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    [{"orgOrder":0,"company":"Alpine Immune Sciences","sponsor":"Not Applicable","pharmaFlowCategory":"DU","amount":"Not Applicable","upfrontCash":"Not Applicable","newsHeadline":"Alpine Immune Sciences Announces Poster Presentation at AACR Virtual Annual Meeting I","therapeuticArea":"Oncology","highestDevelopmentStatus":"Phase I","country":"U.S.A","productType":"Large molecule","productStatus":"New Molecular Entity","date":"April 2020","url1":"","url2":"","graph1":"Oncology","graph2":"Phase I"},{"orgOrder":0,"company":"Alpine Immune Sciences","sponsor":"Not Applicable","pharmaFlowCategory":"DU","amount":"Not Applicable","upfrontCash":"Not Applicable","newsHeadline":"Alpine Immune Sciences Announces ALPN-202 Poster Presentation at AACR Virtual Annual Meeting II","therapeuticArea":"Oncology","highestDevelopmentStatus":"Phase I","country":"U.S.A","productType":"Large molecule","productStatus":"New Molecular Entity","date":"June 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Applicable","newsHeadline":"Alpine Immune Sciences Announces R&D Day to Provide Clinical Updates on Wholly-Owned Programs ALPN-303 and Davoceticept","therapeuticArea":"Oncology","highestDevelopmentStatus":"Phase I","country":"U.S.A","productType":"Large molecule","productStatus":"New Molecular Entity","date":"August 2022","url1":"","url2":"","graph1":"Oncology","graph2":"Phase I"},{"orgOrder":0,"company":"Alpine Immune Sciences","sponsor":"Not Applicable","pharmaFlowCategory":"DU","amount":"Not Applicable","upfrontCash":"Not Applicable","newsHeadline":"Alpine Immune Sciences Terminates Enrollment of Davoceticept Clinical Studies (NEON-1 and NEON-2)","therapeuticArea":"Oncology","highestDevelopmentStatus":"Phase I","country":"U.S.A","productType":"Large molecule","productStatus":"New Molecular Entity","date":"October 2022","url1":"","url2":"","graph1":"Oncology","graph2":"Phase I"}]

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              Alpine Immune Sciences

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              Alpine Immune Sciences Terminates Enrollment of Davoceticept Clinical Studies (NEON-1 and NEON-2)

              Details:

              Decision to terminate enrollment in davoceticept (ALPN-202) conditional CD28 costimulator and dual checkpoint inhibitor studies was made in interest of patient safety after the Company was notified of a second death in the NEON-2 study, attributed to cardiogenic shock.

              Lead Product(s): Davoceticept,Pembrolizumab

              Therapeutic Area: Oncology Product Name: ALPN-202

              Highest Development Status: Phase I Product Type: Large molecule

              Partner/Sponsor/Collaborator: Not Applicable

              Deal Size: Not Applicable Upfront Cash: Not Applicable

              Deal Type: Not Applicable October 24, 2022

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              Alpine Immune Sciences

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              Alpine Immune Sciences Announces R&D Day to Provide Clinical Updates on Wholly-Owned Programs ALPN-303 and Davoceticept

              Details:

              ALPN-303, a best-in-class dual B cell cytokine antagonist being developed for the treatment of B cell mediated inflammatory and autoimmune diseases, and davoceticept (ALPN-202), a conditional CD28 costimulator and dual checkpoint inhibitor for the treatment of cancer.

              Lead Product(s): Davoceticept,Pembrolizumab

              Therapeutic Area: Oncology Product Name: ALPN-202

              Highest Development Status: Phase I Product Type: Large molecule

              Partner/Sponsor/Collaborator: Not Applicable

              Deal Size: Not Applicable Upfront Cash: Not Applicable

              Deal Type: Not Applicable August 30, 2022

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              Alpine Immune Sciences

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              Alpine Immune Sciences Announces Presentations at the 2022 EULAR and ASCO Annual Meetings

              Details:

              Davoceticept (ALPN-202) , first-in-class, conditional CD28 costimulator and dual checkpoint inhibitor intended for treatment of cancer. Preclinical studies of davoceticept have successfully demonstrated superior efficacy in tumor models compared to checkpoint inhibition alone.

              Lead Product(s): Davoceticept,Pembrolizumab

              Therapeutic Area: Oncology Product Name: ALPN-202

              Highest Development Status: Phase I Product Type: Large molecule

              Partner/Sponsor/Collaborator: Not Applicable

              Deal Size: Not Applicable Upfront Cash: Not Applicable

              Deal Type: Not Applicable May 26, 2022

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              Alpine Immune Sciences

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              Alpine Immune Sciences Announces FDA Removes Partial Clinical Hold on NEON-2 Clinical Trial of Davoceticept (ALPN-202) in Combination with Pembrolizumab

              Details:

              Davoceticept (ALPN-202) is first-in-class, conditional CD28 costimulator and dual checkpoint inhibitor intended for treatment of cancer. Preclinical studies of davoceticept have demonstrated superior efficacy in tumor models compared to checkpoint inhibition alone.

              Lead Product(s): Davoceticept,Pembrolizumab

              Therapeutic Area: Oncology Product Name: ALPN-202

              Highest Development Status: Phase I Product Type: Large molecule

              Partner/Sponsor/Collaborator: Not Applicable

              Deal Size: Not Applicable Upfront Cash: Not Applicable

              Deal Type: Not Applicable May 24, 2022

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              Alpine Immune Sciences

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              Alpine Immune Sciences Publishes Key Preclinical Rationale for Davoceticept (ALPN-202), a First-in-Class CD28 Costimulator and Dual Checkpoint Inhibitor, in Nature Communic...

              Details:

              ALPN-202 (Davoceticept), a first-in-class, CD28 costimulator and dual checkpoint inhibitor intended for treatment of cancer. Preclinical studies of davoceticept have successfully demonstrated superior efficacy in tumor models compared to checkpoint inhibition alone.

              Lead Product(s): Davoceticept,Pembrolizumab

              Therapeutic Area: Oncology Product Name: ALPN-202

              Highest Development Status: Phase I Product Type: Large molecule

              Partner/Sponsor/Collaborator: Not Applicable

              Deal Size: Not Applicable Upfront Cash: Not Applicable

              Deal Type: Not Applicable April 04, 2022

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              Alpine Immune Sciences

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              Alpine Immune Sciences Announces Oral Presentation at the 2022 AACR Annual Meeting

              Details:

              ALPN-202 (davoceticept), a first-in-class, conditional CD28 costimulator and dual checkpoint inhibitor is engineered to provide direct T cell costimulation and dual checkpoint inhibition to enable immune system to mount a robust anti-tumor response.

              Lead Product(s): Davoceticept,Pembrolizumab

              Therapeutic Area: Oncology Product Name: ALPN-202

              Highest Development Status: Phase I Product Type: Large molecule

              Partner/Sponsor/Collaborator: Not Applicable

              Deal Size: Not Applicable Upfront Cash: Not Applicable

              Deal Type: Not Applicable March 08, 2022

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              Alpine Immune Sciences

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              Alpine Immune Sciences Reports FDA Partial Clinical Hold on NEON-2 Trial of Davoceticept (ALPN-202) in Combination with Pembrolizumab

              Details:

              The partial clinical hold was prompted by Alpine’s report of a Grade 5 serious adverse event in the NEON-2 trial, evaluating davoceticept (ALPN-202) in combination with pembrolizumab in adults with advanced malignancies.

              Lead Product(s): Davoceticept,Pembrolizumab

              Therapeutic Area: Oncology Product Name: ALPN-202

              Highest Development Status: Phase I Product Type: Large molecule

              Partner/Sponsor/Collaborator: Not Applicable

              Deal Size: Not Applicable Upfront Cash: Not Applicable

              Deal Type: Not Applicable March 07, 2022

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              Merck & Co

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              Alpine Immune Sciences to Collaborate with Merck on Immuno-Oncology Study to Evaluate ALPN-202 in Combination with KEYTRUDA® (pembrolizumab)

              Details:

              The collaboration will evaluate the safety and efficacy of Alpine’s ALPN-202, a first-in-class conditional CD28 costimulator and dual checkpoint inhibitor, in combination with Merck’s anti-PD-1 therapy KEYTRUDA, the first anti-PD-1 therapy approved in the U.S.

              Lead Product(s): Davoceticept,Pembrolizumab

              Therapeutic Area: Oncology Product Name: ALPN-202

              Highest Development Status: Phase I Product Type: Large molecule

              Partner/Sponsor/Collaborator: Alpine Immune Sciences

              Deal Size: Undisclosed Upfront Cash: Undisclosed

              Deal Type: Collaboration June 30, 2021

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              Alpine Immune Sciences

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              Alpine Immune Sciences Announces ALPN-202 Clinical Data Presented at the 2021 ASCO Virtual Annual Meeting

              Details:

              ALPN-202 has been generally well-tolerated as of the data cutoff date. The most common treatment-related adverse events have included immune-related toxicities, particularly cutaneous reactions.

              Lead Product(s): Davoceticept

              Therapeutic Area: Oncology Product Name: ALPN-202

              Highest Development Status: Phase I Product Type: Large molecule

              Partner/Sponsor/Collaborator: Not Applicable

              Deal Size: Not Applicable Upfront Cash: Not Applicable

              Deal Type: Not Applicable June 04, 2021

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              Alpine Immune Sciences

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              Alpine Immune Sciences Announces ALPN-202 Poster Presentation at AACR Virtual Annual Meeting II

              Details:

              Preclinical studies of ALPN-202 have successfully demonstrated superior efficacy in tumor models compared to checkpoint inhibition alone. A phase 1 trial of ALPN-202 in advanced malignancies (NEON-1, NCT04186637) is open for enrollment.

              Lead Product(s): Davoceticept

              Therapeutic Area: Oncology Product Name: Undisclosed

              Highest Development Status: Phase I Product Type: Large molecule

              Partner/Sponsor/Collaborator: Not Applicable

              Deal Size: Not Applicable Upfront Cash: Not Applicable

              Deal Type: Not Applicable June 15, 2020

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