(4r)-1-(tert-butoxycarbonyl)-4-hydroxy-l-proline

Chemistry, 4 End Use API, 22 Related Intermediates

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(4r)-1-(tert-butoxycarbonyl)-4-hydroxy-l-proline

Also known as: 13726-69-7, Boc-hyp-oh, Boc-l-hydroxyproline, Boc-trans-4-hydroxy-l-proline, N-boc-trans-4-hydroxy-l-proline, Boc-hydroxyproline

Molecular Formula

C₁₀H₁₇NO₅

Molecular Weight

231.25 g/mol

InChI Key

BENKAPCDIOILGV-RQJHMYQMSA-N

FDA UNII

RC99P5B8IG

1 2D Structure

(4r)-1-(tert-butoxycarbonyl)-4-hydroxy-l-proline

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

(2S,4R)-4-hydroxy-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid

2.1.2 InChI

InChI=1S/C10H17NO5/c1-10(2,3)16-9(15)11-5-6(12)4-7(11)8(13)14/h6-7,12H,4-5H2,1-3H3,(H,13,14)/t6-,7+/m1/s1

2.1.3 InChI Key

BENKAPCDIOILGV-RQJHMYQMSA-N

2.1.4 Canonical SMILES

CC(C)(C)OC(=O)N1CC(CC1C(=O)O)O

2.1.5 Isomeric SMILES

CC(C)(C)OC(=O)N1C[C@@H](C[C@H]1C(=O)O)O

2.2 Other Identifiers

2.2.1 UNII

RC99P5B8IG

2.3 Synonyms

2.3.1 Depositor-Supplied Synonyms

1. 13726-69-7

2. Boc-hyp-oh

3. Boc-l-hydroxyproline

4. Boc-trans-4-hydroxy-l-proline

5. N-boc-trans-4-hydroxy-l-proline

6. Boc-hydroxyproline

7. (4r)-1-(tert-butoxycarbonyl)-4-hydroxy-l-proline

8. N-boc-(2s,4r)-4-hydroxyproline

9. Trans-n-(tert-butoxycarbonyl)-4-hydroxy-l-proline

10. Rc99p5b8ig

11. Trans-n-boc-4-hydroxy-l-proline

12. (2s,4r)-1-[(tert-butoxy)carbonyl]-4-hydroxypyrrolidine-2-carboxylic Acid

13. (2s,4r)-4-hydroxy-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic Acid

14. 1,2-pyrrolidinedicarboxylic Acid, 4-hydroxy-, 1-(1,1-dimethylethyl) Ester, (2s,4r)-

15. Trans-1-(tert-butoxycarbonyl)-4-hydroxypyrrolidine-2-carboxylic Acid

16. Mfcd00053370

17. 946610-68-0

18. Boc-l-trans-4-hydroxyproline

19. Unii-rc99p5b8ig

20. Boc-trans-hydroxy-l-proline

21. (2s,4r)-1-tert-butyl 4-hydroxy-1,2-pyrrolidinecarboxylate

22. Nsc-343720

23. 1-(tert-butoxycarbonyl)-4-hydroxyproline

24. N-boc-hydroxyproline

25. N-boc-4-hydroxy-l-proline, Trans-

26. Nsc 343720

27. N-boc-hydroxy Proline

28. N-(tert-butoxycarbonyl)hydroxy-l-proline

29. Boc-4(r)-hydroxyproline

30. N-boc-l-hydroxy-proline

31. Boc Trans-4-hydroxyproline

32. Boc-(2s,4r)-hydroxyproline

33. N-boc Trans-4-hydroxyproline

34. Trans-1-(tert-butoxycarbonyl)-4-hydroxy-l-proline

35. Schembl116439

36. Trans 4-hydroxy L-boc-proline

37. Zinc57566

38. (2s,4r)-n-boc-4-hydroxyproline

39. (4r)-1-boc-4-hydroxy-l-proline

40. Cs-m3078

41. Hy-i0781

42. Str07822

43. 1-t-butoxycarbonyl-l-hydroxy-proline

44. Ac-141

45. Akos000277290

46. Akos015836539

47. N-(tert-butoxycarbonyl)-hydroxyproline

48. N-tert-butoxycarbonyl-l-hydroxyproline

49. Boc-hyp-oh, >=98.0% (tlc)

50. N-tert-butoxycarbonyl(4r)-hydroxyproline

51. Ts-00615

52. N-tert-butoxycarbonyl (4r)-hydroxyproline

53. Am20080277

54. N-t-butoxycarbonyl-trans-4-hydroxy-l-proline

55. Trans-1-t-butoxycarbonyl-4-hydroxy-l-proline

56. M03213

57. N-tert-butoxycarbonyl-trans-4-hydroxy-l-proline

58. Trans-4-hydroxy-n-tert-butoxycarbonyl-l-proline

59. (4r)-(tert-butoxycarbonyl)-4-hydroxy-l-proline

60. N-tert-butoxycarbonyl-(2s,4r)-4-hydroxyproline

61. As-813/43496108

62. N-(tert-butyloxycarbonyl)-4-hydroxyproline

63. N-boc-4-hydroxy-l-proline, (4r)-(-)-

64. N-tert-butyloxycarbonyl-trans-4-hydroxy-l-proline

65. (4r)-1-(tert-butoxy Carbonyl)-4-hydroxy-l-proline

66. A1-00438

67. Boc-l-hydroxyproline;boc-trans-4-hydroxy-l-proline

68. J-300152

69. Q-101690

70. (4r)-1-(tert-butyloxycarbonyl)-4-hydroxy-l-proline

71. Q27288047

72. (2s,4r)-1-t-butoxycarbonyl-2-carboxy-4-hydroxypyrrolidine

73. (2s, 4r)-1-t-butoxycarbonyl-4-hydroxy-2-pyrrolidinecarboxylic Acid

74. (2s,4r)-1-(tert-butoxycarbonyl)-2-carboxy-4-hydroxypyrrolidine

75. Boc-(2s,4r)-(-)-4-hydroxypyrrolidine-2-carboxylic Acid

76. Trans-1-(tert-butoxycarbonyl)-4-hydroxypyrrolidine-2-carboxylicacid

77. (2s, 4r)-1-(t-butoxycarbonyl)-4-hydroxy-2-pyrrolidinecarboxylic Acid

78. (2s, 4r)-1-(tert-butoxycarbonyl)-4-hydroxy-2-pyrrolidinecarboxylic Acid

79. (2s,4r) 4-hydroxy-pyrrolidine-1,2-dicarboxylic Acid 1-tert-butyl Ester

80. (2s,4r)-1-(tert-butoxycarbonyl)-4-hydroxy-2-pyrrolidinecarboxylic Acid

81. (2s,4r)-1-(tert-butoxycarbonyl)-4-hydroxy-pyrrolidine-2-carboxylic Acid

82. (2s,4r)-4-hydroxy-1-(t-butoxycarbonyl)-2-pyrrolidinecarboxylic Acid

83. (2s,4r)-4-hydroxy-pyrrolidine-1,2-dicarboxylic Acid 1-tert-butyl Ester

84. 1-(t-butoxycarbonyl)-(2s,4r)-4-hydroxy-2-pyrrolidinecarboxylic Acid

85. (2s,4r)-4-hydroxypyrrolidine-1,2-dicarboxylic Acid 1-tert-butyl Ester

86. 1,2-pyrrolidinedicarboxylic Acid, 4-hydroxy-, 1-(1,1-dimethylethyl) Ester, (2s-trans)-

2.4 Create Date

2005-07-07

3 Chemical and Physical Properties

Molecular Formula	C₁₀H₁₇NO₅
Molecular Weight	231.25 g/mol
XLogP3	0.3
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	3
Exact Mass	231.11067264 g/mol
Monoisotopic Mass	231.11067264 g/mol
Topological Polar Surface Area	87.1 Å²
Heavy Atom Count	16
Formal Charge	0
Complexity	296
Isotope Atom Count	0
Defined Atom Stereocenter Count	2
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

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trans-N-Boc-4-hydroxy-L-proline

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Malladi Drugs & Pharmaceuticals Ltd was founded in 1980 by microbiologist Mr. M L N Sastry. Within a few ...

Malladi Drugs & Pharmaceuticals Ltd was founded in 1980 by microbiologist Mr. M L N Sastry. Within a few years, Malladi established itself as a leader in manufacturing ephedrine and pseudoephedrine salts. Today, it is the leading manufacturer of APIs in the cough and cold segment. It also has a dominant presence in several therapeutic segments like antihistamines, anti-convulsants, anti-depressants and anxiolytics (CNS). Malladi exports its products to around 60 countries and over 85% of its revenue is generated from exports. Its manufacturing facilities have been approved by the FDA, EDQM, KFDA, TGA and various other regulatory agencies.

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SURVIVAL is one of the leading manufacturers in the field of Fine and Specialty Chemicals actively involved in CRAMS, Custom Synthesis & Bulk Production offering new generation products in complex chemistry to Pharmaceutical, Agrochemical and Petrochemical companies. It has a very strong R&D set up & we can assure fast turn around in Synthsizing molecules. With our deep understanding of science and chemistry, we are into functional chemistry, custom synthesis and contract manufacturing catering to many reputed Indian and overseas customers.

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