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Bentonite

Synopsis, Chemistry

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2 NDC API

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Also known as: Benclay, Bentolite l, Bentone 34, Aquagel, Askangel, Magbond

Molecular Formula

Al₂H₂O₆Si

Molecular Weight

180.06 g/mol

InChI Key

SVPXDRXYRYOSEX-UHFFFAOYSA-N

Bentoquatam is a topical medication intended to act as a shield against exposure to the irritating substance urushiol, found in plants such as poison ivy or poison oak. Bentoquatam contains bentonite, a clay, and is only effective as long as the film is visible on the skin.

1 2D Structure

Bentonite

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

dioxosilane;oxo(oxoalumanyloxy)alumane;hydrate

2.1.2 InChI

InChI=1S/2Al.O2Si.H2O.3O/c;;1-3-2;;;;/h;;;1H2;;;

2.1.3 InChI Key

SVPXDRXYRYOSEX-UHFFFAOYSA-N

2.1.4 Canonical SMILES

O.O=[Al]O[Al]=O.O=[Si]=O

2.2 Synonyms

2.2.1 MeSH Synonyms

1. Bentone 34

2. Dimethyldioctadecylammonium Montmorillonite

3. Ivy Block

4. Quaternium 18-bentonite

2.2.2 Depositor-Supplied Synonyms

1. Benclay

2. Bentolite L

3. Bentone 34

4. Aquagel

5. Askangel

6. Magbond

7. Otaylite

8. Tixoton

9. Volclay

10. Wilkinite

11. Bengel

12. Culvin

13. Filgel

14. Akajo

15. Asama

16. Bentogrout

17. Soap Clay

18. Bentonit T

19. Bentolite Hs

20. Bulgarben Ba

21. Accugel F

22. Altonit Sf

23. Bengel A

24. Bengel Fw

25. Southern Bentonite

26. Bengel Hvp

27. Bentosolon 82

28. Aquagel Gold Seal

29. Detercal G 1fc

30. Detercal G 2fc

31. Detercol P 2

32. Bentone 27

33. Accofloc 352

34. Cosintam 403

35. Hi-jel

36. Bengel 11

37. Bengel 15

38. Bengel 23

39. Bentonite 2073

40. Bentone 660

41. Cvis

42. Fulbent 570

43. Volcaly Bentonite Bc

44. Aluminosilicate Hydrate

45. Imvite I.g.b.a

46. Bentonite [jan:nf]

47. Bentonite, Sodium Form

48. Panther Creek Bentonite

49. Clarit Bw 100

50. Clarit Bw 125

51. Black Hills Bh 200

52. Bentonite, Calcian-sodian

53. Unii-a3n5zcn45c

54. G 100 (clay)

55. Ex 0030 (clay)

56. Albagel Premium Usp 4444

57. Ccris 3663

58. Hsdb 392

59. Gk 129sa3

60. Gk 129sa5

61. Aeg 325

62. Ex-m 703

63. Einecs 215-108-5

64. Mfcd00130611

65. Ex 0276

66. 250m

67. Dioxosilane;oxo(oxoalumanyloxy)alumane;hydrate

68. Q20817027

2.3 Create Date

2005-03-27

3 Chemical and Physical Properties

Molecular Formula	Al₂H₂O₆Si
Molecular Weight	180.06 g/mol
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	0
Exact Mass	179.925141 g/mol
Monoisotopic Mass	179.925141 g/mol
Topological Polar Surface Area	78.5 Å²
Heavy Atom Count	9
Formal Charge	0
Complexity	52.4
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	3

4 Drug and Medication Information

4.1 Drug Information

1 of 2
Drug Name	Ivy block
Active Ingredient	Bentoquatam
Dosage Form	Lotion
Route	Topical
Strength	5%
Market Status	Over the Counter
Company	Stand Homeopath

2 of 2
Drug Name	Ivy block
Active Ingredient	Bentoquatam
Dosage Form	Lotion
Route	Topical
Strength	5%
Market Status	Over the Counter
Company	Stand Homeopath

4.2 Drug Indication

Used to prevent or reduce the severity of allergic contact dermatitis due to urushiol, the allergenic resin of poison ivy, poison oak, and poison sumac.

5 Pharmacology and Biochemistry

5.1 Pharmacology

Bentoquatam protects the skin like a shield against poison ivy, poison oak, and poison sumac by physically blocking skin contact with their resin. The best protection against getting these conditions is to avoid contact with these plants. This medicine does not dry oozing and weeping caused by the rash of poison ivy, poison oak, or poison sumac.

5.2 MeSH Pharmacological Classification

Dermatologic Agents

Drugs used to treat or prevent skin disorders or for the routine care of skin. (See all compounds classified as Dermatologic Agents.)

5.3 Mechanism of Action

The mechanism of action is unknown. It is thought topically applied bentoquatam acts as a physical barrier that interferes with the adsorption of antigens onto the skin and reduces absorption of antigens into the skin. It probably does not work by modifying the systemic allergic response.