List of Related Excipient Companies and Suppliers of Alpharma Brand of Propafenone Hydrochloride by Seppic on PharmaCompass.com

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Chemistry

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Also known as: 34183-22-7, Propafenone hcl, Rythmol, Rytmonorm, Arythmol, Pronon
Molecular Formula
C21H28ClNO3
Molecular Weight
377.9  g/mol
InChI Key
XWIHRGFIPXWGEF-UHFFFAOYSA-N
FDA UNII
33XCH0HOCD

Propafenone Hydrochloride
An antiarrhythmia agent that is particularly effective in ventricular arrhythmias. It also has weak beta-blocking activity.
1 2D Structure

Propafenone Hydrochloride

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
1-[2-[2-hydroxy-3-(propylamino)propoxy]phenyl]-3-phenylpropan-1-one;hydrochloride
2.1.2 InChI
InChI=1S/C21H27NO3.ClH/c1-2-14-22-15-18(23)16-25-21-11-7-6-10-19(21)20(24)13-12-17-8-4-3-5-9-17;/h3-11,18,22-23H,2,12-16H2,1H3;1H
2.1.3 InChI Key
XWIHRGFIPXWGEF-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CCCNCC(COC1=CC=CC=C1C(=O)CCC2=CC=CC=C2)O.Cl
2.2 Other Identifiers
2.2.1 UNII
33XCH0HOCD
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Apo-propafenone

2. Arythmol

3. Baxarytmon

4. Cuxafenon

5. Fenoprain

6. Hydrochloride, Propafenone

7. Jutanorm

8. Nistaken

9. Norfenon

10. Pintoform

11. Prolecofen

12. Propafenon Al

13. Propafenon Hexal

14. Propafenon Minden

15. Propafenone

16. Propafenone Hydrochloride, (r)-isomer

17. Propafenone Hydrochloride, (s)-isomer

18. Propafenone, (+-)-isomer

19. Propafenone, (r)-isomer

20. Propafenone, (s)-isomer

21. Propamerck

22. Rythmol

23. Rytmo-puren

24. Rytmogenat

25. Rytmonorm

26. Sa 79

27. Sa-79

28. Sa79

2.3.2 Depositor-Supplied Synonyms

1. 34183-22-7

2. Propafenone Hcl

3. Rythmol

4. Rytmonorm

5. Arythmol

6. Pronon

7. Rythmol Sr

8. Propafenone (hydrochloride)

9. Propafenon Hydrochlorid

10. 1-(2-(2-hydroxy-3-(propylamino)propoxy)phenyl)-3-phenylpropan-1-one Hydrochloride

11. Sa-79 (hydrochloride)

12. 1-[2-[2-hydroxy-3-(propylamino)propoxy]phenyl]-3-phenylpropan-1-one Hydrochloride

13. 1-{2-[2-hydroxy-3-(propylamino)propoxy]phenyl}-3-phenylpropan-1-one Hydrochloride

14. 33xch0hocd

15. Nsc-758640

16. 1-[2-[2-hydroxy-3-(propylamino)propoxy]phenyl]-3-phenylpropan-1-one;hydrochloride

17. Mls000069682

18. Chebi:8466

19. Baxarytmon

20. Fenoprain

21. 2'-(2-hydroxy-3-(propylamino)propoxy)-3-phenylpropiophenone Hydrochloride

22. 1-propanone, 1-(2-(2-hydroxy-3-(propylamino)propoxy)phenyl)-3-phenyl-, Hydrochloride

23. Rhythmonorm

24. Smr000058493

25. 1-[2-[2-hydroxy-3-(propylamino)propoxy]phenyl]-3-phenyl-1-propanone Hydrochloride

26. Sa 79

27. Propafenon Hydrochlorid [german]

28. Sr-01000000192

29. Einecs 251-867-9

30. Unii-33xch0hocd

31. Wz 884

32. Propafenone, Hcl

33. Prestwick_831

34. Rythmol (tn)

35. Mfcd00079243

36. Propafenone Hydrochloride [usan:usp:jan]

37. Opera_id_1835

38. Schembl41412

39. Mls001148185

40. Mls002222267

41. Spectrum1503935

42. Chembl1201063

43. Hy-b0432a

44. Dtxsid101017233

45. Hms1569d19

46. Hms1922m16

47. Pharmakon1600-01503935

48. Bcp28548

49. Tox21_500919

50. Ccg-39061

51. Nsc758640

52. Propafenone Hydrochloride [mi]

53. Akos008901409

54. Propafenone Hydrochloride (jp17/usp)

55. Ks-5030

56. Lp00919

57. Nsc 758640

58. Propafenone Hydrochloride [jan]

59. Propafenone Hydrochloride [usan]

60. Propiophenone, 2'-(2-hydroxy-3-(propylamino)propoxy)-3-phenyl-, Hydrochloride

61. Ncgc00094230-01

62. Ncgc00094230-02

63. Ncgc00094230-03

64. Ncgc00094230-04

65. Ncgc00094230-05

66. Ncgc00261604-01

67. Propafenone Hydrochloride [mart.]

68. Propafenone Hydrochloride [vandf]

69. Ac-11360

70. Ac-33196

71. Propafenone Hydrochloride [usp-rs]

72. Propafenone Hydrochloride [who-dd]

73. Db-048579

74. Eu-0100919

75. Ft-0630579

76. P2301

77. En300-51034

78. D00640

79. P 4670

80. Propafenone Hydrochloride [ep Monograph]

81. Propafenone Hydrochloride [orange Book]

82. Propafenone Hydrochloride [usp Monograph]

83. 183p227

84. A822113

85. J-019481

86. Sr-01000000192-2

87. Sr-01000000192-6

88. Q27108087

89. Z802671518

90. 1-(2-[2-hydroxy-3-(propylamino)propoxy]phenyl)-3-phenyl-1propanone

91. 2'-(2-hydroxy-3-propylaminopropoxy)-3-phenylpropiophenone Hydrochloride

92. Propafenone Hydrochloride, European Pharmacopoeia (ep) Reference Standard

93. 1-[2-[2-oxidanyl-3-(propylamino)propoxy]phenyl]-3-phenyl-propan-1-one Hydrochloride

94. 2-hydroxy-3-[2-(3-phenylpropanoyl)phenoxy]-n-propylpropan-1-aminium Chloride

95. Hydron;1-[2-[2-hydroxy-3-(propylamino)propoxy]phenyl]-3-phenylpropan-1-one;chloride

96. Propafenone Hydrochloride, United States Pharmacopeia (usp) Reference Standard

2.4 Create Date
2005-06-24
3 Chemical and Physical Properties
Molecular Weight 377.9 g/mol
Molecular Formula C21H28ClNO3
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count4
Rotatable Bond Count11
Exact Mass377.1757714 g/mol
Monoisotopic Mass377.1757714 g/mol
Topological Polar Surface Area58.6 Ų
Heavy Atom Count26
Formal Charge0
Complexity368
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Drug and Medication Information
4.1 Drug Information
1 of 6  
Drug NamePropafenone hydrochloride
Drug LabelPropafenone hydrochloride is an antiarrhythmic drug supplied in scored, film-coated tablets of 150 and 225 mg for oral administration. Propafenone has some structural similarities to beta-blocking agents.Chemically, propafenone hydrochloride (HCl) is...
Active IngredientPropafenone hydrochloride
Dosage FormTablet; Capsule, extended release
RouteOral
Strength150mg; 300mg; 225mg; 425mg; 325mg
Market StatusPrescription
CompanyVintage Pharms; Ani Pharms; Par Pharm; Watson Labs; Mutual Pharm

2 of 6  
Drug NameRythmol
PubMed HealthPropafenone (By mouth)
Drug ClassesAntiarrhythmic, Group IC
Drug LabelRYTHMOL SR (propafenone hydrochloride) is an antiarrhythmic drug supplied in extended-release capsules of 225, 325 and 425mg for oral administration.Chemically, propafenone hydrochloride is 2-[2-Hydroxy-3-(propylamino)-propoxy]-3-phenylpropiophe...
Active IngredientPropafenone hydrochloride
Dosage FormTablet
RouteOral
Strength150mg; 300mg; 225mg
Market StatusPrescription
CompanyGlaxosmithkline

3 of 6  
Drug NameRythmol sr
PubMed HealthPropafenone (By mouth)
Drug ClassesAntiarrhythmic, Group IC
Drug LabelRYTHMOL SR (propafenone hydrochloride) is an antiarrhythmic drug supplied in extended-release capsules of 225, 325 and 425mg for oral administration.Chemically, propafenone hydrochloride is 2-[2-Hydroxy-3-(propylamino)-propoxy]-3-phenylpropiophe...
Active IngredientPropafenone hydrochloride
Dosage FormCapsule, extended release
RouteOral
Strength225mg; 425mg; 325mg
Market StatusPrescription
CompanyGlaxosmithkline

4 of 6  
Drug NamePropafenone hydrochloride
Drug LabelPropafenone hydrochloride is an antiarrhythmic drug supplied in scored, film-coated tablets of 150 and 225 mg for oral administration. Propafenone has some structural similarities to beta-blocking agents.Chemically, propafenone hydrochloride (HCl) is...
Active IngredientPropafenone hydrochloride
Dosage FormTablet; Capsule, extended release
RouteOral
Strength150mg; 300mg; 225mg; 425mg; 325mg
Market StatusPrescription
CompanyVintage Pharms; Ani Pharms; Par Pharm; Watson Labs; Mutual Pharm

5 of 6  
Drug NameRythmol
PubMed HealthPropafenone (By mouth)
Drug ClassesAntiarrhythmic, Group IC
Drug LabelRYTHMOL SR (propafenone hydrochloride) is an antiarrhythmic drug supplied in extended-release capsules of 225, 325 and 425mg for oral administration.Chemically, propafenone hydrochloride is 2-[2-Hydroxy-3-(propylamino)-propoxy]-3-phenylpropiophe...
Active IngredientPropafenone hydrochloride
Dosage FormTablet
RouteOral
Strength150mg; 300mg; 225mg
Market StatusPrescription
CompanyGlaxosmithkline

6 of 6  
Drug NameRythmol sr
PubMed HealthPropafenone (By mouth)
Drug ClassesAntiarrhythmic, Group IC
Drug LabelRYTHMOL SR (propafenone hydrochloride) is an antiarrhythmic drug supplied in extended-release capsules of 225, 325 and 425mg for oral administration.Chemically, propafenone hydrochloride is 2-[2-Hydroxy-3-(propylamino)-propoxy]-3-phenylpropiophe...
Active IngredientPropafenone hydrochloride
Dosage FormCapsule, extended release
RouteOral
Strength225mg; 425mg; 325mg
Market StatusPrescription
CompanyGlaxosmithkline

5 Pharmacology and Biochemistry
5.1 MeSH Pharmacological Classification

Voltage-Gated Sodium Channel Blockers

A class of drugs that inhibit the activation of VOLTAGE-GATED SODIUM CHANNELS. (See all compounds classified as Voltage-Gated Sodium Channel Blockers.)


Anti-Arrhythmia Agents

Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade. (See all compounds classified as Anti-Arrhythmia Agents.)


5.2 FDA Pharmacological Classification
5.2.1 Pharmacological Classes
Antiarrhythmic [EPC]

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18-Jan-2021
13-Aug-2024
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DOSAGE - TABLET;ORAL - 150MG **Federal Regist...DOSAGE - TABLET;ORAL - 150MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

USFDA APPLICATION NUMBER - 19151

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DOSAGE - TABLET;ORAL - 225MG **Federal Regist...DOSAGE - TABLET;ORAL - 225MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

USFDA APPLICATION NUMBER - 19151

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DOSAGE - TABLET;ORAL - 300MG **Federal Regist...DOSAGE - TABLET;ORAL - 300MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

USFDA APPLICATION NUMBER - 19151

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DOSAGE - CAPSULE, EXTENDED RELEASE;ORAL - 225...DOSAGE - CAPSULE, EXTENDED RELEASE;ORAL - 225MG

USFDA APPLICATION NUMBER - 21416

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DOSAGE - CAPSULE, EXTENDED RELEASE;ORAL - 325...DOSAGE - CAPSULE, EXTENDED RELEASE;ORAL - 325MG

USFDA APPLICATION NUMBER - 21416

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DOSAGE - CAPSULE, EXTENDED RELEASE;ORAL - 425...DOSAGE - CAPSULE, EXTENDED RELEASE;ORAL - 425MG

USFDA APPLICATION NUMBER - 21416

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