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Pharmaceutical"},{"orgOrder":0,"company":"Essa Pharma","sponsor":"XenoTherapeutics","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"CANADA","productType":"Miscellaneous","year":"2025","type":"Acquisition","leadProduct":"Masofaniten","moa":"||NR3C4","graph1":"Oncology","graph2":"Phase I\/ Phase II","graph3":"Essa Pharma","amount2":0,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Tablet, Film Coated","sponsorNew":"Essa Pharma \/ XenoTherapeutics","highestDevelopmentStatusID":"7","companyTruncated":"Essa Pharma \/ XenoTherapeutics"},{"orgOrder":0,"company":"ExCellThera","sponsor":"CIUSSS de l'Est-de-l'\u00cele-de-Montr\u00e9al","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"CANADA","productType":"Cell & Gene Therapy","year":"2018","type":"Inapplicable","leadProduct":"ECT-001","moa":"Undisclosed","graph1":"Oncology","graph2":"Phase I\/ Phase II","graph3":"ExCellThera","amount2":0,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Infusion","sponsorNew":"ExCellThera \/ CIUSSS de l'Est-de-l'\u00cele-de-Montr\u00e9al","highestDevelopmentStatusID":"7","companyTruncated":"ExCellThera \/ CIUSSS de l'Est-de-l'\u00cele-de-Montr\u00e9al"},{"orgOrder":0,"company":"BriaCell Therapeutics","sponsor":"Memorial Sloan Kettering Cancer Center","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"CANADA","productType":"Cell & Gene Therapy","year":"2025","type":"Collaboration","leadProduct":"Bria-OTS","moa":"Undisclosed","graph1":"Oncology","graph2":"Phase I\/ Phase II","graph3":"BriaCell Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Injection","sponsorNew":"BriaCell Therapeutics \/ Memorial Sloan Kettering Cancer Center","highestDevelopmentStatusID":"7","companyTruncated":"BriaCell Therapeutics \/ Memorial Sloan Kettering Cancer Center"}]

Find Clinical Drug Development Pipelines & Deals | PipelineProspector

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                          Top Deals by Deal Size (USD bn)

                          01

                          Bio-Europe Autumn
                          Not Confirmed
                          Bio-Europe Autumn
                          Not Confirmed

                          Details : The collaboration aims to advance Bria-OTS, a cell & gene therapy, for metastatic breast cancer.

                          Product Name : Bria-OTS

                          Product Type : Cell & Gene Therapy

                          Upfront Cash : Undisclosed

                          October 21, 2025

                          Lead Product(s) : Bria-OTS

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Memorial Sloan Kettering Cancer Center

                          Deal Size : Undisclosed

                          Deal Type : Collaboration

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                          02

                          Bio-Europe Autumn
                          Not Confirmed
                          Bio-Europe Autumn
                          Not Confirmed

                          Details : Through the acquisition , Xeno will leverage Essa pipeline, which consist of EPI-7386 (masofaniten), which is being evaluated for the treatment of prostate cancer.

                          Product Name : EPI-7386

                          Product Type : Miscellaneous

                          Upfront Cash : Undisclosed

                          September 24, 2025

                          Lead Product(s) : Masofaniten,Enzalutamide

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : XenoTherapeutics

                          Deal Size : Undisclosed

                          Deal Type : Acquisition

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                          03

                          Bio-Europe Autumn
                          Not Confirmed
                          Bio-Europe Autumn
                          Not Confirmed

                          Details : Tuspetinib is a convenient once daily oral agent that potently targets SYK, mutated and wild type forms of FLT3, mutated KIT, JAK1/2, and RSK2 kinases.

                          Product Name : HM43239

                          Product Type : Miscellaneous

                          Upfront Cash : Undisclosed

                          September 22, 2025

                          Lead Product(s) : Tuspetinib,Azacitidine,Venetoclax

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Hanmi Pharmaceutical

                          Deal Size : Undisclosed

                          Deal Type : Financing

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                          04

                          Bio-Europe Autumn
                          Not Confirmed
                          Bio-Europe Autumn
                          Not Confirmed

                          Details : HM43239 (tuspetinib) is an oral myeloid kinome inhibitor, is being investigated in combination with venetoclax and azacitidine as a frontline therapy for patients newly diagnosed with AML.

                          Product Name : Undisclosed

                          Product Type : Miscellaneous

                          Upfront Cash : Inapplicable

                          May 05, 2025

                          Lead Product(s) : Tuspetinib,Azacitidine,Venetoclax

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          05

                          Bio-Europe Autumn
                          Not Confirmed
                          Bio-Europe Autumn
                          Not Confirmed

                          Details : HM43239 (tuspetinib) is an oral myeloid kinome inhibitor, is being investigated in combination with venetoclax and azacitidine as a frontline therapy for patients newly diagnosed with AML.

                          Product Name : Undisclosed

                          Product Type : Miscellaneous

                          Upfront Cash : Inapplicable

                          February 20, 2025

                          Lead Product(s) : Tuspetinib,Azacitidine,Venetoclax

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          06

                          Bio-Europe Autumn
                          Not Confirmed
                          Bio-Europe Autumn
                          Not Confirmed

                          Details : PMD-026 is a first-in-class oral pan-RSK inhibitor, being investigated in combination with fulvestrant for +HR/HER2-/ RSK2-high breast cancer.

                          Product Name : Undisclosed

                          Product Type : Miscellaneous

                          Upfront Cash : Inapplicable

                          February 20, 2025

                          Lead Product(s) : PMD-026,Fulvestrant

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          07

                          Bio-Europe Autumn
                          Not Confirmed
                          Bio-Europe Autumn
                          Not Confirmed

                          Details : HM43239 (tuspetinib), an oral Myeloid Kinome Inhibitor, is being investigated in combination with venetoclax and azacitidine as a frontline therapy for patients newly diagnosed with AML.

                          Product Name : Undisclosed

                          Product Type : Miscellaneous

                          Upfront Cash : Inapplicable

                          February 12, 2025

                          Lead Product(s) : Tuspetinib,Azacitidine,Venetoclax

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          08

                          Bio-Europe Autumn
                          Not Confirmed
                          Bio-Europe Autumn
                          Not Confirmed

                          Details : Bria-OTS is a personalized off-the-shelf next-gen immunotherapy, which is being evaluated as monotherapy and in combination Tislelizumab and cyclophosphamide for advanced metastatic breast cancer.

                          Product Name : Bria-OTS

                          Product Type : Cell & Gene Therapy

                          Upfront Cash : Inapplicable

                          February 03, 2025

                          Lead Product(s) : Bria-OTS,Cyclophosphamide,Tislelizumab

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          09

                          Bio-Europe Autumn
                          Not Confirmed
                          Bio-Europe Autumn
                          Not Confirmed

                          Details : HM43239 (tuspetinib), an oral Myeloid Kinome Inhibitor, is being investigated in combination with venetoclax and azacitidine as a frontline therapy for patients newly diagnosed with AML.

                          Product Name : Undisclosed

                          Product Type : Miscellaneous

                          Upfront Cash : Inapplicable

                          January 09, 2025

                          Lead Product(s) : Tuspetinib,Azacitidine,Venetoclax

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          10

                          Bio-Europe Autumn
                          Not Confirmed
                          Bio-Europe Autumn
                          Not Confirmed

                          Details : MDNA11 is a IL-2 beta receptor super-agonist. It is being evaluated in combination with Keytruda for the treatment of solid tumor, renal cell carcinoma & triple negative breast cancer.

                          Product Name : Undisclosed

                          Product Type : Protein

                          Upfront Cash : Inapplicable

                          December 05, 2024

                          Lead Product(s) : MDNA11,Pembrolizumab

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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