Global sales information of Aceclofenac with Finished Drug Prices obtained from US Medicaid's National Average Drug Acquisition Cost

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ACTIVE PHARMA INGREDIENTS

26 API Suppliers, 1 USDMF, 9 CEP/COS, 4 EU WC, 28 KDMF, 17 Listed Suppliers, $ API Reference Price

26 API Suppliers
1 USDMF
9 CEP/COS
4 EU WC
28 KDMF
17 Listed Suppliers
$ API Reference Price

FINISHED DOSAGE FORMULATIONS

138 FDF Dossiers, 52 Europe, 86 Listed Dossiers

138 FDF Dossiers
52 Europe
86 Listed Dossiers

RELATED EXCIPIENT COMPANIES

1 SPI Pharma, 3 DKSH, 8 Gangwal Healthcare, 2 Nanjing Well Pharmaceutical, 3 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd, 2 BASF, 10 Corel Pharma Chem, 4 DFE Pharma, 6 Gangwal Chemicals, 1 Ideal Cures Pvt Ltd, 18 Kerry, 1 Kima Chemical, 3 Lubrizol Life Science Health, 9 Microlex e.U, 1 Nanjing Bold Chemical, 1 Pharmatrans-Sanaq, 2 Pluviaendo, 2 Prachin Chemical, 9 Roquette, 2 Shanghai Shenmei Pharmaceutical Technology Co., Ltd, 9 Sigachi Industries, 1 The Dow Chemical Company, 2 Vasa Pharmachem

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2 NEWS #PharmaBuzz

GLOBAL SALES INFORMATION

51 Finished Drug Prices

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51 Finished Drug Prices

MARKET PLACE

32 APIs, 11 FDF Dossiers

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32 APIs
11 FDF Dossiers

REF. STANDARDS & IMPURITIES

6 EDQM , 8 Others

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6 EDQM
8 Others

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

$ 59

MARKET PLACE

API

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

138

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

0 DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

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GLOBAL SALES INFORMATION

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Annual Reports (USD Million)

Finished Drug Prices

100 RELATED EXCIPIENT COMPANIES

180EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: 89796-99-6, Preservex, Aceclofenaco, Aceclofenacum, Aceclofenac betadex, Chebi:31159

Molecular Formula

C₁₆H₁₃Cl₂NO₄

Molecular Weight

354.2 g/mol

InChI Key

MNIPYSSQXLZQLJ-UHFFFAOYSA-N

FDA UNII

RPK779R03H

Aceclofenac is an oral non-steroidal anti-inflammatory drug (NSAID) with marked anti-inflammatory and analgesic properties used to treat osteoarthritis, rheumatoid arthritis and ankylosing spondylitis. It is reported to have a higher anti-inflammatory action or at least comparable effects than conventional NSAIDs in double-blind studies. Aceclofenac potently inhibits the cyclo-oxygenase enzyme (COX) that is involved in the synthesis of prostaglandins, which are inflammatory mediators that cause pain, swelling, inflammation, and fever. Aceclofenac belongs to BCS Class II as it possesses poor aqueous solubility. It displays high permeability to penetrate into synovial joints where in patients with osteoarthritis and related conditions, the loss of articular cartilage in the area causes joint pain, tenderness, stiffness, crepitus, and local inflammation. Aceclofenac is also reported to be effective in other painful conditions such as dental and gynaecological conditions. In 1991, aceclofenac was developed as an analog of a commonly prescribed NSAID, [DB00586], via chemical modification in effort to improve the gastrointestinal tolerability of the drug. It is a more commonly prescribed drug in Europe.

1 2D Structure

Aceclofenac

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

2-[2-[2-(2,6-dichloroanilino)phenyl]acetyl]oxyacetic acid

2.1.2 InChI

InChI=1S/C16H13Cl2NO4/c17-11-5-3-6-12(18)16(11)19-13-7-2-1-4-10(13)8-15(22)23-9-14(20)21/h1-7,19H,8-9H2,(H,20,21)

2.1.3 InChI Key

MNIPYSSQXLZQLJ-UHFFFAOYSA-N

2.1.4 Canonical SMILES

C1=CC=C(C(=C1)CC(=O)OCC(=O)O)NC2=C(C=CC=C2Cl)Cl

2.2 Other Identifiers

2.2.1 UNII

RPK779R03H

2.3 Synonyms

2.3.1 MeSH Synonyms

1. 2-((2,6-dichlorophenyl)amino)phenylacetoxyacetic Acid

2. Airtal

3. Airtal Difucrem

4. Aital

5. Beofenac

6. Biofenac

7. Bristaflam

8. Clanza Cr

9. Falcol

10. Falcol Difucrem

11. Gerbin

12. Gerbin Difucrem

13. Preservex

14. Sanein

2.3.2 Depositor-Supplied Synonyms

1. 89796-99-6

2. Preservex

3. Aceclofenaco

4. Aceclofenacum

5. Aceclofenac Betadex

6. Chebi:31159

7. 2-[2-[2-(2,6-dichloroanilino)phenyl]acetyl]oxyacetic Acid

8. Mfcd00864296

9. Airtal

10. Rpk779r03h

11. 2-(2-(2-((2,6-dichlorophenyl)amino)phenyl)acetoxy)acetic Acid

12. Ncgc00016957-01

13. Glycolic Acid [o-(2,6-dichloroanilino)phenyl]acetate Ester

14. 2-(2-(2-(2,6-dichlorophenylamino)phenyl)acetoxy)acetic Acid

15. Glycolic Acid, (o-(2,6-dichloroanilino)phenyl)acetate (ester)

16. 2-((2,6-dichlorophenyl)amino)benzeneacetic Acid Carboxymethyl Ester

17. 2-[(2,6-dichlorophenyl)amino]benzeneacetic Acid Carboxymethyl Ester

18. Cas-89796-99-6

19. Dsstox_cid_25522

20. Dsstox_rid_80928

21. Dsstox_gsid_45522

22. 2-[(2',6'-dichlorophenyl)amino]phenylacetoxyacetic Acid

23. Aceclofenacum [latin]

24. Aceclofenaco [spanish]

25. Hifenac

26. 2-[(2-{2-[(2,6-dichlorophenyl)amino]phenyl}acetyl)oxy]acetic Acid

27. Benzeneacetic Acid, 2-((2,6-dichlorophenyl)amino)-, Carboxymethyl Ester

28. Smr000718629

29. Sr-01000802972

30. Aceclofenac [inn:ban]

31. Brn 4884476

32. Unii-rpk779r03h

33. Cincofen

34. [({2-[(2,6-dichlorophenyl)amino]phenyl}acetyl)oxy]acetic Acid

35. Clanza

36. Benzeneacetic Acid, 2-[(2,6-dichlorophenyl)amino]-, Carboxymethyl Ester

37. (2-{2-[(2,6-dichlorophenyl)amino]phenyl}acetoxy)acetic Acid

38. Aceclofenac (tn)

39. Prestwick_772

40. 2-(o-(2,6-dichloranilino)phenylacetoxy)essigsaeure

41. Pr-82/3

42. Aceclofenac (jan/inn)

43. Aceclofenac [mi]

44. Prestwick0_000175

45. Prestwick1_000175

46. Prestwick2_000175

47. Prestwick3_000175

48. Aceclofenac [inn]

49. Aceclofenac [jan]

50. Aceclofenac [mart.]

51. Schembl25734

52. Aceclofenac [who-dd]

53. Bspbio_000069

54. Mls001032069

55. Mls001304028

56. Mls002154226

57. Chembl93645

58. Spbio_001990

59. Bpbio1_000077

60. Dtxsid7045522

61. Aceclofenac, >=98% (hplc)

62. Aceclofenac [ep Monograph]

63. Aceclofenac For Peak Identification

64. Hms1568d11

65. Hms2090g07

66. Hms2095d11

67. Hms2231b03

68. Hms3371a10

69. Hms3712d11

70. Hms3873i03

71. Bcp11932

72. Hy-b0634

73. Zinc3805798

74. Tox21_110710

75. Aceclofenac Betadex [who-dd]

76. Bbl010788

77. Bdbm50109016

78. S4835

79. Stk594349

80. Akos005516194

81. Tox21_110710_1

82. Ab07468

83. Ac-5282

84. Aceclofenac 1.0 Mg/ml In Acetonitrile

85. Ccg-213835

86. Db06736

87. Ks-5033

88. Ncgc00016957-02

89. Ncgc00016957-03

90. Ncgc00016957-05

91. Ba164135

92. Aceclofenac 100 Microg/ml In Acetonitrile

93. Ft-0621715

94. D01545

95. 796a996

96. Q481757

97. 2-(2,6-dichlorophenylamine)phenylacetoxyacetic Acid

98. Sr-01000802972-2

99. Sr-01000802972-3

100. 2-[2-(2,6-dichloroanilino)phenylacetoxy]acetic Acid

101. Brd-k68538666-001-03-2

102. Aceclofenac For Peak Identification, European Pharmacopoeia (ep) Reference Standard

2.4 Create Date

2005-06-24

3 Chemical and Physical Properties

Molecular Formula	C₁₆H₁₃Cl₂NO₄
Molecular Weight	354.2 g/mol
XLogP3	4.3
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	7
Exact Mass	353.0221633 g/mol
Monoisotopic Mass	353.0221633 g/mol
Topological Polar Surface Area	75.6 Å²
Heavy Atom Count	23
Formal Charge	0
Complexity	411
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

4 Drug and Medication Information

4.1 Drug Indication

Aceclofenac is indicated for the relief of pain and inflammation in osteoarthritis, rheumatoid arthritis and ankylosing spondylitis.

5 Pharmacology and Biochemistry

5.1 Pharmacology

Aceclofenac is a NSAID that inhibits both isoforms of COX enzyme, a key enzyme involved in the inflammatory cascade. COX-1 enzyme is a constitutive enzyme involved in prostacyclin production and protective functions of gastric mucosa whereas COX-2 is an inducible enzyme involved in the production of inflammatory mediators in response to inflammatory stimuli. Aceclofenac displays more selectivity towards COX-2 (IC50 of 0.77uM) than COX-1 (IC50 of >100uM), which promotes its gastric tolerance compared to other NSAIDs. The primary metabolite, 4'-hydroxyaceclofenac, also minimally inhibits COX-2 with IC50 value of 36uM. Although the mode of action of aceclofenac is thought to mainly arise from the inhibition of synthesis of prostaglandins (PGE2), aceclofenac also inhibits the production of inflammatory cytokines, interleukins (IL-1, IL-6), and tumor necrosis factors (TNF). It is also reported that aceclofenac also affects the cell adhesion molecules from neutrophils. Aceclofenac also targets the synthesis of glycosaminoglycan and mediates chrondroprotective effects.

5.2 MeSH Pharmacological Classification

Anti-Inflammatory Agents, Non-Steroidal

Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects. (See all compounds classified as Anti-Inflammatory Agents, Non-Steroidal.)

5.3 ATC Code

M01AB16

S76 | LUXPHARMA | Pharmaceuticals Marketed in Luxembourg | Pharmaceuticals marketed in Luxembourg, as published by d'Gesondheetskeess (CNS, la caisse nationale de sante, www.cns.lu), mapped by name to structures using CompTox by R. Singh et al. (in prep.). List downloaded from https://cns.public.lu/en/legislations/textes-coordonnes/liste-med-comm.html. Dataset DOI:10.5281/zenodo.4587355

M - Musculo-skeletal system

M01 - Antiinflammatory and antirheumatic products

M01A - Antiinflammatory and antirheumatic products, non-steroids

M01AB - Acetic acid derivatives and related substances

M01AB16 - Aceclofenac

M - Musculo-skeletal system

M02 - Topical products for joint and muscular pain

M02A - Topical products for joint and muscular pain

M02AA - Antiinflammatory preparations, non-steroids for topical use

M02AA25 - Aceclofenac

5.4 Absorption, Distribution and Excretion

Absorption

Aceclofenac is rapidly and completely absorbed from the gastrointestinal tract and circulates mainly as unchanged drug following oral administration. Peak plasma concentrations are reached around 1.25 to 3 hours post-ingestion, and the drug penetrates into the synovial fluid where the concentration may reach up to 60% of that in the plasma. There is no accumulation in regular dosing, with similar maximum plasma concentration (Cmax) and time to reach peak plasma concentration (Tmax) after single and multiple doses.

Route of Elimination

The main route of elimination is via the urine where the elimination accounts for 70-80% of clearance of the drug. Approximately two thirds of the administered dose is excreted via the urine, mainly as glucuronidated and hydroxylated forms of aceclofenac. About 20% of the dose is excreted into feces.

Volume of Distribution

The volume of distribution is approximately 25 L.

Clearance

The mean clearance rate is approximately 5 L/h.

5.5 Metabolism/Metabolites

4'-hydroxyaceclofenac is the main metabolite detected in plasma however other minor metabolites include diclofenac, 5-hydroxyaceclofenac, 5-hydroxydiclofenac, and 4'-hydroxydiclofenac. It is probable that the metabolism of aceclofenac is mediated by CYP2C9.

Aceclofenac has known human metabolites that include 4'-hydroxy-aceclofenac, 5-hydroxy-aceclofenac, and diclofenac.

S73 | METXBIODB | Metabolite Reaction Database from BioTransformer | DOI:10.5281/zenodo.4056560

5.6 Biological Half-Life

The mean plasma elimination half-life is approximately 4 hours.

5.7 Mechanism of Action

Through COX-2 inhibition, aceclofenac downregulates the production of various inflammatory mediators including prostaglandin E2 (PGE2), IL-1, and TNF from the arachidonic acid (AA) pathway. Inhibition of IL-6 is thought to be mediated by diclofenac converted from aceclofenac. Suppressed action of inflammatory cytokines decreases the production of reactive oxygen species. Aceclofenac is shown to decreased production of nitrous oxide in human articular chondrocytes. In addition, aceclofenac interferes with neutrophil adhesion to endothelium by decreasing the expression of L-selectin (CD62L), which is a cell adhesion molecule expressed on lymphocytes. Aceclofenac is proposed to stimulate the synthesis of glycosaminoglycan in human osteoarthritic cartilage which may be mediated through its inhibitory action on IL-1 production and activity. The chrondroprotective effects are generated by 4'-hydroxyaceclofenac which suppresses IL-1 mediated production of promatrix metalloproteinase-1 and metalloproteinase-3 and interferes with the release of proteoglycan from chrondrocytes.

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Listed Suppliers

01

LGM Pharma

U.S.A

Contract Pharma 2024

Booth #134

LGM Pharma accelerates & optimizes the new product pathway from early development through commercialization.

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U.S.A

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About the Company : LGM Pharma is a global leader in sourcing hard-to-find APIs and intermediates for the pharmaceutical and biotech industries. LGM is also a full service CDMO providing formulation, ...

LGM Pharma is a global leader in sourcing hard-to-find APIs and intermediates for the pharmaceutical and biotech industries. LGM is also a full service CDMO providing formulation, analytical method development and testing, and commercial manufacturing. LGM Pharma offers custom API synthesis, analytical development, and regulatory services. With a network of over 300 accredited CGMP manufacturing partners, LGM provides unparalleled supply chain security. And, with over 100,000 square feet of FDA-inspected cGMP manufacturing and warehouse capacity, LGM Pharma provides a one-stop solution for solid dose, powder, semi-solid and liquid drugs.

02

Jai Radhe Sales

India

CPhI Worldwide, Milan

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Jai Radhe Sales is your partner for all your sourcing needs.

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About the Company : Jai Radhe Sales was founded in 1999 as an out-of-the-box distribution firm specializing in the global supply of high-quality pharmaceutical ingredients. The firm provides complete ...

Jai Radhe Sales was founded in 1999 as an out-of-the-box distribution firm specializing in the global supply of high-quality pharmaceutical ingredients. The firm provides complete sourcing solutions for pharmaceutical products from India, including technical and regulatory assistance. It believes in providing its customers with high-quality products at reasonable prices. It has always endeavored to achieve global standards in the field of pharmaceuticals and has carved out a niche for itself through new methods based on current market needs. Today, it has established itself as a truly global company, with exports to almost every continent.

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Atman Pharmaceuticals

India

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About the Company : Atman Pharmaceuticals is a fully integrated pharmaceutical company that has distinguished itself as a leader in Bulk Drugs (API) marketing both domestically in India and overseas. ...

Atman Pharmaceuticals is a fully integrated pharmaceutical company that has distinguished itself as a leader in Bulk Drugs (API) marketing both domestically in India and overseas. With a heritage spanning over 33 years and vast experience, we have earned a reputation for delivering high-quality and abundant services within the industry. Our emergence as prominent solution providers in the pharmaceutical business underscores our commitment to excellence.

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API Reference Price

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ESTATE, VALSAD DIST.","city":"VAPI, GUJARAT","supplier":"RANKE QUIMICA S.A","supplierCountry":"INDIA","foreign_port":"NA","customer":"RICHTER THEMIS MEDICARE I PVT LTD","customerCountry":"INDIA","quantity":"75.00","actualQuantity":"75","unit":"KGS","unitRateFc":"87.9","totalValueFC":"7496.2","currency":"EUR","unitRateINR":"8236.5","date":"02-Dec-2022","totalValueINR":"617734.48","totalValueInUsd":"7496.2","indian_port":"JNPT","hs_no":"29420090","bill_no":"3559154","productDescription":"Re-Import","marketType":"REGULATED MARKET","country":"INDIA","selfForZScoreResived":"Micronized","supplierPort":"NA","supplierAddress":"","customerAddress":"PLOT.NO.69\/A-2, G.I.D.C.INDL. ESTATE, VALSAD DIST."},{"dataSource":"API Import","activeIngredients":"","year":"2022","qtr":"Q4","strtotime":1669919400,"product":"ACECLOFENAC RTML MICRONIZED REF CODE 70002692 (RE-IMPORT) EXPORTED VIDE SB NO 7633405 DT 21-01-2022","address":"PLOT.NO.69\/A-2, G.I.D.C.INDL. 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ESTATE, VALSAD DIST."},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q1","strtotime":1706639400,"product":"ACECLOFENAC EP8 (FOR PHARMACEUTICAL USE ONLY)","address":"564\/A\/22, ROAD NO.92","city":"HYDERABAD,ANDHRA PRADESH","supplier":"JIANGXI SYNERGY PHARMACEUTICAL","supplierCountry":"CHINA","foreign_port":"SHANGHAI - PU DONG","customer":"VIATRIS","customerCountry":"INDIA","quantity":"250.00","actualQuantity":"250","unit":"KGS","unitRateFc":"126.5","totalValueFC":"32027.7","currency":"USD","unitRateINR":"10638.7","date":"31-Jan-2024","totalValueINR":"2659662.5","totalValueInUsd":"32027.7","indian_port":"Bombay Air","hs_no":"29224990","bill_no":"9908719","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"SHANGHAI - PU DONG","supplierAddress":"O.LTD FENGXIN INDUSTRIAL PARK FENGXIN JIANGXI 330700 P. R.OF CHINASDNF China","customerAddress":"564\/A\/22, ROAD NO.92"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q1","strtotime":1710354600,"product":"ACECLOFENAC EP8(FOR PHARMACEUTICAL USE ONLY)","address":"564\/A\/22, ROAD NO.92","city":"HYDERABAD,ANDHRA PRADESH","supplier":"JIANGXI SYNERGY PHARMACEUTICAL","supplierCountry":"CHINA","foreign_port":"BEIJING","customer":"VIATRIS","customerCountry":"INDIA","quantity":"220.00","actualQuantity":"220","unit":"KGS","unitRateFc":"126.5","totalValueFC":"28067","currency":"USD","unitRateINR":"10594.4","date":"14-Mar-2024","totalValueINR":"2330762.5","totalValueInUsd":"28067","indian_port":"Bombay Air","hs_no":"29224990","bill_no":"2570231","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"BEIJING","supplierAddress":"O.LTD FENGXIN INDUSTRIAL PARK FENGXIN JIANGXI 330700 P. R.OF CHINASDNF China","customerAddress":"564\/A\/22, ROAD NO.92"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1724178600,"product":"ACECLOFENAC EP8 (FOR PHARMACEUTICAL USE ONLY)","address":"564\/A\/22, ROAD NO.92","city":"HYDERABAD,ANDHRA PRADESH","supplier":"JIANGXI SYNERGY PHARMACEUTICAL","supplierCountry":"CHINA","foreign_port":"BEIJING","customer":"VIATRIS","customerCountry":"INDIA","quantity":"175.00","actualQuantity":"175","unit":"KGS","unitRateFc":"126.5","totalValueFC":"22619.3","currency":"USD","unitRateINR":"10733.5","date":"21-Aug-2024","totalValueINR":"1878366.88","totalValueInUsd":"22619.3","indian_port":"Bombay Air","hs_no":"29224990","bill_no":"5169908","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"BEIJING","supplierAddress":"O.LTD FENGXIN INDUSTRIAL PARK FENGXIN JIANGXI 330700 P. R.OF CHINASDNF China","customerAddress":"564\/A\/22, ROAD NO.92"}]

Number of Transactions

Total Quantity (KGS)

Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

Importing Country	Total Quantity (KGS)	Average Price (USD/KGS)	Number of Transactions

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Global sales information of Aceclofenac with Finished Drug Prices obtained from US Medicaid's National Average Drug Acquisition Cost

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CHEMISTRY

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ACTIVE PHARMA INGREDIENTS

26 API Suppliers

1 USDMF

9 CEP/COS

4 EU WC

28 KDMF

17 Listed Suppliers

$ API Reference Price

FINISHED DOSAGE FORMULATIONS

138 FDF Dossiers

52 Europe

86 Listed Dossiers

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EXCIPIENTS BY APPLICATIONS

41 Fillers, Diluents & Binders

20 Direct Compression

19 Thickeners and Stabilizers

14 Coating Systems & Additives

13 Granulation

12 Controlled & Modified Release

12 Lubricants & Glidants

11 Co-Processed Excipients

6 Solubilizers

5 Taste Masking

5 Topical

5 Disintegrants & Superdisintegrants

5 Film Formers & Plasticizers

3 Emulsifying Agents

3 Chewable & Orodispersible Aids

2 Coloring Agents

2 Parenteral

1 API Stability Enhancers

1 Rheology Modifiers

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GLOBAL SALES INFORMATION

51 Finished Drug Prices

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32 APIs

11 FDF Dossiers

REF. STANDARDS & IMPURITIES

6 EDQM

8 Others

ACTIVE PHARMA INGREDIENTS

API REF. PRICE (USD/KG)

$ 59

MARKET PLACE

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FINISHED DOSAGE FORMULATIONS

0 DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES