Athena Athena

X

CAS 148-24-3 manufacturers and suppliers on PharmaCompass

PharmaCompass
CAS 148-24-3
Also known as: Quinolin-8-ol, 8-quinolinol, 148-24-3, Oxyquinoline, Oxine, Quinophenol
Molecular Formula
C9H7NO
Molecular Weight
145.16  g/mol
InChI Key
MCJGNVYPOGVAJF-UHFFFAOYSA-N
FDA UNII
5UTX5635HP

An antiseptic with mild fungistatic, bacteriostatic, anthelmintic, and amebicidal action. It is also used as a reagent and metal chelator, as a carrier for radio-indium for diagnostic purposes, and its halogenated derivatives are used in addition as topical anti-infective agents and oral antiamebics.
1 2D Structure

CAS 148-24-3

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
quinolin-8-ol
2.1.2 InChI
InChI=1S/C9H7NO/c11-8-5-1-3-7-4-2-6-10-9(7)8/h1-6,11H
2.1.3 InChI Key
MCJGNVYPOGVAJF-UHFFFAOYSA-N
2.1.4 Canonical SMILES
C1=CC2=C(C(=C1)O)N=CC=C2
2.2 Other Identifiers
2.2.1 UNII
5UTX5635HP
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 8 Hydroxyquinoline

2. 8 Hydroxyquinoline Sulfate

3. 8 Oxyquinoline

4. 8 Quinolinol

5. 8-hydroxyquinoline Sulfate

6. 8-oxyquinoline

7. 8-quinolinol

8. Bioquin

9. Chinosol

10. Khinozol

11. Leioderm

12. Oxine

13. Oxyquinol

14. Oxyquinoline

15. Oxyquinoline Potassium Sulfate (2:1)

16. Oxyquinoline Sulfate

17. Quinosol

18. Sulfate, 8-hydroxyquinoline

19. Sulfate, Oxyquinoline

20. Superol

2.3.2 Depositor-Supplied Synonyms

1. Quinolin-8-ol

2. 8-quinolinol

3. 148-24-3

4. Oxyquinoline

5. Oxine

6. Quinophenol

7. Oxychinolin

8. 8-quinol

9. 8-oxyquinoline

10. Phenopyridine

11. 8-hydroxychinolin

12. Bioquin

13. Oxybenzopyridine

14. Hydroxybenzopyridine

15. Oxin

16. 1-azanaphthalene-8-ol

17. Tumex

18. 8-chinolinol

19. 8-oq

20. 8-hydroxy-chinolin

21. Fennosan H 30

22. 8-oxychinolin

23. Fennosan

24. Oxyquinol

25. O-oxychinolin

26. Usaf Ek-794

27. Hydroxyquinoline

28. Oxyquinoline [usan]

29. 8-hydroxy-quinoline

30. Nci-c55298

31. Nsc 2039

32. Mfcd00006807

33. Oxoquinoline

34. Albisal

35. Nsc 615011

36. Nsc-2039

37. Nsc285166

38. 8-quinolinol, Homopolymer

39. Nsc-285166

40. Nsc-402623

41. Nsc-615011

42. Mls002702126

43. 5utx5635hp

44. Chembl310555

45. Chebi:48981

46. Nsc 82408

47. Quinoline-8-ol

48. Oxyquinoline (8-hydroxyquinoline)

49. Nsc 82404

50. Nsc-48037

51. Nsc-54230

52. Nsc-82404

53. Nsc-82405

54. Nsc-82409

55. Nsc-82410

56. Nsc-82412

57. Nsc615011

58. J2.960b

59. Oxyquinoline (usan)

60. Ncgc00090708-03

61. Ncgc00090708-05

62. Dsstox_cid_730

63. Dsstox_rid_75758

64. Wln: T66 Bnj Jq

65. Dsstox_gsid_20730

66. Oxine;8-hydroxyquinoline;quinophenol;8-quinolinone

67. Fennosan Hf-15

68. Caswell No. 719

69. 8-chinolinol [czech]

70. O-oxychinolin [german]

71. Quinoline, 8-hydroxy-

72. 84063-18-3

73. Cas-148-24-3

74. Manganese, Bis(8-quinolinolato)-

75. Smr000112313

76. 8-hydroxy-chinolin [german]

77. Ccris 340

78. 8-hydroxy Quinoline

79. Hsdb 4073

80. Einecs 205-711-1

81. Epa Pesticide Chemical Code 059803

82. Brn 0114512

83. Unii-5utx5635hp

84. Oxychinoline

85. Ai3-00483

86. 8-oxyquinolin

87. 8-quinolinone

88. 8-quinolol

89. 8-hydroxiquinoline

90. 8-hydroxychinoline

91. 8-hydroxylquinoline

92. Hqy

93. 8-quinolinol, P.a.

94. Spectrum_001053

95. 3vh9

96. 8-hydroxyquinoline Oxine

97. Spectrum2_000697

98. Spectrum3_000534

99. Spectrum4_000465

100. Spectrum5_001280

101. Oxyquinoline [ii]

102. 8-hydroxyquinoline, 99%

103. Ec 205-711-1

104. Ncimech_000694

105. Oxyquinoline [hsdb]

106. Oxyquinoline [inci]

107. Cid_1923

108. Ncistruc1_000152

109. Ncistruc2_000240

110. Oxyquinol Reference Spectrum

111. Nciopen2_000962

112. Nciopen2_001020

113. Nciopen2_001220

114. Nciopen2_004264

115. Oxyquinoline [vandf]

116. Schembl37189

117. Bspbio_002147

118. Kbiogr_000910

119. Kbioss_001533

120. 5-21-03-00252 (beilstein Handbook Reference)

121. Mls001055492

122. Bidd:er0371

123. Divk1c_000757

124. Spbio_000853

125. 8-hydroxyquinoline, Crystalline

126. Zinc8492

127. Hydroxyquinoline [vandf]

128. 8-hydroxyquinoline [mi]

129. Dtxsid5020730

130. Bdbm32203

131. Hms502f19

132. Kbio1_000757

133. Kbio2_001533

134. Kbio2_004101

135. Kbio2_006669

136. Kbio3_001647

137. Hydroxyquinoline [who-dd]

138. Nsc2039

139. 8-hydroxyquinoline [iarc]

140. Ninds_000757

141. 8-quinolinol (7ci,8ci,9ci)

142. Act08881

143. Hy-b1005

144. Str00721

145. Tox21_113083

146. Tox21_202986

147. Tox21_400006

148. 8-oxychinolin, 8-quinolinol, Oxine

149. Ccg-35870

150. Nsc 48037

151. Nsc 54230

152. Nsc 82405

153. Nsc 82409

154. Nsc 82410

155. Nsc 82412

156. Nsc402623

157. S4547

158. Stk943764

159. 8-hydroxyquinoline Acs Reagent Grade

160. Akos001061311

161. Ac-5109

162. Cs-4502

163. Db11145

164. Nsc 285166

165. Nsc 402623

166. Ps-4553

167. Sb40773

168. 8-hydroxyquinoline, Acs Reagent, 99%

169. Idi1_000757

170. Ncgc00090708-01

171. Ncgc00090708-02

172. Ncgc00090708-04

173. Ncgc00090708-06

174. Ncgc00090708-07

175. Ncgc00090708-08

176. Ncgc00090708-11

177. Ncgc00260531-01

178. Nci60_001712

179. Nci60_002335

180. 8-hydroxyquinoline Acs Grade 100g

181. Sbi-0051472.p003

182. Db-012222

183. Am20050821

184. Ft-0621550

185. H0305

186. 8-quinolinol, Jis Special Grade, >=99.0%

187. 8-quinolinol, Vetec(tm) Reagent Grade, 99%

188. En300-17403

189. C19434

190. D05321

191. P17615

192. Us9394254, 6

193. 8-quinolinol, Pestanal(r), Analytical Standard

194. Ab00052065_08

195. 8-quinolinol, >=99% (perchloric Acid Titration)

196. A808745

197. Ap-065/40180076

198. Q270162

199. Cu-01000012874-2

200. W-108106

201. Brd-k66808046-065-01-1

202. Z56926518

203. F0001-0526

204. 8-quinolinol, Puriss. P.a., Acs Reagent, For The Detection And Determination Of Al, Mg And Others, >=99.0% (nt)

205. 8-quinolinol, Puriss. P.a., Acs Reagent, Reag. Ph. Eur., >=99% (perchloric Acid Titration)

2.4 Create Date
2005-03-25
3 Chemical and Physical Properties
Molecular Weight 145.16 g/mol
Molecular Formula C9H7NO
XLogP32
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count2
Rotatable Bond Count0
Exact Mass145.052763847 g/mol
Monoisotopic Mass145.052763847 g/mol
Topological Polar Surface Area33.1 Ų
Heavy Atom Count11
Formal Charge0
Complexity138
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Therapeutic Uses

A BACTERIOSTATIC & FUNGISTATIC COMPOUND; USED PRINCIPALLY IN TREATMENT OF MINOR BURNS & OF HEMORRHOIDS.

Osol, A. (ed.). Remington's Pharmaceutical Sciences. 16th ed. Easton, Pennsylvania: Mack Publishing Co., 1980., p. 1111


OXYQUINOLINE SULFATE ... IS ... USED ... IN TREATMENT OF ATHLETE'S FOOT, VAGINITIS, & AS A GARGLE, EYEWASH, NASAL DOUCHE, & IN HEMORRHOIDAL PREPARATIONS ... /OXYQUINOLINE SULFATE/

Osol, A. (ed.). Remington's Pharmaceutical Sciences. 16th ed. Easton, Pennsylvania: Mack Publishing Co., 1980., p. 1111


/OVER THE COUNTER/ HYDROXYQUINOLINE IS 1 OF 4 ANTIFUNGAL AGENTS RECOMMENDED FOR ACTIVE TREATMENT OF FUNGUS ASSOCIATED WITH DIAPER RASH & PRICKLY HEAT IN BABIES. /HYDROXYQUINOLINE/

SADIK F; J AM PHARM ASSOC NS10 (JAN): 19-24 (1970)


8-HYDROXYQUNIOLINE SULFATE INHIBITED FORMATION OF ARTIFICIAL CALCULUS IN VITRO & RAT CALCULUS IN VIVO. IN RATS, IT PREVENTED CALCULUS FORMATION WHEN APPLIED BY SWABBING OR BY INTRAORAL INSTILLATION. IN DOGS, FORMATION OF DENTAL PLAQUE WAS INHIBITED 33 TO 98% IN COMPARISON TO PLACEBO. ALSO, 25 TO 58% OF ESTABLISHED PLAQUE ACCUMULATIONS WERE REMOVED, WHEREAS PLACEBO REMOVED 2 TO 22%.

PMID:815301 DEPALMA PD ET AL; J DENT RES 55 (2): 292-8 (1976)


For more Therapeutic Uses (Complete) data for 8-HYDROXYQUINOLINE (7 total), please visit the HSDB record page.


4.2 Drug Indication

Oxyquinoline is used as a biocidal component of several over the counter products. These products are marketed for the purposes of inhibiting abnormal biological growth in the vagina and restoring natural pH.


5 Pharmacology and Biochemistry
5.1 Pharmacology

Oxyquinoline acts as a biocide to eliminate bacteria and fungi.


5.2 ATC Code

A - Alimentary tract and metabolism

A01 - Stomatological preparations

A01A - Stomatological preparations

A01AB - Antiinfectives and antiseptics for local oral treatment

A01AB07 - Oxyquinoline


D - Dermatologicals

D08 - Antiseptics and disinfectants

D08A - Antiseptics and disinfectants

D08AH - Quinoline derivatives

D08AH03 - Oxyquinoline


G - Genito urinary system and sex hormones

G01 - Gynecological antiinfectives and antiseptics

G01A - Antiinfectives and antiseptics, excl. combinations with corticosteroids

G01AC - Quinoline derivatives

G01AC30 - Oxyquinoline


R - Respiratory system

R02 - Throat preparations

R02A - Throat preparations

R02AA - Antiseptics

R02AA14 - Oxyquinoline


5.3 Absorption, Distribution and Excretion

Route of Elimination

Oxyquinoline is excreted in both the primarily in the urine with some in the bile.


IN RATS /MALE, DONRYU STRAIN, IV INJECTION/ 8-HYDROXYQUINOLINE WAS METABOLIZED TO GLUCURONIDE & SULFATE CONJUGATES. MORE 8-HYDROXYQUINOLINE GLUCURONIDE WAS EXCRETED IN URINE THAN 8-HYDROXYQUINOLINE SULFATE CONJUGATE. ONLY THE GLUCURONIDE CONJUGATE WAS EXCRETED IN BILE.

PMID:409509 KIWADA H ET AL; CHEM PHARM BULL 25 (7): 1566-73 (1977)


8-HYDROXYQUINOLINE WAS METABOLIZED TO GLUCURONIDE & SULFATE CONJUGATES AFTER IV ADMIN IN RATS /MALE, DONRYU STRAIN/. THE GLUCURONIDES WERE EXCRETED IN BILE & URINE, BUT THE SULFATES WERE EXCRETED EXCLUSIVELY IN THE URINE. UNMETABOLIZED FORMS WERE ONLY SLIGHTLY EXCRETED.

PMID:96945 SAWADA Y ET AL; CHEM PHARM BULL 26 (5): 1357-63 (1978)


5.4 Metabolism/Metabolites

In the urine, 60% of the dose is excreted as glucuronide conjugates and 23% of the dose as sulfate conjugates. In the bile, 9% of the total dose is found as glucuronide conjugates.


IN RATS /MALE, DONRYU STRAIN, IV INJECTION/ 8-HYDROXYQUINOLINE WAS METABOLIZED TO GLUCURONIDE & SULFATE CONJUGATES.

PMID:409509 KIWADA H ET AL; CHEM PHARM BULL 25 (7): 1566-73 (1977)


8-HYDROXYQUINOLINE WAS METABOLIZED TO GLUCURONIDE & SULFATE CONJUGATES AFTER IV ADMIN IN RATS /MALE, DONRYU STRAIN/. UNMETABOLIZED FORMS WERE ONLY SLIGHTLY EXCRETED.

PMID:96945 SAWADA Y ET AL; CHEM PHARM BULL 26 (5): 1357-63 (1978)


5.5 Mechanism of Action

The mechanism by which oxyquinoline exerts its biocidal effect is unknown.


Flag India
Digital Content Digital Content
URL Supplier Web Content
148-24-3
8 Hydroxyquinoline
Omkrown Pharmachem Pvt Ltd is a private limited company located in Belgaum, India and is engaged in the m...
Omkrown Pharmachem Pvt Ltd is a private limited company located in Belgaum, India and is engaged in the manufacturing of Active Pharmaceutical ingredients and bulk drug intermediates.
The company has been established in 1997 with a vision to establish global presence in bulk drugs, drug intermediates and specialty chemicals.
ASK
US
PHARMACOMPASS
Upload
your Marketing & Sales content
Ask Us for Pharmaceutical Supplier and Partner
Ask Us, Find A Supplier / Partner
No Commissions, No Strings Attached, Get Connected for FREE

What are you looking for?

How can we help you?

The request can't be empty

Please read our Privacy Policy carefully

You must agree to the privacy policy

The name can't be empty
The company can't be empty.
The email can't be empty Please enter a valid email.
The mobile can't be empty
Post Enquiry
POST ENQUIRY