API Export of 00344_FLUKA obtained from Indian Customs Trade Statistics

PharmaCompass

Synopsis

Synopsis

ACTIVE PHARMA INGREDIENTS

0

API Suppliers

API Suppliers

0

USDMF

US DMFs Filed

0

CEP/COS

CEP/COS Certifications

0

JDMF

JDMFs Filed

0

EU WC

EU WC

0

KDMF

KDMF

0

NDC API

NDC API

0

VMF

NDC API

0

Listed Suppliers

Other Suppliers

API REF. PRICE (USD/KG)

MARKET PLACE

0

API

0

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

0

FDF Dossiers

FDF Dossiers

0

FDA Orange Book

FDA (Orange Book)

0

Europe

Europe

0

Canada

Canada

0

Australia

Australia

0

South Africa

South Africa

0

Listed Dossiers

Listed Dossiers

0 DRUGS IN DEVELOPMENT

FDF Dossiers

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

0

EDQM

0

USP

0

JP

0

Others

PATENTS & EXCLUSIVITIES

0

US Patents

0

US Exclusivities

0

Health Canada Patents

DIGITAL CONTENT

0

Data Compilation #PharmaFlow

0

Stock Recap #PipelineProspector

0

Weekly News Recap #Phispers

0

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid

NA

Annual Reports

NA

Finished Drug Prices

NA

0RELATED EXCIPIENT COMPANIES

0EXCIPIENTS BY APPLICATIONS

Chemistry

Click the arrow to open the dropdown
read-moreClick the button for full data set
Also known as: 26172-55-4, Methylchloroisothiazolinone, Cmit, 5-chloro-2-methyl-3(2h)-isothiazolone, 3(2h)-isothiazolone, 5-chloro-2-methyl-, 5-chloro-2-methyl-2h-isothiazol-3-one
Molecular Formula
C4H4ClNOS
Molecular Weight
149.60  g/mol
InChI Key
DHNRXBZYEKSXIM-UHFFFAOYSA-N
FDA UNII
DEL7T5QRPN

5-Chloro-2-Methyl-4-Isothiazolin-3-One
Methylchloroisothiazolinone (MCI) is an isothiazolinone commonly used as a preservative with antibacterial and antifungal properties. It is found within many commercially available cosmetics, lotions, and makeup removers. It is also a known dermatological sensitizer and allergen; some of its side effects include flaky or scaly skin, breakouts, redness or itchiness, and moderate to severe swelling in the eye area. The American Contact Dermatitis Society named Methylchloroisothiazolinone the Contact Allergen of the Year for 2013. Sensitivity to Methylchloroisothiazolinone may be identified with a clinical patch test.
Methylchloroisothiazolinone is a Standardized Chemical Allergen. The physiologic effect of methylchloroisothiazolinone is by means of Increased Histamine Release, and Cell-mediated Immunity.
1 2D Structure

5-Chloro-2-Methyl-4-Isothiazolin-3-One

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
5-chloro-2-methyl-1,2-thiazol-3-one
2.1.2 InChI
InChI=1S/C4H4ClNOS/c1-6-4(7)2-3(5)8-6/h2H,1H3
2.1.3 InChI Key
DHNRXBZYEKSXIM-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CN1C(=O)C=C(S1)Cl
2.2 Other Identifiers
2.2.1 UNII
DEL7T5QRPN
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 5-chloro-2-methyl-4-isothiazolin-3-one Hydrochloride

2. 5-chloro-2-methylisothiazolin-3-one

3. 5-chloro-n-methylisothiazolone

4. 5243-k-cg

5. Methylchloro-isothiazolinone

6. Methylchloroisothiazolinone

2.3.2 Depositor-Supplied Synonyms

1. 26172-55-4

2. Methylchloroisothiazolinone

3. Cmit

4. 5-chloro-2-methyl-3(2h)-isothiazolone

5. 3(2h)-isothiazolone, 5-chloro-2-methyl-

6. 5-chloro-2-methyl-2h-isothiazol-3-one

7. 5-chloro-2-methyl-3-isothiazolone

8. 5-chloro-n-methylisothiazolone

9. 5-chloro-2-methylisothiazolin-3-one

10. 5-chloro-2-methylisothiazol-3(2h)-one

11. 5-chloro-2-methyl-1,2-thiazol-3-one

12. Chloromethylisothiazolinone

13. 5-chloro-n-methylisothiazolin-3-one

14. Hs 818

15. N-methyl-5-chloroisothiazolone

16. 4-isothiazolin-3-one, 5-chloro-2-methyl-

17. 5-chloro-2-methyl-4-isothiazoline-3-one

18. Del7t5qrpn

19. N-methyl-5-chloroisothiazolin-3-one

20. 5-chloro-2-methyl-3(2h)-isothiazolinone

21. 5-chloro-2-methyl-1,2-thiazol-3(2h)-one

22. Chebi:53621

23. 2,3-dihydro-2-methyl-3-oxo-5-chloroisothiazole

24. Kathon Cg 5243

25. Ncgc00181041-01

26. Bioace

27. Kathon Ixe

28. 5-chloro-2-methyl-4-isothiazolin-3-one, Tech Grade, >14% In Water. Cmi/mi >2.0

29. Dsstox_cid_14286

30. Dsstox_rid_79138

31. Dsstox_gsid_34286

32. 5-chloro-2-methyl-4-isothiazolin-3-one 100 Microg/ml In Acetonitrile

33. N-methyl-5-chloroisothiazolone (5-chloro-2-methyl-4-isothiazolin-3-one)

34. 5-chloro-2-methyl-4-isothiazolin-3-one (active Ingredient >14%, Cmi/mi 2.5 - 4.0)

35. Cas-26172-55-4

36. A 33 (bactericide)

37. Unii-del7t5qrpn

38. Hs 818 (antiseptic)

39. Einecs 247-500-7

40. Brn 1210149

41. 5-chloro-2-methyl-4-isothiazolin-3-one D3 (methyl D3)

42. 5-chloro-2-methyl-4-isothiazolin-3-one (cmi)

43. 2-methyl-5-chloro-3-isothiazolone

44. 5-chloro-2-methyl-isothiazol-3-one

45. 2-methyl-5-chloroisothiazolin-3-one

46. 5-chloro-2-methyl-2h-isothiazolin-3-one

47. T 360

48. Schembl20686

49. Schembl111860

50. Chembl1738962

51. Dtxsid9034286

52. Hsdb 8270

53. Zinc2002061

54. Tox21_112689

55. Tox21_300199

56. Hs-818

57. Mfcd00792550

58. Akos006230760

59. Cs-w022348

60. Db14197

61. Gs-3223

62. Methylchloroisothiazolinone [ii]

63. Methylchloroisothiazolinone [mi]

64. Methylchloroisothiazolinone [inci]

65. Ncgc00181041-02

66. Ncgc00254127-01

67. 5-chloro-2-methyl-3-isothiazolone-[d3]

68. Am806586

69. Methylchloroisothiazolinone [vandf]

70. 5-chloro-2-methyl-isothiazol-3(2h)-one

71. Methylchloroisothiazolinone [mart.]

72. Db-007017

73. Methylchloroisothiazolinone [who-dd]

74. 5-chloro-2-methyl-3-isothiazolone (~90%)

75. Ft-0620267

76. 5-chlor-2-methyl-4-isothiazolin-3-one

77. H10371

78. Q204121

79. Sr-01000944864

80. 5-chloro-2-methyl-2,3-dihydro-1,2-thiazol-3-one

81. Sr-01000944864-1

82. W-107193

83. 5-chloro-2-methyl-4-isothiazolin-3-one (cmi/mi > 2.0)

84. 5-chloro-2-methyl-4-isothiazolin-3-one (>14% Solution In Water)

85. 5-chloro-2-methyl-4-isothiazolin-3-one 100 Microg/ml In Methanol

2.4 Create Date
2005-03-27
3 Chemical and Physical Properties
Molecular Weight 149.60 g/mol
Molecular Formula C4H4ClNOS
XLogP30.9
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count2
Rotatable Bond Count0
Exact Mass148.9702126 g/mol
Monoisotopic Mass148.9702126 g/mol
Topological Polar Surface Area45.6 Ų
Heavy Atom Count8
Formal Charge0
Complexity156
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Indication

Methylchloroisothiazolinone is approved for use within allergenic epicutaneous patch tests which are indicated for use as an aid in the diagnosis of allergic contact dermatitis (ACD) in persons 6 years of age and older.


5 Pharmacology and Biochemistry
5.1 MeSH Pharmacological Classification

Anti-Infective Agents

Substances that prevent infectious agents or organisms from spreading or kill infectious agents in order to prevent the spread of infection. (See all compounds classified as Anti-Infective Agents.)


Disinfectants

Substances used on inanimate objects that destroy harmful microorganisms or inhibit their activity. Disinfectants are classed as complete, destroying SPORES as well as vegetative forms of microorganisms, or incomplete, destroying only vegetative forms of the organisms. They are distinguished from ANTISEPTICS, which are local anti-infective agents used on humans and other animals. (From Hawley's Condensed Chemical Dictionary, 11th ed) (See all compounds classified as Disinfectants.)


5.2 FDA Pharmacological Classification
5.2.1 Active Moiety
METHYLCHLOROISOTHIAZOLINONE
5.2.2 FDA UNII
DEL7T5QRPN
5.2.3 Pharmacological Classes
Chemical Structure [CS] - Allergens

ABOUT THIS PAGE

Ask Us for Pharmaceutical Supplier and Partner
Ask Us, Find A Supplier / Partner
No Commissions, No Strings Attached, Get Connected for FREE

What are you looking for?

How can we help you?

The request can't be empty

Please read our Privacy Policy carefully

You must agree to the privacy policy

The name can't be empty
The company can't be empty.
The email can't be empty Please enter a valid email.
The mobile can't be empty