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Pharma Services Category of Siegfried AG

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API Development

Analytical Method Development

Analytical Testing Services

Biologic Drugs

Capsule

Clinical Supply

Container Qualification

Continuous Flow Process

Contract Services

Controlled Substance

Custom Synthesis & Manufacturing

Distillation / Liquid API

Drying

Formulation Development

GMP Manufacturing

Granule / Pellet

Halogenation

Hazardous Chemistry

High Potency APIs (HPAPIs)

High Temperature Reaction (> 200 °C)

Injectable / Parenteral

Low Temperature / Cryogenic conditions

Materials

Micronization

Organometallic Chemistry

Phosgenation

Preformulation & Material Science

Process Development & Optimization

Resolution of Racemic Mixture

Scale Up

Solution

Stability Studies

Tablet

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Siegfried AG

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SWITZERLAND

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Process Optimization

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- Service Details

Siegfried’s chemical expertise centers on the development and production of active pharmaceutical ingredients and intermediates, thus making Siegfried the ideal partner for both cGMP and non-cGMP active pharmaceutical ingredients and intermediates.

- Directory Listing

Pharma Service: API Manufacturing

Category: Process Development & Optimization

Sub Category: Overview

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Development of Customized APIs

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- Service Details

Siegfried’s chemical expertise centers on the development and production of active pharmaceutical ingredients and intermediates, thus making Siegfried the ideal partner for both cGMP and non-cGMP active pharmaceutical ingredients and intermediates.

- Directory Listing

Pharma Service: API & Drug Product Development

Category: API Development

Sub Category: Custom Synthesis

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Development of Customized Intermediates

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Siegfried offers experience and proficiency in the chemical and pharmaceutical industry. Siegfried is the ideal partner for both cGMP and non-cGMP intermediates.

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Pharma Service: API & Drug Product Development

Category: API Development

Sub Category: Fine Chemical / Intermediate

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Production of Customized APIs

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- Service Details

Siegfried’s chemical expertise centers on the development and production of active pharmaceutical ingredients and intermediates, thus making Siegfried the ideal partner for both cGMP and non-cGMP active pharmaceutical ingredients and intermediates.

- Directory Listing

Pharma Service: API Manufacturing

Category: Custom Synthesis & Manufacturing

Sub Category: Overview

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Cryogenic Reactions

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Special technologies and manufacturing processes including full scale cryogenics, phosgenation, hazardous reactions, isolation technology, micro-reactors, and spray drying, and having 800 liters hastelloy C22 reactor for cryogenic reactions, and temperature range -100°C to 250°C.

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Pharma Service: API & Drug Product Development

Category: API Development

Sub Category: Low Temperature / Cryogenic Condition (-78 °C)

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Cryogenic Reactions

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Special technologies and manufacturing processes including full scale cryogenics, phosgenation, hazardous reactions, isolation technology, micro-reactors, and spray drying, and having 800 liters hastelloy C22 reactor for cryogenic reactions, and temperature range -100°C to 250°C.

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Pharma Service: API Manufacturing

Category: Low Temperature / Cryogenic conditions

Sub Category: Overview

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Micro-Reactors

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Special technologies and manufacturing processes including full scale cryogenics, phosgenation, hazardous reactions, isolation technology, micro-reactors, and spray drying

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Pharma Service: API Manufacturing

Category: Continuous Flow Process

Sub Category: Overview

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Spray Drying

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Special technologies and manufacturing processes including full scale cryogenics, phosgenation, hazardous reactions, isolation technology, micro-reactors, and spray drying

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Pharma Service: API Manufacturing

Category: Drying

Sub Category: Overview

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Controlled Substances (Predominantly Opiate B...

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Siegfried offers a combination of experience and proficiency in both the chemical and pharmaceutical segments. Siegfried’s chemical expertise centers on the development and production of active pharmaceutical ingredients and intermediates.

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Pharma Service: API Manufacturing

Category: Controlled Substance

Sub Category: Overview

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cGMP Scale Up

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- Service Details

Siegfried’s chemical expertise centers on the development and production of active pharmaceutical ingredients and intermediates, and help cGMP scale up and clinical trial manufacture in pilot throughout the entire product life cycle.

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Pharma Service: API Manufacturing

Category: Scale Up

Sub Category: Overview

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Ideal Partner for cGMP API & Intermediate Man...

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- Service Details

Compliance is our commitment. Expect more with Siegfried as your preferred partner as we are committed to continuous accountable improvement and quality-centered management of all company processes and activities. The quality policy within Siegfried forms an integral part of our overall company

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Pharma Service: API Manufacturing

Category: GMP Manufacturing

Sub Category: Overview

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Phosgenation Reaction Capabilities

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Siegfried has vast experience with reactions from the various classes including scale-up of reactions to commercial quantities.

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Pharma Service: API Manufacturing

Category: Phosgenation

Sub Category: Overview

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Clinical Trial Manufacture in Pilot Throughou...

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- Service Details

Siegfried’s chemical expertise centers on the development and production of active pharmaceutical ingredients and intermediates, and help cGMP scale up and clinical trial manufacture in pilot throughout the entire product life cycle.

- Directory Listing

Pharma Service: API Manufacturing

Category: Clinical Supply

Sub Category: Overview

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Development of Entirely New Synthetic Routes

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Our talented and innovative development chemists are well experienced either in the development of entirely new synthetic routes or adapting and optimizing an existing process (from Siegfried or our customers).

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Pharma Service: API Manufacturing

Category: Custom Synthesis & Manufacturing

Sub Category: Route Scouting

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Salt Screening

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- Service Details

Siegfried will work closely with you to understand your needs, and will establish the development objectives and scope for process optimization you can expect. Depending on the relevant process status and clinical phase needs.

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Pharma Service: API & Drug Product Development

Category: Preformulation & Material Science

Sub Category: Salt Screening

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Crystallization Program

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- Service Details

Siegfried will work closely with you to understand your needs, and will establish the development objectives and scope for process optimization you can expect. Depending on the relevant process status and clinical phase needs.

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Pharma Service: API & Drug Product Development

Category: API Development

Sub Category: Crystallization Process

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Evaluation of Robust Parameters for Microniza...

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- Service Details

Physical Operations are crucial steps in API Manufacturing which have to be understood and controlled. We at Siegfried understand the importance of physical operation steps like e.g. extraction, distillation, crystallization, filtration or centrifugation and drying technologies.

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Pharma Service: API Manufacturing

Category: Micronization

Sub Category: Overview

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Jet Mill Micronizer

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- Service Details

With Siegfried you are able to profit from a vast knowledge acquired from over 1,600 chemical development projects. Over the last ten years alone, Siegfried’s chemists have commercialized over 50 New Chemical Entities (NCEs) and applied a range of chemistries, having temperature range -100°C

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Pharma Service: API & Drug Product Development

Category: API Development

Sub Category: Micronization

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Kilo Lab & Pilot Plant

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Siegfried has stainless steel, glass-lined and hastelloy C22 reactors (10-1000 liters), 1 segregated chamber for hazardous reactions, stand-alone unit concept : reactor, condenser & receiver, units interconnected & connected to filters, centrifuges or other devices with flexible hoses.

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Pharma Service: API & Drug Product Development

Category: API Development

Sub Category: Scale-Up Capabilities

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Short Path & 15 Theoretical Plates Distillati...

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- Service Details

With Siegfried you are able to profit from a vast knowledge acquired from over 1,600 chemical development projects. Over the last ten years alone, Siegfried’s chemists have commercialized over 50 New Chemical Entities (NCEs) and applied a range of chemistries, having temperature range -100°C

- Directory Listing

Pharma Service: API Manufacturing

Category: Distillation / Liquid API

Sub Category: Overview

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Short Path & 15 Theoretical Plates Distillati...

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- Service Details

With Siegfried you are able to profit from a vast knowledge acquired from over 1,600 chemical development projects. Over the last ten years alone, its have commercialized over 50 New Chemical Entities and applied a range of chemistries, has 15 theoretical plates distillation line.

- Directory Listing

Pharma Service: API & Drug Product Development

Category: API Development

Sub Category: Distillation / Liquid APIs

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High Temperature Range Capabilities -100°C t...

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- Service Details

With Siegfried you are able to profit from a vast knowledge acquired from over 1,600 chemical development projects. Over the last ten years alone, Siegfried’s chemists have commercialized over 50 New Chemical Entities (NCEs) and applied a range of chemistries, having temperature range -100°C

- Directory Listing

Pharma Service: API Manufacturing

Category: High Temperature Reaction (> 200 °C)

Sub Category: Overview

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Synthetic Route Investigation

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- Service Details

Our talented and innovative development chemists are well experienced either in the development of entirely new synthetic routes or adapting and optimizing an existing process (from Siegfried or our customers).

- Directory Listing

Pharma Service: API & Drug Product Development

Category: API Development

Sub Category: Route Evaluation & Development

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Hazardous Reactions

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Special technologies and manufacturing processes including full scale cryogenics, phosgenation, hazardous reactions, isolation technology, micro-reactors, and spray drying, and 1 segregate chamber for hazardous reactions.

- Directory Listing

Pharma Service: API Manufacturing

Category: Hazardous Chemistry

Sub Category: Overview

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Analytical Development

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Modernly equipped, we provide the following range of analytical services to help bring your drug substance development project & cGMP manufacture to fruition:

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Pharma Service: Analytical

Category: Analytical Method Development

Sub Category: Overview

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High Potency Materials

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We offer an extensive range of chemistries & process capabilities at production scale to efficiently manufacture demanding drug substances, intermediates and complex synthetic processes. Among the range of materials produced are controlled substances and high potency materials.

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Pharma Service: API Manufacturing

Category: High Potency APIs (HPAPIs)

Sub Category: Overview

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Process Optimization & Improvement

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- Service Details

Siegfried offers a broad base of know-how in complex oral and sterile formulations of drug products available for custom development and manufacturing (CDMO), and licensing.

- Directory Listing

Pharma Service: API Manufacturing

Category: Process Development & Optimization

Sub Category: Overview

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Pilot Manufacturing and Scale up

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- Service Details

Siegfried can help you save time & accelerate your drug development via our versatile cGMP pilot manufacturing & scale-up capabilities. Our core strength is taking a chemical process from development and scaling it up into a cost-effective & robust manufacturing process.

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Pharma Service: API & Drug Product Development

Category: Formulation Development

Sub Category: Scale-Up Capabilities

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Clinical Trial Manufacturing & Production

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- Service Details

Siegfried offers a broad base of know-how in complex oral and sterile formulations of drug products available for custom development and manufacturing (CDMO), and licensing.

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Pharma Service: API & Drug Product Development

Category: Formulation Development

Sub Category: Clinical Supply

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Complex Sterile Formulation Manufacturing

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- Service Details

Siegfried offers a broad base of know-how in complex oral and sterile formulations of drug products available for custom development and manufacturing (CDMO), and licensing.

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Pharma Service: API & Drug Product Development

Category: Formulation Development

Sub Category: Sterile Liquid Formulation

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Complex Sterile Formulation Manufacturing

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Siegfried offers a broad base of know-how in complex oral and sterile formulations of drug products available for custom development and manufacturing (CDMO), and licensing.

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Pharma Service: Drug Product Manufacturing

Category: Injectable / Parenteral

Sub Category: Overview

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Development of Tablet Formulations

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Siegfried is your expert in complex oral drug delivery systems with the most advanced development, manufacturing and packaging capabilities in the CDMO industry installed in state of the art facilities located in Zofingen (Switzerland) and Hal Far (Malta).

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Pharma Service: API & Drug Product Development

Category: Formulation Development

Sub Category: Tablet

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Tablet Manufacturing

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- Service Details

Siegfried is your expert in complex oral drug delivery systems with the most advanced development, manufacturing and packaging capabilities in the CDMO industry installed in state of the art facilities located in Zofingen (Switzerland) and Hal Far (Malta).

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Pharma Service: Drug Product Manufacturing

Category: Tablet

Sub Category: Overview

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Development of Capsule Formulations

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Siegfried is your expert in complex oral drug delivery systems with the most advanced development, manufacturing and packaging capabilities in the CDMO industry installed in state of the art facilities located in Zofingen (Switzerland) and Hal Far (Malta).

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Pharma Service: API & Drug Product Development

Category: Formulation Development

Sub Category: Capsule

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Capsule Manufacturing

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- Service Details

Siegfried is your expert in complex oral drug delivery systems with the most advanced development, manufacturing and packaging capabilities in the CDMO industry installed in state of the art facilities located in Zofingen (Switzerland) and Hal Far (Malta).

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Pharma Service: Drug Product Manufacturing

Category: Capsule

Sub Category: Overview

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Metal-Organic Reactions

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Siegfried has vast experience with reactions from the following classes including scale-up of those reactions to commercial quantities, e.g. Boronic acids, Cyro reactions down up to -100°C, Grignard reaction, Lithium-Halogen exchange, Ortho-Lithiation, Reformatsky reaction, Organozinc reaction.

- Directory Listing

Pharma Service: API Manufacturing

Category: Organometallic Chemistry

Sub Category: Overview

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Development of Analytical Methods

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- Service Details

Our analytical departments support the whole product lifecycle of drug substances and drug products with scientific competence and an extensive instrument pool. Optimization of existing analytical methods to improve robustness or efficiency.

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Pharma Service: Analytical

Category: Analytical Method Development

Sub Category: Overview

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500 Method Validations in Accordance with ICH...

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- Service Details

Our analytical departments support the whole product lifecycle of drug substances and drug products with scientific competence and an extensive instrument pool. Validation, verification and Transfer of analytical methods.

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Pharma Service: Analytical

Category: Analytical Method Development

Sub Category: Method Development and Validation

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Stability Studies

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Stability studies for drug substances and drug products according to ICH requirements; performed in our own qualified stability chambers, compatibility studies of binary or complex mixtures of API(s) with excipient(s) performed to Support early development phases.

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Pharma Service: Analytical

Category: Stability Studies

Sub Category: Overview

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Cleaning Validations

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- Service Details

Our analytical departments support the whole product lifecycle of drug substances and drug products with scientific competence and an extensive instrument pool.

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Pharma Service: Analytical

Category: Analytical Testing Services

Sub Category: Chromatography (TLC / LC / HPLC / UPLC / GC)

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Technology Transfer

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Based on more than 30 years of experience and application with an extensive range and type of products, we help in scale-up and technology transfer to the commercial site.

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Pharma Service: API & Drug Product Development

Category: Formulation Development

Sub Category: Tech Transfer

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Excipients Compatibility

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Based on more than 30 years of experience and application with an extensive range and type of products, our customers gain more knowledge, Innovation and technological expertise through the following services: API characterization and excipients compatibility

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Pharma Service: API & Drug Product Development

Category: Preformulation & Material Science

Sub Category: Excipient Screening

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API Characterization

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Based on more than 30 years of experience and application with an extensive range and type of products, our customers gain more knowledge, Innovation and technological expertise through the following services: API characterization and excipients compatibility

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Pharma Service: API & Drug Product Development

Category: Preformulation & Material Science

Sub Category: API Screening

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Pre-Formulation for Early Safety Studies

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Based on more than 30 years of experience and application with an extensive range and type of products, our customers gain more knowledge, Innovation and technological expertise through the following services: pre-formulation for early safety studies.

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Pharma Service: API & Drug Product Development

Category: Preformulation & Material Science

Sub Category: Overview

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Packaging Screening for Up-Front Stability

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Based on more than 30 years of experience and application with an extensive range and type of products, our customers gain more knowledge, Innovation and technological expertise through the following services: Packaging screening for up-front stability.

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Pharma Service: Analytical

Category: Container Qualification

Sub Category: Testing Services

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Oral Disintegrating Tablet

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- Service Details

Our state-of-the-art equipment and development department offers a wide range of the following technologies for tablet compression (IR, SR, Oral Disintegrating Tablets, minitablets).

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Pharma Service: Drug Product Manufacturing

Category: Tablet

Sub Category: Fast Disintegrating

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Mini-Tablet

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- Service Details

Our state-of-the-art equipment and development department offers a wide range of the following technologies for tablet compression (IR, SR, Oral Disintegrating Tablets, minitablets).

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Pharma Service: Drug Product Manufacturing

Category: Tablet

Sub Category: Overview

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Chewable Tablet

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- Service Details

Our state-of-the-art equipment and development department offers a wide range of the following technologies for tablet compression (IR, SR, Oral Disintegrating Tablets, minitablets).

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Pharma Service: Drug Product Manufacturing

Category: Tablet

Sub Category: Chewable / Suckable

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Sustained Release Tablet

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Our state-of-the-art equipment and development department offers a wide range of the following technologies for tablet compression (IR, SR, Oral Disintegrating Tablets, minitablets).

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Pharma Service: Drug Product Manufacturing

Category: Tablet

Sub Category: Sustained Release

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Coated Granules for Sustained Release

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Siegfried is a trendsetter in the CMO industry, offering a broad range of various in-house techniques for the development & manufacturing, ranging from rapid-release tablets to controlled-release formulations, specializing in pellet & granule coating.

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Pharma Service: Drug Product Manufacturing

Category: Granule / Pellet

Sub Category: Modified Release

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Coated Pellets for Sustained Release

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Siegfried is a trendsetter in the CMO industry, offering a broad range of various in-house techniques for the development & manufacturing, ranging from rapid-release tablet formulations, specializing in pellet extrusion and spheronisation (CR, DR, SR).

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Pharma Service: Drug Product Manufacturing

Category: Granule / Pellet

Sub Category: Modified Release

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Film Coated Tablet

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Our state-of-the-art equipment and development department offers a wide range of the following technologies for coating (granules, pellets, tablets, IR, DR, SF).

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Pharma Service: Drug Product Manufacturing

Category: Tablet

Sub Category: Coated

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Hard Gelatin Capsule

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- Service Details

Our state-of-the-art equipment and development department offers a wide range of the following technologies hard gelatin capsule filling (granules, powder, pellets).

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Pharma Service: Drug Product Manufacturing

Category: Capsule

Sub Category: Hard Capsule

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Injection Preparations in Ampoules & Vials

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- Service Details

Our state-of-the-art equipment and development department offers a wide range of the following technologies, and we also offer development of other administration forms (e.g., injection preparations, eye drops, etc.) under non-GMP conditions.

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Pharma Service: Drug Product Manufacturing

Category: Injectable / Parenteral

Sub Category: Overview

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Eye Drops

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- Service Details

Our state-of-the-art equipment and development department offers a wide range of the following technologies, and we also offer development of other administration forms (e.g., injection preparations, eye drops, etc.) under non-GMP conditions.

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Pharma Service: Drug Product Manufacturing

Category: Solution

Sub Category: Ophthalmic

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High Containment Facilities And Capabilities

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- Service Details

The increasing trend seen for active pharmaceutical ingredients (API) currently under worldwide development is towards ever higher potency levels and pharmacological activity. Such increased compound potency involves, however, associated potential occupational health hazards.

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Pharma Service: API Manufacturing

Category: High Potency APIs (HPAPIs)

Sub Category: Overview

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Pre-Filled Syringes

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- Service Details

In the critical field of sterile manufacturing where quality is at the highest standard in our industry, Siegfried is your expert in simple and complex formulations at our state-of-the-art facilities located in Hameln (Germany) and Irvine (USA).

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Pharma Service: Drug Product Manufacturing

Category: Injectable / Parenteral

Sub Category: Pre-Filled Syringe

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Powder For Injection

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- Service Details

In the critical field of sterile manufacturing where quality is at the highest standard in our industry, Siegfried is your expert in simple and complex formulations at our state-of-the-art facilities located in Hameln (Germany) and Irvine (USA).

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Pharma Service: Drug Product Manufacturing

Category: Injectable / Parenteral

Sub Category: Overview

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Injectable Preparations of Small Molecules

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Siegfried offers a broad base of know-how in complex oral and sterile formulations of drug products available for custom development and manufacturing (CDMO), and licensing.

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Pharma Service: Drug Product Manufacturing

Category: Injectable / Parenteral

Sub Category: Overview

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Injectable Preparations of Biological Product...

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- Service Details

Siegfried offers a broad base of know-how in complex oral and sterile formulations of drug products available for custom development and manufacturing (CDMO), and licensing.

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Pharma Service: Drug Product Manufacturing

Category: Biologic Drugs

Sub Category: Overview

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Chiral Resolutions

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- Service Details

Siegfried has vast experience with reactions from the various classes including scale-up of reactions to commercial quantities.

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Pharma Service: API Manufacturing

Category: Resolution of Racemic Mixture

Sub Category: Overview

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Chiral Catalysis

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- Service Details

Siegfried has vast experience with reactions from the various classes including scale-up of reactions to commercial quantities.

- Directory Listing

Pharma Service: API Manufacturing

Category: Resolution of Racemic Mixture

Sub Category: Overview

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Halogenation Reactions

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- Service Details

Siegfried has vast experience with reactions from the various classes including scale-up of reactions to commercial quantities.

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Pharma Service: API Manufacturing

Category: Halogenation

Sub Category: Overview

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Injectable Preparations of Proteins

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- Service Details

Siegfried offers a broad base of know-how in complex oral and sterile formulations of drug products available for custom development and manufacturing (CDMO), and licensing.

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Pharma Service: Drug Product Manufacturing

Category: Biologic Drugs

Sub Category: Protein / Peptide

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Injectable Preparations of Antibodies

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- Service Details

Siegfried offers a broad base of know-how in complex oral and sterile formulations of drug products available for custom development and manufacturing (CDMO), and licensing.

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Pharma Service: Drug Product Manufacturing

Category: Biologic Drugs

Sub Category: Monoclonal Antibody

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Injectable Preparations of Oligonucleotides

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- Service Details

Siegfried offers a broad base of know-how in complex oral and sterile formulations of drug products available for custom development and manufacturing (CDMO), and licensing.

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Pharma Service: Drug Product Manufacturing

Category: Biologic Drugs

Sub Category: Overview

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Purity Profiles & Impurity Tracking

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- Service Details

Siegfried recognizes and understands the importance of requisite analytical parameters & controls, as they are vital for ensuring effective and robust processes.

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Pharma Service: Analytical

Category: Analytical Method Development

Sub Category: Impurity Isolation and Identification

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Genotoxic Contamination

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- Service Details

Siegfried recognizes and understands the importance of requisite analytical parameters & controls, as they are vital for ensuring effective and robust processes.

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Pharma Service: Analytical

Category: Analytical Method Development

Sub Category: Impurity Isolation and Identification

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Heavy Metal Determination

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Siegfried recognizes and understands the importance of requisite analytical parameters & controls, as they are vital for ensuring effective and robust processes.

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Pharma Service: Analytical

Category: Analytical Testing Services

Sub Category: Trace / Elemental / Heavy Metals

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Ampoules

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Our award-winning new facility can produce sterile liquid vials and ampoules, manufactured under aseptic conditions on eight automated RABs protected filling lines, to terminally sterilize them, if needed.

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Pharma Service: Packaging

Category: Contract Services

Sub Category: Ampoule

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- Service Details

Our award-winning new facility can produce sterile liquid vials and ampoules, manufactured under aseptic conditions on eight automated RABs protected filling lines, to terminally sterilize them, if needed.

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Pharma Service: Packaging

Category: Contract Services

Sub Category: Vial

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Cartridges

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With Siegfried's Hameln state-of-the-art facility in Germany, we provide our customers with more capabilities and capacity in the critical field of the parenterals manufacturing, visual inspection and packaging.

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Pharma Service: Packaging

Category: Contract Services

Sub Category: Cartridge

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Squeeze tubes

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With Siegfried's Hameln state-of-the-art facility in Germany, we provide our customers with more capabilities and capacity in the critical field of the parenterals manufacturing, visual inspection and packaging.

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Pharma Service: Packaging

Category: Contract Services

Sub Category: Tube

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Screw Cap Bottles

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With Siegfried's Hameln state-of-the-art facility in Germany, we provide our customers with more capabilities and capacity in the critical field of the parenterals manufacturing, visual inspection and packaging.

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Pharma Service: Packaging

Category: Contract Services

Sub Category: Bottle

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Pre-Filled Syringes (PFS)

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With Siegfried's Hameln state-of-the-art facility in Germany, we provide our customers with more capabilities and capacity in the critical field of the parenterals manufacturing, visual inspection and packaging.

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Pharma Service: Packaging

Category: Contract Services

Sub Category: Pre-Filled Syringe

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Dropper Tip Bottles

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- Service Details

With Siegfried's Hameln state-of-the-art facility in Germany, we provide our customers with more capabilities and capacity in the critical field of the parenterals manufacturing, visual inspection and packaging.

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Pharma Service: Packaging

Category: Materials

Sub Category: Dropper

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Syringes

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- Service Details

With Siegfried's Hameln state-of-the-art facility in Germany, we provide our customers with more capabilities and capacity in the critical field of the parenterals manufacturing, visual inspection and packaging.

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Pharma Service: Packaging

Category: Materials

Sub Category: Syringe & Needle

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cGMP API Spray Drying

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- Service Details

Siegfried offers large-scale contract cGMP spray drying with a pilot spray dryer, which is suitable for use with flammable solvents & can operate with hazardous air pollutant solvents. The API spray drying facilities are closed looped with nitrogen.

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Pharma Service: API Manufacturing

Category: Drying

Sub Category: Spray Drying

Pharma Services Category of Siegfried AG

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