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    Also known as: 50-98-6, (-)-ephedrine hydrochloride, L-ephedrine hydrochloride, 1-ephedrine hydrochloride, Ephedrine hcl, Ephedrine (hydrochloride)
    Molecular Formula
    C10H16ClNO
    Molecular Weight
    201.69  g/mol
    InChI Key
    BALXUFOVQVENIU-GNAZCLTHSA-N
    FDA UNII
    NLJ6390P1Z
    Ephedrine Hydrochloride
    A phenethylamine found in EPHEDRA SINICA. PSEUDOEPHEDRINE is an isomer. It is an alpha- and beta-adrenergic agonist that may also enhance release of norepinephrine. It has been used for asthma, heart failure, rhinitis, and urinary incontinence, and for its central nervous system stimulatory effects in the treatment of narcolepsy and depression. It has become less extensively used with the advent of more selective agonists.
    1 2D Structure

    Ephedrine Hydrochloride

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    (1R,2S)-2-(methylamino)-1-phenylpropan-1-ol;hydrochloride
    2.1.2 InChI
    InChI=1S/C10H15NO.ClH/c1-8(11-2)10(12)9-6-4-3-5-7-9;/h3-8,10-12H,1-2H3;1H/t8-,10-;/m0./s1
    2.1.3 InChI Key
    BALXUFOVQVENIU-GNAZCLTHSA-N
    2.1.4 Canonical SMILES
    CC(C(C1=CC=CC=C1)O)NC.Cl
    2.1.5 Isomeric SMILES
    C[C@@H]([C@@H](C1=CC=CC=C1)O)NC.Cl
    2.2 Other Identifiers
    2.2.1 UNII
    NLJ6390P1Z
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Ephedrine

    2. Ephedrine Erythro Isomer

    3. Ephedrine Renaudin

    4. Ephedrine Sulfate

    5. Erythro Isomer Of Ephedrine

    6. Hydrochloride, Ephedrine

    7. Renaudin, Ephedrine

    8. Sal Phedrine

    9. Sal-phedrine

    10. Salphedrine

    11. Sulfate, Ephedrine

    2.3.2 Depositor-Supplied Synonyms

    1. 50-98-6

    2. (-)-ephedrine Hydrochloride

    3. L-ephedrine Hydrochloride

    4. 1-ephedrine Hydrochloride

    5. Ephedrine Hcl

    6. Ephedrine (hydrochloride)

    7. Nlj6390p1z

    8. Nsc-759611

    9. Ephedronguent

    10. (1r,2s)-2-(methylamino)-1-phenylpropan-1-ol Hydrochloride

    11. Altusin

    12. Dsstox_cid_25825

    13. Dsstox_rid_81156

    14. Dsstox_gsid_45825

    15. Ephedrinium Chloride

    16. L-ephedrine, Hydrochloride

    17. (-)-ephedrin Hydrochloride

    18. Cas-50-98-6

    19. Einecs 200-074-6

    20. (1r,2s)-2-(methylamino)-1-phenylpropan-1-ol;hydrochloride

    21. Unii-nlj6390p1z

    22. Ephedrine Hydrochloride [usan:ban:jan]

    23. Ncgc00094665-01

    24. Rezipres

    25. (1r,2s)-(-)-ephedrine Hydrochloride

    26. Ephedrini Hydrochloridum

    27. N-methyl-beta-oxy-beta-phenylisopropylaminhydrochlorid [german]

    28. Benzenemethanol, Alpha-(1-(methylamino)ethyl)-, Hydrochloride, (r-(r*,s*))-

    29. Ec 200-074-6

    30. Schembl22822

    31. Ephedrine Hydrochloride (tn)

    32. Ephedrine Hydrochloride Racemic

    33. N-methyl-beta-oxy-beta-phenylisopropylaminhydrochlorid

    34. Chembl2146102

    35. Dtxsid1045825

    36. Chebi:31541

    37. Hy-b1195a

    38. Str01942

    39. Ephedrine Hydrochloride [mi]

    40. Tox21_111310

    41. Ephedrine Hydrochloride (jp17/usp)

    42. Ephedrine Hydrochloride [jan]

    43. Akos015895154

    44. Tox21_111310_1

    45. Ccg-229523

    46. Cs-4803

    47. Ephedrine Hydrochloride [mart.]

    48. Ephedrine Hydrochloride [vandf]

    49. Nsc 759611

    50. Benzenemethanol, .alpha.-[(1s)-1-(methylamino)ethyl]-, Hydrochloride, (.alpha.r)-

    51. Benzenemethanol, Alpha-((1s)-1-(methylamino)ethyl)-, Hydrochloride, (alphar)-

    52. Benzenemethanol, Alpha-(1-(methylamino)ethyl)-, Hydrochloride, (theta-(theta,s))-

    53. Ephedrine Hydrochloride [usp-rs]

    54. Ephedrine Hydrochloride [who-dd]

    55. Ephedrine Hydrochloride [who-ip]

    56. Ncgc00015408-03

    57. (1r,2s)-(-)-ephedrinehydrochloride

    58. Ephedrine Hydrochloride [ep Impurity]

    59. Ephedrine Hydrochloride [orange Book]

    60. (-)-ephedrine Hydrochloride [who-ip]

    61. (1r,2s)-(-)-ephedrine Hydrochloride, 99%

    62. Ephedrine Hydrochloride [ep Monograph]

    63. D01386

    64. Ephedrine Hydrochloride [usp Monograph]

    65. Ephedrini Hydrochloridum [who-ip Latin]

    66. 066e127

    67. Q27284939

    68. (1r,2s)-ephedrine Hydrochloride 1.0 Mg/ml In Methanol (as Free Base)

    69. Ephedrine Hydrochloride, United States Pharmacopeia (usp) Reference Standard

    70. (r-(r*,s*))-.alpha.-(1-(methylamino)ethyl)benzenemethanol Hydrochloride [who-ip]

    71. Benzenemethanol, .alpha.-(1-(methylamino)ethyl)-, Hydrochloride, (r-(r*,s*))-

    72. Benzenemethanol, Alpha-((1s)-1-(methylamino)ethyl)-, Hydrochloride (1:1), (alphar)-

    73. Ephedrine Hydrochloride, Drug Precursor, European Pharmacopoeia (ep) Reference Standard

    2.4 Create Date
    2005-06-24
    3 Chemical and Physical Properties
    Molecular Weight 201.69 g/mol
    Molecular Formula C10H16ClNO
    Hydrogen Bond Donor Count3
    Hydrogen Bond Acceptor Count2
    Rotatable Bond Count3
    Exact Mass201.0920418 g/mol
    Monoisotopic Mass201.0920418 g/mol
    Topological Polar Surface Area32.3 Ų
    Heavy Atom Count13
    Formal Charge0
    Complexity121
    Isotope Atom Count0
    Defined Atom Stereocenter Count2
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Adrenergic Agents

    Drugs that act on adrenergic receptors or affect the life cycle of adrenergic transmitters. Included here are adrenergic agonists and antagonists and agents that affect the synthesis, storage, uptake, metabolism, or release of adrenergic transmitters. (See all compounds classified as Adrenergic Agents.)

    Sympathomimetics

    Drugs that mimic the effects of stimulating postganglionic adrenergic sympathetic nerves. Included here are drugs that directly stimulate adrenergic receptors and drugs that act indirectly by provoking the release of adrenergic transmitters. (See all compounds classified as Sympathomimetics.)

    Central Nervous System Stimulants

    A loosely defined group of drugs that tend to increase behavioral alertness, agitation, or excitation. They work by a variety of mechanisms, but usually not by direct excitation of neurons. The many drugs that have such actions as side effects to their main therapeutic use are not included here. (See all compounds classified as Central Nervous System Stimulants.)

    Vasoconstrictor Agents

    Drugs used to cause constriction of the blood vessels. (See all compounds classified as Vasoconstrictor Agents.)

    4.2 FDA Pharmacological Classification
    4.2.1 Pharmacological Classes
    Adrenergic beta-Agonists [MoA]; Increased Norepinephrine Activity [PE]; Norepinephrine Releasing Agent [EPC]; alpha-Adrenergic Agonist [EPC]; beta-Adrenergic Agonist [EPC]; Adrenergic alpha-Agonists [MoA]

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    13-Jan-2021
    30-Aug-2024
    KGS
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