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31 RELATED EXCIPIENT COMPANIES

51EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: 70059-30-2, Cimetidine hcl, Cimetidinehydrochloride, Cimetidine (hydrochloride), Cimetex, 2-cyano-1-methyl-3-(2-(((5-methylimidazol-4-yl)methyl)thio)ethyl)guanidine monohydrochloride
Molecular Formula
C10H17ClN6S
Molecular Weight
288.80  g/mol
InChI Key
QJHCNBWLPSXHBL-UHFFFAOYSA-N
FDA UNII
WF10491673

Cimetidine Hydrochloride
A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.
1 2D Structure

Cimetidine Hydrochloride

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
1-cyano-2-methyl-3-[2-[(5-methyl-1H-imidazol-4-yl)methylsulfanyl]ethyl]guanidine;hydrochloride
2.1.2 InChI
InChI=1S/C10H16N6S.ClH/c1-8-9(16-7-15-8)5-17-4-3-13-10(12-2)14-6-11;/h7H,3-5H2,1-2H3,(H,15,16)(H2,12,13,14);1H
2.1.3 InChI Key
QJHCNBWLPSXHBL-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CC1=C(N=CN1)CSCCNC(=NC)NC#N.Cl
2.2 Other Identifiers
2.2.1 UNII
WF10491673
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Altramet

2. Biomet

3. Biomet400

4. Cimetidine

5. Cimetidine Hcl

6. Eureceptor

7. Hcl, Cimetidine

8. Histodil

9. Hydrochloride, Cimetidine

10. N-cyano-n'-methyl-n''-(2-(((5-methyl-1h-imidazol-4-yl)methyl)thio)ethyl)guanidine

11. Sk And F 92334

12. Sk And F-92334

13. Sk And F92334

14. Skf 92334

15. Skf-92334

16. Skf92334

17. Tagamet

2.3.2 Depositor-Supplied Synonyms

1. 70059-30-2

2. Cimetidine Hcl

3. Cimetidinehydrochloride

4. Cimetidine (hydrochloride)

5. Cimetex

6. 2-cyano-1-methyl-3-(2-(((5-methylimidazol-4-yl)methyl)thio)ethyl)guanidine Monohydrochloride

7. N-cyano-n'-methyl-n''-[2-[[(5-methyl-1h-imidazol-4-yl)methyl]thio]ethyl]guanidine Hydrochloride

8. Endo

9. Tagamet Liquid

10. Wf10491673

11. Tagamet Injection

12. Guanidine, N''-cyano-n-methyl-n'-(2-(((5-methyl-1h-imidazol-4-yl)methyl)thio)ethyl)-, Monohydrochloride

13. Chebi:50362

14. N-cyano-n'-methyl-n''-(2-(((5-methyl-1h-imidazol-4-yl)methyl)thio)ethyl)guanidine Hydrochloride

15. Cimetidine Hydrochloride [usan]

16. Einecs 274-297-2

17. Unii-wf10491673

18. Einecs 276-264-8

19. Cimetidine Hydrochloride [usan:usp]

20. 71989-90-7

21. Schembl42142

22. Schembl42144

23. Cimetidine Hydrochloride (tn)

24. Cimetidine Hydrochloride (usp)

25. Chembl1201051

26. Schembl11156749

27. Dtxsid10990302

28. Cimetidine Hydrochloride [mi]

29. Cimetidine Hydrochloride In Sodium Chloride 0.9% In Plastic Container

30. Hy-14289a

31. Mfcd01724314

32. Tagamet Hydrochloride In Sodium Chloride 0.9% In Plastic Container

33. Akos015961108

34. Akos037643350

35. Ac-4278

36. Cimetidine Hydrochloride [mart.]

37. Cimetidine Hydrochloride [vandf]

38. Cimetidine Hydrochloride [usp-rs]

39. Cimetidine Hydrochloride [who-dd]

40. 1-cyano-2-methyl-3-[2-[(5-methyl-1h-imidazol-4-yl)methylsulfanyl]ethyl]guanidine;hydrochloride

41. As-15040

42. Guanidine, N'-cyano-n-methyl-n'-(2-(((5-methyl-1h-imidazol-4-yl)methyl)thio)ethyl)-, Monohydrochloride

43. N-cyano-n'-methyl-n''-(2-(((5-methyl-1h-imidazol-4-yl)methyl)thio)ethyl)guanidine Monohydrochloride

44. Db-055373

45. Cs-0031039

46. Ft-0602954

47. Cimetidine Hydrochloride [orange Book]

48. Cimetidine Hydrochloride [ep Monograph]

49. Cimetidine Hydrochloride [usp Monograph]

50. D03503

51. 059c302

52. A923492

53. W-104570

54. Q27122038

55. Cimetidine Hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material

56. Cimetidine Hydrochloride, United States Pharmacopeia (usp) Reference Standard

57. Cimetidine Hydrochloride, European Pharmacopoeia (ep) Reference Standard, European Pharmacopoeia (ep) Reference Standard

58. Guanidine, N-cyano-n'-methyl-n''-[2-[[(5-methyl-1h-imidazol-4-yl)methyl]thio]ethyl]-, Monohydrochloride

59. N-cyano-n''-methyl-n'-(2-{[(4-methyl-1h-imidazol-5-yl)methyl]sulfanyl}ethyl)guanidine--hydrogen Chloride (1/1)

2.4 Create Date
2005-08-08
3 Chemical and Physical Properties
Molecular Weight 288.80 g/mol
Molecular Formula C10H17ClN6S
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count4
Rotatable Bond Count7
Exact Mass288.0923934 g/mol
Monoisotopic Mass288.0923934 g/mol
Topological Polar Surface Area114 Ų
Heavy Atom Count18
Formal Charge0
Complexity296
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Drug and Medication Information
4.1 Drug Information
1 of 2  
Drug NameCimetidine hydrochloride
Drug LabelCimetidine is a histamine H2 receptor-antagonist. Chemically it is N"-cyano-N-methyl-N'-[2-[[(5-methyl-1H-imidazol-4-yl)methyl]thio]-ethyl]-guanidine.The molecular formula for cimetidine hydrochloride is C10H16N6S HCl and the molecular weight i
Active IngredientCimetidine hydrochloride
Dosage FormInjectable; Solution
RouteInjection; Oral
Strengtheq 300mg base/2ml; eq 300mg base/5ml
Market StatusPrescription
CompanyWockhardt; Hi Tech Pharma; Ani Pharms; Pharm Assoc; Dava Pharms

2 of 2  
Drug NameCimetidine hydrochloride
Drug LabelCimetidine is a histamine H2 receptor-antagonist. Chemically it is N"-cyano-N-methyl-N'-[2-[[(5-methyl-1H-imidazol-4-yl)methyl]thio]-ethyl]-guanidine.The molecular formula for cimetidine hydrochloride is C10H16N6S HCl and the molecular weight i
Active IngredientCimetidine hydrochloride
Dosage FormInjectable; Solution
RouteInjection; Oral
Strengtheq 300mg base/2ml; eq 300mg base/5ml
Market StatusPrescription
CompanyWockhardt; Hi Tech Pharma; Ani Pharms; Pharm Assoc; Dava Pharms

5 Pharmacology and Biochemistry
5.1 MeSH Pharmacological Classification

Cytochrome P-450 CYP1A2 Inhibitors

Drugs and compounds which inhibit or antagonize the biosynthesis or actions of CYTOCHROME P-450 CYP1A2. (See all compounds classified as Cytochrome P-450 CYP1A2 Inhibitors.)


Anti-Ulcer Agents

Various agents with different action mechanisms used to treat or ameliorate PEPTIC ULCER or irritation of the gastrointestinal tract. This has included ANTIBIOTICS to treat HELICOBACTER INFECTIONS; HISTAMINE H2 ANTAGONISTS to reduce GASTRIC ACID secretion; and ANTACIDS for symptomatic relief. (See all compounds classified as Anti-Ulcer Agents.)


Histamine H2 Antagonists

Drugs that selectively bind to but do not activate histamine H2 receptors, thereby blocking the actions of histamine. Their clinically most important action is the inhibition of acid secretion in the treatment of gastrointestinal ulcers. Smooth muscle may also be affected. Some drugs in this class have strong effects in the central nervous system, but these actions are not well understood. (See all compounds classified as Histamine H2 Antagonists.)


5.2 FDA Pharmacological Classification
5.2.1 Pharmacological Classes
Histamine-2 Receptor Antagonist [EPC]; Histamine H2 Receptor Antagonists [MoA]

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