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    Chemistry

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    Also known as: 61-76-7, Phenylephrine hcl, Biomydrin, Nostril, (r)-phenylephrine hydrochloride, L-phenylephrine hydrochloride
    Molecular Formula
    C9H14ClNO2
    Molecular Weight
    203.66  g/mol
    InChI Key
    OCYSGIYOVXAGKQ-FVGYRXGTSA-N
    FDA UNII
    04JA59TNSJ
    Phenylephrine Hydrochloride
    An alpha-1 adrenergic agonist used as a mydriatic, nasal decongestant, and cardiotonic agent.
    1 2D Structure

    Phenylephrine Hydrochloride

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    3-[(1R)-1-hydroxy-2-(methylamino)ethyl]phenol;hydrochloride
    2.1.2 InChI
    InChI=1S/C9H13NO2.ClH/c1-10-6-9(12)7-3-2-4-8(11)5-7;/h2-5,9-12H,6H2,1H3;1H/t9-;/m0./s1
    2.1.3 InChI Key
    OCYSGIYOVXAGKQ-FVGYRXGTSA-N
    2.1.4 Canonical SMILES
    CNCC(C1=CC(=CC=C1)O)O.Cl
    2.1.5 Isomeric SMILES
    CNC[C@@H](C1=CC(=CC=C1)O)O.Cl
    2.2 Other Identifiers
    2.2.1 UNII
    04JA59TNSJ
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. (r)-3-hydroxy-alpha-((methylamino)methyl)benzenemethanol

    2. Metaoxedrin

    3. Metasympatol

    4. Mezaton

    5. Neo Synephrine

    6. Neo-synephrine

    7. Neosynephrine

    8. Phenylephrine

    9. Phenylephrine Tannate

    10. Tannate, Phenylephrine

    2.3.2 Depositor-Supplied Synonyms

    1. 61-76-7

    2. Phenylephrine Hcl

    3. Biomydrin

    4. Nostril

    5. (r)-phenylephrine Hydrochloride

    6. L-phenylephrine Hydrochloride

    7. (r)-(-)-phenylephrine Hydrochloride

    8. Phenylephrine.hcl

    9. Mydfrin

    10. Metaoxedrine Chloride

    11. Vazculep

    12. Neo-synephrine

    13. Adrianol

    14. Neophryn

    15. Prefrin

    16. Rhinall

    17. Alcon Efrin

    18. (-)-phenylephrine Hydrochloride

    19. Nci-c55641

    20. Efricel

    21. Isopto Frin

    22. Prefrin Liquifilm

    23. (r)-3-(1-hydroxy-2-(methylamino)ethyl)phenol Hydrochloride

    24. 3-[(1r)-1-hydroxy-2-(methylamino)ethyl]phenol;hydrochloride

    25. Afrin 4 Hour Nasal Spray

    26. Nsc-757273

    27. 04ja59tnsj

    28. Phenylephrine (hydrochloride)

    29. Mls000069696

    30. Ncgc00024257-04

    31. Neosympatol

    32. Synethenate

    33. Almefrin

    34. Consdrin

    35. Emagrin

    36. Fenilfar

    37. Histabid

    38. Idrianol

    39. Lexatol

    40. Oftalfrine

    41. Phenistan

    42. Pyristan

    43. Smr000058497

    44. Stanephrin

    45. Sucraphen

    46. Synasal

    47. Fenox

    48. Meta-sympatol

    49. Alcon-efrin

    50. (r)-(-)-1-(3-hydroxyphenyl)-2-methylaminoethanol Hydrochloride

    51. [(2r)-2-hydroxy-2-(3-hydroxyphenyl)ethyl]-methylazanium;chloride

    52. Dsstox_cid_1142

    53. Op-isophrin

    54. Dsstox_rid_75972

    55. Neo-synesin 1

    56. Dsstox_gsid_21142

    57. Neooxedrine Chloride

    58. 3-[(1r)-1-hydroxy-2-(methylamino)ethyl]phenol Hydrochloride

    59. Consdrin Hydrochloride

    60. Isophrin Hydrochloride

    61. Vasosulf

    62. Relief

    63. Metaoxedrine Hydrochloride

    64. Neosynephrine Hydrochloride

    65. Sudafed Pe

    66. Chebi:8094

    67. Op-isophrin-z

    68. Cas-61-76-7

    69. Meta-synephrine Hydrochloride

    70. Ccris 219

    71. Levophenylephrine Hydrochloride

    72. Phenylephrine Hydrochloride, L-

    73. R-(-)-m-synephrine Hydrochloride

    74. D-(-)-phenylephrine Hydrochloride

    75. Einecs 200-517-3

    76. Unii-04ja59tnsj

    77. M-methylaminoethanolphenol Hydrochloride

    78. Benzedrex Nasal Spray, Regular

    79. Sr-01000075286

    80. Mfcd00012605

    81. Phenylephrine Hydrochloride [usp:jan]

    82. Vicks Sinex Vapospray

    83. Neo-synephrine (tn)

    84. L-1-(m-hydroxyphenyl)-2-methyl-aminoethanol Hydrochloride

    85. Vicks Sinex Nasal Spray

    86. 1-m-hydroxy-alpha-(methylaminomethyl)benzyl Alcohol Hydrochloride

    87. Opera_id_1786

    88. (-)-m-hydroxy-alpha-((methylamino)methyl)benzyl Alcohol Hydrochloride

    89. (r)-3-hydroxy-alpha-((methylamino)methyl)benzenemethanol Hydrochloride

    90. (-)-alpha-hydroxy-beta-(methylamino)ethyl-alpha-(3-hydroxybenzene) Hydrochloride

    91. Benzenemethanol, 3-hydroxy-alpha-((methylamino)methyl)-, Hydrochloride, (-)-

    92. Ec 200-517-3

    93. Schembl24654

    94. Mls006012005

    95. Spectrum1500483

    96. Phenylephrine Hydrochloride,(s)

    97. Chembl1200339

    98. Dtxsid3021142

    99. L(-)-phenylephrine Hydrochloride

    100. Hms1920h08

    101. Pharmakon1600-01500483

    102. Bcp23410

    103. Hy-b0471

    104. Tox21_110897

    105. Tox21_201261

    106. Tox21_302846

    107. Tox21_500920

    108. Ccg-39113

    109. Nsc757273

    110. S2569

    111. Akos022190146

    112. Benzenemethanol, 3-hydroxy-alpha-((methylamino)methyl)-, Hydrochloride (r)-

    113. Benzyl Alcohol, M-hydroxy-alpha-((methylamino)methyl)-, Hydrochloride, (-)-

    114. Tox21_110897_1

    115. Lp00920

    116. Nsc 757273

    117. Benzenemethanol, 3-hydroxy-alpha-((methylamino)methyl)-, Hydrochloride, (alphar)-

    118. Phenylephrine Hydrochloride (jp17/usp)

    119. Phenylephrine Hydrochloride [mi]

    120. Ncgc00024257-08

    121. Ncgc00094231-01

    122. Ncgc00256496-01

    123. Ncgc00258813-01

    124. Ncgc00261605-01

    125. Phenylephrine Hydrochloride [jan]

    126. Bp166231

    127. Bcp0726000237

    128. Phenylephrine Hydrochloride [mart.]

    129. Phenylephrine Hydrochloride [vandf]

    130. Phenylephrine Hydrochloride [usp-rs]

    131. Phenylephrine Hydrochloride [who-dd]

    132. (r)-(-)-phenylephrine Hydrochloride, Powder

    133. Eu-0100920

    134. P0398

    135. Sw219446-1

    136. Vu0239753-6

    137. D00511

    138. D70603

    139. P 6126

    140. Phenylephrine Hydrochloride [orange Book]

    141. A833410

    142. Phenylephrine Hydrochloride [ep Monograph]

    143. Phenylephrine Hydrochloride [usp Monograph]

    144. Omidria Component Phenylephrine Hydrochloride

    145. Q-201561

    146. Sr-01000075286-1

    147. Phenylephrine Hydrochloride Component Of Omidria

    148. Prefrin-a Component Phenylephrine Hydrochloride

    149. Q27107758

    150. (r)-(-)-phenylephrine Hydrochloride, Analytical Standard

    151. Cyclomydril Component Phenylephrine Hydrochloride

    152. Phenergan Vc Component Phenylephrine Hydrochloride

    153. Phenylephrine Hydrochloride Component Of Prefrin-a

    154. Pherazine Vc Component Phenylephrine Hydrochloride

    155. Phenylephrine Hydrochloride Component Of Cyclomydril

    156. Phenylephrine Hydrochloride Component Of Phenergan Vc

    157. Phenylephrine Hydrochloride Component Of Pherazine Vc

    158. Promethazine Vc Component Phenylephrine Hydrochloride

    159. Phenylephrine Hydrochloride Component Of Promethazine Vc

    160. (r)-(-)-phenylephrine Hydrochloride, Tested According To Ph.eur.

    161. Advil Congestion Relief Component Phenylephrine Hydrochloride

    162. Benzenemethanol, 3-hydroxy-a-[(methylamino)methyl]-, Hydrochloride,(ar)-

    163. Phenylephrine Hydrochloride Component Of Advil Congestion Relief

    164. Phenylephrine Hydrochloride, British Pharmacopoeia (bp) Reference Standard

    165. Phenylephrine Hydrochloride, European Pharmacopoeia (ep) Reference Standard

    166. (-)-m-hydroxy-.alpha.-((methylamino)methyl)benzyl Alcohol Hydrochloride

    167. Benzenemethanol, 3-hydroxy-.alpha.-((methylamino)methyl)-, Hydrochloride (r)-

    168. Benzenemethanol, 3-hydroxy-alpha-((methylamino)methyl)-, Hydrochloride (1:1), (alphar)-

    169. Phenylephrine Hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material

    170. Phenylephrine Hydrochloride, United States Pharmacopeia (usp) Reference Standard

    171. Phenylephrine Hydrochloride For Peak Identification, European Pharmacopoeia (ep) Reference Standard

    172. R-(-)-phenylephrine Hydrochloride Solution, 1.0 Mg/ml In Methanol (as Free Base), Ampule Of 1 Ml, Certified Reference Material

    2.4 Create Date
    2005-11-20
    3 Chemical and Physical Properties
    Molecular Weight 203.66 g/mol
    Molecular Formula C9H14ClNO2
    Hydrogen Bond Donor Count4
    Hydrogen Bond Acceptor Count3
    Rotatable Bond Count3
    Exact Mass203.0713064 g/mol
    Monoisotopic Mass203.0713064 g/mol
    Topological Polar Surface Area52.5 Ų
    Heavy Atom Count13
    Formal Charge0
    Complexity130
    Isotope Atom Count0
    Defined Atom Stereocenter Count1
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 2  
    Drug NamePhenylephrine hydrochloride
    Drug LabelNEO-SYNEPHRINE hydrochloride, brand of phenylephrine hydrochloride injectino, is a vasoconstrictor and pressor drug chemically related to epinephrine and ephedrine. NEO-SYNEPHRINE hydrochloride is a synthetic sympathomimetic agent in sterile form f...
    Active IngredientPhenylephrine hydrochloride
    Dosage FormSolution/drops; Solution
    RouteOphthalmic; Iv (infusion)
    Strength10mg/ml (10mg/ml); 10%; 2.5%
    Market StatusPrescription
    CompanyWest Ward Pharm; Paragon Bioteck

    2 of 2  
    Drug NamePhenylephrine hydrochloride
    Drug LabelNEO-SYNEPHRINE hydrochloride, brand of phenylephrine hydrochloride injectino, is a vasoconstrictor and pressor drug chemically related to epinephrine and ephedrine. NEO-SYNEPHRINE hydrochloride is a synthetic sympathomimetic agent in sterile form f...
    Active IngredientPhenylephrine hydrochloride
    Dosage FormSolution/drops; Solution
    RouteOphthalmic; Iv (infusion)
    Strength10mg/ml (10mg/ml); 10%; 2.5%
    Market StatusPrescription
    CompanyWest Ward Pharm; Paragon Bioteck

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Mydriatics

    Agents that dilate the pupil. They may be either sympathomimetics or parasympatholytics. (See all compounds classified as Mydriatics.)

    Nasal Decongestants

    Drugs designed to treat inflammation of the nasal passages, generally the result of an infection (more often than not the common cold) or an allergy related condition, e.g., hay fever. The inflammation involves swelling of the mucous membrane that lines the nasal passages and results in inordinate mucus production. The primary class of nasal decongestants are vasoconstrictor agents. (From PharmAssist, The Family Guide to Health and Medicine, 1993) (See all compounds classified as Nasal Decongestants.)

    Sympathomimetics

    Drugs that mimic the effects of stimulating postganglionic adrenergic sympathetic nerves. Included here are drugs that directly stimulate adrenergic receptors and drugs that act indirectly by provoking the release of adrenergic transmitters. (See all compounds classified as Sympathomimetics.)

    Vasoconstrictor Agents

    Drugs used to cause constriction of the blood vessels. (See all compounds classified as Vasoconstrictor Agents.)

    Adrenergic alpha-1 Receptor Agonists

    Compounds that bind to and activate ADRENERGIC ALPHA-1 RECEPTORS. (See all compounds classified as Adrenergic alpha-1 Receptor Agonists.)

    Cardiotonic Agents

    Agents that have a strengthening effect on the heart or that can increase cardiac output. They may be CARDIAC GLYCOSIDES; SYMPATHOMIMETICS; or other drugs. They are used after MYOCARDIAL INFARCT; CARDIAC SURGICAL PROCEDURES; in SHOCK; or in congestive heart failure (HEART FAILURE). (See all compounds classified as Cardiotonic Agents.)

    5.2 FDA Pharmacological Classification
    5.2.1 Pharmacological Classes
    alpha-1 Adrenergic Agonist [EPC]; Adrenergic alpha1-Agonists [MoA]

    API Reference Price

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    02-Jan-2021
    30-Aug-2024
    KGS
    overview
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    Average Price (USD/KGS)

    Number of Transactions

    Total Quantity (KGS)

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    Quantity (KGS) & Unit rate (USD/KGS) over time

    API Imports and Exports

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    (KGS)    		 Average Price
    (USD/KGS)    		 Number of Transactions

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