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1. Camphor, (+-)-isomer
2. Camphor, (1r)-isomer
3. Camphor, (1s)-isomer
1. 76-22-2
2. 2-camphanone
3. Dl-camphor
4. (+/-)-camphor
5. 2-bornanone
6. 1,7,7-trimethylbicyclo[2.2.1]heptan-2-one
7. (+)-camphor
8. Bornan-2-one
9. Root Bark Oil
10. Kampfer
11. 21368-68-3
12. Spirit Of Camphor
13. 2-camphonone
14. Gum Camphor
15. 464-48-2
16. L-(-)-camphor
17. 1,7,7-trimethylnorcamphor
18. Alphanon
19. 1,7,7-trimethylbicyclo[2.2.1]-2-heptanone
20. D-(+)-camphor
21. 2-keto-1,7,7-trimethylnorcamphane
22. Formosa Camphor
23. Laurel Camphor
24. Matricaria Camphor
25. Camphor, Synthetic
26. 4,7,7-trimethylbicyclo[2.2.1]heptan-3-one
27. Bornane, 2-oxo-
28. Camphor (synthetic)
29. Huile De Camphre
30. Chebi:36773
31. 2-kamfanon
32. Bicyclo[2.2.1]heptan-2-one, 1,7,7-trimethyl-
33. Dl-bornan-2-one
34. (-)-alcanfor
35. Norcamphor, 1,7,7-trimethyl-
36. Camphor, (1r,4r)-(+)-
37. Synthetic Camphor
38. 1,7,7-trimethylbicyclo(2.2.1)heptan-2-one
39. Camphor Oil
40. Camphor Powder
41. Formosa
42. Bicyclo[2.2.1]heptan-2-one, 1,7,7-trimethyl-, (.+/-.)-
43. Japan Camphor
44. Camphor (usp)
45. Bicyclo[2.2.1]heptan-2-one, 1,7,7-trimethyl-, (1r)-
46. Racemic Camphor
47. Disperseyellow3
48. Dl-2-bornanone
49. Heet (salt/mix)
50. Dextro,laevo-camphor
51. Sarna (salt/mix)
52. (?)-camphor
53. Dl-camphor (jp17)
54. (.+/-.)-camphor
55. Camphor Powder - Synthetic
56. (1rs,4rs)-1,7,7-trimethylbicyclo(2.2.1)heptan-2-one
57. Dsstox_cid_10955
58. Dsstox_rid_78860
59. Dsstox_gsid_30955
60. Schembl16068
61. Camphor, (.+/-.)-
62. Mls001055495
63. Chembl15768
64. Divk1c_000724
65. Gtpl2422
66. Dtxsid5030955
67. Hms502e06
68. Kbio1_000724
69. Bicyclo[2.2.1]heptan-2-one, 1,7,7-trimethyl-, (1s)-
70. Ninds_000724
71. Hms2268a06
72. Hms3885j06
73. Hy-n0808
74. Tox21_200237
75. Bbl012963
76. Mfcd00074738
77. S3851
78. S4516
79. Stk803534
80. ( Inverted Exclamation Marka)-camphor
81. Akos000118728
82. Akos022060577
83. Ac-5284
84. Ccg-266237
85. Ccg-266238
86. Db14156
87. Lmpr0102120001
88. Un 2717
89. Cas-76-22-2
90. Idi1_000724
91. Ncgc00090681-05
92. Ncgc00090730-01
93. Ncgc00090730-02
94. Ncgc00090730-05
95. Ncgc00257791-01
96. Ac-15523
97. Smr000386909
98. Vs-03622
99. (1r,4r)-1,7,7-trimethylnorbornan-2-one
100. Db-051377
101. Db-056037
102. Db-070734
103. C1251
104. Cs-0009813
105. Ft-0607017
106. Ft-0607018
107. Ft-0608303
108. 4,7,7-trimethyl-3-bicyclo[2.2.1]heptanone
109. 1,7,7-trimethyl-bicyclo[2.2.1]heptan-6-one
110. C00809
111. C18369
112. D00098
113. E75814
114. 1,7,7-trimethyl-bicyclo[2.2.1]heptan-2-one
115. A838646
116. Q181559
117. Q-200784
118. W-109539
119. W-110530
120. (+/-)-1,7,7-trimethyl-bicyclo[2,2,1]heptane-2-one
121. F0001-0763
122. Z940713494
| Molecular Weight | 152.23 g/mol |
|---|---|
| Molecular Formula | C10H16O |
| XLogP3 | 2.2 |
| Hydrogen Bond Donor Count | 0 |
| Hydrogen Bond Acceptor Count | 1 |
| Rotatable Bond Count | 0 |
| Exact Mass | 152.120115130 g/mol |
| Monoisotopic Mass | 152.120115130 g/mol |
| Topological Polar Surface Area | 17.1 Ų |
| Heavy Atom Count | 11 |
| Formal Charge | 0 |
| Complexity | 217 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 2 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently Bonded Unit Count | 1 |
Anti-Infective Agents, Local
National Library of Medicine's Medical Subject Headings online file (MeSH, 2014); Available from, as of July 31, 2014: https://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?term=Camphor
It /SRP: was formerly/ used ... In humans for inflamed joints, sprains, and rheumatic and other inflammatory conditions such as colds in throat and chest. ... patient may feel improved /however/ inflammation is not affected.
Osol, A. (ed.). Remington's Pharmaceutical Sciences. 16th ed. Easton, Pennsylvania: Mack Publishing Co., 1980., p. 724
MEDICATION (VET): Locally, camphor is weakly antiseptic and has a rubefacient action when applied to skin. It is a common ingredient of many liniments.
Jones, L.M., et al. Veterinary Pharmacology & Therapeutics. 4th ed. Ames: Iowa State University Press, 1977., p. 414
MEDICATION (VET): /Camphor/ ... As a steam inhalant has been popular in respiratory diseases of horses and poultry. Orally, it has been popular in antiferment and carminative mixtures for calf scours, and in expectorant mixtures.
Rossoff, I.S. Handbook of Veterinary Drugs. New York: Springer Publishing Company, 1974., p. 74
For more Therapeutic Uses (Complete) data for CAMPHOR (10 total), please visit the HSDB record page.
Keep pharmaceutical preparations and moth-repellents out of the reach of children and irresponsible people. Label camphorated oil appropriately to avoid mistaking it for castor oil and cough syrups. Do not place camphor ointments into infants' nostrils. Do not use the rubefacient on abraded skin.
IPCS; Poisons Information Monograph 095: Camphor. (Date of last update: May 1989). Available from, as of June 30, 2014: https://www.inchem.org/documents/pims/pharm/camphor.htm#SectionTitle:1.5%20Brand%20names,%20Trade%20na
Camphor and camphor containing products should be avoided in children who have a history of febrile convulsions or other predisposing factors for convulsions.
National Poisons Information Service Center, United Kingdom; Poisons Information Monograph: Camphor. (March 1996). Available from, as of June 30, 2014: https://www.inchem.org/documents/ukpids/ukpids/ukpid19.htm
Camphor should not be applied to the nostrils of infants even in small quantities, as this may cause immediate collapse.
SWEETMAN, S.C. (ed.) Martindale-The Complete Drug Reference. 36th ed. London: The Pharmaceutical Press, 2009., p. 2273
The UK Committee on the Review of Medicines recommended that camphor should not be included in products intended for the treatment of hepatic and biliary disorders, gallstones, colic, renal disorders, urinary tract infections, or ureteral stones. The use of camphor parenterally or as irrigants was considered undesirable due to the associated safety hazard.
SWEETMAN, S.C. (ed.) Martindale-The Complete Drug Reference. 36th ed. London: The Pharmaceutical Press, 2009., p. 2273
For more Drug Warnings (Complete) data for CAMPHOR (11 total), please visit the HSDB record page.
...fatalities in children have been recorded from 1g.
SWEETMAN, S.C. (ed.) Martindale-The Complete Drug Reference. 36th ed. London: The Pharmaceutical Press, 2009., p. 2273
...The literature from 1964-1983 /was reviewed/, and... the mean dose ingested by patients with major symptoms /was/ 124 mg/kg, with the mean dose in fatal cases being 199 mg/kg. /It was/... suggested, based on /the/ analysis of these figures, that patients ingesting <10 mg/kg of camphor and displaying no symptoms required no treatment. Adults have survived ingestions of up to 42 g, but usually doses in excess of 2 g produce dangerous effects. Fatal doses in children have ranged from 0.7-1.0 g.
National Poisons Information Service Center, United Kingdom; Poisons Information Monograph: Camphor. (March 1996). Available from, as of June 30, 2014: https://www.inchem.org/documents/ukpids/ukpids/ukpid19.htm
Dosages exceeding 2.0 grams have been reported to be /CNS depressant/ and may cause convulsions, delirium, hallucinations, and death.
McGuffin M, Hobbs C et al., eds; American Herbal Products Association's Botanical Safety Handbook. p. 31 (1997)
Anti-Infective Agents, Local
Substances used on humans and other animals that destroy harmful microorganisms or inhibit their activity. They are distinguished from DISINFECTANTS, which are used on inanimate objects. (See all compounds classified as Anti-Infective Agents, Local.)
Camphor is rapidly absorbed from the mucous membranes and the gastrointestinal tract. ... It is also absorbed through inhalation, through dermal application, and by nasal instillation.
Ford MD, Delaney KA, Ling LJ, Erickson T; Clinical Toxicology. W.B. Saunders Company., Philadelphia, PA. 2001, p. 339
... after camphor ingestion by mothers ... camphor was detectable in maternal blood 15 min after ingestion, but not after 8 hr. At delivery 36 hr later ... it was present in amnionic fluid, cord and fetal blood and fetal brain, liver and kidneys.
Gosselin, R.E., R.P. Smith, H.C. Hodge. Clinical Toxicology of Commercial Products. 5th ed. Baltimore: Williams and Wilkins, 1984., p. III-85
Alimentary absorption of pure camphor, or of alcohol solution ... is quite rapid, but from the oil preparation absorption is constant. Camphor is ... slowly absorbed from sc or im depots.
Thienes, C., and T.J. Haley. Clinical Toxicology. 5th ed. Philadelphia: Lea and Febiger, 1972., p. 16
Absorbed camphor is mainly eliminated as the oxidized camphorol in the urine, although some appears in the breath, sweat, and feces.
Rossoff, I.S. Handbook of Veterinary Drugs. New York: Springer Publishing Company, 1974., p. 74
For more Absorption, Distribution and Excretion (Complete) data for CAMPHOR (7 total), please visit the HSDB record page.
In the liver microsomes of female mice, two induction phases during inhalation of DL-camphor were found. During the first 24 hr the apparent molar activity of the ethylumbelliferone dealkylase decreased. In the second phase, the molar ethylumbelliferone dealkylase activity was constant.
Mohn G; Different phases of hydroxylase induction in liver microsomes of female mice during inhalation of cyclohexane and D,L-camphor; Microsomes Drug Oxid, Proc Int Symp, 3rd: 59-66 (1977)
The metabolism of (+)-camphor and (-)-camphor was investigated in rabbits after administration /through/ stomach tube; metabolites of (+)-camphor were (+)-borneol, (+)-5-endo-hydroxycamphor, and (+)-3-endohydroxycamphor.
ROBERTSON JS, HUSSAIN M; METABOLISM OF CAMPHORS AND RELATED COMPOUNDS; BIOCHEM J 113 (1): 57-65 (1969)
Camphor is rapidly oxidized to campherols (2-hydroxycamphor and 3-hydroxycamphor), and then conjugated in the liver to the glucuronide form. Camphor-related metabolites are relatively fat-soluble and may accumulate in fatty tissue.
IPCS; Poisons Information Monograph 095: Camphor. (Date of last update:May 1989). Available from, as of June 30, 2014: https://www.inchem.org/documents/pims/pharm/camphor.htm#SectionTitle:1.5%20Brand%20names,%20Trade%20na
167 minutes (200 mg camphor ingested alone); 93 minutes (200 mg camphor ingested with a solvent - Tween 80).
National Poisons Information Service Center, United Kingdom; Poisons Information Monograph: Camphor. (March 1996). Available from, as of June 30, 2014: https://www.inchem.org/documents/ukpids/ukpids/ukpid19.htm
Camphor is a naturally occurring compound that is used as a major active ingredient of balms and liniments supplied as topical analgesics. ... Capsaicin and menthol, two other topically applied agents widely used for similar purposes, are known to excite and desensitize sensory nerves by acting on two members of transient receptor potential (TRP) channel superfamily: heat-sensitive TRP vanilloid subtype 1 (TRPV1) and cold-sensitive TRP channel M8, respectively. Camphor has recently been shown to activate TRPV3, and here /investigators/ show that camphor also activates heterologously expressed TRPV1, requiring higher concentrations than capsaicin. Activation was enhanced by phospholipase C-coupled receptor stimulation mimicking inflamed conditions. Similar camphor-activated TRPV1-like currents were observed in isolated rat DRG neurons and were strongly potentiated after activation of protein kinase C with phorbol-12-myristate-13-acetate. Camphor activation of rat TRPV1 was mediated by distinct channel regions from capsaicin, as indicated by camphor activation in the presence of the competitive inhibitor capsazepine and in a capsaicin-insensitive point mutant. Camphor did not activate the capsaicin-insensitive chicken TRPV1. TRPV1 desensitization is believed to contribute to the analgesic actions of capsaicin. /The authors/ found that, although camphor activates TRPV1 less effectively, camphor application desensitized TRPV1 more rapidly and completely than capsaicin. Conversely, TRPV3 current sensitized after repeated camphor applications, which is inconsistent with the analgesic role of camphor. /Investigators/ also found that camphor inhibited several other related TRP channels, including ankyrin-repeat TRP 1 (TRPA1). The camphor-induced desensitization of TRPV1 and block of TRPA1 may underlie the analgesic effects of camphor.
PMID:16192383 Xu H et al; J Neurosci. 25(39):8924-37 (2005).
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