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Chemistry

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Also known as: 7235-40-7, Beta carotene, Beta,beta-carotene, Betacarotene, Solatene, Provitamin a
Molecular Formula
C40H56
Molecular Weight
536.9  g/mol
InChI Key
OENHQHLEOONYIE-JLTXGRSLSA-N
FDA UNII
01YAE03M7J

Beta Carotene
A carotenoid that is a precursor of VITAMIN A. Beta carotene is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC).
1 2D Structure

Beta Carotene

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
1,3,3-trimethyl-2-[(1E,3E,5E,7E,9E,11E,13E,15E,17E)-3,7,12,16-tetramethyl-18-(2,6,6-trimethylcyclohexen-1-yl)octadeca-1,3,5,7,9,11,13,15,17-nonaenyl]cyclohexene
2.1.2 InChI
InChI=1S/C40H56/c1-31(19-13-21-33(3)25-27-37-35(5)23-15-29-39(37,7)8)17-11-12-18-32(2)20-14-22-34(4)26-28-38-36(6)24-16-30-40(38,9)10/h11-14,17-22,25-28H,15-16,23-24,29-30H2,1-10H3/b12-11+,19-13+,20-14+,27-25+,28-26+,31-17+,32-18+,33-21+,34-22+
2.1.3 InChI Key
OENHQHLEOONYIE-JLTXGRSLSA-N
2.1.4 Canonical SMILES
CC1=C(C(CCC1)(C)C)C=CC(=CC=CC(=CC=CC=C(C)C=CC=C(C)C=CC2=C(CCCC2(C)C)C)C)C
2.1.5 Isomeric SMILES
CC1=C(C(CCC1)(C)C)/C=C/C(=C/C=C/C(=C/C=C/C=C(/C=C/C=C(/C=C/C2=C(CCCC2(C)C)C)\C)\C)/C)/C
2.2 Other Identifiers
2.2.1 UNII
01YAE03M7J
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Bellacarotin

2. Beta Carotene

3. Betacarotene

4. Carotaben

5. Carotene, Beta

6. Max Caro

7. Max-caro

8. Maxcaro

9. Provatene

10. Solatene

11. Vetoron

2.3.2 Depositor-Supplied Synonyms

1. 7235-40-7

2. Beta Carotene

3. Beta,beta-carotene

4. Betacarotene

5. Solatene

6. Provitamin A

7. Carotaben

8. Provatene

9. Serlabo

10. All-trans-beta-carotene

11. Food Orange 5

12. Kpmk

13. Lucaratin

14. Betavit

15. Natural Yellow 26

16. Karotin

17. Provatenol

18. Beta-karotin

19. B-carotene

20. B,b-carotene

21. .beta.-carotene

22. C.i. Food Orange 5

23. .beta.,.beta.-carotene

24. Zlut Prirodni 26

25. All-trans-.beta.-carotene

26. Ci Food Orange 5

27. Carotene,beta

28. Beta-carotin

29. Beta -carotene

30. Beta;-carotene

31. Ci 40800

32. Ci 75130

33. .beta. Carotene

34. Lucarotin 30sun

35. C.i. 75130

36. Nsc 62794

37. Beta, Beta-carotene

38. Betacarotene [inn]

39. (all-e)-1,1'-(3,7,12,16-tetramethyl-1,3,5,7,9,11,13,15,17-octadecanonaene-1,18-diyl)bis(2,6,6-trimethylcyclohexene)

40. 1,3,3-trimethyl-2-[(1e,3e,5e,7e,9e,11e,13e,15e,17e)-3,7,12,16-tetramethyl-18-(2,6,6-trimethylcyclohexen-1-yl)octadeca-1,3,5,7,9,11,13,15,17-nonaenyl]cyclohexene

41. 116-32-5

42. Ins-160a(iii)

43. Ins No.160a(iii)

44. Caroten Base 35468

45. Rovimix .beta.-carotene

46. E-160a(iii)

47. Mls001066383

48. 01yae03m7j

49. 2,2'-((1e,3e,5e,7e,9e,11e,13e,15e,17e)-3,7,12,16-tetramethyloctadeca-1,3,5,7,9,11,13,15,17-nonaene-1,18-diyl)bis(1,3,3-trimethylcyclohex-1-ene)

50. Chebi:17579

51. Nsc62794

52. Betacarotene (inn)

53. Nsc-62794

54. 1,1'-(3,7,12,16-tetramethyl-1,3,5,7,9,11,13,15,17-octadecanonaene-1,18-diyl)bis(2,6,6-trimethylcyclohexene), (all E)-

55. Ncgc00096081-01

56. Smr000112037

57. C.i.-40800

58. Solatene (caps)

59. Karotin [czech]

60. Cyclohexene, 1,1'-(3,7,12,16-tetramethyl-1,3,5,7,9,11,13,15,17-octadecanonaene-1,18-diyl)bis(2,6,6-trimethyl-, (all-e)-

61. .beta.-carotene, All-trans-

62. Betacarotenum [latin]

63. Beta Carotene [usan]

64. Betacaroteno

65. Betacaroteno [spanish]

66. Betacarotenum

67. Mfcd00001556

68. Beta-carotene, All-trans-

69. Betacarotenum [inn-latin]

70. Betacaroteno [inn-spanish]

71. Zlut Prirodni 26 [czech]

72. 1,1'-[(1e,3e,5e,7e,9e,11e,13e,15e,17e)-3,7,12,16-tetramethyloctadeca-1,3,5,7,9,11,13,15,17-nonaene-1,18-diyl]bis(2,6,6-trimethylcyclohexene)

73. Trans-beta-carotene

74. Ccris 3245

75. Hsdb 3264

76. Diet,beta-carotene Supplementation

77. E160a

78. Sr-01000763803

79. Einecs 230-636-6

80. Beta Carotene [usan:usp]

81. Unii-01yae03m7j

82. Lucarotin

83. Lurotin

84. Beta-carotine

85. All-e-b-carotene

86. Rovimix B-carotene

87. Carotene, .beta.

88. Solatene (tn)

89. Cyclohexene, 1,1'-(3,7,12,16-tetramethyl-1,3,5,7,9,11,13,15,17-octadecanonaene-1,18-diyl)bis[2,6,6-trimethyl-, (all-e)-

90. I(2)-carotene

91. Carotene Base 80s

92. All-trans-b-carotene

93. Beta Carotene Natural

94. Beta Carotene (usp)

95. Trans-.beta.-carotene

96. Carotene, Provitamin A

97. All Trans Beta-carotene

98. B-carotene - 30%

99. All-e-.beta.-carotene

100. All-epsilon-beta-carotene

101. Dsstox_cid_253

102. Spectrum5_000505

103. .beta., .beta.-carotene

104. Bmse000832

105. Ec 230-636-6

106. C40h56 (beta-carotene)

107. (9z,13z)-beta-carotene

108. Beta Carotene [dsc]

109. Beta-carotene [fcc]

110. Chembl1293

111. Dsstox_rid_75466

112. Bidd:pxr0110

113. Dsstox_gsid_20253

114. Beta Carotene [hsdb]

115. Beta-carotene [inci]

116. Betacarotene [mart.]

117. Bspbio_003404

118. Beta Carotene [vandf]

119. Betacarotene [who-dd]

120. Carotene,beta [vandf]

121. .beta.-carotene [mi]

122. Beta Carotene [usp-rs]

123. Dtxsid3020253

124. Bdbm54988

125. Cid_5280489

126. Hms501a12

127. .beta.,.beta.-carotene, Neo B

128. Betacarotene [ep Impurity]

129. Ci 40800 [inci]

130. Ci 75130 [inci]

131. Hms2091m17

132. Pharmakon1600-01500143

133. Betacarotene [ep Monograph]

134. Beta Carotene [orange Book]

135. Hy-n0411

136. Zinc6845076

137. Beta-carotene, >=97.0% (uv)

138. Tox21_111557

139. Ccg-36062

140. Lmpr01070001

141. Nsc755910

142. S1767

143. Beta Carotene [usp Monograph]

144. Akos015896682

145. Ac-1869

146. Db06755

147. Nsc-755910

148. Sdccgmls-0066579.p001

149. Idi1_000330

150. Ncgc00096081-02

151. As-13354

152. Xc175229

153. Cas-7235-40-7

154. Sbi-0051295.p003

155. N1547

156. Sw220035-1

157. C02094

158. D03101

159. Ab00051925_06

160. Ab00051925_07

161. Beta-carotene, Vetec(tm) Reagent Grade, >=93%

162. Q306135

163. Q-200706

164. Sr-01000763803-2

165. Sr-01000763803-3

166. Sr-01000763803-4

167. Beta-carotene (constituent Of Spirulina) [dsc]

168. Beta-carotene, Type I, Synthetic, >=93% (uv), Powder

169. 89648336-f9b2-44a0-9bf8-62e73369cb9b

170. Beta Carotene, United States Pharmacopeia (usp) Reference Standard

171. Beta-carotene, Type Ii, Synthetic, >=95% (hplc), Crystalline

172. Beta-carotene (constituent Of Lycopene And Tomato Extract Containing Lycopene) [dsc]

173. Beta-carotene, Pharmaceutical Secondary Standard; Certified Reference Material

174. Cyclohexane,1,1'-(3,7,12,16-tetramethyl-1,18-octadecanediyl)bis[2,2,6-trimethyl-

175. (all-e)-1,1'-(3,7,12,16-tetramethyl-1,3,5, 7,9,11,13,15,17-octadecanonaene-1,18-diyl)bis[2,6, 6-trimethylcyclohexene]

176. (all-e)-1,1'-(3,7,12,16-tetramethyl-1,3,5,7,9,11,13,15,17-octadecanonaene-1,18-diyl)bis

177. (all-e)-1,1'-(3,7,12,16-tetramethyl-1,3,5,7,9,11,13,15,17-octadecanonaene-1,18-diyl)bis[2,6,6-trimethyl-cyclohexene

178. 1,18-bis(2,6,6-trimethyl-1-cyclohexenyl)-3,7,12,16-tetramethyl-1,3,5,7,9,11,13,15,17-octadecanonene

2.4 Create Date
2004-09-16
3 Chemical and Physical Properties
Molecular Weight 536.9 g/mol
Molecular Formula C40H56
XLogP313.5
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count0
Rotatable Bond Count10
Exact Mass536.438201786 g/mol
Monoisotopic Mass536.438201786 g/mol
Topological Polar Surface Area0 Ų
Heavy Atom Count40
Formal Charge0
Complexity1120
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count9
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Therapeutic Uses

Antioxidants

National Library of Medicine's Medical Subject Headings online file (MeSH, 1999)


THERAPY WITH ORAL BETA-CAROTENE IN PATIENT WITH POLYMORPHOUS LIGHT ERUPTION; COMPLETE REMISSION OCCURRED IN 32% (6/19) TREATED WITH BETA-CAROTENE.

PMID:427019 PARRISH JA ET AL; BR J DERMATOL 100 (2): 187 (1979)


MEDICATION (VET): VITAMIN A PRECURSOR FOR ALL SPECIES EXCEPT CATS.

Budavari, S. (ed.). The Merck Index - Encyclopedia of Chemicals, Drugs and Biologicals. Rahway, NJ: Merck and Co., Inc., 1989., p. 282


The effects of chronic oral administration of beta-carotene, a carotenoid partially metabolized to retinol, on plasma lipid concentrations have not been well studied; therefore, 61 subjects were studied over 12 mo while they were enrolled in a skin cancer prevention study in which patients were randomly assigned to receive either placebo (n = 30) or 50 mg beta-carotene/day orally (n = 31). At study entry and 1 yr later, fasting blood samples were obtained for measurement of triglycerides, total cholesterol, high density lipoprotein cholesterol, retinol, and beta-carotene. Retinol concentrations changed minimally in both groups; beta-carotene concentration increased an average of 12.1 + or - 47 nmol/L in the placebo group and 4279 + or - 657 nmol/l in the active treatment group. Both groups experienced similar small increases in triglyceride and total cholesterol concentrations and small decreases in high density lipoprotein cholesterol. Daily oral administration of 50 mg beta-carotene/day did not affect plasma lipid concentrations.

PMID:2000818 Nierenberg DW et al; Am J Clin Nutr 53 (3): 652-4 (1991)


For more Therapeutic Uses (Complete) data for BETA-CAROTENE (10 total), please visit the HSDB record page.


4.2 Drug Warning

NOT EFFECTIVE AS SUNSCREEN IN NORMAL INDIVIDUALS & SHOULD NOT BE USED FOR THAT PURPOSE ... USED WITH CAUTION IN PT WITH IMPAIRED RENAL OR HEPATIC FUNCTION BECAUSE SAFE USE ... HAS NOT BEEN ESTABLISHED.

American Society of Hospital Pharmacists. Data supplied on contract from American Hospital Formulary Service and other current ASHP sources., p. 1976


Beta carotene is well tolerated. Carotenodermia is usually the only adverse effect. Patients should be forewarned that carotenodermia will develop after 2-6 weeks of therapy, usually first noticed as yellowness of the palms of the hands or soles of the feet and to a lesser extent of the face. Some patients may experience loose stools during beta carotene therapy, but this is sporadic and may not require discontinuance of therapy. Ecchymoses and arthralgia have been reported rarely

McEvoy, G.K. (ed.). American Hospital Formulary Service. AHFS Drug Information. American Society of Health-System Pharmacists, Bethesda, MD. 2006., p. 3555


Beta carotene should be used with caution in patients with impaired renal or hepatic function because safe use of the drug in the presence of these conditions has not been established. Although abnormally high blood concentrations of vitamin A do not occur during beta carotene therapy, patients receiving beta carotene should be advised against taking supplementary vitamin A because beta carotene will fulfill normal vitamin A requirements. Patients should be cautioned that large quantities of green or yellow vegetables or their juices or extracts are not suitable substitutes for crystalline beta carotene because consumption of excessive quantities of these vegetables may cause adverse effects such as leukopenia or menstrual disorders. Patients should be warned that the protective effect of beta carotene is not total and that they may still develop considerable burning and edema after sufficient exposure to sunlight. Each patient must establish his own time limit of exposure.

McEvoy, G.K. (ed.). American Hospital Formulary Service. AHFS Drug Information. American Society of Health-System Pharmacists, Bethesda, MD. 2006., p. 3556


There are no adequate and controlled studies to date in humans. Beta carotene should be used during pregnancy only when the potential benefits justify the possible risks to the fetus. The effect of beta carotene on fertility in humans is not known.

McEvoy, G.K. (ed.). American Hospital Formulary Service. AHFS Drug Information. American Society of Health-System Pharmacists, Bethesda, MD. 2006., p. 3556


For more Drug Warnings (Complete) data for BETA-CAROTENE (11 total), please visit the HSDB record page.


4.3 Drug Indication

Beta-carotene is FDA approved to be used as a nutrient supplement and to be even added in infant formula as a source of vitamin A. It is also approved to be used as a color additive for food products, drugs (with the label of "only as a color additive") and cosmetics. It is used commonly for the reduction of photosensitivity in patients with erythropoietic protoporphyria and other photosensitivity diseases.


5 Pharmacology and Biochemistry
5.1 Pharmacology

Oral administration of beta-carotene increases the serum concentration of beta-carotene by 60% but it does not change the concentration found in the heart, liver or kidneys. In vitro studies in hepatocytes have shown that beta-carotene ameliorates oxidative stress, enhances antioxidant activity and decreases apoptosis. Other than the antioxidant activities, some other actions have been correlated to beta-carotene. It is thought to have detoxifying properties, as well as to help increase resistance to inflammation and infection and increase immune response and enhance RNA production.


5.2 MeSH Pharmacological Classification

Provitamins

Precursor forms of vitamins. (See all compounds classified as Provitamins.)


5.3 ATC Code

A - Alimentary tract and metabolism

A11 - Vitamins

A11C - Vitamin a and d, incl. combinations of the two

A11CA - Vitamin a, plain

A11CA02 - Betacarotene


D - Dermatologicals

D02 - Emollients and protectives

D02B - Protectives against uv-radiation

D02BB - Protectives against uv-radiation for systemic use

D02BB01 - Betacarotene


5.4 Absorption, Distribution and Excretion

Absorption

After administration of beta-carotene, some of the administered dose is absorbed into the circulatory system unchanged and stored in the fat tissue. The coadministration of beta-carotene and a high-fat content diet is correlated to a better absorption of beta-carotene. The absorption is also dependent on the isomeric form of the molecule where the cis conformation seems to present a higher bioavailability. The absorption of beta-carotene is thought to be performed in 6-7 hours. The reported AUC of beta-carotene when administered orally from 0 to 440 hours after initial administration was reported to be 26.3 mcg.h/L. The maximal concentration of beta-carotene is attained in a dual pharmacokinetic profile after 6 hours and again after 32 hours with a concentration of 0.58 micromol/L.


Route of Elimination

The unabsorbed carotene is excreted in feces. It is also excreted in feces and urine as metabolites. The consumption of dietary fiber can increase the fecal excretion of fats and other fat-soluble compounds such as beta-carotene.


Volume of Distribution

No pharmacokinetic studies have been performed regarding the volume of distribution of beta-carotene.


Clearance

The clearance rate of beta-carotene administered orally is 0.68 nmol/L each hour.


Carotenoids are absorbed and transported via lymphatics to the liver. They circulate in association with lipoproteins, and are found in liver, adrenal, testes, and adipose tissue, and can be converted to vitamin A in numerous tissues, including the liver. Some beta carotene is absorbed as such and circulates in association with lipoproteins; it apparently partitions into body lipids and can be converted to vitamin A in numerous tissues, including the liver.

Hardman, J.G., L.E. Limbird, P.B., A.G. Gilman. Goodman and Gilman's The Pharmacological Basis of Therapeutics. 10th ed. New York, NY: McGraw-Hill, 2001., p. 1781


Absorption of beta-carotene depends on the presence of dietary fat and bile in the intestinal tract.

Thomson/Micromedex. Drug Information for the Health Care Professional. Volume 1, Greenwood Village, CO. 2006.


Unchanged beta-carotene is found in various tissues, primarily fat tissues, adrenal glands, and ovaries. Small concentrations are found in the liver.

Thomson/Micromedex. Drug Information for the Health Care Professional. Volume 1, Greenwood Village, CO. 2006.


Only about one-third of beta-carotene or other carotenoids is absorbed by human beings. The absorption of carotenoids takes place in a relatively nonspecific fashion and depends upon the presence of bile and absorbable fat in the intestinal tract; it is greatly decreased by steatorrhea, chronic diarrhea, and very-low-fat diets.

Hardman, J.G., L.E. Limbird, P.B., A.G. Gilman. Goodman and Gilman's The Pharmacological Basis of Therapeutics. 10th ed. New York, NY: McGraw-Hill, 2001., p. 1781


For more Absorption, Distribution and Excretion (Complete) data for BETA-CAROTENE (9 total), please visit the HSDB record page.


5.5 Metabolism/Metabolites

Beta-carotene is broken down in the mucosa of the small intestine and liver by beta-carotene dioxygenase to retinal which is a form of vitamin A. The function of this enzyme is vital as it decides if the beta-carotene is transformed to vitamin A or if it circulates in the plasma as beta-carotene. Less than a quarter of the ingested beta-carotene from root vegetables and about half of the beta-carotene from leafy green vegetables are converted to vitamin A.


A portion of the beta-carotene is converted to retinol in the wall of the small intestine, principally by its initial cleavage at the 15,15' double bond to form two molecules of retinal. Some of the retinal is further oxidized to retinoic acid; only one-half is reduced to retinol, which is then esterified and transported in the lymph. ...

Hardman, J.G., L.E. Limbird, P.B., A.G. Gilman. Goodman and Gilman's The Pharmacological Basis of Therapeutics. 10th ed. New York, NY: McGraw-Hill, 2001., p. 1781


Approximately 20 to 60% of beta-carotene is metabolized to retinaldehyde and then converted to retinol, primarily in the intestinal wall. A small amount of beta-carotene is converted to vitamin A in the liver. The proportion of beta-carotene converted to vitamin A diminishes inversely to the intake of beta-carotene, as long as the dosages are higher than one to two times the daily requirements. High doses of beta-carotene do not lead to abnormally high serum concentrations of vitamin A.

Thomson/Micromedex. Drug Information for the Health Care Professional. Volume 1, Greenwood Village, CO. 2006.


Beta carotene may be converted to 2 molecules of retinal by cleavage at the 15-15' double bond in the center of the molecule. Most of the retinal is reduced to retinol which is then conjugated with glucuronic acid and excreted in urine and feces. Some retinal may be further oxidized to retinoic acid which can be decarboxylated and further metabolized, secreted into bile, and excreted in feces as the glucuronide.

McEvoy, G.K. (ed.). American Hospital Formulary Service. AHFS Drug Information. American Society of Health-System Pharmacists, Bethesda, MD. 2006., p. 3556


Two pathways have been suggested for the conversion of carotenoids to vitamin A in mammals, central cleavage and excentric cleavage. An enzyme, beta-carotenoid-15,15'-dioxygenase, has been partly purified from the intestines of several species and has been identified in several other organs and species. The enzyme, which converts beta-carotene into two molecules of retinal in good yield, requires molecular oxygen and is inhibited by sulfhydryl binding reagents and iron binding reagents. Most provitamin A carotenoids, including the beta-apo-carotenals, are cleaved to retinal by this enzyme. Its maximal activity in the rabbit is approximately 200 times that required to meet nutritional needs but is less than 50% of that expected to produce signs of vitamin A toxicity. Excentric cleavage unquestionably occurs in plants and some microorganisms and might occur in mammals. Thus far, however, carotenoid dioxygenase with excentric bond specificity has been identified in mammals, the yield of beta-apo-carotenals from beta-carotene in vivo and in vitro is very low, and beta-apo-carotenals are formed nonbiologically from beta-carotene.

PMID:2643691 Olson JA; J Nutr 119 (1): 105-8 (1989)


The carotenes are not converted to retinol very rapidly, so that overdoses of the carotenes do not cause vitamin A toxicity. /Carotenes/

Shoden & Griffin; Fundamentals of Clinical Nutrition: 77 (1980)


5.6 Biological Half-Life

The apparent half-life of beta-carotene is of 6-11 days after initial administration.


5.7 Mechanism of Action

Beta-carotene is an antioxidant that presents significant efficacy against the reactive oxygen species singlet oxygen. Beta-carotene acts as a scavenger of lipophilic radicals within the membranes of every cell compartments. It also presents an oxidative modification of LDL. The presence of long chains of conjugated double bonds is responsible for its antioxidative properties by allowing beta-carotene to chelate oxygen-free radicals and dissipate their energy. The chelation of free radicals inhibits the peroxidation of lipids. The effect of beta-carotene in the immune response is thought to be related to the direct effect on the thymus which increases the production of immune cells.


IN HEMATOPORPHYRIN PHOTOSENSITIZED MICE BETA-CAROTENE SHOWED PHOTOPROTECTION WAS DUE TO FREE RADICAL SCAVENGING OR SINGLET O QUENCHING BUT ALSO A POSSIBLE ROLE OF 400 NM LIGHT ABSORPTION, A PROPERTY OF BETA-CAROTENE.

PMID:839088 MOSHELL AN, BJORNSON L; J INVEST DERMATOL 68 (3): 157 (1977)


Beta carotene protects patients with erythropoietic protoporphyria against severe photosensitivity reactions (burning sensation, edema, erythema, pruritus, and/or cutaneous lesions). The drug has no effect on the basic biochemical abnormality of erythropoietic protoporphyria (eg, erythrocyte, plasma, and stool concentrations of protoporphyrins are not altered by the drug). The precise mechanism by which the drug exerts photoprotection has not been established. There is some evidence that photosensitizers may act through the formation of singlet excited oxygen and/or free radicals. Since in vitro studies indicate that beta carotene can quench free radicals and singlet excited oxygen, this may be the mechanism by which the drug acts. It is unlikely that beta carotene acts simply as a filter for the wavelengths of light that induce phototoxic effects.

McEvoy, G.K. (ed.). American Hospital Formulary Service. AHFS Drug Information. American Society of Health-System Pharmacists, Bethesda, MD. 2006., p. 3556


beta-Carotene inhibits UV-B carcinogenesis. beta-Carotene is an excellent quencher of singlet oxygen, and can quench free radicals. beta-Carotene has been shown to quench singlet oxygen/free radical reactions in the skin of porphyric mice, and has been found to quench excited species formed on irradiation of mouse skin by UV-B.

PMID:1881965 Black HS, Mathews-Roth MM; Photochem Photobiol 53 (5): 707-16 (1991)


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","supplierCountry":"CHINA","foreign_port":"BEIJING","customer":"MMR CHEMICALS","customerCountry":"INDIA","quantity":"100.00","actualQuantity":"100","unit":"KGS","unitRateFc":"19.8","totalValueFC":"1990.6","currency":"USD","unitRateINR":"1464.2","date":"11-Sep-2021","totalValueINR":"146421","totalValueInUsd":"1990.6","indian_port":"MADRAS AIR","hs_no":"29143990","bill_no":"5395539","productDescription":"Intermediate","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"BEIJING","supplierAddress":"","customerAddress":"NO. 67, 14TH CROSS, SRINIVASA NAGAR SUNKADAKATTE,"},{"dataSource":"API Import","activeIngredients":"","year":"2021","qtr":"Q3","strtotime":1631557800,"product":"BETA CAROTENE 20%POWDER(LOT NO:20210813)(INTERMEDIATE CHEMICALS)","address":"NO.20 & 21, 9TH MILE,TUMKUR ROAD, WIDIA POST","city":"CHIKKABIDAARKALLU BANGALORE, KARNA","supplier":"PHARMATECH ASIA GROUP","supplierCountry":"CHINA","foreign_port":"#N\/A","customer":"BIO-GEN EXTRACTS","customerCountry":"INDIA","quantity":"200.00","actualQuantity":"200","unit":"KGS","unitRateFc":"140","totalValueFC":"28149.8","currency":"USD","unitRateINR":"10353","date":"14-Sep-2021","totalValueINR":"2070600","totalValueInUsd":"28149.8","indian_port":"MADRAS AIR","hs_no":"29143990","bill_no":"5428451","productDescription":"Intermediate","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"#N\/A","supplierAddress":"","customerAddress":"NO.20 & 21, 9TH MILE,TUMKUR ROAD, WIDIA POST"},{"dataSource":"API Import","activeIngredients":"","year":"2021","qtr":"Q3","strtotime":1631557800,"product":"BETA CAROTENE 20%POWDER(LOT NO:20210821)(INTERMEDIATE CHEMICALS)","address":"NO.20 & 21, 9TH MILE,TUMKUR ROAD, WIDIA POST","city":"CHIKKABIDAARKALLU BANGALORE, KARNA","supplier":"PHARMATECH ASIA GROUP","supplierCountry":"CHINA","foreign_port":"#N\/A","customer":"BIO-GEN EXTRACTS","customerCountry":"INDIA","quantity":"500.00","actualQuantity":"500","unit":"KGS","unitRateFc":"143","totalValueFC":"71882.5","currency":"USD","unitRateINR":"10574.9","date":"14-Sep-2021","totalValueINR":"5287425","totalValueInUsd":"71882.5","indian_port":"MADRAS AIR","hs_no":"29143990","bill_no":"5428451","productDescription":"Intermediate","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"#N\/A","supplierAddress":"","customerAddress":"NO.20 & 21, 9TH MILE,TUMKUR ROAD, WIDIA POST"}]
21-Jan-2021
30-Aug-2024
KGS
overview
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Average Price (USD/KGS)

Number of Transactions

Total Quantity (KGS)

Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

Importing Country Total Quantity
(KGS)
Average Price
(USD/KGS)
Number of Transactions

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