

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NDC API

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VMF

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Listed Suppliers

API REF. PRICE (USD/KG)

$

$ 0

MARKET PLACE

3

API

2

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

15

FDF Dossiers

3

FDA Orange Book

FDA (Orange Book)

9

Europe

1

Canada

2

Australia

0

South Africa

0

Listed Dossiers

8DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

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EDQM

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USP

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JP

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PATENTS & EXCLUSIVITIES

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US Patents

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US Exclusivities

2

Health Canada Patents

DIGITAL CONTENT

1

Data Compilation #PharmaFlow

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Stock Recap #PipelineProspector

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Weekly News Recap #Phispers

13

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

23,620,004

Annual Reports (USD Million)

1,099

Finished Drug Prices

18 RELATED EXCIPIENT COMPANIES

34EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: Interleukin1 receptor antagonist (human isoform x reduced),n2-l-methionyl- (9ci)

Molecular Formula

C₂₀H₂₃N₅O₇S₂

Molecular Weight

509.6 g/mol

InChI Key

HMLGSIZOMSVISS-ONJSNURVSA-N

Anakinra

1 2D Structure

Anakinra

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

(7R)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(2,2-dimethylpropanoyloxymethoxyimino)acetyl]amino]-3-ethenyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

2.1.2 InChI

InChI=1S/C20H23N5O7S2/c1-5-9-6-33-16-12(15(27)25(16)13(9)17(28)29)23-14(26)11(10-7-34-19(21)22-10)24-32-8-31-18(30)20(2,3)4/h5,7,12,16H,1,6,8H2,2-4H3,(H2,21,22)(H,23,26)(H,28,29)/b24-11-/t12-,16?/m1/s1

2.1.3 InChI Key

HMLGSIZOMSVISS-ONJSNURVSA-N

2.1.4 Canonical SMILES

CC(C)(C)C(=O)OCON=C(C1=CSC(=N1)N)C(=O)NC2C3N(C2=O)C(=C(CS3)C=C)C(=O)O

2.1.5 Isomeric SMILES

CC(C)(C)C(=O)OCO/N=C(/C1=CSC(=N1)N)\C(=O)N[C@H]2C3N(C2=O)C(=C(CS3)C=C)C(=O)O

2.2 Synonyms

2.2.1 Depositor-Supplied Synonyms

1. Interleukin1 Receptor Antagonist (human Isoform X Reduced),n2-l-methionyl- (9ci)

2.3 Create Date

2015-02-16

3 Chemical and Physical Properties

Molecular Formula	C₂₀H₂₃N₅O₇S₂
Molecular Weight	509.6 g/mol
XLogP3	1.1
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	12
Rotatable Bond Count	10
Exact Mass	509.10389044 g/mol
Monoisotopic Mass	509.10389044 g/mol
Topological Polar Surface Area	227 Å²
Heavy Atom Count	34
Formal Charge	0
Complexity	961
Isotope Atom Count	0
Defined Atom Stereocenter Count	1
Undefined Atom Stereocenter Count	1
Defined Bond Stereocenter Count	1
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

Drugs in Development

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FDF Dossiers

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FDA Orange Book

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Europe

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Canada

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Australia

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Related Excipient Companies

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Excipients by Applications

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Solubilizers

Parenteral

Topical

Emulsifying Agents

Thickeners and Stabilizers

Film Formers & Plasticizers

Surfactant & Foaming Agents

Co-Processed Excipients

Direct Compression

Rheology Modifiers

API Stability Enhancers

Digital Content

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DATA COMPILATION #PharmaFlow

NEWS #PharmaBuzz

Global Sales Information

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US Medicaid Prescriptions

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Finished Drug Prices

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Annual Reports

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Market Place

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APIs

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FDF DOSSIERS

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Patents & EXCLUSIVITIES

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Health Canada Patents

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