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Find Clinical Drug Pipeline Developments & Deals by Surrozen
The Company intends to use the net proceeds from the private placement to fund the SZN-043 clinical development program, including the expansion of the SZN-043 Phase 1b clinical trial for the treatment of severe alcohol-associated hepatitis.
SZN-043 is a hepatocyte-targeted R-spondin mimetic, monoclonal antibody. It is being evaluated for the treatment of severe liver diseases, initially focusing on alcohol-associated hepatitis.
SZN-043, an R-Spondin mimetic by enhancing Wnt signaling in a cell-targeted manner, in preclinical data it showed rapid, transient increases in hepatocyte proliferation and was well tolerated in non-clinical toxicology studies.
Under the terms of the agreement, Boehringer Ingelheim will receive an exclusive, worldwide license to develop SZN-413 and other Fzd4-specific Wnt-modulating molecules for all purposes, including as a treatment for retinal diseases.
SZN-413, a bi-specific antibody that targets FZD4 and LRP5, induced Wnt signaling and upregulated blood-retinal barrier gene expression in retinal ECs. SZN-413 reduced the pathologic neovascularization area size compared to vehicle and comparable to the positive control.
In preclinical models of liver injury and fibrosis, SZN-043 has been shown to selectively activate Wnt signaling, stimulate transient hepatocyte proliferation, improve liver function and reduce fibrosis with no treatment-related adverse effects observed in GLP toxicology.
The data demonstrate that in an acute dextran sodium sulfate (DSS) epithelial damage model, SZN-1326 promoted mucosal healing by transiently inducing epithelial progenitor cell expansion and accelerating epithelial repair.
SZN-1326 is the first development candidate designed using Surrozen’s SWAP™ technology and targets the Wnt-signaling pathway in the intestinal epithelium. In preclinical animal models of acute and chronic colitis.
Preclinical data suggest that SZN-413 can simultaneously address retinal non-perfusion and leakage in blood vessels in retinal vascular diseases for the treatment of diabetic retinopathy.
SZN-043 binds to the ASGR receptor and increases ALP serum concentration by interfering with ALP elimination occurring through the ASGR receptor. The Preclinical studies of SZN-043 showing improved liver metabolic function.
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