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Inapplicable"}]

Find Clinical Drug Development Pipelines & Deals | PipelineProspector

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                          Top Deals by Deal Size (USD bn)

                          01

                          Pharmex
                          Not Confirmed
                          Pharmex
                          Not Confirmed

                          Details : GZR18 (Bofanglutide) tablet is an investigational, once-daily oral GLP-1 receptor agonist, which is being developing for the treatment of obesity.

                          Product Name : GZR18

                          Product Type : Peptide

                          Upfront Cash : Inapplicable

                          March 10, 2025

                          Lead Product(s) : Bofanglutide

                          Therapeutic Area : Nutrition and Weight Loss

                          Highest Development Status : Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          02

                          Pharmex
                          Not Confirmed
                          Pharmex
                          Not Confirmed

                          Details : GZR18 (bofanglutide) is a long-acting glucagon-like peptide-1 (GLP-1) receptor agonist (RA) being developed for type 2 diabetes and chronic weight management for obese or overweight patients.

                          Product Name : GZR18

                          Product Type : Peptide

                          Upfront Cash : Inapplicable

                          December 18, 2024

                          Lead Product(s) : Bofanglutide

                          Therapeutic Area : Nutrition and Weight Loss

                          Highest Development Status : Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          03

                          Pharmex
                          Not Confirmed
                          Pharmex
                          Not Confirmed

                          Details : AstraZeneca has licensed global rights to ECC5004/AZD5004 from Eccogene. ECC5004 is currently undergoing mid-stage clinical trials for the treatment of obesity and Type 2 diabetes.

                          Product Name : ECC5004

                          Product Type : Other Small Molecule

                          Upfront Cash : $185.0 million

                          October 23, 2024

                          Lead Product(s) : ECC5004

                          Therapeutic Area : Nutrition and Weight Loss

                          Highest Development Status : Phase II

                          Sponsor : AstraZeneca

                          Deal Size : $2,010.0 million

                          Deal Type : Licensing Agreement

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                          04

                          Pharmex
                          Not Confirmed
                          Pharmex
                          Not Confirmed

                          Details : IBI362 (Mazdutide) is a GLP-1R and GCGR dual agonist peptide, subcutaneous injection, which is being evaluated in phase 2 clinical trials for the treatment of Obesity.

                          Product Name : IBI362

                          Product Type : Peptide

                          Upfront Cash : Inapplicable

                          October 29, 2023

                          Lead Product(s) : Mazdutide

                          Therapeutic Area : Nutrition and Weight Loss

                          Highest Development Status : Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          05

                          Pharmex
                          Not Confirmed
                          Pharmex
                          Not Confirmed

                          Details : XW003 is a novel, biased long-lasting GLP-1 peptide analogue optimized for improved biological activity and once weekly dosing. GLP-1 analogs are effective tools in managing type 2 diabetes, obesity, and have demonstrated clinical potential as a treatmen...

                          Product Name : XW003

                          Product Type : Peptide

                          Upfront Cash : Inapplicable

                          October 27, 2022

                          Lead Product(s) : Ecnoglutide

                          Therapeutic Area : Nutrition and Weight Loss

                          Highest Development Status : Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          06

                          Pharmex
                          Not Confirmed
                          Pharmex
                          Not Confirmed

                          Details : Mazdutide (IBI362) is a long-acting synthetic peptide related to mammalian OXM, which uses a fatty acid side chain to prolong the duration of action and allow once-weekly administration.In higher-dose cohorts, mazdutide up-titrated to 10 mg and 9 mg were...

                          Product Name : IBI362

                          Product Type : Peptide

                          Upfront Cash : Inapplicable

                          October 17, 2022

                          Lead Product(s) : Mazdutide

                          Therapeutic Area : Nutrition and Weight Loss

                          Highest Development Status : Phase II

                          Sponsor : Eli Lilly

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          07

                          Pharmex
                          Not Confirmed
                          Pharmex
                          Not Confirmed

                          Details : IBI362 having mazdutide is a long-acting synthetic peptide related to mammalian oxyntomodulin (OXM), which uses a fatty acid side chain to prolong the duration of action and allow once-weekly administration.

                          Product Name : IBI362

                          Product Type : Peptide

                          Upfront Cash : Inapplicable

                          August 06, 2022

                          Lead Product(s) : Mazdutide

                          Therapeutic Area : Nutrition and Weight Loss

                          Highest Development Status : Phase II

                          Sponsor : Eli Lilly

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          08

                          Pharmex
                          Not Confirmed
                          Pharmex
                          Not Confirmed

                          Details : In cohort 1-3 (low-dose), IBI362 (mazdutide) demonstrated favorable tolerability and a safety profile, with mean percent reduction from baseline in body weight of up to 6.4% for participants receiving mazdutide at week 12.

                          Product Name : IBI362

                          Product Type : Peptide

                          Upfront Cash : Inapplicable

                          June 13, 2022

                          Lead Product(s) : Mazdutide

                          Therapeutic Area : Nutrition and Weight Loss

                          Highest Development Status : Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          09

                          Pharmex
                          Not Confirmed
                          Pharmex
                          Not Confirmed

                          Details : At Week 24, each dose of IBI362 (mazdutide) showed significant efficacy on body weight loss compared with placebo in a dose-dependent manner and brought multiple cardio-metabolic benefits to participants.

                          Product Name : IBI362

                          Product Type : Peptide

                          Upfront Cash : Inapplicable

                          May 09, 2022

                          Lead Product(s) : Mazdutide

                          Therapeutic Area : Nutrition and Weight Loss

                          Highest Development Status : Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          10

                          Pharmex
                          Not Confirmed
                          Pharmex
                          Not Confirmed

                          Details : IBI362 (LY3305677) is a novel weekly-dose glucagon-like peptide-1 and glucagon receptor dual agonist being developed for the treatment of obesity and type 2 diabetes.

                          Product Name : IBI362

                          Product Type : Peptide

                          Upfront Cash : Inapplicable

                          August 18, 2021

                          Lead Product(s) : Mazdutide

                          Therapeutic Area : Nutrition and Weight Loss

                          Highest Development Status : Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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