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CAS 7783-20-2 manufacturers and suppliers on PharmaCompass

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  • Chemistry
MFCD00003391
Also known as: 7783-20-2, Ammonium sulphate, Mascagnite, Diammonium sulfate, Sulfuric acid diammonium salt, Ammoniumsulfate
Molecular Formula
H8N2O4S
Molecular Weight
132.14  g/mol
InChI Key
BFNBIHQBYMNNAN-UHFFFAOYSA-N
FDA UNII
SU46BAM238

Sulfuric acid diammonium salt. It is used in CHEMICAL FRACTIONATION of proteins.
1 2D Structure

MFCD00003391

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
diazanium;sulfate
2.1.2 InChI
InChI=1S/2H3N.H2O4S/c;;1-5(2,3)4/h2*1H3;(H2,1,2,3,4)
2.1.3 InChI Key
BFNBIHQBYMNNAN-UHFFFAOYSA-N
2.1.4 Canonical SMILES
[NH4+].[NH4+].[O-]S(=O)(=O)[O-]
2.2 Other Identifiers
2.2.1 UNII
SU46BAM238
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Sulfate, Ammonium

2.3.2 Depositor-Supplied Synonyms

1. 7783-20-2

2. Ammonium Sulphate

3. Mascagnite

4. Diammonium Sulfate

5. Sulfuric Acid Diammonium Salt

6. Ammoniumsulfate

7. Ammonium Sulfate (2:1)

8. Sulfuric Acid, Diammonium Salt

9. Ammonium Sulfate Solution

10. Sulfuric Acid Ammonium Salt (1:2)

11. Ammonium Sulfate [nf]

12. Mfcd00003391

13. Su46bam238

14. Actamaster

15. Ammonium Sulfate (nf)

16. Diammonium Sulphate

17. Caswell No. 048

18. Diazanium Sulfate

19. Sulfatom Ammoniya

20. Ammonium Sulfate (solution)

21. Sulfatom Ammoniya [russian]

22. Hsdb 471

23. Einecs 231-984-1

24. Nsc 77671

25. Ammonium Sulfate, Solution

26. Epa Pesticide Chemical Code 005601

27. Unii-su46bam238

28. Diazanium;sulfate

29. Sulphate Of Ammonia

30. Einecs 268-364-5

31. Einecs 269-077-8

32. (c10-c16)alkyl Alcohol Sulfuric Acid, Ammonium Salt

33. Sda 15-062-01

34. (c6-c10) Linear Alkyl Sulfate, Ammonium Salt

35. Ammonium Sulfate Acs Grade

36. Ammonium Sulfate, Ultrapure

37. Ec 231-984-1

38. Ammonium Sulfate, Cp,98%

39. Ammonium Sulfate [ii]

40. Ammonium Sulfate [mi]

41. Ammonium Sulfate [fcc]

42. (c10-c16) Alkylalcohol Sulfuric Acid, Ammonium Salt

43. Ammonium Sulfate [hsdb]

44. Ammonium Sulfate [inci]

45. Dtxsid1029704

46. Sulfuric Acid, Mono-c6-10-alkyl Esters, Ammonium Salts

47. (nh4)2so4

48. Sulfuric Acid, Mono-c10-16-alkyl Esters, Ammonium Salts

49. Ammonium Sulfate [who-dd]

50. Ammonium Sulfate, 99+% (acs)

51. Ammonium Sulphate (2:1)

52. Ammonium Sulphate,>/=99.0%,ar

53. Ammonium Sulfate, Saturated Solution

54. Ammonium Sulfate, Trace Metals Grade

55. Akos015856589

56. (n H4)2 (s O4)

57. Ammonium Sulfate, 0.5m Aqueous Solution

58. Ammonium Sulfate, 99.99% Metals Basis

59. Ammonium Sulfate, 99.999% (metals Basis)

60. Ft-0622348

61. D08853

2.4 Create Date
2006-03-21
3 Chemical and Physical Properties
Molecular Weight 132.14 g/mol
Molecular Formula H8N2O4S
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count0
Exact Mass132.02047791 g/mol
Monoisotopic Mass132.02047791 g/mol
Topological Polar Surface Area90.6 Ų
Heavy Atom Count7
Formal Charge0
Complexity62.2
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count3
4 Drug and Medication Information
4.1 Therapeutic Uses

Ammonium sulfate is a non-CNS depressant anesthetic agent, which has been reported to provide pain relief lasting days to weeks, with few reported side effects in adult studies.

PMID:9570603 Hertl MC et al; Regional Anesthesia Pain Med 23 (2): 152-8 (1998)


5 Pharmacology and Biochemistry
5.1 Absorption, Distribution and Excretion

In aqueous environments, such as the body the ammonium sulfate is completely dissociated into the ammonium (NH4 +) and the sulfate (SO4 2-) ions. At physiological pH in aqueous media, the ammonium ion is in equilibrium with un-ionized ammonia ... The ammonium ion serves a major role in the maintenance of the acid-base balance. In the normal pH range of blood, the NH4+/NH3 /ratio/ is about 100. An ammonium ion via the equilibrium with ammonia is readily taken up. Some evidence exists also for an active transport of the ammonium ion from the intestinal tract. It was shown that ammonia transport by the human colon still occurred when the luminal pH was reduced to 5, where nonionized ammonia would be virtually absent. Absorbed ammonium is transported to the liver and metabolized to urea and excreted via the kidneys. Minor amounts of nitrogen are incorporated in the physiological N-pool. Absorption of sulfate depends on the amount ingested. 30 - 44 % of sulfate was excreted in the 24 hr urine after oral administration of magnesium or sodium sulfate (5.4 g sulfate) in volunteers. At high sulfate doses that exceed intestinal absorption, sulfate is excreted in feces. Intestinal sulfate may bind water into the lumen and cause diarrhea in high doses. Sulfate is a normal constituent of human blood and does not accumulate in tissues. Sulfate levels are regulated by the kidney through a reabsorption mechanism. Sulfate is usually eliminated by renal excretion. It has also an important role in the detoxification of various endogenous and exogenous compounds, as it may combine with these to form soluble sulfate esters that are excreted in the urine.

Organization for Economic Cooperation and Development; Screening Information Data Set for Ammonium sulfate, CAS #7783-20-2, p.16 (October 2004). Available from, as of May 6, 2010: https://www.chem.unep.ch/irptc/sids/OECDSIDS/sidspub.html


In rabbit, hamster and guinea pig studies it was demonstrated that (35)S-labeled ammonium sulfate aerosols with a size of 0.3 and 0.6 um (MMAD) reached the lung. However a substantial proportion of the compound was found in the nose. The clearance from the lung (via the blood and urinary tract) was determined to be 18 to 20 min. From the collectable sulfate in the urinary tract 95 % was excreted within 6 hr. The results of clearance studies suggested that there was no species difference. The induction of aryl hydrocarbon hydroxylase (an enzyme that acts in the metabolism of benzo(a)pyrene and other carcinogens) in the lung is not inhibited by ammonium sulfate (there are reports of other air pollutants that cause this effect).

Organization for Economic Cooperation and Development; Screening Information Data Set for Ammonium sulfate, CAS #7783-20-2, p.16 (October 2004). Available from, as of May 6, 2010: https://www.chem.unep.ch/irptc/sids/OECDSIDS/sidspub.html


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